... can trigger the endocytosis of the signalling complex, which is followed either by the recycling of the receptor or degradation of the complex in the lysosome [ 35 ]. The extent of Wnt signalling in cells is regulated by receptor degradation mediated by a network of E3 Ubiquitin ligases and regulatory...

... signalling pathway. In a recent paper published in the Biochemical Journal [ Biochem. J. (2019) 476 , 535–546], Wang and colleagues revealed that niclosamide down-regulates β-catenin-dependent WNT signalling in colorectal cancer cells by degrading components of the pathway via autophagy. Autophagy...

... © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 intestinal epithelial homoeostasis mRNA stability non-coding RNAs translation Wnt signalling In response to stressful environmental conditions, post-transcriptional regulation...

... during animal development; in the adult nervous system it regulates the structure and function of synapses. Wnt-signalling dysfunction is associated with several neurodegenerative diseases such as schizophrenia and Alzheimer's disease. The use of natural compounds is an interesting strategy in the search...

... © The Authors Journal compilation © 2014 Biochemical Society 2014 cell migration contact inhibition of locomotion neural crest cell planar cell polarity Wnt signalling The neural crest is a transient embryonic cell population that originates at the border of the future central...

...Andrea Venerando; Cristina Girardi; Maria Ruzzene; Lorenzo A. Pinna It has been reported that pyrvinium pamoate (PyrPam), an FDA (U.S. Food and Drug Administration)-approved anthelminthic drug, is a potent inhibitor of Wnt signalling by a mechanism which implies the direct activation of protein...

... 2011 3 5 2011 10 5 2011 10 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 cardiac differentiation cardiomyogenesis embryonal carcinoma cell embryonic stem cell Wnt signalling CL6G52 cells were plated at 1 × 10 4 cells/well in 400 μl...

... sclerostin systematic evolution of ligands by exponential enrichment (SELEX) Wnt signalling Sclerostin is an extracellular protein secreted by osteocytes that acts to negatively regulate bone formation [ 1 , 2 ]. Loss-of-function mutations in the gene coding for sclerostin, SOST , result...

... pathways to provide the fuel and basic components for new cells. Ultimately, the successful co-ordination of cell-specific biology with cellular metabolism underscores multicellular processes as diverse as embryonic development, adult tissue remodelling and cancer cell biology. The Wnt signalling network...

... compilation © 2009 Biochemical Society 2009 cAMP-responsive-element-binding protein (CREB)-binding protein (CBP) colorectal cancer histone acetylation Pygopus transcription Wnt signalling The canonical Wnt/Wg (wingless) signal transduction pathway is required for embryonic development...

... of an important link between cellular glucose sensing and the Wnt/β-catenin signalling pathway in macrophages. Their data strongly indicate that the Wnt/β-catenin pathway of Wnt signalling is responsive to physiological concentrations of nutrients but also suggests that that this system could be inappropriately...

... carcinogenesis glucuronic acid (GlcA) heparan sulphate iduronic acid Wnt signalling Heparan sulphate (HS) is a negatively charged polysaccharide present at the cell surface and is required for the biological activity of circulating soluble and insoluble extracellular ligands [ 1 ]. HS is required...

...Thilo HAGEN; Jaswinder K. SETHI; Neale FOXWELL; Antonio VIDAL-PUIG β-Catenin plays a dual role as an adhesion molecule in adherens junctions at the plasma membrane and as a key intermediate in the canonical Wnt signalling pathway. The cytosolic soluble pool of β-catenin, involved...

... ). 21 9 1998 26 10 1998 4 11 1998 The Biochemical Society, London © 1999 1999 Notch signalling TUP1 transcriptional repression Wnt signalling Biochem. J. (1999) 337, 13 17 (Printed in Great Britain) 13 RESEARCH COMMUNICATION Groucho/transducin-like Enhancer of split (TLE...