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Keywords: X-ray crystallography
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Biochem J (2025) BCJ20240739.
Published: 26 June 2025
... crystallography molecular dynamics Influenza B virus HLA-B*18:01 CD8+ T cells X-ray crystallography molecular dynamics Influenza B virus HLA-B*18:01 CD8+ T cells X-ray crystallography molecular dynamics La Trobe University (LTU) La Trobe University RTP Scholarship Australian Institute...
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Biochem J (2021) 478 (5): 1117–1136.
Published: 10 March 2021
... in different stages of the life cycle of the parasite. To gain further insight into its biological activity, we solved the structure of N-terminal histone chaperone domain of PfAsf1 (1–159 amino acids) by X-ray crystallography to a resolution of 2.4 Å. The structure is composed of two beta-sheet to form a beta...
Includes: Supplementary data
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Biochem J (2020) 477 (24): 4769–4783.
Published: 24 December 2020
... crystallography curvature endocytosis heterodimer APPL1 APPL2 curvature endocytosis heterodimerization structure x-ray crystallography In response to extracellular stimuli, signaling transduction usually elicits endocytosis and intracellular trafficking of plasma membrane receptors, which...
Includes: Supplementary data
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Biochem J (2020) 477 (19): 3833–3838.
Published: 12 October 2020
... 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 glutamine methylation HEMK2 SAM/SAH TRMT112 x-ray crystallography Post-translational modifications of proteins, including phosphorylation, acetylation, and methylation...
Includes: Supplementary data
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Biochem J (2019) 476 (6): 975–989.
Published: 22 March 2019
... on behalf of the Biochemical Society 2019 encapsulated ferritin encapsulin ferritin mass spectrometry X-ray crystallography The encapsulin protein family is structurally related to the HK97 bacteriophage shell protein and they form icosahedral nanocages of between 25 and 35 nm in diameter...
Includes: Supplementary data
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Biochem J (2018) 475 (14): 2257–2269.
Published: 25 July 2018
... simulation phosphatidylinositol 4 5-bisphosphate phosphatidylinositol 4-phosphate 5-kinase X-ray crystallography zPIP5Kα (GenBank: AAH95318.1) and the mutant proteins were prepared as reported previously [ 14 ]. In brief, the plasmid of pET41b harboring the codon-optimized gene of zPIP5Kα (kinase...
Includes: Supplementary data
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Biochem J (2017) 474 (4): 539–556.
Published: 03 February 2017
.... This would explain how an apparently low affinity for inositol phosphates can be biologically relevant to the localisation of kindlins to the plasma membrane and their subsequent activation of integrins. lipid clustering molecular dynamics PH domain surface plasmon resonance X-ray crystallography...
Includes: Supplementary data
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Biochem J (2016) 473 (14): 2023–2032.
Published: 12 July 2016
... metalloenzyme X-ray crystallography The carbonic anhydrases (CAs, EC 4.2.1.1) belong to a superfamily of metalloenzymes which use as substrates some unusually chemically simple molecules/ions, as they catalyse the interconversion between CO 2 and bicarbonate [ 1 – 13 ]. Although this reaction may...
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Biochem J (2016) 473 (11): 1593–1604.
Published: 27 May 2016
... transforming growth factor-β (TGF-β) X-ray crystallography Gremlin-1 is an extracellular antagonist of the bone morphogenetic proteins (BMPs) and functions by directly neutralizing its ligands and inhibiting BMP signalling [ 1 – 4 ]. BMPs, together with their antagonists, are responsible...
Includes: Supplementary data
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Biochem J (2016) 473 (1): 55–66.
Published: 09 December 2015
... states of Cys 105 were determined by MS and native PAGE. chaperone cysteine DJ-1 superfamily oxidation SAV1875 Staphylococcus aureus X-ray crystallography Staphylococcus aureus is one of the most common pathogens, causing various diseases ranging from mild infections...
Includes: Supplementary data
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Biochem J (2015) 468 (2): 245–257.
Published: 22 May 2015
... calorimetry nuclear magnetic resonance spectroscopy X-ray crystallography We solved the structures of β1- and β2-carbohydrate-binding modules (CBMs) of AMP-activated protein kinase (AMPK) bound to a branched carbohydrate. The additional threonine within the β2-module allows it to bind single α1,6...
Includes: Supplementary data
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Biochem J (2015) 468 (1): 159–166.
Published: 05 May 2015
... fragment of any Notch ligand structure to date. Comparison with the Jagged1 structures reveals similarities and differences between the ligand families and potential receptor binding sites. cell signalling cell surface protein C2 domain epidermal growth factor (EGF)-like repeat Notch X-ray...
Includes: Supplementary data
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Biochem J (2014) 464 (3): 387–399.
Published: 05 December 2014
... belongs to a novel family of flavoproteins which catalyses the condensation of two aminoacetone molecules yielding 3,6-dimethyl-2,5-dihydropyrazine and, eventually, 2,5-dimethylpyrazine. aminoacetone 2   5-dimethylpyrazine enzyme structure flavoprotein X-ray crystallography Streptococci...
Includes: Supplementary data
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Biochem J (2014) 463 (3): 405–412.
Published: 10 October 2014
... the same 2-oxoacid decarboxylations. archaea macromolecular assembly multienzyme complex 2-oxoacid dehydrogenase thermophile X-ray crystallography Using the Stratagene QuikChange® site-directed mutagenesis protocol, the five C-terminal amino acids of the T. acidophilum E2 were...
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Biochem J (2014) 462 (3): 415–424.
Published: 22 August 2014
... mechanism MD simulation Salmonella typhi X-ray crystallography The disruption of the bacterial growth cycle by preventing the synthesis and assembly of key components involved in bacterial processes has proven to be a successful strategy for the development of novel antibacterial drugs [ 1 – 3...
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Biochem J (2014) 461 (2): 335–345.
Published: 26 June 2014
... differential scanning fluorimetry (DSF) glycoside hydrolyase X-ray crystallography Chitosan is a polycationic saccharide and previous studies have demonstrated that the chito-oligomer derived from chitosan has a variety of bioactivities, including antimicrobial [ 1 ], antioxidant [ 2 ] and inhibition...
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Biochem J (2013) 454 (3): 491–499.
Published: 29 August 2013
...-ray crystallography Water flow across cellular membranes is a fundamental process of all living cells and is mediated by a highly conserved family of integral membrane proteins known as AQPs (aquaporins). AQPs are tetramers with each protomer functioning as an individual channel, consisting...
Includes: Supplementary data
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Biochem J (2013) 454 (3): 459–466.
Published: 29 August 2013
... protein light chain 3 beta (LC3) NMR spectroscopy optineurin protein–protein interaction selective autophagy X-ray crystallography For GST pull downs using cell lysates HEK (human embryonic kidney)-293T cells were transfected with expression constructs encoding the protein of interest using...
Includes: Supplementary data
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Biochem J (2013) 451 (2): e1–e3.
Published: 28 March 2013
...- and IL-13-mediated inflammatory responses to generate a novel antibody to the third ectodomain (D3) of IL-13Rα1 (IL-13 receptor α1), which forms a requisite binding site for both interleukins. This antibody potently neutralizes both IL-4 and IL-13 activities in vitro . Using X-ray crystallography...
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Biochem J (2013) 449 (2): 415–425.
Published: 14 December 2012
... the active sites of E1, E2 and E3. In the GCS, LA is attached to a lysine of the H protein that is structurally homologous with E2lipD. binding-induced folding lipoate protein ligase lipoyl domain NMR spectroscopy protein–protein interaction X-ray crystallography In Escherichia coli , E2lipD...
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Biochem J (2012) 448 (3): 417–423.
Published: 21 November 2012
... ). cancer epidermal growth factor receptor (EGFR) erlotinib gefitinib inhibitor molecular dynamics receptor tyrosine kinase (RTK) X-ray crystallography Activating mutations in the EGFR (epidermal growth factor receptor) are now well accepted as oncogenic drivers in such cancers as NSCLC (non...
Includes: Supplementary data
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Biochem J (2012) 448 (2): 213–220.
Published: 07 November 2012
... the original work is properly cited. autoinhibition insulin receptor kinase receptor tyrosine kinase (RTK) receptor tyrosine kinase-like orphan receptor 2 (Ror2) tropomyosin receptor kinase A (TrkA) X-ray crystallography Recent clinical success with targeted inhibitors of the kinases EGFR...
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Biochem J (2012) 448 (1): 55–65.
Published: 18 October 2012
... and identifies potential sites through which Rpn12 might form protein–protein interactions. We demonstrate that mutating residues at one of these sites impairs Rpn12 binding to Rpn10 in vitro and reduces Rpn10 incorporation into proteasomes in vivo. PCI domain proteasome ubiquitin X-ray crystallography...
Includes: Supplementary data
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Biochem J (2012) 447 (3): 335–351.
Published: 05 October 2012
... 2012 calcium-binding domain structure enzyme activation inhibitor complex proteinase proteolysis X-ray crystallography The present review will focus on insights about calpains and their functioning that have largely been derived from recombinant protein approaches, calpain crystal...
Includes: Multimedia, Supplementary data
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Biochem J (2012) 446 (1): 149–157.
Published: 27 July 2012
...-driven pathologies, and consequently inhibition of enzymatic activity has been considered as a therapeutic strategy for allergic inflammation and asthma [ 8 – 10 ]. chitinase chitinase-like proteins glycan glycan array glycobiology protein structure lectin X-ray crystallography Along...
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Biochem J (2011) 437 (3): 413–422.
Published: 13 July 2011
... isomerase activity and are inhibited by drugs including rapamycin and tacrolimus. We determined the structure of the Mip homologue [BpML1 ( Burkholderia pseudomallei Mip-like protein 1)] from the human pathogen and biowarfare threat B. pseudomallei by NMR and X-ray crystallography. The crystal structure...
Includes: Supplementary data
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Biochem J (2010) 428 (1): 67–74.
Published: 28 April 2010
... comprises two homologous domains, the differing substrate preferences of which present a new avenue for domain-selective inhibitor design. We have co-crystallized lisW-S, a C-domain-selective derivative of the drug lisinopril, with human testis ACE and determined a structure using X-ray crystallography...
Includes: Supplementary data
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Biochem J (2010) 425 (3): 513–522.
Published: 15 January 2010
... identifying surfaces that could be targeted with drug-like molecules to block the protein function. Chagas disease enzyme mechanism NMR spectroscopy peroxidase X-ray crystallography Structure refinement was carried out using the maximum-likelihood restrained method with simple scaling...
Includes: Supplementary data
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Biochem J (2009) 421 (1): 87–96.
Published: 12 June 2009
...-Hydroxyecdysone is the activated form of ecdysone and has been shown to be critical for the maturation of the arylphorin receptor in vivo and in vitro [ 19 ]. arylphorin ecdysone glycosylation protein stability protein structure X-ray crystallography Glycosylation is an important cellular...
Includes: Supplementary data
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Biochem J (2008) 414 (1): 81–91.
Published: 29 July 2008
...–disulfide oxidoreductase (TDOR) thioredoxin-like protein X-ray crystallography Thiol–disulfide oxidoreductases (TDORs) occur in most cell types, where they function in the control of the redox state of cysteine-residue side chains. Many TDORs are structurally highly related and contain the active...
Includes: Supplementary data
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Biochem J (2008) 411 (1): 181–190.
Published: 13 March 2008
... (glutaminyl-peptide cyclotransferase QC) pyroglutamate (pGlu) hydrogen-bond network proton transfer site-directed mutagenesis synchrotron X-ray crystallography QCs (glutaminyl cyclases; glutaminyl-peptide cyclotransferases, EC 2.3.2.5) catalyse the conversion of protein N-terminal glutamine...
Includes: Supplementary data
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Biochem J (2006) 399 (3): 427–434.
Published: 13 October 2006
... transforming growth factor-β-activated kinase 1-binding protein 1 (TAB1) transforming growth factor-β-activated kinase 1 (TAK1) pro-inflammatory cytokine X-ray crystallography TAK1 (transforming growth factor-β-activated kinase 1) is activated when cells are stimulated with bacterial LPS...
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Biochem J (2006) 399 (2): 199–204.
Published: 27 September 2006
... Society, London 2006 angiogenesis human thymidine phosphorylase product inhibition pyrimidine nucleoside phosphorylase structure X-ray crystallography HTP (human thymidine phosphorylase; EC 2.4.2.4) belongs to the PYNP (pyrimidine nucleoside phosphorylase) family and catalyses...