... 30 9 2020 1 10 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 antibiotic resistance HigBA protein–DNA protein–protein interactions toxin–antitoxin X-ray structure Toxin–antitoxin (TA) systems are pairs of genes...

... Commons Attribution License 4.0 (CC BY-NC-ND) . GCN2 kinase x-ray structure GCN2, general control nonderepressible 2 kinase, is one of four known vertebrate kinases — GCN2, PERK, PKR, and HRI — that respond to cellular stress by deactivating the eukaryotic initiation factor 2 alpha (eIF2α...

... interactions rational protein engineering receptor tyrosine kinases X-ray structure Recombinant protein ligands and receptors have shown great promise as biotherapeutics [ 1 , 2 ], with more and more drugs of this type being approved for clinical use. Modified ligands or receptors with altered...

... The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 carbohydrate-binding domain Clostridium perfringens protein–glycan interactions sialic acid X-ray structure Sialic acids are the most abundant terminal carbohydrate residues present...

... and identifies a promising mesotrypsin inhibitor as a starting point for the development of anticancer protein therapeutics. cancer therapy directed evolution enzyme inhibition mesotrypsin protease inhibitor protein engineering proteolysis X-ray structure The human serine protease...

... 2016 © 2016 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2016 acetylcholinesterase butyrylcholinesterase 6-methyluracil molecular modelling slow-binding inhibition X-ray structure MG (myasthenia gravis) is a chronic autoimmune...

... or [email protected] ). 12 2 2015 27 5 2015 1 6 2015 10 6 2015 © 2015 Authors; published by Portland Press Limited 2015 We have determined the X-ray structure of a new monocopper oxidase, GlxA, and shown it be important for glycan deposition at the hyphal tip...

...%. conformational dynamics FK506-binding protein 12 (FKBP12) linebroadening analysis NMR slow exchange X-ray structure The peptide prolyl isomerase FKBP12 (FK506-binding protein 12) was initially characterized for its role in binding the immunosuppressants FK506 and rapamycin. The ternary complex...

... and closed conformations and probe the reaction mechanism through the binding of transition state mimics. We confirm that the nucleophilic attack occurs on the β-phosphate. deoxyuridine triphosphate nucleotidohydrolase (dUTPase) mechanism nucleotide binding Trypanosoma X-ray structure...

... compilation © 2013 Biochemical Society 2013 acetylcholinesterase Alzheimer's disease butyrylcholinesterase huprine inhibitor tacrine X-ray structure Figure 1 Chemical structure of tacrine, (7 S ,11 S )-huprine W and (7 S ,11 S )-huprine triazole Tacrine and huprine W are both used...

... isomerization. Many of the residues exhibiting resonance doubling also participate in conformational line-broadening transition(s) that occur ~10 5 -fold more rapidly, proposed previously to arise from a single global process. The 1.70 Å (1 Å=0.1 nm) resolution X-ray structure of the H87V variant is strikingly...

.... Delbruck H. Gotz F. Sievert V. Bussow K. Behlke J. Heinemann U. X-ray structure of fumarylacetoacetate hydrolase family member Homo sapiens FLJ36880 Biol. Chem. 2004 385 935 942 25 Ho S. N. Hunt H. D. Horton R. M. Pullen J. K. Pease L. R. Site...

...Winfried Meining; Arne Skerra We describe the 2.3 Å (1 Å=0.1 nm) X-ray structure of α 1 m (α 1 -microglobulin), an abundant protein in human blood plasma, which reveals the β-barrel fold typical for lipocalins with a deep pocket lined by four loops at its open rim. Loop #1 harbours the residue Cys...

... with the precursors of hepsin itself, HGF (hepatocyte growth factor), the coagulation Factors VII, IX, X and XII [ 6 ], urokinase [ 8 ] and Ln-332 (laminin-332) [ 9 ]. Fab fragment human hepsin antibody induced conformational change prostate cancer transmembrane serine protease X-ray structure...

... Society 2009 acute intermittent porphyria dipyrromethane haem human porphobilinogen deaminase X-ray structure Thin colourless plate-like crystals grew after several weeks. The best crystal diffracted X-rays to a resolution of 2.8 Å and the space group was determined to be orthorhombic...

...Arnaud Pailot; Katia D'Ambrosio; Catherine Corbier; François Talfournier; Guy Branlant One of the most striking features of several X-ray structures of CoA-independent ALDHs (aldehyde dehydrogenases) in complex with NAD(P) is the conformational flexibility of the NMN moiety. However, the fact...

... hydrogen peroxide activation myoglobin mutant NMR spectra peroxidase activity X-ray structure Abbreviations used: Mb, myoglobin; HM-H, protohaemin-6(7)- l -histidine methyl ester; T67R/S92D Mb-H, T67R/S92D myoglobin reconstituted with HM-H; HPA, p -hydroxyphenyl propionic acid. Biochem. J...

...Peter T. ERSKINE; Leighton COATES; Danica BUTLER; James H. YOUELL; Amanda A. BRINDLEY; Steve P. WOOD; Martin J. WARREN; Peter M. SHOOLINGIN-JORDAN; Jonathan B. COOPER The X-ray structure of yeast 5-aminolaevulinic acid dehydratase, in which the catalytic site of the enzyme is complexed...

..., Switzerland. 19 11 2002 27 2 2003 5 3 2003 5 3 2003 The Biochemical Society, London ©2003 2003 family 18 chitinase hevamine wheat X-ray structure xylanase inhibitor Abbreviations used: GH, glycoside hydrolase; r.m.s. root mean square; tri-NAG, N , N′ , N...

..., or DsBs, exhibit a CGHC sequence, while glutaredoxin possesses a CPYC active site [6,7]. It has been shown that changing the CGPC site of thioredoxin to CGHC results in the protein behaving more as an oxidant, with an alteration of its redox potential to more positive values [5]. X-ray structures have...

... 1DYS.PDB. 6 12 1999 25 1 2000 3 3 2000 The Biochemical Society, London © 2000 2000 cellobiohydrolase cellulose glycoside hydrolase X-ray structure Biochem. J. (2000) 348, 201 207 (Printed in Great Britain) 201 Structure and function of Humicola insolens family 6...