... (adherens junctions) and epithelial cell–cell adhesion. In the present study, the effect of acetaldehyde on the AJs and on the interactions between E-cadherin, β-catenin and PTP1B was determined in Caco-2 cell monolayers. Treatment of cell monolayers with acetaldehyde induced redistribution of E-cadherin...

... modifications of α-crystallin accumulate that can reduce chaperone function; this is compounded in cataract lenses. Extensive in vitro glycation, carbamylation and oxidation all decrease chaperone ability. In the present study, we report the effect of the modifiers malondialdehyde, acetaldehyde...

... as non-competitive. The estimated K m value of AlDH for furfural was found to be about 5 μ M, which was lower than that for acetaldehyde (10 μ M). For ADH, however, the estimated K m value for furfural (1.2mM) was higher than that for acetaldehyde (0.4mM). The inhibition of the three enzymes by 5...

... was confirmed by DNase I footprinting and electrophoretic mobility-shift assays (EMSAs). Ethanol-fed livers exhibit increased protein binding to region −416 to −336 on DNase I footprinting analysis, which was found to be NF-κB and AP-1 on EMSA and supershift analysis. Acetaldehyde treatment of H4IIE cells led...