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Articles

Reconstituted systems for studying the architecture and dynamics of actin networks

Alice Cantat, Alexandra Colin

Biochem J (2025) 482 (11): BCJ20253044.

https://doi.org/10.1042/BCJ20253044

Published: 23 May 2025

...Alice Cantat; Alexandra Colin Actin, a ubiquitous protein essential for numerous cellular functions, is found in all eukaryotes. Despite extensive research across molecular to organismal scales, fundamental questions persist regarding the regulation of dynamic actin architectures, their interaction...

View article titled, Reconstituted systems for studying the architecture and dynamics of actin networks

Articles

The open to closed D-loop conformational switch determines length in filopodia-like actin bundles

Jonathan R. Gadsby, Pantelis Savvas Ioannou, Richard Butler, Julia Mason, Alison J. Smith, Ulrich Dobramysl, Stacey E. Chin, Claire Dobson, Jennifer L. Gallop

Biochem J (2024) 481 (24): 1977–1995.

https://doi.org/10.1042/BCJ20240367

Published: 23 December 2024

... across tissues. Their major structural component is parallel bundles of actin filaments that assemble from the cell membrane. Whilst the length of filopodia is central to their function, it is not known how their lengths are determined by actin bundle dynamics. Here, we identified a set of monoclonal...

View article titled, The open to closed D-loop conformational switch determines length in filopodia-like actin bundles

Includes: Multimedia, Supplementary data

Articles

Binding partners regulate unfolding of myosin VI to activate the molecular motor

Ália dos Santos, Natalia Fili, Yukti Hari-Gupta, Rosemarie E. Gough, Lin Wang, Marisa Martin-Fernandez, Jesse Aaron, Eric Wait, Teng-Leong Chew, Christopher P. Toseland

Biochem J (2022) 479 (13): 1409–1428.

https://doi.org/10.1042/BCJ20220025

Published: 04 July 2022

...Ália dos Santos; Natalia Fili; Yukti Hari-Gupta; Rosemarie E. Gough; Lin Wang; Marisa Martin-Fernandez; Jesse Aaron; Eric Wait; Teng-Leong Chew; Christopher P. Toseland Myosin VI is the only minus-end actin motor and it is coupled to various cellular processes ranging from endocytosis...

View article titled, Binding partners regulate unfolding of myosin VI to activate the molecular motor

Includes: Supplementary data

Articles

α-catenin isoforms are regulated by glucose and involved in regulating insulin secretion in rat clonal β-cell models

Waruni C. Dissanayake, Brie Sorrenson, Kate L. Lee, Sandra Barre, Peter R. Shepherd

Biochem J (2020) 477 (4): 763–772.

https://doi.org/10.1042/BCJ20190832

Published: 20 February 2020

..., simultaneous depletion of α-E catenin and α-N catenin decreased the actin polymerisation to a similar degree as latrunculin treatment and inhibition of ARP 2/3 mediated actin branching with CK666 attenuated the α-catenin depletion effect on GSIS. This suggests α-catenin mediated actin remodelling may...

View article titled, α-catenin isoforms are regulated by glucose and involved in regulating insulin secretion in rat clonal β-cell models

Articles

Actin polymerization downstream of integrins: signaling pathways and mechanotransduction

Stéphane Romero, Christophe Le Clainche, Alexis M. Gautreau

Biochem J (2020) 477 (1): 1–21.

https://doi.org/10.1042/BCJ20170719

Published: 08 January 2020

... matrix (ECM). Integrins and their connections to the actin cytoskeleton are crucial for monitoring cell attachment and the physical properties of the substratum. Cell adhesion dynamics are modulated in complex ways by the polymerization of branched and linear actin arrays, which in turn reinforce ECM...

View article titled, Actin polymerization downstream of integrins: signaling pathways and mechanotransduction

Articles

Hypertrophic cardiomyopathy-linked variants of cardiac myosin-binding protein C3 display altered molecular properties and actin interaction

Sahar I. Da'as, Khalid Fakhro, Angelos Thanassoulas, Navaneethakrishnan Krishnamoorthy, Alaaeldin Saleh, Brian L. Calver, Bared Safieh-Garabedian, Egon Toft, George Nounesis, F. Anthony Lai, Michail Nomikos

Biochem J (2018) 475 (24): 3933–3948.

https://doi.org/10.1042/BCJ20180685

Published: 14 December 2018

... located within the C1 and C2 domains of MyBP-C, a region known to interact with sarcomeric protein, actin. Injection of the variant complementary RNAs in zebrafish embryos was observed to recapitulate phenotypic aspects of HCM in patients. Interestingly, V3- and V5-cRNA injection produced the most severe...

View article titled, Hypertrophic cardiomyopathy-linked variants of cardiac myosin-binding protein C3 display altered molecular properties and actin interaction

Includes: Supplementary data

Articles

LIMK2-1, a new isoform of human LIMK2, regulates actin cytoskeleton remodeling via a different signaling pathway than that of its two homologs, LIMK2a and LIMK2b

Béatrice Vallée, Hélène Cuberos, Michel Doudeau, Fabienne Godin, David Gosset, Patrick Vourc'h, Christian R. Andres, Hélène Bénédetti

Biochem J (2018) 475 (23): 3745–3761.

https://doi.org/10.1042/BCJ20170961

Published: 06 December 2018

...Béatrice Vallée; Hélène Cuberos; Michel Doudeau; Fabienne Godin; David Gosset; Patrick Vourc'h; Christian R. Andres; Hélène Bénédetti LIMK1 and LIMK2 (LIMKs, LIM kinases) are kinases that play a crucial role in cytoskeleton dynamics by independently regulating both actin filament and microtubule...

View article titled, LIMK2-1, a new isoform of human LIMK2, regulates actin cytoskeleton remodeling via a different signaling pathway than that of its two homologs, LIMK2a and LIMK2b

Includes: Supplementary data

Articles

Cilium structure, assembly, and disassembly regulated by the cytoskeleton

In Collection

Editors' pick of review article highlights published in the Biochemical Journal in 2018 & 2019

Mary Mirvis, Tim Stearns, W. James Nelson

Biochem J (2018) 475 (14): 2329–2353.

https://doi.org/10.1042/BCJ20170453

Published: 31 July 2018

... of assembly and disassembly that are controlled by complex inter-relationships with the cytoskeleton. Microtubules form the core of the cilium, the axoneme, and are regulated by post-translational modifications, associated proteins, and microtubule dynamics. Although actin and septin cytoskeletons...

View article titled, Cilium structure, assembly, and disassembly regulated by the cytoskeleton

Articles

Effect of the actin- and calcium-regulating activities of ITPKB on the metastatic potential of lung cancer cells

Selina Bäder, Elina Glaubke, Saskia Grüb, Stefanie Muhs, Jasmin Wellbrock, Marcus Nalaskowski, Tobias Lange, Sabine Windhorst

Biochem J (2018) 475 (12): 2057–2071.

https://doi.org/10.1042/BCJ20180238

Published: 26 June 2018

... activity. In addition, ITPKB binds to F-actin making it likely that, similar to ITPKA, it controls actin dynamics. Thus, the treatment of ITPKA-expressing lung cancer with ITPKA inhibitors simultaneously inhibiting ITPKB may counteract the therapy. Based on these considerations, we analyzed if ITPKB...

View article titled, Effect of the actin- and calcium-regulating activities of ITPKB on the metastatic potential of lung cancer cells

Includes: Supplementary data

Articles

Cellular and disease functions of the Prader–Willi Syndrome gene MAGEL2

Klementina Fon Tacer, Patrick Ryan Potts

Biochem J (2017) 474 (13): 2177–2190.

https://doi.org/10.1042/BCJ20160616

Published: 16 June 2017

... ubiquitin ligase, and the USP7 deubiquitinating enzyme. The M AGEL2- US P7- T RIM27 (or MUST) complex facilitates the retromer recycling pathway through ubiquitination and activation of the WASH actin nucleation promoting factor. This review provides an overview of the MAGE protein family of ubiquitin...

View article titled, Cellular and disease functions of the Prader–Willi Syndrome gene MAGEL2

Articles

CCM2 and PAK4 act downstream of atrial natriuretic peptide signaling to promote cell spreading

Koichi Miura, Takashi Nojiri, Yoshiharu Akitake, Koji Ando, Shigetomo Fukuhara, Masahiro Zenitani, Toru Kimura, Jun Hino, Mikiya Miyazato, Hiroshi Hosoda, Kenji Kangawa

Biochem J (2017) 474 (11): 1897–1918.

https://doi.org/10.1042/BCJ20160841

Published: 19 May 2017

..., guanylyl cyclase-A (GC-A), ANP maintains cardiovascular homeostasis by exerting diuretic, natriuretic, and hypotensive effects mediated, in part, by endothelial cells. Both in vivo and in vitro , ANP enhances endothelial barrier function by reducing RhoA activity and reorganizing the actin cytoskeleton. We...

View article titled, CCM2 and PAK4 act downstream of atrial natriuretic peptide signaling to promote cell spreading

Includes: Multimedia, Supplementary data

Articles

The C-terminal dimerization motif of cyclase-associated protein is essential for actin monomer regulation

Shohei Iwase, Shoichiro Ono

Biochem J (2016) 473 (23): 4427–4441.

https://doi.org/10.1042/BCJ20160329

Published: 25 November 2016

...Shohei Iwase; Shoichiro Ono Cyclase-associated protein (CAP) is a conserved actin-regulatory protein that functions together with actin depolymerizing factor (ADF)/cofilin to enhance actin filament dynamics. CAP has multiple functional domains, and the function to regulate actin monomers is carried...

View article titled, The C-terminal dimerization motif of cyclase-associated protein is essential for actin monomer regulation

Includes: Supplementary data

Articles

Physiological and pathophysiological functions of Swiprosin-1/EFhd2 in the nervous system

Dirk Mielenz, Frank Gunn-Moore

Biochem J (2016) 473 (16): 2429–2437.

https://doi.org/10.1042/BCJ20160168

Published: 11 August 2016

... with the use of recombinant EFhd2 protein, and integrated them with in vivo data in order to interpret the emerging role of EFhd2 in synaptic plasticity and in the pathophysiology of neurodegenerative disorders, particularly involving the tauopathies. We also discuss its functions in actin remodelling through...

View article titled, Physiological and pathophysiological functions of Swiprosin-1/EFhd2 in the nervous system

Articles

Hypertrophic cardiomyopathy mutations in the calponin-homology domain of ACTN2 affect actin binding and cardiomyocyte Z-disc incorporation

Natalie J. Haywood, Marcin Wolny, Brendan Rogers, Chi H. Trinh, Yu Shuping, Thomas A. Edwards, Michelle Peckham

Biochem J (2016) 473 (16): 2485–2493.

https://doi.org/10.1042/BCJ20160421

Published: 11 August 2016

... cardiomyopathy (HCM). We have investigated the effects of two mutations identified from HCM patients, A119T and G111V, on the secondary and tertiary structure of a purified actin binding domain (ABD) of ACTN2 by circular dichroism and X-ray crystallography, and show small but distinct changes for both mutations...

View article titled, Hypertrophic cardiomyopathy mutations in the calponin-homology domain of ACTN2 affect actin binding and cardiomyocyte Z-disc incorporation

Articles

Secretagogin affects insulin secretion in pancreatic β-cells by regulating actin dynamics and focal adhesion

Seo-Yun Yang, Jae-Jin Lee, Jin-Hee Lee, Kyungeun Lee, Seung Hoon Oh, Yu-Mi Lim, Myung-Shik Lee, Kong-Joo Lee

Biochem J (2016) 473 (12): 1791–1803.

https://doi.org/10.1042/BCJ20160137

Published: 10 June 2016

... phase of insulin secretion was significantly impaired by knocking down SCGN in NIT-1 cells. In addition, we found that SCGN interacts with the actin cytoskeleton in the plasma membrane and regulates actin remodelling in a glucose-dependent manner. Since actin dynamics are known to regulate focal...

View article titled, Secretagogin affects insulin secretion in pancreatic β-cells by regulating actin dynamics and focal adhesion

Includes: Supplementary data

Articles

Actin polymerization is stimulated by actin cross-linking protein palladin

Ritu Gurung, Rahul Yadav, Joseph G. Brungardt, Albina Orlova, Edward H. Egelman, Moriah R. Beck

Biochem J (2016) 473 (4): 383–396.

https://doi.org/10.1042/BJ20151050

Published: 09 February 2016

...Ritu Gurung; Rahul Yadav; Joseph G. Brungardt; Albina Orlova; Edward H. Egelman; Moriah R. Beck The actin scaffold protein palladin regulates both normal cell migration and invasive cell motility, processes that require the co-ordinated regulation of actin dynamics. However, the potential effect...

View article titled, Actin polymerization is stimulated by actin cross-linking protein palladin

Articles

The motor function of Drosophila melanogaster myosin-5 is activated by calcium and cargo-binding protein dRab11

Huan-Hong Ji, Hai-Man Zhang, Mei Shen, Lin-Lin Yao, Xiang-dong Li

Biochem J (2015) 469 (1): 135–144.

https://doi.org/10.1042/BJ20141330

Published: 19 June 2015

... proteins. We found that the actin-activated ATPase activity of DmM5 is significantly lower than that of the truncated DmM5 having the C-terminal globular tail domain (GTD) deleted, indicating that the GTD is the inhibitory domain. The actin-activated ATPase activity of DmM5 is significantly activated...

View article titled, The motor function of Drosophila melanogaster myosin-5 is activated by calcium and cargo-binding protein dRab11

Articles

Vinculin-dependent actin bundling regulates cell migration and traction forces

Karry M. Jannie, Shawn M. Ellerbroek, Dennis W. Zhou, Sophia Chen, David J. Crompton, Andrés J. García, Kris A. DeMali

Biochem J (2015) 465 (3): 383–393.

https://doi.org/10.1042/BJ20140872

Published: 22 January 2015

...Karry M. Jannie; Shawn M. Ellerbroek; Dennis W. Zhou; Sophia Chen; David J. Crompton; Andrés J. García; Kris A. DeMali Vinculin binding to actin filaments is thought to be critical for force transduction within a cell, but direct experimental evidence to support this conclusion has been limited...

View article titled, Vinculin-dependent actin bundling regulates cell migration and traction forces

Articles

Saltatory formation, sliding and dissolution of ER–PM junctions in migrating cancer cells

Hayley Dingsdale, Emmanuel Okeke, Muhammad Awais, Lee Haynes, David N. Criddle, Robert Sutton, Alexei V. Tepikin

Biochem J (2013) 451 (1): 25–32.

https://doi.org/10.1042/BJ20121864

Published: 14 March 2013

..., long-distance sliding and dissolution. The individual ER–PM junctions formed near the leading edge of migrating cells (usually within 0.5 μm of polymerized actin and close to focal adhesions) and appeared suddenly without sliding from the interior of the cell. The long distance sliding and dissolution...

View article titled, Saltatory formation, sliding and dissolution of ER–PM junctions in migrating cancer cells

Includes: Multimedia, Supplementary data

Articles

Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin

Keefe T. Chan, David W. Roadcap, Nicholas Holoweckyj, James E. Bear

Biochem J (2012) 444 (1): 89–96.

https://doi.org/10.1042/BJ20120209

Published: 26 April 2012

...Keefe T. Chan; David W. Roadcap; Nicholas Holoweckyj; James E. Bear Dynamic rearrangement of actin filament networks is critical for cell motility, phagocytosis and endocytosis. Coronins facilitate these processes, in part, by their ability to bind F-actin (filamentous actin). We previously...

View article titled, Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin

Includes: Supplementary data

Articles

Novel role for the Lu/BCAM–spectrin interaction in actin cytoskeleton reorganization

Emmanuel Collec, Marie-Christine Lecomte, Wassim El Nemer, Yves Colin, Caroline Le Van Kim

Biochem J (2011) 436 (3): 699–708.

https://doi.org/10.1042/BJ20101717

Published: 27 May 2011

... the half-life of Lu/BCAM at the MDCK (Madin–Darby canine kidney) cell surface, and increased Lu/BCAM-mediated cell adhesion and spreading on laminin 511/521. We have shown that the Lu/BCAM–spectrin interaction mediated actin reorganization during cell adhesion and spreading on laminin 511/521...

View article titled, Novel role for the Lu/BCAM–spectrin interaction in actin cytoskeleton reorganization

Includes: Supplementary data

Articles

Enhancement of myosin II/actin turnover at the contractile ring induces slower furrowing in dividing HeLa cells

Tomo Kondo, Kozue Hamao, Keiju Kamijo, Hiroshi Kimura, Makiko Morita, Masayuki Takahashi, Hiroshi Hosoya

Biochem J (2011) 435 (3): 569–576.

https://doi.org/10.1042/BJ20100837

Published: 13 April 2011

...-actin (filamentous actin) in the CR (contractile ring) of dividing cells. Recently, we reported that HeLa cells expressing non-phosphorylatable MRLC show a delay in the speed of furrow ingression, suggesting that pMRLC plays an important role in the control of furrow ingression. However, it is still...

View article titled, Enhancement of myosin II/actin turnover at the contractile ring induces slower furrowing in dividing HeLa cells

Includes: Supplementary data

Articles

Molecular targets of oxidative stress

Simon V. Avery

Biochem J (2011) 434 (2): 201–210.

https://doi.org/10.1042/BJ20101695

Published: 11 February 2011

... 2011 Biochemical Society 2011 actin iron–sulfur cluster lipid peroxidation mistranslation protein aggregation protein oxidation Organisms have evolved a number of strategies to counter oxidative stress, and these responses have received considerable research attention in recent years...

View article titled, Molecular targets of oxidative stress

Articles

Duration of fusion pore opening and the amount of hormone released are regulated by myosin II during kiss-and-run exocytosis

Ryo Aoki, Tetsuya Kitaguchi, Manami Oya, Yu Yanagihara, Mai Sato, Atsushi Miyawaki, Takashi Tsuboi

Biochem J (2010) 429 (3): 497–504.

https://doi.org/10.1042/BJ20091839

Published: 14 July 2010

... 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 actin dense-core vesicle exocytosis myosin II total internal reflection fluorescence microscopy (TIRF microscopy) Hormone secretion mediates intercellular communication to control various activities...

View article titled, Duration of fusion pore opening and the amount of hormone released are regulated by myosin II during kiss-and-run exocytosis

Includes: Supplementary data

Articles

Myopathy-causing actin mutations promote defects in serum-response factor signalling

Balázs Visegrády, Laura M. Machesky

Biochem J (2010) 427 (1): 41–48.

https://doi.org/10.1042/BJ20091641

Published: 15 March 2010

...Balázs Visegrády; Laura M. Machesky Mutations in the gene encoding skeletal muscle α-actin ( ACTA1 ) account for approx. 20% of patients with the muscular disorder nemaline myopathy. Nemaline myopathy is a muscular wasting disease similar to muscular dystrophy, but distinguished by deposits...

View article titled, Myopathy-causing actin mutations promote defects in serum-response factor signalling

Articles

A role for actin in regulating apoptosis/programmed cell death: evidence spanning yeast, plants and animals

Vernonica E. Franklin-Tong, Campbell W. Gourlay

Biochem J (2008) 413 (3): 389–404.

https://doi.org/10.1042/BJ20080320

Published: 15 July 2008

... of the factors involved in PCD networks have ancient origins that pre-date multicellularity and, indeed, eukaryotes themselves. A subject attracting much attention is the role that the actin cytoskeleton, itself a cellular component with ancient origins, plays in cell death regulation. Actin, a key cellular...

View article titled, A role for actin in regulating apoptosis/programmed cell death: evidence spanning yeast, plants and animals

Articles

Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes

Jianyong Zhang, Tomonori Hosoya, Atsushi Maruyama, Keizo Nishikawa, Jonathan M. Maher, Tsutomu Ohta, Hozumi Motohashi, Akiyoshi Fukamizu, Shigeki Shibahara, Ken Itoh, Masayuki Yamamoto

Biochem J (2007) 404 (3): 459–466.

https://doi.org/10.1042/BJ20061611

Published: 29 May 2007

...-related gene 1) from associating with Nrf2, diminishing their co-operative enhancement of HO - 1 promoter activity. Mutational analysis of the Neh5 domain revealed a motif that shares significant homology with β-actin and ARP1 (actin-related protein 1). Mutagenesis of this motif selectively decreased HO...

View article titled, Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes

Articles

The toxofilin–actin–PP2C complex of Toxoplasma : identification of interacting domains

Gaelle Jan, Violaine Delorme, Violaine David, Celine Revenu, Angelita Rebollo, Xavier Cayla, Isabelle Tardieux

Biochem J (2007) 401 (3): 711–719.

https://doi.org/10.1042/BJ20061324

Published: 12 January 2007

...Gaelle Jan; Violaine Delorme; Violaine David; Celine Revenu; Angelita Rebollo; Xavier Cayla; Isabelle Tardieux Toxofilin is a 27 kDa protein isolated from the human protozoan parasite Toxoplasma gondii , which causes toxoplasmosis. Toxofilin binds to G-actin, and in vitro studies have shown...

View article titled, The toxofilin–actin–PP2C complex of Toxoplasma : identification of interacting domains

Articles

Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization

Jean Paul ten Klooster, Eva E. Evers, Lennert Janssen, Laura M. Machesky, Frits Michiels, Peter Hordijk, John G. Collard

Biochem J (2006) 397 (1): 39–45.

https://doi.org/10.1042/BJ20051957

Published: 14 June 2006

... the actin cytoskeleton through the GTPase, Rac1. Using yeast two-hybrid screening and biochemical assays, we found that Tiam1 interacts with the p21-Arc [Arp (actin-related protein) complex] subunit of the Arp2/3 complex. Association occurred through the N-terminal pleckstrin homology domain...

View article titled, Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization

Articles

The increase in mitochondrial association with actin precedes Bax translocation in apoptosis

Ho Lam Tang, Anh-Huy Phan Le, Hong Lok Lung

Biochem J (2006) 396 (1): 1–5.

https://doi.org/10.1042/BJ20060241

Published: 26 April 2006

...Ho Lam Tang; Anh-Huy Phan Le; Hong Lok Lung Accumulating evidence indicates the potential role of actin cytoskeleton in facilitating the mitochondrial recruitment of various pro-apoptotic proteins from the cytosol to initiate apoptosis. In the present paper, we report the observation...

View article titled, The increase in mitochondrial association with actin precedes Bax translocation in apoptosis

Articles

Protein tyrosine phosphatase hPTPN20a is targeted to sites of actin polymerization

Michelle T. Fodero-Tavoletti, Matthew P. Hardy, Brent Cornell, Frosa Katsis, Christine M. Sadek, Christina A. Mitchell, Bruce E. Kemp, Tony Tiganis

Biochem J (2005) 389 (2): 343–354.

https://doi.org/10.1042/BJ20041932

Published: 05 July 2005

..., colocalizing with the microtubule-organizing centre and intracellular membrane compartments, including the endoplasmic reticulum and the Golgi apparatus. Stimulation of cells with epidermal growth factor, osmotic shock, pervanadate, or integrin ligation targeted hPTPN20a to actin-rich structures that included...

View article titled, Protein tyrosine phosphatase hPTPN20a is targeted to sites of actin polymerization

Includes: Supplementary data

Articles

The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ

Claire E. EYERS, Helen McNEILL, Axel KNEBEL, Nick MORRICE, Simon J. C. ARTHUR, Ana CUENDA, Philip COHEN

Biochem J (2005) 389 (1): 127–135.

https://doi.org/10.1042/BJ20050387

Published: 21 June 2005

...Claire E. EYERS; Helen McNEILL; Axel KNEBEL; Nick MORRICE; Simon J. C. ARTHUR; Ana CUENDA; Philip COHEN A protein expressed in immune cells and muscle was detected in muscle extracts as a substrate for several SAPKs (stress-activated protein kinases). It interacted specifically with the F-actin...

View article titled, The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ

Articles

Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex

Thomas H. MILLARD, Stewart J. SHARP, Laura M. MACHESKY

Biochem J (2004) 380 (1): 1–17.

https://doi.org/10.1042/bj20040176

Published: 15 May 2004

...Thomas H. MILLARD; Stewart J. SHARP; Laura M. MACHESKY The assembly of a branched network of actin filaments provides the mechanical propulsion that drives a range of dynamic cellular processes, including cell motility. The Arp2/3 complex is a crucial component of such filament networks. Arp2/3...

View article titled, Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex

Articles

Rho GTPases have diverse effects on the organization of the actin filament system

Pontus ASPENSTRÖM, Åsa FRANSSON, Jan SARAS

Biochem J (2004) 377 (2): 327–337.

https://doi.org/10.1042/bj20031041

Published: 15 January 2004

...Pontus ASPENSTRÖM; Åsa FRANSSON; Jan SARAS The Rho GTPases are related to the Ras proto-oncogenes and consist of 22 family members. These proteins have important roles in regulating the organization of the actin filament system, and thereby the morphogenesis of vertebrate cells as well...

View article titled, Rho GTPases have diverse effects on the organization of the actin filament system

Articles

MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta

Jacquelyn A. WOODINGS, Stewart J. SHARP, Laura M. MACHESKY

Biochem J (2003) 371 (2): 463–471.

https://doi.org/10.1042/bj20021962

Published: 15 April 2003

...Jacquelyn A. WOODINGS; Stewart J. SHARP; Laura M. MACHESKY We have found that MIM-B, a putative metastasis suppressor protein, is implicated in actin cytoskeletal control and interaction with a protein tyrosine phosphatase (PTP). MIM was originally described as a protein whose mRNA was M issing i n...

View article titled, MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta

Articles

Regulation of endocytic traffic by Rho GTPases

Britta QUALMANN, Harry MELLOR

Biochem J (2003) 371 (2): 233–241.

https://doi.org/10.1042/bj20030139

Published: 15 April 2003

...Britta QUALMANN; Harry MELLOR The members of the Rho subfamily of small GTPases are key regulators of the actin cytoskeleton. However, recent studies have provided evidence for multiple additional roles for these signalling proteins in controlling endocytic traffic. Here we review our current...

View article titled, Regulation of endocytic traffic by Rho GTPases

Articles

Identification of cofilin and LIM-domain-containing protein kinase 1 as novel interaction partners of 14-3-3zeta

Jörg BIRKENFELD, Heinrich BETZ, Dagmar ROTH

Biochem J (2003) 369 (1): 45–54.

https://doi.org/10.1042/bj20021152

Published: 01 January 2003

...Jörg BIRKENFELD; Heinrich BETZ; Dagmar ROTH Proteins of the 14-3-3 family have been implicated in various physiological processes, and are thought to function as adaptors in various signal transduction pathways. In addition, 14-3-3 proteins may contribute to the reorganization of the actin...

View article titled, Identification of cofilin and LIM-domain-containing protein kinase 1 as novel interaction partners of 14-3-3zeta

Articles

Further characterization of the interaction between the cytoskeletal proteins talin and vinculin

Mark D. BASS, Bipin PATEL, Igor G. BARSUKOV, Ian J. FILLINGHAM, Robert MASON, Beverley J. SMITH, Clive R. BAGSHAW, David R. CRITCHLEY

Biochem J (2002) 362 (3): 761–768.

https://doi.org/10.1042/bj3620761

Published: 08 March 2002

...Mark D. BASS; Bipin PATEL; Igor G. BARSUKOV; Ian J. FILLINGHAM; Robert MASON; Beverley J. SMITH; Clive R. BAGSHAW; David R. CRITCHLEY The cytoskeletal protein talin, which is thought to couple integrins to F-actin, contains three binding sites (VBS1—VBS3) for vinculin, a protein implicated...

View article titled, Further characterization of the interaction between the cytoskeletal proteins talin and vinculin

Articles

Cross-talk unfolded: MARCKS proteins

Anna ARBUZOVA, Arndt A. P. SCHMITZ, Guy VERGÈRES

Biochem J (2002) 362 (1): 1–12.

https://doi.org/10.1042/bj3620001

Published: 08 February 2002

... emerging that MARCKS proteins are ‘natively unfolded'. Interestingly, domains similar to the effector domain have been discovered in other proteins. Furthermore, since the effector domain enhances the polymerization of actin in vitro , MARCKS proteins have been proposed to mediate regulation of the actin...

View article titled, Cross-talk unfolded: MARCKS proteins

Articles

Sac phosphatase domain proteins

William E. HUGHES, Frank T. COOKE, Peter J. PARKER

Biochem J (2000) 350 (2): 337–352.

https://doi.org/10.1042/bj3500337

Published: 23 August 2000

...William E. HUGHES; Frank T. COOKE; Peter J. PARKER Advances in our understanding of the roles of phosphatidylinositol phosphates in controlling cellular functions such as endocytosis, exocytosis and the actin cytoskeleton have included new insights into the phosphatases that are responsible...

View article titled, Sac phosphatase domain proteins

Articles

Annexin II is associated with mRNAs which may constitute a distinct subpopulation

Anni VEDELER, Hanne HOLLÅS

Biochem J (2000) 348 (3): 565–572.

https://doi.org/10.1042/bj3480565

Published: 07 June 2000

...] and complement of poly(Abinding proteins [10]. For example, c-myc mRNA is found enriched in cytoskeleton-bound polysomes, whereas actin mRNA is found in both free and cytoskeleton-bound polysomes, and b # -microglobulin mRNA is highly enriched in membrane- bound polysomes [9,11]. Analysis of the protein...

View article titled, Annexin II is associated with mRNAs which may constitute a distinct subpopulation

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