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A role for PAK1 mediated phosphorylation of β-catenin Ser552 in the regulation of insulin secretion

Brie Sorrenson, Waruni C. Dissanayake, Fengyun Hu, Kate L. Lee, Peter R. Shepherd

Biochem J (2021) 478 (8): 1605–1615.

https://doi.org/10.1042/BCJ20200862

Published: 28 April 2021

... a role for Ser552 phosphorylation in regulating insulin secretion ( Figure 1B ). This was associated with an increase in F-actin ( Figure 1C,D ) consistent with phosphorylation of Ser552 being involved in the regulation of rearrangements of the actin cytoskeleton. We did not observe any impact...

View article titled, A role for PAK1 mediated phosphorylation of β-catenin Ser552 in the regulation of insulin secretion

Articles

Cytoskeleton regulators CAPZA2 and INF2 associate with CFTR to control its plasma membrane levels under EPAC1 activation

João D. Santos, Francisco R. Pinto, João F. Ferreira, Margarida D. Amaral, Manuela Zaccolo, Carlos M. Farinha

Biochem J (2020) 477 (13): 2561–2580.

https://doi.org/10.1042/BCJ20200287

Published: 10 July 2020

... on CFTR interaction with several proteins among which PDZ domain-containing proteins (PDZ proteins) play an essential role. Indeed, NHERF1 anchors CFTR to the PM and to the actin cytoskeleton [ 5 , 7 ]. In the PDZ-dependent CFTR-NHERF1 complex, NHERF1 interacts with ezrin and this NHERF1-ezrin interaction...

View article titled, Cytoskeleton regulators CAPZA2 and INF2 associate with CFTR to control its plasma membrane levels under EPAC1 activation

Includes: Supplementary data

Articles

FilGAP and its close relatives: a mediator of Rho–Rac antagonism that regulates cell morphology and migration

Fumihiko Nakamura

Biochem J (2013) 453 (1): 17–25.

https://doi.org/10.1042/BJ20130290

Published: 13 June 2013

...Fumihiko Nakamura Cell migration, phagocytosis and cytokinesis are mechanically intensive cellular processes that are mediated by the dynamic assembly and contractility of the actin cytoskeleton. GAPs (GTPase-activating proteins) control activities of the Rho family proteins including Cdc42, Rac1...

View article titled, FilGAP and its close relatives: a mediator of Rho–Rac antagonism that regulates cell morphology and migration

Articles

Cell polarity during motile processes: keeping on track with the exocyst complex

Maud Hertzog, Philippe Chavrier

Biochem J (2011) 433 (3): 403–409.

https://doi.org/10.1042/BJ20101214

Published: 14 January 2011

... 8 2010 7 10 2010 12 10 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 actin cytoskeleton exocyst complex invasion motility neuronal development small GTPase The Ral subgroup of small GTP-binding proteins comprises the highly related RalA...

View article titled, Cell polarity during motile processes: keeping on track with the exocyst complex

Articles

Modulation of mammary cancer cell migration by 15-deoxy-Δ 12,14 -prostaglandin J 2 : implications for anti-metastatic therapy

Anne R. Diers, Brian P. Dranka, Karina C. Ricart, Joo Yeun Oh, Michelle S. Johnson, Fen Zhou, Manuel A. Pallero, Thomas M. Bodenstine, Joanne E. Murphy-Ullrich, Danny R. Welch, Aimee Landar

Biochem J (2010) 430 (1): 69–78.

https://doi.org/10.1042/BJ20091193

Published: 28 July 2010

... concentrations where there are no observed effects on Keap1 or cytotoxicity. actin cytoskeleton focal adhesion post-translational protein modification reactive lipid species redox signalling thiol To determine the extent of modification of Keap1 by 15d-PGJ 2 , JC cells were treated...

View article titled, Modulation of mammary cancer cell migration by 15-deoxy-Δ 12,14 -prostaglandin J 2 : implications for anti-metastatic therapy

Includes: Supplementary data

Articles

The emerging importance of group II PAKs

Claire M. Wells, Gareth E. Jones

Biochem J (2010) 425 (3): 465–473.

https://doi.org/10.1042/BJ20091173

Published: 15 January 2010

... correspondence should be addressed (email [email protected] ). 3 8 2009 30 9 2009 1 10 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 actin cytoskeleton cancer inflammatory response knockout-mouse study neurological disorder p21-activated kinase...

View article titled, The emerging importance of group II PAKs

Articles

N-terminus-mediated dimerization of ROCK-I is required for RhoE binding and actin reorganization

Ritu Garg, Kirsi Riento, Nicholas Keep, Jonathan D. H. Morris, Anne J. Ridley

Biochem J (2008) 411 (2): 407–414.

https://doi.org/10.1042/BJ20071342

Published: 27 March 2008

... correspondence should be addressed (email [email protected] ). 1 10 2007 15 1 2008 23 1 2008 23 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 actin cytoskeleton GTP-binding protein Rho GTPase Rho-associated kinase (ROCK) RhoE (Rnd3...

View article titled, N-terminus-mediated dimerization of ROCK-I is required for RhoE binding and actin reorganization

Articles

A direct interaction with calponin inhibits the actin-nucleating activity of gelsolin

Imen Ferjani, Abdellatif Fattoum, Sutherland K. Maciver, Christine Bénistant, Anne Chahinian, Mohamed Manai, Yves Benyamin, Claude Roustan

Biochem J (2006) 396 (3): 461–468.

https://doi.org/10.1042/BJ20051690

Published: 29 May 2006

... the prevention of calponin's actin-binding activities. 1 To whom correspondence should be addressed (email [email protected] ). 19 10 2005 2 3 2006 15 3 2006 15 3 2006 The Biochemical Society, London 2006 actin cytoskeleton actin-nucleating activity calponin...

View article titled, A direct interaction with calponin inhibits the actin-nucleating activity of gelsolin

Articles

Perturbation of actin dynamics induces NF-κB activation in myelomonocytic cells through an NADPH oxidase-dependent pathway

Gaelle KUSTERMANS, Jamel EL BENNA, Jacques PIETTE, Sylvie LEGRAND-POELS

Biochem J (2005) 387 (2): 531–540.

https://doi.org/10.1042/BJ20041318

Published: 05 April 2005

.... We have shown that NF-κB activation in response to the perturbation of actin dynamics required reactive oxygen species, as demonstrated by the effect of antioxidants. Actin cytoskeleton disruption by cytochalasin D induced O 2 − release from human monocytes, through the activation of the NADPH...

View article titled, Perturbation of actin dynamics induces NF-κB activation in myelomonocytic cells through an NADPH oxidase-dependent pathway

Articles

Gelsolin binds to polyphosphoinositide-free lipid vesicles and simultaneously to actin microfilaments

Jocelyn MÉRÉ, Anne CHAHINIAN, Sutherland K. MACIVER, Abdellatif FATTOUM, Nadir BETTACHE, Yves BENYAMIN, Claude ROUSTAN

Biochem J (2005) 386 (1): 47–56.

https://doi.org/10.1042/BJ20041054

Published: 08 February 2005

...Jocelyn MÉRÉ; Anne CHAHINIAN; Sutherland K. MACIVER; Abdellatif FATTOUM; Nadir BETTACHE; Yves BENYAMIN; Claude ROUSTAN Gelsolin is a calcium-, pH- and lipid-dependent actin filament severing/capping protein whose main function is to regulate the assembly state of the actin cytoskeleton. Gelsolin...

View article titled, Gelsolin binds to polyphosphoinositide-free lipid vesicles and simultaneously to actin microfilaments

Articles

Inhibition of Rac activation as a mechanism for negative regulation of actin cytoskeletal reorganization and cell motility by cAMP

Shin-ya NAGASAWA, Noriko TAKUWA, Naotoshi SUGIMOTO, Hiroshi MABUCHI, Yoh TAKUWA

Biochem J (2005) 385 (3): 737–744.

https://doi.org/10.1042/BJ20041060

Published: 24 January 2005

....) using polycarbonate filters with 8 μm pores as described previously [ 5 , 15 ]. actin cytoskeleton cAMP cell motility prostaglandin E 2 protein kinase A Rac Cell migration plays a critical role in a wide variety of physiological and pathological phenomena, including morphogenic...

View article titled, Inhibition of Rac activation as a mechanism for negative regulation of actin cytoskeletal reorganization and cell motility by cAMP

Articles

Rho GTPases and leucocyte-induced endothelial remodelling

Jaime MILLÁN, Anne J. RIDLEY

Biochem J (2005) 385 (2): 329–337.

https://doi.org/10.1042/BJ20041584

Published: 07 January 2005

... in these responses. 1 To whom correspondence should be addressed, at the Ludwig Institute for Cancer Research (email [email protected] ). 15 9 2004 8 10 2004 21 10 2004 21 10 2004 The Biochemical Society, London 2005 actin cytoskeleton intercellular adhesion molecule-1...

View article titled, Rho GTPases and leucocyte-induced endothelial remodelling

Articles

Myristoylated alanine-rich C kinase substrate (MARCKS) is involved in myoblast fusion through its regulation by protein kinase Cα and calpain proteolytic cleavage

Sandrine DULONG, Sebastien GOUDENEGE, Karine VUILLIER-DEVILLERS, Stéphane MANENTI, Sylvie POUSSARD, Patrick COTTIN

Biochem J (2004) 382 (3): 1015–1023.

https://doi.org/10.1042/BJ20040347

Published: 07 September 2004

... should be addressed (email [email protected] ). 4 3 2004 7 7 2004 7 7 2004 7 7 2004 The Biochemical Society, London 2004 actin cytoskeleton Ca 2+ calpain myristoylated alanine-rich C kinase substrate (MARCKS) myogenesis protein kinase Cα (PKCα...

View article titled, Myristoylated alanine-rich C kinase substrate (MARCKS) is involved in myoblast fusion through its regulation by protein kinase Cα and calpain proteolytic cleavage

Articles

Actin filaments play a permissive role in the inhibition of store-operated Ca 2+ entry by extracellular ATP in rat brown adipocytes

Mariko OMATSU-KANBE, Masaru SHIBATA, Takefumi YAMAMOTO, Takahiro ISONO, Hiroshi MATSUURA

Biochem J (2004) 381 (2): 389–396.

https://doi.org/10.1042/BJ20040378

Published: 06 July 2004

... to increase cytosolic free Ca 2+ [ 7 – 10 ] and to modulate proliferation [ 11 ] and membrane trafficking [ 12 ]. actin cytoskeleton brown adipocyte extracellular ATP P2 receptor store-operated Ca 2+ entry Cells cultured on the glass coverslips were transferred into 12-well plastic...

View article titled, Actin filaments play a permissive role in the inhibition of store-operated Ca 2+ entry by extracellular ATP in rat brown adipocytes

Articles

Actin depolymerization-induced tyrosine phosphorylation of cortactin: the role of Fer kinase

Lingzhi FAN, Caterina Di CIANO-OLIVEIRA, Scott A. WEED, Andrew W. B. CRAIG, Peter A. GREER, Ori D. ROTSTEIN, András KAPUS

Biochem J (2004) 380 (2): 581–591.

https://doi.org/10.1042/bj20040178

Published: 01 June 2004

... cytoskeleton remodelling. 1 To whom correspondence should be addressed (e-mail [email protected] ). 2 2 2004 16 3 2004 19 3 2004 19 3 2004 The Biochemical Society, London ©2004 2004 actin cytoskeleton depolymerization cortactin Fer kinase latrunculin B...

View article titled, Actin depolymerization-induced tyrosine phosphorylation of cortactin: the role of Fer kinase

Articles

Characterization of an ankyrin repeat-containing Shank2 isoform (Shank2E) in liver epithelial cells

Ryan R. McWILLIAMS, Elizabeth GIDEY, Laura FOUASSIER, Scott A. WEED, R. Brian DOCTOR

Biochem J (2004) 380 (1): 181–191.

https://doi.org/10.1042/bj20031577

Published: 15 May 2004

... at the apical membrane. 1 To whom correspondence should be addressed (e-mail [email protected] ). 15 10 2003 13 2 2004 16 2 2004 16 2 2004 The Biochemical Society, London ©2004 2004 actin cytoskeleton apical domain cortactin binding protein 1 (CortBP1) lipid raft...

View article titled, Characterization of an ankyrin repeat-containing Shank2 isoform (Shank2E) in liver epithelial cells

Articles

Actions by actin: reciprocal regulation of cortactin activity by tyrosine kinases and F-actin

Susan J. GUNST

Biochem J (2004) 380 (1): e7–e8.

https://doi.org/10.1042/bj20040559

Published: 15 May 2004

... organization of the actin cytoskeleton. 1 e-mail [email protected] 5 4 2004 14 4 2004 25 5 2004 The Biochemical Society, London ©2004 2004 actin cytoskeleton actin polymerization Arp2/3 complex Fyn/Fer kinases tyrosine phosphorylation Biochem. J. (2004) 380, e7 e8...

View article titled, Actions by actin: reciprocal regulation of cortactin activity by tyrosine kinases and F-actin

Articles

Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression

Carolin NEUMANN-GIESEN, Bianca FALKENBACH, Peter BEICHT, Stephanie CLAASEN, Georg LÜERS, Claudia A. O. STUERMER, Volker HERZOG, Ritva TIKKANEN

Biochem J (2004) 378 (2): 509–518.

https://doi.org/10.1042/bj20031100

Published: 01 March 2004

...-1 as a signalling protein in actin-dependent processes. Key words: actin cytoskeleton, filopodia, flotillin, protein acyl- ation, rafts, reggie. INTRODUCTION The reggie proteins, also named flotillins, were originally de- scribed as axonal regeneration proteins up-regulated after a lesion...

View article titled, Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression

Articles

Evidence for secretion-like coupling involving pp60src in the activation and maintenance of store-mediated Ca2+ entry in mouse pancreatic acinar cells

Pedro C. REDONDO, Ana I. LAJAS, Ginés M. SALIDO, Antonio GONZALEZ, Juan A. ROSADO, José A. PARIENTE

Biochem J (2003) 370 (1): 255–263.

https://doi.org/10.1042/bj20021505

Published: 15 February 2003

... is mediated by an interaction of the endoplasmic reticulum (ER) with the plasma membrane (PM) and is modulated by the actin cytoskeleton. To explore this possibility further we have now investigated the role of the actin cytoskeleton in the activation and maintenance of SMCE in pancreatic acinar cells, a more...

View article titled, Evidence for secretion-like coupling involving pp60src in the activation and maintenance of store-mediated Ca2+ entry in mouse pancreatic acinar cells

Articles

Calmodulin inhibitors trigger the proteolytic processing of membrane type-1 matrix metalloproteinase, but not its shedding in glioblastoma cells

Borhane ANNABI, Anthony PILORGET, Nathalie BOUSQUET-GAGNON, Denis GINGRAS, Richard BÉLIVEAU

Biochem J (2001) 359 (2): 325–333.

https://doi.org/10.1042/bj3590325

Published: 08 October 2001

... independent of the CaM substrate interaction. We also propose that TIMP-2 acts as a negative regulator of MT1-MMP-dependent activities promoted by the action of CaM inhibitors in U-87 glioblastoma cells. Key words: actin cytoskeleton, cell migration, glioma, MT1- MMP, TIMP-2. membrane domain does not seem...

View article titled, Calmodulin inhibitors trigger the proteolytic processing of membrane type-1 matrix metalloproteinase, but not its shedding in glioblastoma cells

Articles

The neurofibromatosis 2 protein product merlin selectively binds F-actin but not G-actin, and stabilizes the filaments through a lateral association

Marianne F. JAMES, Nitasha MANCHANDA, Charo GONZALEZ-AGOSTI, John H. HARTWIG, Vijaya RAMESH

Biochem J (2001) 356 (2): 377–386.

https://doi.org/10.1042/bj3560377

Published: 24 May 2001

... is supported by electron microscopy, which demonstrates that merlin binds periodically along cyto- skeletal actin filaments. Comparison of these findings with those reported for ERM proteins reveal a distinct role for merlin in actin filament dynamics. Key words: actin cytoskeleton, ezrin}radixin}moesin family...

View article titled, The neurofibromatosis 2 protein product merlin selectively binds F-actin but not G-actin, and stabilizes the filaments through a lateral association

Articles

Activation of store-mediated calcium entry by secretion-like coupling between the inositol 1,4,5-trisphosphate receptor type II and human transient receptor potential (hTrp1) channels in human platelets

Juan A. ROSADO, Stewart O. SAGE

Biochem J (2001) 356 (1): 191–198.

https://doi.org/10.1042/bj3560191

Published: 08 May 2001

... that, as with secretion, the actin filaments at the cell periphery act as a negative clamp which prevents constitutive coupling. In addition, the actin cytoskeleton plays a positive role, since disruption of the actin network inhibited the coupling when the Ca 2+ stores were depleted. These results provide strong...

View article titled, Activation of store-mediated calcium entry by secretion-like coupling between the inositol 1,4,5-trisphosphate receptor type II and human transient receptor potential (hTrp1) channels in human platelets

Articles

Fine mapping of the α-actinin binding site within cysteine-rich protein

Brooke D. HARPER, Mary C. BECKERLE, Pascal POMIÈS

Biochem J (2000) 350 (1): 269–274.

https://doi.org/10.1042/bj3500269

Published: 09 August 2000

... to the disruption of a key structural element. 1 To whom correspondence should be addressed (e-mail [email protected] ). 18 2 2000 22 5 2000 7 6 2000 The Biochemical Society, London © 2000 2000 actin cytoskeleton glycine-rich repeat muscle myogenesis Biochem. J...

View article titled, Fine mapping of the α-actinin binding site within cysteine-rich protein

Articles

The N-terminal LIM domain negatively regulates the kinase activity ofLIM-kinase 1

Kyoko NAGATA, Kazumasa OHASHI, Neng YANG, Kensaku MIZUNO

Biochem J (1999) 343 (1): 99–105.

https://doi.org/10.1042/bj3430099

Published: 24 September 1999

... Institute, Graduate School of Science, Tohoku University, Aoba-ku, Sendai 980-8578, Japan (e-mail [email protected] ). 26 4 1999 17 6 1999 16 7 1999 The Biochemical Society, London © 1999 1999 actin cytoskeleton LIM domain LIM-kinase protein kinase PDZ domain...

View article titled, The N-terminal LIM domain negatively regulates the kinase activity ofLIM-kinase 1

Articles

Evidence for the involvement of a small subregion of the endoplasmic reticulum in the inositol trisphosphate receptor-induced activation of Ca2+ inflow in rat hepatocytes

Roland B. GREGORY, Robert A. WILCOX, Leise A. BERVEN, Nicole C. R. VAN STRATEN, Gijs A. VAN DER MAREL, Jacques H. VAN BOOM, Gregory J. BARRITT

Biochem J (1999) 341 (2): 401–408.

https://doi.org/10.1042/bj3410401

Published: 08 July 1999

...Roland B. GREGORY; Robert A. WILCOX; Leise A. BERVEN; Nicole C. R. VAN STRATEN; Gijs A. VAN DER MAREL; Jacques H. VAN BOOM; Gregory J. BARRITT The roles of a subregion of the endoplasmic reticulum (ER) and the cortical actin cytoskeleton in the mechanisms by which Ins(1,4,5) P 3 induces...

View article titled, Evidence for the involvement of a small subregion of the endoplasmic reticulum in the inositol trisphosphate receptor-induced activation of Ca2+ inflow in rat hepatocytes

NARROW

A role for PAK1 mediated phosphorylation of β-catenin Ser552 in the regulation of insulin secretion

Cytoskeleton regulators CAPZA2 and INF2 associate with CFTR to control its plasma membrane levels under EPAC1 activation

FilGAP and its close relatives: a mediator of Rho–Rac antagonism that regulates cell morphology and migration

Cell polarity during motile processes: keeping on track with the exocyst complex

Modulation of mammary cancer cell migration by 15-deoxy-Δ 12,14 -prostaglandin J 2 : implications for anti-metastatic therapy

The emerging importance of group II PAKs

N-terminus-mediated dimerization of ROCK-I is required for RhoE binding and actin reorganization

A direct interaction with calponin inhibits the actin-nucleating activity of gelsolin

Perturbation of actin dynamics induces NF-κB activation in myelomonocytic cells through an NADPH oxidase-dependent pathway

Gelsolin binds to polyphosphoinositide-free lipid vesicles and simultaneously to actin microfilaments

Inhibition of Rac activation as a mechanism for negative regulation of actin cytoskeletal reorganization and cell motility by cAMP

Rho GTPases and leucocyte-induced endothelial remodelling

Myristoylated alanine-rich C kinase substrate (MARCKS) is involved in myoblast fusion through its regulation by protein kinase Cα and calpain proteolytic cleavage

Actin filaments play a permissive role in the inhibition of store-operated Ca 2+ entry by extracellular ATP in rat brown adipocytes

Actin depolymerization-induced tyrosine phosphorylation of cortactin: the role of Fer kinase

Characterization of an ankyrin repeat-containing Shank2 isoform (Shank2E) in liver epithelial cells

Actions by actin: reciprocal regulation of cortactin activity by tyrosine kinases and F-actin

Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression

Evidence for secretion-like coupling involving pp60src in the activation and maintenance of store-mediated Ca2+ entry in mouse pancreatic acinar cells

Calmodulin inhibitors trigger the proteolytic processing of membrane type-1 matrix metalloproteinase, but not its shedding in glioblastoma cells

The neurofibromatosis 2 protein product merlin selectively binds F-actin but not G-actin, and stabilizes the filaments through a lateral association

Activation of store-mediated calcium entry by secretion-like coupling between the inositol 1,4,5-trisphosphate receptor type II and human transient receptor potential (hTrp1) channels in human platelets

Fine mapping of the α-actinin binding site within cysteine-rich protein

The N-terminal LIM domain negatively regulates the kinase activity ofLIM-kinase 1

Evidence for the involvement of a small subregion of the endoplasmic reticulum in the inositol trisphosphate receptor-induced activation of Ca2+ inflow in rat hepatocytes

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