.... Together our findings highlight an important link between the TGF-β1-induced MAPK and p53 signalling pathways in the regulation of S100A2 expression and pro-tumorigenic actions. activator protein-1 (AP-1) HaCaT cell Hep3B cell p53 protein S100 protein SMAD-binding element Members...

.... activator protein-1 (AP-1) aldo-keto reductase 1B10 (AKR1B10) epidermal growth factor (EGF) hepatocellular carcinoma (HCC) insulin AKR1B10 (aldo-keto reductase 1B10), also named ARL-1 (aldose reductase-like-1), is overexpressed in primary liver and lung carcinomas [ 1 , 2 ]. AKR1B10 promotes...

... Biochemical Society 2008 activator protein-1 (AP-1) brain astrocytes brain inflammation Jun N-terminal kinase (JNK) matrix metalloproteinase-3 (MMP-3) transcriptional regulation MMPs (matrix metalloproteinases) are zinc-dependent endopeptidases that are mainly involved in turnover...

..., AICAR can even induce apoptosis without AMPK activation [ 16 ], which is evidently causally linked to the absence of LKB1, a serine/threonine tumour suppressor kinase, which normally phosphorylates AMPK [ 17 ]. activator protein-1 (AP-1) AMP-activated protein kinase (AMPK) human papillomavirus...

...-inactivated FBS, and passages 18–23 were used for the experiments. activator protein-1 (AP-1) α-difluoromethylornithine growth arrest intestinal epithelium ornithine decarboxylase transcriptional regulation The epithelium of the intestinal mucosa is a rapidly self-renewing tissue in the body...

... To whom correspondence should be addressed (email [email protected] ). 26 6 2006 7 9 2006 11 10 2006 11 10 2006 The Biochemical Society, London 2007 activator protein-1 (AP-1) ceruloplasmin copper gene regulation luciferase transcription Cp (ceruloplasmin...

..., and β-galactosidase activity was determined colorimetrically using the Reporter Lysis assay system. All transfections were performed in duplicate wells in at least three separate experiments. c-Jun CYP2J2 cytochrome P450 activator protein-1 (AP-1) Hepatic cytochromes P450 (CYPs...

... sub- genomic replicon-expressing and Ad-NS5A-transduced cells are regulated by two distinct signalling pathways involving p38 MAPK and JNK via AP-1 that is linked to increased oxidative stress and therefore to an increased antioxidant MnSOD response. Key words: activator protein-1 (AP-1), hepatitis C...

...% of mammalian bZIP transcription factors contain a residue analogous to serine-43 of BATF in their DNA binding domains, the phosphorylation event described here represents a mechanism that is potentially applicable to the regulation of many bZIP proteins. Key words: activator protein-1 (AP-1), basic leucine...

... at the level of the IL-8 promoter. While ERK1/2 activation could be linked to enhanced DNA binding of activator protein-1 (AP-1), p38 MAPK signalling did not affect AP-1 DNA binding. Taken together, these results provide the first evidence that LPS from H. pylori stimulates IL-8 release from cells...