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Keywords: adhesion
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Biochem J (2015) 465 (3): 383–393.
Published: 22 January 2015
.... In the present study, we found mutation (R1049E) of the vinculin tail impairs its ability to bind F-actin, stimulate actin polymerization, and bundle F-actin in vitro . Further, mutant (R1049E) vinculin expressing cells are altered in cell migration, which is accompanied by changes in cell adhesion, cell...
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Biochem J (2012) 442 (1): 13–25.
Published: 27 January 2012
... to its abundance in controlling cellular functions, ubiquitylation is also of key relevance to human pathologies, including cancer and inflammation. In the present review, we focus on its role in the control of cell adhesion, polarity and directional migration. It will become clear that protein...
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Biochem J (2009) 420 (1): 49–56.
Published: 28 April 2009
...Chunlei Gao; Scott D. Blystone Integrin αvβ3-mediated adhesion of haemopoietic cells to vitronectin results in β3 tyrosine phosphorylation and Rho activation which is necessary for adhesion. Previously, we have shown that the RhoGEF (Rho guanine-nucleotide-exchange factor) Vav1 could associate...
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Biochem J (2007) 405 (3): 417–428.
Published: 13 July 2007
... supported primary human aortic SMC (smooth-muscle cell) attachment through α5β1 and α4β1 integrins. Cells on fibulin-5 spread poorly and displayed prominent membrane ruffles but no stress fibres or focal adhesions, unlike cells on fibronectin that also binds these integrins. Cell migration and proliferation...
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Biochem J (2003) 372 (2): 485–493.
Published: 01 June 2003
... unclear. One possible function could be to regulate the processes of chondrocyte hypertrophy through direct cell–type X collagen interactions. Adhesions of embryonic chick chondrocytes, and cell lines with known expression of collagen-binding integrins (MG63 and HOS), were assayed on chick type X collagen...
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Biochem J (2003) 369 (2): 311–318.
Published: 15 January 2003
... of the cations required for adhesion, the concentrations of LAPβ 1 required for binding and the ability of a small-molecule inhibitor of α v β 3 , SB223245, to block the interaction. Using glutathione S-transferase fusion proteins we have mapped a minimal integrin-binding loop in LAPβ 1 and then used...
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Biochem J (2001) 357 (3): 843–850.
Published: 25 July 2001
...Charlotte A. LEWIS; Paul A. TOWNSEND; Clare M. ISACKE CD44 is the principal cell surface receptor for the extracellular matrix glycosaminoglycan hyaluronan, and binding to this ligand underlies CD44-mediated cell attachment and migration. As would be expected for a widely expressed adhesion...
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Biochem J (2000) 345 (3): 611–619.
Published: 25 January 2000
... during the early steps of the infectious process. The adhesive molecules present on the cell surface of S. aureus include the collagen adhesin (Cna) [10], fibronectin-binding proteins A and B (FnBPA and FnBPB) [11], the clumping factors A and B (ClfA and ClfB), which bind fibrinogen [12,13], an elastin...
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Biochem J (2000) 345 (2): 385–392.
Published: 10 January 2000
...Lisa D. FINKELSTEIN; Yoji SHIMIZU Cell adhesion mediated by β1 integrin receptors leads to the initiation of intracellular signals that affect cell differentiation and survival. Here we have analysed the mechanism by which the α4β1 integrin activates the mitogen-activated protein kinase pathway...
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Biochem J (1999) 344 (2): 527–533.
Published: 24 November 1999
...) in the adjacent ninth type III repeat, which synergizes with RGD. Arg-Arg-Glu-Thr-Ala-Trp-Ala (RRETAWA) is a novel peptidic ligand for α5β1, identified by phage display, which blocks α5β1-mediated cell adhesion to fibronectin. A key question is the location of the binding sites for these ligand sequences within...
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Biochem J (1999) 342 (2): 379–386.
Published: 24 August 1999
... attachment of the parasite to the host cell. Apical attachment coincides with the polarized discharge of parasite secretory vesicles called micro- nemes [4,5], suggesting that micronemal proteins have a role in parasite adhesion to the host cell. In a recent study with calcium ionophores, we demonstrated...
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Biochem J (1999) 340 (1): 95–101.
Published: 10 May 1999
...-phosphatidic acid (DiC8-PA) to human eosinophils resulted in CD11b/CD18-dependent adhesion, both to STZ particles and fibronectin-coated wells, without significant upregulation of CD11b/CD18. The DiC8-PA-induced adhesion was not mediated via the fatty acid moiety, because other C8-lipids such as 1,2-diC8...
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Biochem J (1999) 339 (1): 119–125.
Published: 25 March 1999
... that a strong dynamic phosphorylation exists in serine and threonine residues of the β 2 integrins. 1 To whom correspondence should be addressed (e-mail [email protected] ). 13 11 1998 4 1 1999 20 1 1999 The Biochemical Society, London © 1999 1999 adhesion...
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Biochem J (1999) 338 (2): 471–478.
Published: 22 February 1999
...Marianne J. RATCLIFFE; Caroline SMALES; James M. STADDON Inflammatory mediators such as histamine and thrombin increase the tight-junction permeability of endothelial cells. Tight-junction permeability may be independently controlled, but is dependent on the adherens junction, where adhesion...