...Marie-Soleil Gauthier; Neil B. Ruderman In recent years, it has become widely accepted that obesity is characterized by a chronic low-grade inflammation of adipose tissue that predisposes affected individuals to insulin resistance, Type 2 diabetes and other disorders associated with the metabolic...

... compensatory mechanisms are in place. In this issue of the Biochemical Journal , Wong et al. characterize new members of the CTRPs [C1q-TNFα (tumour necrosis factor α)-related proteins]. They establish that some CTRPs are produced primarily in the stromal vascular fraction of adipose tissue...

... designated as CTRP ( C 1q/ T NF- r elated p rotein) 1–7, and in the present study describe CTRP10. In the present study, we show that CTRP1, CTRP2, CTRP3, CTRP5 and CTRP7 transcripts are expressed predominantly by adipose tissue. In contrast, placenta and eye expressed the highest levels of CTRP6 and CTRP10...

.... 1 To whom correspondence should be addressed (email [email protected] ). 5 2 2008 15 5 2008 19 5 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 adipose tissue adipose triacylglycerol lipase (ATGL) fatty acid metabolism hormone-sensitive...

... is also unknown. In the present study, we identified ACAM (adipocyte adhesion molecule), a novel homologue of the CTX (cortical thymocyte marker in Xenopus ) gene family. ACAM cDNA was isolated during PCR-based cDNA subtraction, and its mRNA was shown to be up-regulated in WATs (white adipose tissues...

... mRNA, DD16, specifically induced during the course of adipocyte differentiation. DD16 mRNAs are present in several tissues, but among the tissues tested, a remarkably higher level of expression was found in white adipose tissue. The DD16 cDNA encoded a polypeptide of 415 amino acids containing a single...

... of the ovine ACC-α gene. Three promoters, PI, PII and PIII, are dispersed throughout 50kb of genomic DNA. Expression from PI is limited to adipose tissue and liver. Sequence comparison of the proximal promoters of ovine and mouse PIs demonstrates high nucleotide identity and that they are characterized...

... a decrease in adipose tissue mass in ASP-deficient female mice, even when TG clearance is normal [11]. These opposing viewpoints have been discussed in two recent review articles [12,13]. In spite of the fact that adipsin and factor B are also involved in ASP production via the alternative complement pathway...

...Karine MOULIN; Nathalie TRUEL; Mireille ANDRÉ; Emmanuelle ARNAULD; Maryse NIBBELINK; Béatrice COUSIN; Christian DANI; Luc PÉNICAUD; Louis CASTEILLA In mammals, two types of adipose tissue are present, brown and white. They develop sequentially, as brown fat occurs during late gestation whereas...

...Peter KLATT; Judith CACHO; M. Dolores CRESPO; Emilio HERRERA; Pilar RAMOS Nitric oxide has been implicated in the inhibition of catecholamine-stimulated lipolysis in adipose tissue by as yet unknown mechanisms. In the present study, it is shown that the nitric oxide donor, 2,2-diethyl-1-nitroso...

...Chantal JEHL-PIETRI; Claire BASTIE; Isabelle GILLOT; Serge LUQUET; Paul A. GRIMALDI Nutritional long-chain fatty acids control adipose tissue mass by regulating the number and the size of adipocytes. It is now established that peroxisome-proliferator-activated receptors (PPARs) play crucial...

... role in the development of impaired insulin action on adipose tissue and skeletal muscle. In this study we undertook to investigate the potential of GSH depletion to induce insulin resistance, by utilizing the GSH synthesis inhibitor, L -buthionine-[ S , R ]-sulfoximine (BSO). GSH depletion (20-80...