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Keywords: aggregation
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Biochem J (2022) 479 (18): 1999–2011.
Published: 30 September 2022
...Mei Nakagawa; Takayuki Obita; Mineyuki Mizuguchi Destabilization of human transthyretin leads to its aggregation into amyloid fibrils, which causes a rare, progressive and fatal systemic disorder called ATTR amyloidosis. By contrast, murine transthyretin is known to be very stable and therefore...
Includes: Supplementary data
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Biochem J (2020) 477 (1): 111–120.
Published: 08 January 2020
...Igor Lima; Ambuja Navalkar; Samir K. Maji; Jerson L. Silva; Guilherme A.P. de Oliveira; Elio A. Cino Aggregation is the cause of numerous protein conformation diseases. A common facet of these maladies is the transition of a protein from its functional native state into higher order forms...
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Biochem J (2015) 468 (3): 485–493.
Published: 15 June 2015
...Eva Illes-Toth; Mafalda Ribeiro Ramos; Roberto Cappai; Caroline Dalton; David P Smith Misfolding and aggregation of α-synuclein (α-syn) into Lewy bodies is associated with a range of neurological disorders, including Parkinson's disease (PD). The cell-to-cell transmission of α-syn pathology has...
Includes: Supplementary data
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Biochem J (2015) 468 (1): 99–108.
Published: 05 May 2015
... was used to remove remaining free label. aggregation antibody α 1 -antitrypsin polymerization protein stability α 1 -Antitrypsin ( SERPINA1 ) is an acute-phase glycoprotein, secreted by hepatocytes and abundant in the plasma. A member of the serpin superfamily, the primary role of α 1...
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Biochem J (2013) 453 (3): 337–344.
Published: 12 July 2013
... of the EGFR kinase domain asymmetric dimer. Activation of the kinase domain by Peptide C also enhances phosphorylation of other substrates. Aggregation of the EGFR kinase domain by Peptide C probably underlies activation, and Peptide C precipitates several other proteins. Peptide C was found to form fibrils...
Includes: Supplementary data
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Biochem J (2010) 432 (2): 275–282.
Published: 12 November 2010
... of classical and dynamic light scattering and NMR spectroscopy to demonstrate that AHSP forms a heterodimeric complex with α o that inhibits α o aggregation and promotes α o folding in the absence of haem. These findings indicate that AHSP may function as an α o -specific chaperone, and suggest an important...
Includes: Supplementary data
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Biochem J (2009) 421 (1): 71–77.
Published: 12 June 2009
...Yo-hei Watanabe; Yosuke Nakazaki; Ryoji Suno; Masasuke Yoshida The ClpB chaperone forms a hexamer ring and rescues aggregated proteins in co-operation with the DnaK system. Each subunit of ClpB has two nucleotide-binding modules, AAA (ATPase associated with various cellular activities)-1 and AAA-2...
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Biochem J (2008) 409 (3): 691–699.
Published: 15 January 2008
...Paul Evans; Christine Slingsby; B. A. Wallace Age-related cataract is a result of crystallins, the predominant lens proteins, forming light-scattering aggregates. In the low protein turnover environment of the eye lens, the crystallins are susceptible to modifications that can reduce stability...
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Biochem J (2007) 404 (2): 299–308.
Published: 14 May 2007
... be addressed (email spk@temple.edu ). 19 10 2006 29 1 2007 13 2 2007 13 2 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 aggregation calcium mitogen-activated protein kinase (MAPK) protein kinase C Src family kinase Platelet activation...
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Biochem J (2007) 403 (2): 343–351.
Published: 26 March 2007
... , and the other with five more octapeptide repeats, rPrP 10OR . We found that the insertion mutant proteins are more prone to aggregate, and the degree and kinetics of aggregation are proportional to the number of inserts. The octapeptide-repeat and α-helix 1 regions are important in aggregate formation, because...
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Biochem J (2005) 388 (1): 151–157.
Published: 10 May 2005
... LEA protein from wheat, have been subjected to functional analysis. Heat-stress experiments with citrate synthase, which is susceptible to aggregation at high temperatures, suggest that LEA proteins do not behave as classical molecular chaperones, but they do exhibit a protective, synergistic effect...
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Biochem J (2002) 368 (1): 293–300.
Published: 15 November 2002
...-specific ligands in murine platelets. We show that levels of GPVI—FcRγ of the order of 50% and 20% of wild-type levels caused 2- and 5-fold shifts to the right respectively in the dose—response curve for aggregation in response to collagen, the snake toxin convulxin and the monoclonal antibody JAQ1...
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