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Keywords: aging
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Biochem J (2020) 477 (14): 2715–2720.
Published: 29 July 2020
... possibly in physiological aging. The potential bifunctional role of LBR on cellular senescence establishment, namely its role in chromatin structure together with its enzymatic activity contributing to cholesterol synthesis, provide a new target to develop potential anti-aging therapies...
Biochem J (2018) 475 (20): 3189–3200.
Published: 23 October 2018
...Michael G. Friedrich; Zhen Wang; Kevin L. Schey; Roger J. W. Truscott The breakdown of long-lived proteins (LLPs) is associated with aging, as well as disease; however, our understanding of the molecular processes involved is still limited. Of particular relevance, cross-linked proteins are often...
Includes: Supplementary data
Biochem J (2016) 473 (15): 2295–2314.
Published: 28 July 2016
... the aging process, are associated with reduced mitochondrial quality and quantity in muscle. This has strong negative implications for whole-body metabolic health and the preservation of muscle mass. A number of traditional, as well as novel regulatory pathways exist in muscle that control both...
Biochem J (2015) 471 (3): 307–322.
Published: 16 October 2015
... the diseases of old age, including type 2 diabetes (T2D), cardiovascular disease (CVD) and cancer. Developing new ways to improve health in the elderly is therefore a top priority for biomedical research. Although our understanding of the molecular basis of these morbidities has advanced rapidly...
Biochem J (2014) 464 (2): 221–229.
Published: 14 November 2014
..., whereas the role of testosterone in the regulation of longevity-associated gene expressions remains largely unclear. The klotho gene, predominantly expressed in the kidney, has recently been discovered to be an aging suppressor gene. In the present study, we investigated the regulatory effects of...
Biochem J (2014) 459 (1): 127–135.
Published: 14 March 2014
... suppression of the activities of mitochondrial ETC (electron-transport chain) oxidoreductases retards the aging process and extends lifespan. Underexpression of both CcO subunits, induced by RNAi, resulted in decreases in the respective mRNA and protein levels, CcO holoenzyme activity, rate of mitochondrial...
Includes: Supplementary data
Biochem J (2014) 458 (2): 343–353.
Published: 14 February 2014
... sensitivity of Caenorhabditis elegans rad-6 mutants, and confers resistance to 5-fluoroorotic acid anti-metabolites. We find that disruption of de novo pyrimidine synthesis impairs metabolism and shortens lifespan. aging growth metabolism mitochondria UMP synthase Organisms are...
Includes: Supplementary data
Biochem J (2013) 456 (2): 219–229.
Published: 08 November 2013
...Ying Feng; Barnabas G. Williams; Françoise Koumanov; Adrian J. Wolstenholme; Geoffrey D. Holman Caenorhabditis elegans is widely used as a model for investigation of the relationships between aging, nutrient restriction and signalling via the DAF-2 (abnormal dauer formation 2) receptor for insulin...
Includes: Supplementary data
Biochem J (2012) 444 (1): 1–10.
Published: 26 April 2012
... controlling mitochondrial pathways through the deacetylation of target enzymes. In general, SIRT3 activity and subsequent control of enzymes involved in energy metabolism is consistent with an overall role of protecting against age-related diseases. In fact, experimental and genetic evidence has linked SIRT3...
Biochem J (2011) 435 (1): 207–216.
Published: 15 March 2011
...Rachael A. Dunlop; Ulf T. Brunk; Kenneth J. Rodgers Cellular deposits of oxidized and aggregated proteins are hallmarks of a variety of age-related disorders, but whether such proteins contribute to pathology is not well understood. We previously reported that oxidized proteins form lipofuscin...
Includes: Supplementary data
Biochem J (2010) 432 (3): 585–595.
Published: 25 November 2010
...Andrew M. Pickering; Alison L. Koop; Cheryl Y. Teoh; Gennady Ermak; Tilman Grune; Kelvin J. A. Davies Oxidized cytoplasmic and nuclear proteins are normally degraded by the proteasome, but accumulate with age and disease. We demonstrate the importance of various forms of the proteasome during...
Includes: Supplementary data
Biochem J (2010) 427 (1): 105–112.
Published: 15 March 2010
...John F. O'Toole; Hiral V. Patel; Colin J. Naples; Hisashi Fujioka; Charles L. Hoppel Kidney function declines with advancing age and mitochondria have been implicated. In the present study we have examined the integrated function of mitochondria isolated from kidneys of 6- and 24-month-old Fischer...
Includes: Supplementary data
Biochem J (2009) 423 (2): 219–231.
Published: 25 September 2009
... © The Authors Journal compilation © 2009 Biochemical Society 2009 aging ATPase mitochondria nitrative stress structure–activity relationship tyrosine nitration Protein nitration constitutes a post-translational modification that occurs mainly at Tyr (tyrosine) residues in vivo as a...
Biochem J (2009) 421 (1): 97–106.
Published: 12 June 2009
... Clinical Phase I for pretreatment of OP intoxication. Phosphylated ChEs (cholinesterases) can undergo a spontaneous time-dependent process called ‘aging’ during which the conjugate is dealkylated, leading to creation of an enzyme that cannot be reactivated. hBChE inhibited by phosphoramidates such as tabun...
Biochem J (2009) 419 (2): 437–445.
Published: 27 March 2009
... −/− null mutant. Results from the present study suggest that the antioxidant and anti-apoptotic activities of dPrx5 play a critical role in development and aging of the fly. 1 To whom correspondence should be addressed (email borr@smu.edu ). 2 10 2008 22 12 2008 7 1 2009 7 1...
Biochem J (2009) 418 (1): 1–12.
Published: 28 January 2009
...Susan Broughton; Linda Partridge Enormous strides in understanding aging have come from the discovery that mutations in single genes can extend healthy life-span in laboratory model organisms such as the yeast Saccharomyces , the fruit fly Drosophila melanogaster , the nematode worm Caenorhabditis...
Biochem J (2008) 410 (1): 131–140.
Published: 29 January 2008
...Rachael A. Dunlop; Roger T. Dean; Kenneth J. Rodgers Oxidized protein deposition and accumulation have been implicated in the aetiology of a wide variety of age-related pathologies. Protein oxidation in vivo commonly results in the in situ modification of amino acid side chains, generating new...
Biochem J (2007) 407 (3): 321–329.
Published: 12 October 2007
... implicated in delaying the aging process and progression of neurodegenerative diseases. In recent years, significant efforts have been made to explore the catalytic properties and physiological functions of these enzymes. In the current review, we present recent progress in this area, with the focus on...
Biochem J (2007) 405 (3): 583–589.
Published: 13 July 2007
...Dikran Toroser; Rajindar S. Sohal The nature of the mechanisms underlying the age-related decline in glutathione (GSH) synthetic capacity is at present unclear. Steady-state kinetic parameters of mouse liver GCL (glutamate–cysteine ligase), the rate-limiting enzyme in GSH synthesis, and levels of...
Biochem J (2006) 398 (3): 319–337.
Published: 29 August 2006
... the maintenance of genome stability. In particular, mutations in genes of the RecQ family of DNA helicases result in chromosomal instability diseases of premature aging and/or cancer predisposition. We will discuss the mechanisms of RecQ helicases in pathways of DNA metabolism. A review of RecQ...
Biochem J (2006) 397 (1): 25–29.
Published: 14 June 2006
... To whom correspondence should be addressed (email peter.aronson@yale.edu ). 15 3 2006 31 3 2006 12 4 2006 12 4 2006 The Biochemical Society, London 2006 aging anion exchange citrate dicarboxylate Indy succinate Aging is a complex biological process...
Biochem J (2006) 394 (3): 605–615.
Published: 24 February 2006
... arterial smooth muscle relaxation [Adachi, Weisbrod, Pimentel, Ying, Sharov, Schöneich and Cohen (2004) Nat. Med. 10 , 1200–1207]. This mechanism may be impaired through the irreversible oxidation of functionally important cysteine residues as a consequence of oxidative stress and aging. To establish...
Biochem J (2005) 391 (2): 277–284.
Published: 10 October 2005
...Anne-Cécile V. Bayne; Robin J. Mockett; William C. Orr; Rajindar S. Sohal The generation of superoxide anion radicals (O 2 •− ) and hydrogen peroxide (H 2 O 2 ) during mitochondrial respiration has been widely postulated to be causally linked to the aging process. The hypothesis that a specific...
Biochem J (2005) 391 (1): 59–67.
Published: 26 September 2005
...Claudio Costantini; Richard Weindruch; Giuliano Della Valle; Luigi Puglielli Aging is the single most important risk factor for AD (Alzheimer's disease). However, the molecular events that connect normal aging to AD are mostly unknown. The abnormal accumulation of Aβ (amyloid β-peptide) in the form...
Includes: Supplementary data
Biochem J (2004) 382 (1): 131–136.
Published: 10 August 2004
...Igor REBRIN; Anne-Cécile V. BAYNE; Robin J. MOCKETT; William C. ORR; Rajindar S. SOHAL The main purpose of the present study was to test the hypothesis that the aging process is associated with a pro-oxidizing shift in the cellular redox state. The amounts of the redox-sensitive free aminothiols...
Biochem J (2004) 380 (3): 919–928.
Published: 15 June 2004
... experimental groups. This finding indicates that the senescent cells fully compensate for increased proton leakage by enhanced electron-transport activity in the routine state. These results provide a new insight into age-associated defects in mitochondrial function and compensatory mechanisms in intact cells...
Biochem J (2004) 377 (2): 489–497.
Published: 15 January 2004
... amount of membrane-skeleton-associated band 3 (and of PTP1B) during the release of spectrin-free vesicles, suggesting a more complex modality of interaction of PTP1B with band 3 in the erythrocyte membrane. Analysis of erythrocytes of different cell ages revealed that PTP1B, unlike the other enzymes...
Biochem J (2000) 348 (2): 425–432.
Published: 23 May 2000
...Hsin-Chen LEE; Pen-Hui YIN; Ching-You LU; Chin-Wen CHI; Yau-Huei WEI Mitochondrial respiratory function is impaired in the target tissues of patients with mitochondrial diseases and declines with age in various human tissues. It is generally accepted that respiratory-chain defects result in...
Biochem J (2000) 345 (3): 481–485.
Published: 25 January 2000
... undergo racemization of the aspartic acid residue Asp 1211 and isomerization of the bond between this residue and Gly 1212 . These spontaneous non-enzymic chemical reactions takes place in vivo in bone, and the degree of racemization and isomerization of CTx molecules may be an index of the biological age...