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Keywords: allosteric regulation
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Articles
Journal:
Biochemical Journal
Biochem J (2025) 482 (09): 467–483.
Published: 06 May 2025
...Jordan A. Compton; Wayne M. Patrick The enzyme 6-phosphofructokinase (PFK) phosphorylates d -fructose 6-phosphate, producing d -fructose 1,6-bisphosphate. The canonical version—discovered almost 90 years ago—is ATP-dependent, allosterically regulated and catalyses the first committed step...
Includes: Supplementary data
Articles
Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks
Available to PurchaseUday Kiran Velagapudi, Élise Rouleau-Turcotte, Ramya Billur, Xuwei Shao, Manisha Patil, Ben E. Black, John M. Pascal, Tanaji T. Talele
Journal:
Biochemical Journal
Biochem J (2024) 481 (6): 437–460.
Published: 13 March 2024
... contributed equally to this work. 27 9 2023 29 1 2024 19 2 2024 © 2024 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2024 allosteric regulation crystallography HXMS PARP veliparib analogs The catalytic activity of PARP1...
Includes: Supplementary data
Articles
The choreography of protein kinase PDK1 and its diverse substrate dance partners
Available to PurchaseIn Collection
Cell signaling in the 21st century
Journal:
Biochemical Journal
Biochem J (2023) 480 (19): 1503–1532.
Published: 04 October 2023
... Society 2023 Correspondence: Ricardo M. Biondi ([email protected]) 6 6 2023 24 8 2023 31 8 2023 AGC kinase allosteric regulation PDPK1 phosphorylation/dephosphorylation protein conformation protein kinase regulation During a search for PDK1...
Articles
Emerging functions of pseudoenzymes
Open AccessIn Collection
Cell signaling in the 21st century
Journal:
Biochemical Journal
Biochem J (2023) 480 (10): 715–728.
Published: 19 May 2023
... Press and the Biochemical Society under a transformative agreement with Individual. allosteric regulation catalytic motif molecular scaffolds molecular switch protein moonlighting substrate trap Pseudoenzymes are proteins that lack conserved catalytic amino acids when compared...
Articles
Allosteric pluripotency: challenges and opportunities
Available to PurchaseMadoka Akimoto, Karla Martinez Pomier, Bryan VanSchouwen, Jung Ah Byun, Mariia Khamina, Giuseppe Melacini
Journal:
Biochemical Journal
Biochem J (2022) 479 (7): 825–838.
Published: 11 April 2022
... 2021 17 3 2022 21 3 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 agonism allosteric regulation antagonism cAMP kinases protein kinase A Allosteric regulation pertains to the control of biological function...
Articles
Eiji Okamura, Kinuka Ohtaka, Ryuichi Nishihama, Kai Uchida, Ayuko Kuwahara, Keiichi Mochida, Masami Yokota Hirai
Journal:
Biochemical Journal
Biochem J (2021) 478 (12): 2217–2232.
Published: 18 June 2021
... analysis suggested that the different sensitivities convergently evolved in the bryophyte and angiosperm lineages. Site-directed mutagenesis of AtPGDH1 revealed that Asp 538 and Asn 556 residues in the ACT domain are involved in allosteric regulation by the effectors. These findings provide insight...
Includes: Supplementary data
Articles
Sunitinib inhibits RNase L by destabilizing its active dimer conformation
Available to PurchaseJinle Tang, Yingjie Wang, Huan Zhou, Yuxin Ye, Manisha Talukdar, Ziyang Fu, Zhihong Liu, Jihui Li, Dante Neculai, Jiali Gao, Hao Huang
Journal:
Biochemical Journal
Biochem J (2020) 477 (17): 3387–3399.
Published: 17 September 2020
... mM (NH 4 ) 2 SO 4 , and 20% PEG4000). Crystals were flash-frozen in liquid N 2 . All diffraction data were collected at the BL17U1 beamline of Shanghai Synchrotron Radiation Facility and indexed, integrated, and scaled using XDS [ 25 ]. allosteric regulation dimerization drug discovery...
Includes: Supplementary data
Articles
Margaux Leemans, Christian Galicia, Egon Deyaert, Elise Daems, Linda Krause, Jone Paesmans, Els Pardon, Jan Steyaert, Arjan Kortholt, Frank Sobott, Dagmar Klostermeier, Wim Versées
Journal:
Biochemical Journal
Biochem J (2020) 477 (7): 1203–1218.
Published: 02 April 2020
.... 20 11 2019 9 3 2020 13 3 2020 13 3 2020 © 2020 The Author(s) 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . allosteric...
Includes: Supplementary data
Articles
Biochemical characterization of phospho enol pyruvate carboxykinases from Arabidopsis thaliana
Available to PurchaseBruno E. Rojas, Matías D. Hartman, Carlos M. Figueroa, Laura Leaden, Florencio E. Podestá, Alberto A. Iglesias
Journal:
Biochemical Journal
Biochem J (2019) 476 (20): 2939–2952.
Published: 18 October 2019
... enzymes exhibited high affinity for oxaloacetate and ATP, reinforcing their role as decarboxylases. We employed a high-throughput screening for putative allosteric regulators using differential scanning fluorometry and confirmed their effect on enzyme activity by performing enzyme kinetics. Ath PEPCK1...
Includes: Supplementary data
Articles
Guarding the gateway to histidine biosynthesis in plants: Medicago truncatula ATP-phosphoribosyltransferase in relaxed and tense states
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2018) 475 (16): 2681–2697.
Published: 31 August 2018
[email protected] ) 11 4 2018 30 7 2018 1 8 2018 2 8 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 allosteric regulation AMP ATP-PRT crystal structure histidine biosynthesis PRPP Prokaryotes, lower eukaryotes...
Articles
Crystal structure and pH-dependent allosteric regulation of human β-ureidopropionase, an enzyme involved in anticancer drug metabolism
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Journal:
Biochemical Journal
Biochem J (2018) 475 (14): 2395–2416.
Published: 31 July 2018
... that protonation state changes play a crucial role in the allosteric regulation mechanism. Disruption of dimer–dimer interfaces by site-directed mutagenesis generated dimeric, inactive enzyme variants. The crystal structure of the T299C variant refined to 2.08 Å resolution revealed high structural conservation...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2018) 475 (12): 2025–2042.
Published: 26 June 2018
... understood in the light of AGC kinase regulation. allosteric regulation aurora kinases protein dynamics The regulation of the AGC-family kinases has been extensively studied [ 29 ]. The canonical activation pathway for AGC kinases is the co-ordinated phosphorylation of both the HM...
Articles
Role of the potassium/lysine cationic center in catalysis and functional asymmetry in membrane-bound pyrophosphatases
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2018) 475 (6): 1141–1158.
Published: 26 March 2018
... Press Limited on behalf of the Biochemical Society 2018 allosteric regulation cation transporter enzyme kinetics membrane-bound pyrophosphatase protein evolution pyrophosphate Scheme 1. K + and Na + binding to the enzyme–substrate complex. Scheme 2. Substrate binding...
Articles
Mechanistic insights into the allosteric regulation of Pseudomonas aeruginosa aspartate kinase
Available to PurchaseChang-Cheng Li, Mei-Jia Yang, Li Liu, Tao Li, Cui-Ting Peng, Li-Hui He, Ying-Jie Song, Yi-Bo Zhu, Ya-Lin Shen, Jing Yang, Ning-Lin Zhao, Chang Zhao, Qiao-Xia Zhou, Hong Li, Mei Kang, Ai-Ping Tong, Hong Tang, Rui Bao
Journal:
Biochemical Journal
Biochem J (2018) 475 (6): 1107–1119.
Published: 20 March 2018
... identified and a general amino acid effector motif of AK family is described. ACT domain allosteric regulation aspartate kinase crystal structure Pseudomonas aeruginosa Aspartate kinase (AK, EC 2.7.2.4), also known as aspartokinase, is committed in the first step of the Asp-derived amino...
Includes: Supplementary data
Articles
Stromal cell-derived factor-1 (CXCL12) activates integrins by direct binding to an allosteric ligand-binding site (site 2) of integrins without CXCR4
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2018) 475 (4): 723–732.
Published: 16 February 2018
... (e.g. presented on proteoglycans) can rapidly activate integrins in an allosteric manner by binding to site 2 in the absence of CXCR4. The allosteric integrin activation by SDF1 is a novel target for drug discovery. allosteric regulation chemokines integrins stromal cell-derived factor-1...
Includes: Supplementary data
Articles
A dimeric catalytic core relates the short and long forms of ATP-phosphoribosyltransferase
Available to PurchaseGerd Mittelstädt, Wanting Jiao, Emma K. Livingstone, Gert-Jan Moggré, Ali Reza Nazmi, Emily J. Parker
Journal:
Biochemical Journal
Biochem J (2018) 475 (1): 247–260.
Published: 05 January 2018
..., which differ in their molecular architecture and mechanism of allosteric regulation. The short-form ATP-PRT is a hetero-octamer, with four HisG chains that comprise only the catalytic domains and four separate chains of HisZ required for allosteric regulation by histidine. The long-form ATP-PRT is homo...
Articles
Toward a systems approach to the human cytochrome P450 ensemble: interactions between CYP2D6 and CYP2E1 and their functional consequences
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Journal:
Biochemical Journal
Biochem J (2017) 474 (20): 3523–3542.
Published: 10 October 2017
... ensemble and suggest a role of interactions of CYP2E1 with CYP2D6 in pharmacologically important instances of alcohol–drug interactions. allosteric regulation cytochrome P450 drug metabolism membrane proteins protein–protein interactions Correspondence: Dmitri R. Davydov ( dmrdavyd...
Articles
New insight on the S100A1–STIP1 complex highlights the important relationship between allostery and entropy in protein function
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2017) 474 (17): 2977–2980.
Published: 17 August 2017
... allosteric regulation calcium signaling entropy NMR spectroscopy It has long been known that calcium signaling is a centerpiece for intracellular processes. The S100 proteins contain two EF-hand motifs and form signaling competent hetero- or homodimers when bound to calcium. These proteins mediate...
Articles
MGDG, PG and SQDG regulate the activity of light-dependent protochlorophyllide oxidoreductase
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Journal:
Biochemical Journal
Biochem J (2017) 474 (7): 1307–1320.
Published: 23 March 2017
... found out that phosphatidylglycerol and sulfoquinovosyl diacylglycerol are allosteric regulators of the nucleotide binding, which increase the affinity towards NADPH a 100-fold. Moreover, we showed for the first time that NADH can, like NADPH, form active complexes with Pchlide and POR, however, at much...
Articles
Cullin neddylation may allosterically tune polyubiquitin chain length and topology
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Journal:
Biochemical Journal
Biochem J (2017) 474 (5): 781–795.
Published: 20 February 2017
...-in to be used in the MD simulations. © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 allosteric regulation Nedd8 polyubiquitination ubiquitin ligases Covalent ligation of ubiquitin to substrates and ubiquitins is achieved via a three...
Includes: Supplementary data
Articles
An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour
Open AccessNeda Motamedi-Shad, Alistair M. Jagger, Maximilian Liedtke, Sarah V. Faull, Arjun Scott Nanda, Enrico Salvadori, Joshua L. Wort, Christopher W.M. Kay, Narinder Heyer-Chauhan, Elena Miranda, Juan Perez, Adriana Ordóñez, Imran Haq, James A. Irving, David A. Lomas
Journal:
Biochemical Journal
Biochem J (2016) 473 (19): 3269–3290.
Published: 27 September 2016
... with 1 M H 2 SO 4 , and an endpoint measurement of HRP activity at 450 nm was made using a SpectraMax M2e plate reader (Molecular Devices). All steps were performed at room temperature. allosteric regulation antibodies protein aggregation protein conformation protein–protein interactions...
Includes: Supplementary data
Articles
Inhibitory serpins. New insights into their folding, polymerization, regulation and clearance
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2016) 473 (15): 2273–2293.
Published: 28 July 2016
... on behalf of the Biochemical Society 2016 allosteric regulation heparin metastability polymerization proteinase inhibition protein folding receptor binding serpin The initial identification of a relationship that would grow into the serpin superfamily of proteins was made in 1980...
Articles
Calcium-insensitive splice variants of mammalian E1 subunit of 2-oxoglutarate dehydrogenase complex with tissue-specific patterns of expression
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2016) 473 (9): 1165–1178.
Published: 26 April 2016
... glutamine. It is subject to allosteric regulation by NADH and the ATP/ADP ratio, and by Ca 2+ through binding to the E1 subunit. The latter involves a unique Ca 2+ -binding site which includes D 114 ADLD (site 1). Here, we describe three splice variants of E1 in which either the exon expressing this site...
Includes: Supplementary data
Articles
Discovery of a novel inhibitor of kinesin-like protein KIFC1
Available to PurchaseWei Zhang, Ling Zhai, Yimin Wang, Rebecca J. Boohaker, Wenyan Lu, Vandana V. Gupta, Indira Padmalayam, Robert J. Bostwick, E. Lucile White, Larry J. Ross, Joseph Maddry, Subramaniam Ananthan, Corinne E. Augelli-Szafran, Mark J. Suto, Bo Xu, Rongbao Li, Yonghe Li
Journal:
Biochemical Journal
Biochem J (2016) 473 (8): 1027–1035.
Published: 08 April 2016
.... Cells were seeded into 96-well tissue culture-treated microtitre plates at a density of 3000–4000 cells/well. After overnight incubation, the cells were treated with SR31527 for 96 h. Cell viability was measured by the CellTiter-Glo Assay (Promega). allosteric regulation breast cancer inhibitor...
Includes: Supplementary data
Articles
Directed evolution of Tau class glutathione transferases reveals a site that regulates catalytic efficiency and masks co-operativity
Available to PurchaseIrine Axarli, Abdi W. Muleta, Dimitrios Vlachakis, Sophia Kossida, Georgia Kotzia, Anastasios Maltezos, Prathusha Dhavala, Anastassios C. Papageorgiou, Nikolaos E. Labrou
Journal:
Biochemical Journal
Biochem J (2016) 473 (5): 559–570.
Published: 24 February 2016
... shuffling showed allosteric kinetics and enhanced detoxifying potential towards the herbicide fluorodifen. Its structure was determined. New engineered GSTs could be useful in biotechnology as efficient bioscavengers. allosteric regulation enzyme catalysis enzyme kinetics enzyme structure...
Includes: Supplementary data
Articles
Structure-dynamic determinants governing a mode of regulatory response and propagation of allosteric signal in splice variants of Na + /Ca 2+ exchange (NCX) proteins
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Journal:
Biochemical Journal
Biochem J (2015) 465 (3): 489–501.
Published: 22 January 2015
...Moshe Giladi; Su Youn Lee; Reuben Hiller; Ka Young Chung; Daniel Khananshvili The Ca 2+ -dependent allosteric regulation of Na + /Ca 2+ exchanger (NCX) proteins represents Ca 2+ interaction with the cytosolic domains, CBD1 (calcium-binding domain 1) and CBD2, which is associated either...
Includes: Supplementary data
Articles
Sulfonylurea receptors regulate the channel pore in ATP-sensitive potassium channels via an intersubunit salt bridge
Available to PurchaseDavid Lodwick, Richard D. Rainbow, Hussein N. Rubaiy, Mohammed Al Johi, Geerten W. Vuister, Robert I. Norman
Journal:
Biochemical Journal
Biochem J (2014) 464 (3): 343–354.
Published: 05 December 2014
... have mapped a cytoplasmic interaction between Kir6 and SUR subunits of ATP-sensitive potassium channels. We identify residues forming a key salt-bridge controlling transfer of allosteric information from agonist/antagonist binding to gating of the channel pore. allosteric regulation...
Includes: Supplementary data
Articles
Bogumil Zelent, Anne Raimondo, Amy Barrett, Carol W. Buettger, Pan Chen, Anna L. Gloyn, Franz M. Matschinsky
Journal:
Biochemical Journal
Biochem J (2014) 459 (3): 551–564.
Published: 11 April 2014
... formation between these two allosterically regulated proteins. 11 10 2013 3 2 2014 26 2 2014 26 2 2014 allosteric regulation co-operativity diabetes fructose phosphate ester glucokinase glucokinase regulatory protein metabolic regulation © 2014 Author(s) 2014...
Includes: Supplementary data
Articles
Mutational analysis of residues in the regulatory CBS domains of Moorella thermoacetica pyrophosphatase corresponding to disease-related residues of human proteins
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Journal:
Biochemical Journal
Biochem J (2011) 433 (3): 497–504.
Published: 14 January 2011
... CBS-PPase. 1 Correspondence may be addressed to either of these authors (email [email protected] or [email protected] ). adenine nucleotide allosteric regulation cystathionine β-synthase domain (CBS domain) inorganic pyrophosphatase Moorella thermoacetica mutagenesis 5...
Includes: Supplementary data
Articles
Structural and mechanistic insight into how antibodies inhibit serine proteases
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Journal:
Biochemical Journal
Biochem J (2010) 430 (2): 179–189.
Published: 13 August 2010
... for interfering with the catalytic machinery of proteases. 1 To whom correspondence should be addressed (email [email protected] ). 27 4 2010 11 6 2010 14 6 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 allosteric regulation antibody inhibition mechanism...
Includes: Multimedia, Supplementary data
Articles
Cystic fibrosis transmembrane regulator fragments with the Phe 508 deletion exert a dual allosteric control over the master kinase CK2
Available to PurchaseMario A. Pagano, Oriano Marin, Giorgio Cozza, Stefania Sarno, Flavio Meggio, Kate J. Treharne, Anil Mehta, Lorenzo A. Pinna
Journal:
Biochemical Journal
Biochem J (2010) 426 (1): 19–29.
Published: 27 January 2010
...-terminal amides on Rink Amide PEGA {poly[acryloyl-bis(aminopropyl)poly(ethylene glycol)]} resin (Novabiochem) as previously described [ 22 ]. allosteric regulation cystic fibrosis cystic fibrosis transmembrane regulator (CFTR) molecular modelling protein kinase CK2 Eukaryotic life...
Includes: Supplementary data
Articles
Molecular basis of the inhibitor selectivity and insights into the feedback inhibition mechanism of citramalate synthase from Leptospira interrogans
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2009) 421 (1): 133–143.
Published: 12 June 2009
... 4.0 (GraphPad Software). 24 2 2009 7 4 2009 7 4 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 allosteric regulation crystal structure feedback inhibition mechanism selectivity Leptospirosis is a zoonotic infectious disease which occurs...
Includes: Supplementary data
Articles
Dual roles of Lys 57 at the dimer interface of human mitochondrial NAD(P) + -dependent malic enzyme
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Journal:
Biochemical Journal
Biochem J (2009) 420 (2): 201–209.
Published: 13 May 2009
.... In the present study, we decipher the functional role of the residue Lys 57 , which resides at the fumarate-binding site and dimer interface, and thus may be involved in the allosteric regulation and subunit–subunit interaction of the enzyme. In the present study, Lys 57 is replaced with alanine, cysteine...
Articles
Evidence for allosteric regulation of pH-sensitive System A (SNAT2) and System N (SNAT5) amino acid transporter activity involving a conserved histidine residue
Available to PurchaseFiona E. Baird, Jorge J. Pinilla-Tenas, William L. J. Ogilvie, Vadival Ganapathy, Harinder S. Hundal, Peter M. Taylor
Journal:
Biochemical Journal
Biochem J (2006) 397 (2): 369–375.
Published: 28 June 2006
... + binding, which involves an H + -modifier site associated with C-terminal histidine residues. 1 To whom correspondence should be addressed (email [email protected] ). 4 1 2006 3 4 2006 21 4 2006 21 4 2006 The Biochemical Society, London 2006 allosteric...
Articles
Structure and function of steroid receptor AF1 transactivation domains: induction of active conformations
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Journal:
Biochemical Journal
Biochem J (2005) 391 (3): 449–464.
Published: 25 October 2005
...; indeed, a handful of co-repressors may be sufficient to accurately fulfil the task in hand. AF1 transactivation domain allosteric regulation protein–nucleic acid interaction protein–protein interaction post-translational modification secondary structure steroid receptor The AF1 domain...
Articles
Identification of C-terminal motifs responsible for transmission of inhibition by ATP of mammalian phosphofructokinase, and their contribution to other allosteric effects
Available to PurchaseOscar H. MARTÍNEZ-COSTA, Carmen HERMIDA, Cristina SÁNCHEZ-MARTÍNEZ, Belén SANTAMARÍA, Juan J. ARAGÓN
Journal:
Biochemical Journal
Biochem J (2004) 377 (1): 77–84.
Published: 01 January 2004
... correspondence should be addressed (e-mail [email protected] ). 9 7 2003 2 9 2003 16 9 2003 16 9 2003 The Biochemical Society, London ©2004 2004 allosteric regulation allosteric transition enzyme engineering enzyme regulation glycolysis phosphofructokinase...
Articles
Structural and functional roles of Cys-238 and Cys-295 in Escherichia coli phosphofructokinase-2
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Journal:
Biochemical Journal
Biochem J (2003) 376 (1): 277–283.
Published: 15 November 2003
... 2003 The Biochemical Society, London ©2003 2003 allosteric regulation eosin-5-maleimide phosphofructokinase-2 pyrene N-(1-pyrenyl) maleimide SH group Abbreviations used: DTT, dithiothreitol; EM, eosin 5-maleimide; fru-1,6-bisP, fructose 1,6-bisphosphate; fru-6-P, fructose 6...
Articles
N-terminal truncation affects the kinetics and structure of fructose-6-phosphate 2-kinase/fructose-2,6-bisphosphatase from Arabidopsis thaliana
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Journal:
Biochemical Journal
Biochem J (2001) 359 (3): 591–597.
Published: 25 October 2001
... of the N-terminus decreased the kinase/phosphatase activity ratio by 4-fold, and decreased the affinity for the substrate fructose 6-phosphate. The data show that the N-terminus is important both for subunit assembly and for defining the kinetic properties of the enzyme. allosteric regulation enzyme...
Articles
A single point mutation leads to an instability of the hetero-octameric structure of yeast phosphofructokinase
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Journal:
Biochemical Journal
Biochem J (1999) 341 (1): 15–23.
Published: 24 June 1999
... 1999 The Biochemical Society, London © 1999 1999 allosteric regulation glycolysis mutagenesis in vitro PFK genes yeast metabolism Biochem. J. (1999) 341, 15 23 (Printed in Great Britain) 15 A single point mutation leads to an instability of the hetero-octameric structure of yeast...
