...Jingqi Wang; Lou Fourriere; Paul A. Gleeson The production of neurotoxic amyloid-β peptides (Aβ) is central to the initiation and progression of Alzheimer's disease (AD) and involves sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. APP and the secretases...

...Lisa Merthan; Amelie Haller; Dietmar R. Thal; Bjoern von Einem; Christine A.F. von Arnim One hallmark of Alzheimer's disease (AD) is the presence of amyloid plaques, which mainly consist of the amyloid precursor protein (APP) cleavage product amyloid β (Aβ). For cleavage to occur, the APP must...

...Wei Hong Toh; Paul A. Gleeson Alzheimer's disease (AD) is characterized by the accumulation of amyloid plaques in the brain consisting of an aggregated form of amyloid β-peptide (Aβ) derived from sequential amyloidogenic processing of the amyloid precursor protein (APP) by membrane-bound proteases...

... (CLSM). Maturation of full-length meprin β is required for its activity as a cell surface sheddase, releasing the ectodomains of transmembrane proteins, as previously shown for the amyloid precursor protein (APP). 1 These authors contributed equally to the work. 2 To whom correspondence...

...Paul A. Jowsey; Peter G. Blain Fe65 binds the amyloid precursor protein (APP) and regulates the secretase-mediated processing of APP into several proteolytic fragments, including amyloid β-peptides (Aβ) and APP intracellular domain (AICD). Aβ accumulation in neural plaques is a pathological feature...

...Anke Wahler; Anja-Silke Beyer; Ilona E. Keller; Cathrin Schnack; Björn von Einem; Christian Pröpper; Tobias M. Boeckers; Ithan D. Peltan; Dudley K. Strickland; Bradley T. Hyman; Christine A. F. von Arnim APP (amyloid precursor protein) and LRP1 (low-density lipoprotein receptor-related protein 1...

... 9 2010 6 9 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 a disintegrin and metalloproteinase 17 (ADAM17) amyloid precursor protein glycosylphosphatidylinositol (GPI) Jagged1 lipid raft Notch Proteolytic cleavage of proteins within...

... of senile plaques is one of the main characteristics of AD. In the present study, we show that two members of the neurotrophin receptor superfamily, TrkA (tyrosine kinase receptor A) and p75 NTR (p75 neurotrophin receptor), differentially regulate the processing of APP (amyloid precursor protein): TrkA...

...Raghda LAHDO; Laurence de LA FOURNIÈRE-BESSUEILLE APP (amyloid precursor protein), together with Chol (cholesterol) and ApoE (apolipoprotein E), has been linked to Alzheimer's disease. We have examined the hypothesis that interaction of APP with the lipid membranes is modulated by Chol and ApoE...

... that is known to down-regulate APP (β-amyloid precursor protein) metabolism by associating with the cytoplasmic domain of APP, but the detailed mechanisms are still unknown. Thus the X11L-associated protein XB51 is believed to regulate APP metabolism by modifying X11L function through its interaction with X11L...

...Tarek KASHOUR; Teralee BURTON; Alexander DIBROV; Francis M. AMARA The association of familial Alzheimer's disease (FAD) with mutations in Alzheimer's amyloid precursor protein (APP) suggests important functions for APP in the central nervous system. Mutations in APP impair its function to confer...