...) and Alzheimer's disease (AD). Their precise mechanism in these pathologies remains uncertain, but both inflammatory and lysosomal roles have been observed for GRNs. Among the seven GRNs, GRN-3 is well characterized and is implicated within the context of FTD. However, the relationship between GRN-3 and amyloid-β...

...Ioannis Dafnis; Christina Raftopoulou; Christina Mountaki; Evgenia Megalou; Vassilis I. Zannis; Angeliki Chroni The β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) initiates the production of amyloid-β peptide (Aβ), which is central to the pathogenesis of Alzheimer's disease (AD...

...Helen Poska; Martin Haslbeck; Firoz Roshan Kurudenkandy; Erik Hermansson; Gefei Chen; George Kostallas; Axel Abelein; Henrik Biverstål; Sophie Crux; André Fisahn; Jenny Presto; Jan Johansson Formation of fibrils of the amyloid-β peptide (Aβ) is suggested to play a central role in neurodegeneration...

... individuals of the same or different species. However, recent exciting data suggest that the transmissibility of misfolded proteins within the brain is a property that goes way beyond the rare prion diseases. Evidence indicates that non-prion aggregates [tau, α-syn (α-synuclein), Aβ (amyloid-β) and Htt...

... of the amyloid cascade causing Alzheimer's disease. In the present study we show that PPARγ overexpression in cultured cells dramatically reduced Aβ (amyloid-β) secretion, affecting the expression of the APP (Aβ precursor protein) at a post-transcriptional level. APP down-regulation did not involve the pathway...