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1-13 of 13
Keywords: androgen receptor
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Articles
Claire Soave, Charles Ducker, Seongho Kim, Thomas Strahl, Rayna Rosati, Yanfang Huang, Peter E. Shaw, Manohar Ratnam
Journal:
Biochemical Journal
Biochem J (2022) 479 (14): 1519–1531.
Published: 21 July 2022
...Claire Soave; Charles Ducker; Seongho Kim; Thomas Strahl; Rayna Rosati; Yanfang Huang; Peter E. Shaw; Manohar Ratnam Prostate cancer (PCa) growth requires tethering of the androgen receptor (AR) to chromatin by the ETS domain transcription factor ELK1 to coactivate critical cell proliferation genes...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2021) 478 (15): 2999–3014.
Published: 10 August 2021
...Teddy Kamata; Chun-Song Yang; Bryce M. Paschal We recently described a signal transduction pathway that contributes to androgen receptor (AR) regulation based on site-specific ADP-ribosylation by PARP7, a mono-ADP-ribosyltransferase implicated in several human cancers. ADP-ribosylated AR...
Articles
Journal:
Biochemical Journal
Biochem J (2014) 464 (2): 221–229.
Published: 14 November 2014
... of testosterone on renal klotho gene expression in vivo and in vitro . In testosterone-administered mouse kidney and NRK-52E cells, increased klotho expression was accompanied by the up-regulation of the nuclear androgen receptor (AR). Overexpression of AR enhanced the expression of klotho mRNA and protein...
Articles
Regulation of the transcriptional activation of the androgen receptor by the UXT-binding protein VHL
Journal:
Biochemical Journal
Biochem J (2013) 456 (1): 55–66.
Published: 24 October 2013
...Shuliang Chen; Ke Chen; Qinghua Zhang; Hanhua Cheng; Rongjia Zhou Loss and/or inactivation of the VHL (von Hippel–Lindau) tumour suppressor causes various tumours. Using a yeast two-hybrid system, we have identified the AR (androgen receptor) co-activator UXT (ubiquitously expressed transcript...
Includes: Supplementary data
Articles
Kyung-Chul Choi, SiYong Park, Beom Jin Lim, Ah-Reum Sung, Yoo-Hyun Lee, Masaki Shiota, Akira Yokomizo, Seiji Naito, Younghwa Na, Ho-Geun Yoon
Journal:
Biochemical Journal
Biochem J (2011) 433 (1): 235–244.
Published: 15 December 2010
...Kyung-Chul Choi; SiYong Park; Beom Jin Lim; Ah-Reum Sung; Yoo-Hyun Lee; Masaki Shiota; Akira Yokomizo; Seiji Naito; Younghwa Na; Ho-Geun Yoon Increasing evidence suggests that AR (androgen receptor) acetylation is critical for prostate cancer cell growth. In the present study, we identified Pro-B3...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2010) 425 (3): 575–583.
Published: 15 January 2010
... expression is under tight androgenic control that we have shown to be mediated by its ~2.5 kb 3′UTR (3′ untranslated region). Reporter deletion analysis of the NKX3.1 3′UTR identified three regions that were transactivated by DHT (5α-dihydrotestosterone) in the AR (androgen receptor)-expressing prostate...
Articles
Journal:
Biochemical Journal
Biochem J (2008) 416 (3): 453–462.
Published: 26 November 2008
... prostate cancer cells. Here, we examined regulation of human TGF -β 1 promoter activity by androgen in prostate cancer cells. The full-length (−3363 to +110) promoter showed a high level of activity in response to androgen in PC3mm2 cells expressing AR (androgen receptor). Further deletion analysis...
Articles
Journal:
Biochemical Journal
Biochem J (2006) 393 (3): 789–795.
Published: 13 January 2006
...Andrii Domanskyi; Katja T. Virtanen; Jorma J. Palvimo; Olli A. Jänne ARIP4 [AR (androgen receptor)-interacting protein 4] is a member of the SNF2-like family of proteins. Its sequence similarity to known proteins is restricted to the centrally located SNF2 ATPase domain. ARIP4 is an active ATPase...
Articles
Hao Yun WONG, Jan A. BURGHOORN, Marije van LEEUWEN, Petra E. de RUITER, Esther SCHIPPERS, Leen J. BLOK, Ka Wan LI, Henk L. DEKKER, Luitzen de JONG, Jan TRAPMAN, J. Anton GROOTEGOED, Albert O. BRINKMANN
Journal:
Biochemical Journal
Biochem J (2004) 383 (2): 267–276.
Published: 08 October 2004
...Hao Yun WONG; Jan A. BURGHOORN; Marije van LEEUWEN; Petra E. de RUITER; Esther SCHIPPERS; Leen J. BLOK; Ka Wan LI; Henk L. DEKKER; Luitzen de JONG; Jan TRAPMAN; J. Anton GROOTEGOED; Albert O. BRINKMANN Phosphorylation of the human AR (androgen receptor) is directly correlated with the appearance...
Articles
Bekir CINAR, Fan YEUNG, Hiroyuki KONAKA, Marty W. MAYO, Michael R. FREEMAN, Haiyen E. ZHAU, Leland W. K. CHUNG
Journal:
Biochemical Journal
Biochem J (2004) 379 (2): 421–431.
Published: 15 April 2004
...) was used as an AR (androgen receptor)-responsive gene to examine the underlying mechanism by which the NF-κB p65 transcription factor down-regulates the transcriptional activity of AR in cells. We observed that activation of NF-κB by TNFα (tumour necrosis factor α) inhibited both basal and androgen...
Articles
Latif A. WAFA, Helen CHENG, Mira A. RAO, Colleen C. NELSON, Michael COX, Martin HIRST, Ivan SADOWSKI, Paul S. RENNIE
Journal:
Biochemical Journal
Biochem J (2003) 375 (2): 373–383.
Published: 15 October 2003
...Latif A. WAFA; Helen CHENG; Mira A. RAO; Colleen C. NELSON; Michael COX; Martin HIRST; Ivan SADOWSKI; Paul S. RENNIE The AR (androgen receptor) is a ligand-regulated transcription factor, which belongs to the steroid receptor family and plays an essential role in growth and development...
Articles
Magdalena DUDKOWSKA, Agnieszka STACHURSKA, Wanda CHMURZYŃSKA, Barbara GRZELAKOWSKA-SZTABERT, Małgorzata MANTEUFFEL-CYMBOROWSKA
Journal:
Biochemical Journal
Biochem J (2001) 353 (2): 317–323.
Published: 08 January 2001
...Magdalena DUDKOWSKA; Agnieszka STACHURSKA; Wanda CHMURZYŃSKA; Barbara GRZELAKOWSKA-SZTABERT; Małgorzata MANTEUFFEL-CYMBOROWSKA The cross-talk in vivo between two signalling pathways activated by testosterone via intracellular androgen receptor, and induced by damage to renal tubules evoked by anti...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 350 (1): 123–129.
Published: 09 August 2000
... that the GRE A unit does not bind the androgen receptor (AR). The modification of three nucleotides in the poorly conserved half-sites 2 and 3, converting GRE A into two overlapping high-affinity GREs (ov-cGRE), resulted in co-operative binding of the AR. Furthermore, ov-cGRE efficiently mediated androgen...