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Keywords: andrographolide
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Andrographolide activates the canonical Wnt signalling pathway by a mechanism that implicates the non-ATP competitive inhibition of GSK-3β: autoregulation of GSK-3β in vivo

Cheril Tapia-Rojas, Andreas Schüller, Carolina B. Lindsay, Roxana C. Ureta, Cristóbal Mejías-Reyes, Juan Hancke, Francisco Melo, Nibaldo C. Inestrosa
Journal: Biochemical Journal
Biochem J (2015) 466 (2): 415–430.
https://doi.org/10.1042/BJ20140207
Published: 20 February 2015
... for drugs with the therapeutic potential to activate this signalling pathway. In the present study, we report that andrographolide (ANDRO), a component of Andrographis paniculata , is a potent activator of Wnt signalling. Our results indicate that ANDRO activates this pathway, inducing the transcription...
View articletitled, Andrographolide activates the canonical Wnt signalling pathway by a mechanism that implicates the non-ATP competitive inhibition of GSK-3β: autoregulation of GSK-3β in vivo
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Includes: Supplementary data