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Articles

Anti-tumor and anti-metastatic activity of the FGF2 118–126 fragment dependent on the loop structure

Hossein Allahmoradi, S. Mohsen Asghari, Atieh Ahmadi, Elham Assareh, Mahboobeh Nazari

Biochem J (2022) 479 (12): 1285–1302.

https://doi.org/10.1042/BCJ20210830

Published: 21 June 2022

... and increased animals’ survival without causing weight loss, but the linear peptide BGF2 had no significant anti-tumor effects. According to immunohistochemical studies, the anti-tumor properties of BGF1 were associated with suppression of tumor cell proliferation (Ki-67 expression), angiogenesis (CD31...

View articletitled, Anti-tumor and anti-metastatic activity of the FGF2 118–126 fragment dependent on the loop structure

Includes: Supplementary data

Articles

Processing of syndecan-2 by matrix metalloproteinase-14 and effect of its cleavage on VEGF-induced tube formation of HUVECs

Young Hun Lee, Jun Hyoung Park, Dong Huey Cheon, Taeyoung Kim, Yae Eun Park, Eok-Soo Oh, Ji Eun Lee, Seung-Taek Lee

Biochem J (2017) 474 (22): 3719–3732.

https://doi.org/10.1042/BCJ20170340

Published: 01 November 2017

..., and angiogenesis. Previously, we found that rat SDC2 is shed by matrix metalloproteinase-7 (MMP-7) in colon cancer cells. Here, we analyzed the susceptibility of rat SDC2 to various MMPs. We found that the rat SDC2 ectodomain (ECD) fused to the C-terminal Fc region, which was expressed in mammalian cells...

View articletitled, Processing of syndecan-2 by matrix metalloproteinase-14 and effect of its cleavage on VEGF-induced tube formation of HUVECs

Includes: Supplementary data

Articles

The sweet side of AMPK signaling: regulation of GFAT1

John W. Scott, Jonathan S. Oakhill

Biochem J (2017) 474 (7): 1289–1292.

https://doi.org/10.1042/BCJ20170006

Published: 23 March 2017

... to physiological or small-molecule activators leads to a reduction in cellular protein O-GlcNAcylation. Further work revealed that AMPK-dependent phosphorylation of GFAT1 promotes angiogenesis in endothelial cells. This elegant study demonstrates that the AMPK–GFAT1 signaling axis serves as an important...

View articletitled, The sweet side of AMPK signaling: regulation of GFAT1

Articles

GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis

Darya Zibrova, Franck Vandermoere, Olga Göransson, Mark Peggie, Karina V. Mariño, Anne Knierim, Katrin Spengler, Cora Weigert, Benoit Viollet, Nicholas A. Morrice, Kei Sakamoto, Regine Heller

Biochem J (2017) 474 (6): 983–1001.

https://doi.org/10.1042/BCJ20160980

Published: 07 March 2017

... protection and angiogenesis, but the underlying mechanisms are incompletely understood. Using a label-free phosphoproteomic analysis, we identified glutamine:fructose-6-phosphate amidotransferase 1 (GFAT1) as an AMPK substrate. GFAT1 is the rate-limiting enzyme in the hexosamine biosynthesis pathway (HBP...

View articletitled, GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis

Includes: Supplementary data

Articles

Circular trimers of gelatinase B/matrix metalloproteinase-9 constitute a distinct population of functional enzyme molecules differentially regulated by tissue inhibitor of metalloproteinases-1

Jennifer Vandooren, Benjamin Born, Inna Solomonov, Ewa Zajac, Radka Saldova, Michael Senske, Estefanía Ugarte-Berzal, Erik Martens, Philippe E. Van den Steen, Jo Van Damme, Angeles Garcia-Pardo, Matheus Froeyen, Elena I. Deryugina, James P. Quigley, Søren K. Moestrup, Pauline M. Rudd, Irit Sagi, Ghislain Opdenakker

Biochem J (2015) 465 (2): 259–270.

https://doi.org/10.1042/BJ20140418

Published: 06 January 2015

... , this finding was reflected in a higher extent of TIMP-1 inhibition of angiogenesis induced by trimers compared with monomers. Our results show that proMMP-9 trimers constitute a novel structural and functional entity that is differentially regulated by TIMP-1. 1 To whom correspondence should...

View articletitled, Circular trimers of gelatinase B/matrix metalloproteinase-9 constitute a distinct population of functional enzyme molecules differentially regulated by tissue inhibitor of metalloproteinases-1

Articles

Identification and characterization of a mirror-image oligonucleotide that binds and neutralizes sphingosine 1-phosphate, a central mediator of angiogenesis

Werner G. Purschke, Kai Hoehlig, Klaus Buchner, Dirk Zboralski, Frank Schwoebel, Axel Vater, Sven Klussmann

Biochem J (2014) 462 (1): 153–162.

https://doi.org/10.1042/BJ20131422

Published: 24 July 2014

...-1), was effectively blocked by NOX-S93 in a cellular angiogenesis assay employing primary human endothelial cells. These data provide further evidence for the relevance of extracellular S1P as a central mediator of angiogenesis, suggesting pharmacological S1P neutralization as a promising treatment...

View articletitled, Identification and characterization of a mirror-image oligonucleotide that binds and neutralizes sphingosine 1-phosphate, a central mediator of angiogenesis

Articles

YB-1: oncoprotein, prognostic marker and therapeutic target?

Annette Lasham, Cristin G. Print, Adele G. Woolley, Sandra E. Dunn, Antony W. Braithwaite

Biochem J (2013) 449 (1): 11–23.

https://doi.org/10.1042/BJ20121323

Published: 07 December 2012

... regulates multiple proliferation pathways, overrides cell-cycle check points, promotes replicative immortality and genomic instability, may regulate angiogenesis, has a role in invasion and metastasis, and promotes inflammation. We also argue that there is strong and sufficient evidence to suggest that YB-1...

View articletitled, YB-1: oncoprotein, prognostic marker and therapeutic target?

Articles

Signal transduction by vascular endothelial growth factor receptors

Sina Koch, Sònia Tugues, Xiujuan Li, Laura Gualandi, Lena Claesson-Welsh

Biochem J (2011) 437 (2): 169–183.

https://doi.org/10.1042/BJ20110301

Published: 28 June 2011

... three receptor tyrosine kinases. Signalling is modulated through neuropilins, which act as VEGF co-receptors. Heparan sulfate and integrins are also important modulators of VEGF signalling. Therapeutic agents that interfere with VEGF signalling have been developed with the aim of decreasing angiogenesis...

View articletitled, Signal transduction by vascular endothelial growth factor receptors

Includes: Multimedia, Supplementary data

Articles

Silencing of hHS6ST2 inhibits progression of pancreatic cancer through inhibition of Notch signalling

Kai Song, Qin Li, Yong-Bo Peng, Jie Li, Kan Ding, Li-Juan Chen, Cheng-Hao Shao, Li-Jun Zhang, Ping Li

Biochem J (2011) 436 (2): 271–282.

https://doi.org/10.1042/BJ20110297

Published: 13 May 2011

... and identify total proteins from PC cells. Our data suggest that hHS6ST2 potentiates Notch signalling in PC cells. We also identified a role for hHS6ST2 in the growth and tumorigenicity of these cells which, at least in part, acts through Notch-mediated EMT (epithelial–mesenchymal transition) and angiogenesis...

View articletitled, Silencing of hHS6ST2 inhibits progression of pancreatic cancer through inhibition of Notch signalling

Includes: Supplementary data

Articles

Hypoxia down-regulates sFlt-1 (sVEGFR-1) expression in human microvascular endothelial cells by a mechanism involving mRNA alternative processing

Takayuki Ikeda, Li Sun, Naoki Tsuruoka, Yasuhito Ishigaki, Yasuo Yoshitomi, Yoshino Yoshitake, Hideto Yonekura

Biochem J (2011) 436 (2): 399–407.

https://doi.org/10.1042/BJ20101490

Published: 13 May 2011

...Takayuki Ikeda; Li Sun; Naoki Tsuruoka; Yasuhito Ishigaki; Yasuo Yoshitomi; Yoshino Yoshitake; Hideto Yonekura sFlt-1 (soluble Flt-1) potently inhibits angiogenesis by binding extracellularly to VEGF (vascular endothelial growth factor). In the present paper, we report that hypoxia down-regulates...

View articletitled, Hypoxia down-regulates sFlt-1 (sVEGFR-1) expression in human microvascular endothelial cells by a mechanism involving mRNA alternative processing

Includes: Supplementary data

Articles

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

Ian M. Evans, Azadeh Bagherzadeh, Mark Charles, Tony Raynham, Chris Ireson, Alexandra Boakes, Lloyd Kelland, Ian C. Zachary

Biochem J (2010) 429 (3): 565–572.

https://doi.org/10.1042/BJ20100578

Published: 14 July 2010

...Ian M. Evans; Azadeh Bagherzadeh; Mark Charles; Tony Raynham; Chris Ireson; Alexandra Boakes; Lloyd Kelland; Ian C. Zachary VEGF (vascular endothelial growth factor) plays an essential role in angiogenesis during development and in disease largely mediated by signalling events initiated by binding...

View articletitled, Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

Articles

Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation

Christina Wehrle, Paul Van Slyke, Daniel J. Dumont

Biochem J (2009) 423 (3): 375–380.

https://doi.org/10.1042/BJ20091010

Published: 12 October 2009

..., the angiopoietins, Tie2 initiates signalling pathways that modulate vascular stability and angiogenesis. Deletion of either the Tie2 or Ang1 (angiopoietin-1) gene in mice results in lethal vascular defects, signifying their importance in vascular development. The mechanism employed by the Tie2 signalling machinery...

View articletitled, Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation

Articles

Neuropilins: structure, function and role in disease

Caroline Pellet-Many, Paul Frankel, Haiyan Jia, Ian Zachary

Biochem J (2008) 411 (2): 211–226.

https://doi.org/10.1042/BJ20071639

Published: 27 March 2008

... mediate the functions of their various ligands in different cell types. This review will describe NRP structure and biology with a focus on recent advances that provide novel insight into the role of NRPs in angiogenesis and neurogenesis. Also highlighted is the recent emergence of NRPs as novel...

View articletitled, Neuropilins: structure, function and role in disease

Articles

Polyphosphate blocks tumour metastasis via anti-angiogenic activity

Kyu Yeon Han, Bok Sil Hong, Yae Jin Yoon, Chang Min Yoon, Yoon-Keun Kim, Young-Guen Kwon, Yong Song Gho

Biochem J (2007) 406 (1): 49–55.

https://doi.org/10.1042/BJ20061542

Published: 26 July 2007

... and vertebrates. Despite its wide distribution in mammalian tissues and plasma, the biological functions of polyP on tumour metastasis and angiogenesis have not been previously examined. In the present study, we have shown that polyP effectively blocked in vivo pulmonary metastasis of B16BL6 cells by suppression...

View articletitled, Polyphosphate blocks tumour metastasis via anti-angiogenic activity

Articles

Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implications for drug design

Kamel EL Omari, Annelies Bronckaers, Sandra Liekens, Maria-Jésus Pérez-Pérez, Jan Balzarini, David K. Stammers

Biochem J (2006) 399 (2): 199–204.

https://doi.org/10.1042/BJ20060513

Published: 27 September 2006

... is implicated in angiogenesis and apoptosis and therefore is a prime target for drug design, including antitumour therapies. An HTP structure in a closed conformation complexed with an inhibitor has previously been solved. Earlier kinetic studies revealed an ordered release of thymine followed by ribose...

View articletitled, Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implications for drug design

Articles

A VEGF/JAK2/STAT5 axis may partially mediate endothelial cell tolerance to hypoxia

Andrew C. Dudley, David Thomas, James Best, Alicia Jenkins

Biochem J (2005) 390 (2): 427–436.

https://doi.org/10.1042/BJ20050351

Published: 23 August 2005

... and nutrients to oxygen-starved tissues. This process is termed angiogenesis and is common in certain cancers with hypoxic foci and in areas of focal ischaemia in the diabetic retina. In the present study, we report on the activation of the JAK2/STAT5 pathway (where JAK stands for Janus kinase and STAT stands...

View articletitled, A VEGF/JAK2/STAT5 axis may partially mediate endothelial cell tolerance to hypoxia

Articles

The ADAMTS metalloproteinases

Sarah PORTER, Ian M. CLARK, Lara KEVORKIAN, Dylan R. EDWARDS

Biochem J (2005) 386 (1): 15–27.

https://doi.org/10.1042/BJ20040424

Published: 08 February 2005

... are extracellular, multidomain enzymes whose known functions include: (i) collagen processing as procollagen N-proteinase; (ii) cleavage of the matrix proteoglycans aggrecan, versican and brevican; (iii) inhibition of angiogenesis; and (iv) blood coagulation homoeostasis as the von Willebrand factor cleaving...

View articletitled, The ADAMTS metalloproteinases

Articles

Binding of endostatin to endothelial heparan sulphate shows a differential requirement for specific sulphates

Fiona H. BLACKHALL, Catherine L. R. MERRY, Malcolm LYON, Gordon C. JAYSON, Judah FOLKMAN, Kashi JAVAHERIAN, John T. GALLAGHER

Biochem J (2003) 375 (1): 131–139.

https://doi.org/10.1042/bj20030730

Published: 01 October 2003

...Fiona H. BLACKHALL; Catherine L. R. MERRY; Malcolm LYON; Gordon C. JAYSON; Judah FOLKMAN; Kashi JAVAHERIAN; John T. GALLAGHER Endostatin is a naturally occurring proteolytic fragment of the C-terminal domain of collagen XVIII. It inhibits angiogenesis by a mechanism that appears to involve binding...

View articletitled, Binding of endostatin to endothelial heparan sulphate shows a differential requirement for specific sulphates

Articles

Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization

Steen V. PETERSEN, Zuzana VALNICKOVA, Jan J. ENGHILD

Biochem J (2003) 374 (1): 199–206.

https://doi.org/10.1042/bj20030313

Published: 15 August 2003

... in the eye. Thus the systemic delivery of PEDF has the potential to affect angiogenesis or neurotrophic processes throughout the body, significantly expanding the putative physiological role of the protein. A complete map of all post-translational modifications revealed that authentic plasma PEDF carries...

View articletitled, Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization

Articles

Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury

Hideto YONEKURA, Yasuhiko YAMAMOTO, Shigeru SAKURAI, Ralica G. PETROVA, Md. Joynal ABEDIN, Hui LI, Kiyoshi YASUI, Masayoshi TAKEUCHI, Zenji MAKITA, Shin TAKASAWA, Hiroshi OKAMOTO, Takuo WATANABE, Hiroshi YAMAMOTO

Biochem J (2003) 370 (3): 1097–1109.

https://doi.org/10.1042/bj20021371

Published: 15 March 2003

... may contribute to our understanding of the molecular basis for the diversity of cellular responses to AGE and for individual variations in the susceptibility to diabetic vascular complications. Key words: alternative splicing, angiogenesis, diabetic vascular complication, non-enzymic glycation...

View articletitled, Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury

Articles

Essential role of an activator protein-2 (AP-2)/specificity protein 1 (Sp1) cluster in the UVB-mediated induction of the human vascular endothelial growth factor in HaCaT keratinocytes

Peter BRENNEISEN, Ralf BLAUDSCHUN, Jens GILLE, Lars SCHNEIDER, Ralf HINRICHS, Meinhard WLASCHEK, Sabine EMING, Karin SCHARFFETTER-KOCHANEK

Biochem J (2003) 369 (2): 341–349.

https://doi.org/10.1042/bj20021032

Published: 15 January 2003

...Peter BRENNEISEN; Ralf BLAUDSCHUN; Jens GILLE; Lars SCHNEIDER; Ralf HINRICHS; Meinhard WLASCHEK; Sabine EMING; Karin SCHARFFETTER-KOCHANEK Chronic sun exposure of the skin has long been postulated to enhance cutaneous angiogenesis, resulting in highly vascularized skin cancers. As the UVB component...

View articletitled, Essential role of an activator protein-2 (AP-2)/specificity protein 1 (Sp1) cluster in the UVB-mediated induction of the human vascular endothelial growth factor in HaCaT keratinocytes

Articles

Identification of an octamer element required for in vivo expression of the TIE1 gene in endothelial cells

Stephane C. BOUTET, Thomas QUERTERMOUS, Bahaa M. FADEL

Biochem J (2001) 360 (1): 23–29.

https://doi.org/10.1042/bj3600023

Published: 08 November 2001

... be addressed, at the Division of Cardiovascular Medicine, Stanford University (e-mail [email protected] ). 26 3 2001 22 8 2001 11 9 2001 The Biochemical Society, London ©2001 2001 angiogenesis transcription vascular development Abbreviations used: EMSA...

View articletitled, Identification of an octamer element required for in vivo expression of the TIE1 gene in endothelial cells

Articles

A precursor form of vascular endothelial growth factor arises by initiation from an upstream in-frame CUG codon

Meng Kian TEE, Robert B. JAFFE

Biochem J (2001) 359 (1): 219–226.

https://doi.org/10.1042/bj3590219

Published: 24 September 2001

...Meng Kian TEE; Robert B. JAFFE Vascular endothelial growth factor (VEGF) is a mitogen in physiological and pathological angiogenesis. Understanding the expression of different VEGF isoforms might be important for distinguishing angiogenesis in tissue development, vascular remodelling and tumour...

View articletitled, A precursor form of vascular endothelial growth factor arises by initiation from an upstream in-frame CUG codon

Articles

Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species

Marc A. LAFLEUR, Morley D. HOLLENBERG, Susan J. ATKINSON, Vera KNÄUPER, Gillian MURPHY, Dylan R. EDWARDS

Biochem J (2001) 357 (1): 107–115.

https://doi.org/10.1042/bj3570107

Published: 25 June 2001

...Marc A. LAFLEUR; Morley D. HOLLENBERG; Susan J. ATKINSON; Vera KNÄUPER; Gillian MURPHY; Dylan R. EDWARDS Thrombin, a critical enzyme in the coagulation cascade, has also been associated with angiogenesis and activation of the zymogen form of matrix metalloproteinase-2 (MMP-2 or gelatinase-A). We...

View articletitled, Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species

Articles

Localization of membrane-type 1 matrix metalloproteinase in caveolae membrane domains

Borhane ANNABI, Marie-Paule LACHAMBRE, Nathalie BOUSQUET-GAGNON, Martine PAGÉ, Denis GINGRAS, Richard BÉLIVEAU

Biochem J (2001) 353 (3): 547–553.

https://doi.org/10.1042/bj3530547

Published: 25 January 2001

...-dependent cell migration by caveolin 1 also suggests that the localization of MT1-MMP to caveolin-enriched domains might have an important function in the control of its enzymic activity. angiogenesis cancer caveolin cell migration glioblastoma Biochem. J. (2001) 353, 547 553 (Printed in Great...

View articletitled, Localization of membrane-type 1 matrix metalloproteinase in caveolae membrane domains

Articles

Signalling properties of an HIV-encoded angiogenic peptide mimicking vascular endothelial growth factor activity

Patrick SCHEIDEGGER, Wolfgang WEIGLHOFER, Stéphanie SUAREZ, Sandra CONSOLE, Johannes WALTENBERGER, Michael S. PEPPER, Rolf JAUSSI, Kurt BALLMER-HOFER

Biochem J (2001) 353 (3): 569–578.

https://doi.org/10.1042/bj3530569

Published: 25 January 2001

... binding, implying different binding sites for the TAT peptide and VEGF. This suggests that TAT binds VEGF receptors at new sites that might be useful targets for pharmacological intervention during pathological angiogenesis. The thioredoxin/basic-peptide chimaeras are functional agonists that mediate VEGF...

View articletitled, Signalling properties of an HIV-encoded angiogenic peptide mimicking vascular endothelial growth factor activity

Articles

Tyrosine phosphorylation of the vascular endothelial-growth-factor receptor-2 (VEGFR-2) is modulated by Rho proteins

Denis GINGRAS, Sylvie LAMY, Richard BÉLIVEAU

Biochem J (2000) 348 (2): 273–280.

https://doi.org/10.1042/bj3480273

Published: 23 May 2000

... induced an increase in the tyrosine phosphorylation of the VEGFR-2, whereas overexpression of a dominant-inactive form of the protein was without effect. Taken together, these results indicate that Rho proteins may play an important role in angiogenesis by modulating the tyrosine phosphorylation levels...

View articletitled, Tyrosine phosphorylation of the vascular endothelial-growth-factor receptor-2 (VEGFR-2) is modulated by Rho proteins

Articles

Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3

Takao KIMURA, Tomoko WATANABE, Koichi SATO, Junko KON, Hideaki TOMURA, Ken-ichi TAMAMA, Atsushi KUWABARA, Tsugiyasu KANDA, Isao KOBAYASHI, Hideo OHTA, Michio UI, Fumikazu OKAJIMA

Biochem J (2000) 348 (1): 71–76.

https://doi.org/10.1042/bj3480071

Published: 09 May 2000

... in human aortic endothelial cells (HAECs). The extent of the S1P-induced responses are comparable to those stimulated by vascular endothelial growth factor, one of the most potent stimulators of angiogenesis. These responses to S1P were mimicked by dihydrosphingosine 1-phosphate, an S1P receptor agonist...

View articletitled, Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3

Articles

The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells

Andrea J. WARNER, Jennifer LOPEZ-DEE, Emma L. KNIGHT, James R. FERAMISCO, Sally A. PRIGENT

Biochem J (2000) 347 (2): 501–509.

https://doi.org/10.1042/bj3470501

Published: 10 April 2000

..., in a phosphorylation-dependent fashion, when co-expressed in human embryonic kidney 293 cells. Furthermore, we demonstrate that in the two-hybrid assay, both Shc and Sck SH2 domains can associate with the related receptor Flt1. angiogenesis receptor tyrosine kinase signalling VEGF. Biochem. J. (2000) 347, 501...

View articletitled, The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells

Articles

Vascular endothelial growth factor stimulates dephosphorylation of the catenins p120 and p100 in endothelial cells

Elaine Y. M. WONG, Louise MORGAN, Caroline SMALES, Paul LANG, Sharon E. GUBBY, James M. STADDON

Biochem J (2000) 346 (1): 209–216.

https://doi.org/10.1042/bj3460209

Published: 08 February 2000

...Elaine Y. M. WONG; Louise MORGAN; Caroline SMALES; Paul LANG; Sharon E. GUBBY; James M. STADDON Vascular endothelial growth factor (VEGF) is an endothelium-specific mitogen that induces angiogenesis and increases vascular permeability. These processes involve regulation of cell-cell adhesion...

View articletitled, Vascular endothelial growth factor stimulates dephosphorylation of the catenins p120 and p100 in endothelial cells

Articles

Expression and characterization of novel thrombospondin 1 type I repeat fusion proteins

Aziz N. QABAR, Jeff BULLOCK, Louis MATEJ, Peter POLVERINI

Biochem J (2000) 346 (1): 147–153.

https://doi.org/10.1042/bj3460147

Published: 08 February 2000

... the exception). The existence of two conformationally distinct structures in the TSP family (trimers and pentamers) prompted us to investigate the contribution of TSP1 trimeric structure to its inhibitory role in angiogenesis. We expressed full-length recombinant human TSP1, its type I repeats, and murine TSP3...

View articletitled, Expression and characterization of novel thrombospondin 1 type I repeat fusion proteins

Articles

Angiostatin inhibits endothelial and melanoma cellular invasion by blocking matrix-enhanced plasminogen activation

M. Sharon STACK, Stephen GATELY, Lisa M. BAFETTI, Jan J. ENGHILD, Gerald A. SOFF

Biochem J (1999) 340 (1): 77–84.

https://doi.org/10.1042/bj3400077

Published: 10 May 1999

...M. Sharon STACK; Stephen GATELY; Lisa M. BAFETTI; Jan J. ENGHILD; Gerald A. SOFF Angiostatin, a kringle-containing fragment of plasminogen, is a potent inhibitor of angiogenesis. The mechanism(s) responsible for the anti-angiogenic properties of angiostatin are unknown. We now report that human...

View articletitled, Angiostatin inhibits endothelial and melanoma cellular invasion by blocking matrix-enhanced plasminogen activation

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