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Keywords: angiogenesis
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Biochem J (2022) 479 (12): 1285–1302.
Published: 21 June 2022
... and increased animals’ survival without causing weight loss, but the linear peptide BGF2 had no significant anti-tumor effects. According to immunohistochemical studies, the anti-tumor properties of BGF1 were associated with suppression of tumor cell proliferation (Ki-67 expression), angiogenesis (CD31...
Includes: Supplementary data
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Biochem J (2017) 474 (22): 3719–3732.
Published: 01 November 2017
..., and angiogenesis. Previously, we found that rat SDC2 is shed by matrix metalloproteinase-7 (MMP-7) in colon cancer cells. Here, we analyzed the susceptibility of rat SDC2 to various MMPs. We found that the rat SDC2 ectodomain (ECD) fused to the C-terminal Fc region, which was expressed in mammalian cells...
Includes: Supplementary data
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Biochem J (2017) 474 (7): 1289–1292.
Published: 23 March 2017
... to physiological or small-molecule activators leads to a reduction in cellular protein O-GlcNAcylation. Further work revealed that AMPK-dependent phosphorylation of GFAT1 promotes angiogenesis in endothelial cells. This elegant study demonstrates that the AMPK–GFAT1 signaling axis serves as an important...
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Biochem J (2017) 474 (6): 983–1001.
Published: 07 March 2017
... protection and angiogenesis, but the underlying mechanisms are incompletely understood. Using a label-free phosphoproteomic analysis, we identified glutamine:fructose-6-phosphate amidotransferase 1 (GFAT1) as an AMPK substrate. GFAT1 is the rate-limiting enzyme in the hexosamine biosynthesis pathway (HBP...
Includes: Supplementary data
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Biochem J (2013) 449 (1): 11–23.
Published: 07 December 2012
... regulates multiple proliferation pathways, overrides cell-cycle check points, promotes replicative immortality and genomic instability, may regulate angiogenesis, has a role in invasion and metastasis, and promotes inflammation. We also argue that there is strong and sufficient evidence to suggest that YB-1...
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Biochem J (2011) 437 (2): 169–183.
Published: 28 June 2011
... three receptor tyrosine kinases. Signalling is modulated through neuropilins, which act as VEGF co-receptors. Heparan sulfate and integrins are also important modulators of VEGF signalling. Therapeutic agents that interfere with VEGF signalling have been developed with the aim of decreasing angiogenesis...
Includes: Multimedia, Supplementary data
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Biochem J (2011) 436 (2): 271–282.
Published: 13 May 2011
... and identify total proteins from PC cells. Our data suggest that hHS6ST2 potentiates Notch signalling in PC cells. We also identified a role for hHS6ST2 in the growth and tumorigenicity of these cells which, at least in part, acts through Notch-mediated EMT (epithelial–mesenchymal transition) and angiogenesis...
Includes: Supplementary data
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Biochem J (2010) 429 (3): 565–572.
Published: 14 July 2010
...Ian M. Evans; Azadeh Bagherzadeh; Mark Charles; Tony Raynham; Chris Ireson; Alexandra Boakes; Lloyd Kelland; Ian C. Zachary VEGF (vascular endothelial growth factor) plays an essential role in angiogenesis during development and in disease largely mediated by signalling events initiated by binding...
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Biochem J (2009) 423 (3): 375–380.
Published: 12 October 2009
..., the angiopoietins, Tie2 initiates signalling pathways that modulate vascular stability and angiogenesis. Deletion of either the Tie2 or Ang1 (angiopoietin-1) gene in mice results in lethal vascular defects, signifying their importance in vascular development. The mechanism employed by the Tie2 signalling machinery...
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Biochem J (2008) 411 (2): 211–226.
Published: 27 March 2008
... ], or to antibodies directed against either the VEGF or Sema3A binding domains [ 19 ], have identified key residues and structural features required for ligand binding. angiogenesis cancer neuron semaphorin vascular endothelial growth factor (VEGF) NRP1 (neuropilin-1) was originally identified...
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Biochem J (2007) 406 (1): 49–55.
Published: 26 July 2007
... and vertebrates. Despite its wide distribution in mammalian tissues and plasma, the biological functions of polyP on tumour metastasis and angiogenesis have not been previously examined. In the present study, we have shown that polyP effectively blocked in vivo pulmonary metastasis of B16BL6 cells by suppression...
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Biochem J (2006) 399 (2): 199–204.
Published: 27 September 2006
... is implicated in angiogenesis and apoptosis and therefore is a prime target for drug design, including antitumour therapies. An HTP structure in a closed conformation complexed with an inhibitor has previously been solved. Earlier kinetic studies revealed an ordered release of thymine followed by ribose...
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Biochem J (2005) 390 (2): 427–436.
Published: 23 August 2005
... and nutrients to oxygen-starved tissues. This process is termed angiogenesis and is common in certain cancers with hypoxic foci and in areas of focal ischaemia in the diabetic retina. In the present study, we report on the activation of the JAK2/STAT5 pathway (where JAK stands for Janus kinase and STAT stands...
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Biochem J (2005) 386 (1): 15–27.
Published: 08 February 2005
... are extracellular, multidomain enzymes whose known functions include: (i) collagen processing as procollagen N-proteinase; (ii) cleavage of the matrix proteoglycans aggrecan, versican and brevican; (iii) inhibition of angiogenesis; and (iv) blood coagulation homoeostasis as the von Willebrand factor cleaving...
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Biochem J (2003) 375 (1): 131–139.
Published: 01 October 2003
...Fiona H. BLACKHALL; Catherine L. R. MERRY; Malcolm LYON; Gordon C. JAYSON; Judah FOLKMAN; Kashi JAVAHERIAN; John T. GALLAGHER Endostatin is a naturally occurring proteolytic fragment of the C-terminal domain of collagen XVIII. It inhibits angiogenesis by a mechanism that appears to involve binding...
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Biochem J (2001) 359 (1): 219–226.
Published: 24 September 2001
...Meng Kian TEE; Robert B. JAFFE Vascular endothelial growth factor (VEGF) is a mitogen in physiological and pathological angiogenesis. Understanding the expression of different VEGF isoforms might be important for distinguishing angiogenesis in tissue development, vascular remodelling and tumour...
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Biochem J (2001) 353 (3): 547–553.
Published: 25 January 2001
...-dependent cell migration by caveolin 1 also suggests that the localization of MT1-MMP to caveolin-enriched domains might have an important function in the control of its enzymic activity. angiogenesis cancer caveolin cell migration glioblastoma Biochem. J. (2001) 353, 547 553 (Printed in Great...
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Biochem J (2001) 353 (3): 569–578.
Published: 25 January 2001
... binding, implying different binding sites for the TAT peptide and VEGF. This suggests that TAT binds VEGF receptors at new sites that might be useful targets for pharmacological intervention during pathological angiogenesis. The thioredoxin/basic-peptide chimaeras are functional agonists that mediate VEGF...
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Biochem J (2000) 348 (2): 273–280.
Published: 23 May 2000
... induced an increase in the tyrosine phosphorylation of the VEGFR-2, whereas overexpression of a dominant-inactive form of the protein was without effect. Taken together, these results indicate that Rho proteins may play an important role in angiogenesis by modulating the tyrosine phosphorylation levels...
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Biochem J (2000) 346 (1): 209–216.
Published: 08 February 2000
...Elaine Y. M. WONG; Louise MORGAN; Caroline SMALES; Paul LANG; Sharon E. GUBBY; James M. STADDON Vascular endothelial growth factor (VEGF) is an endothelium-specific mitogen that induces angiogenesis and increases vascular permeability. These processes involve regulation of cell-cell adhesion...
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Biochem J (2000) 346 (1): 147–153.
Published: 08 February 2000
... the exception). The existence of two conformationally distinct structures in the TSP family (trimers and pentamers) prompted us to investigate the contribution of TSP1 trimeric structure to its inhibitory role in angiogenesis. We expressed full-length recombinant human TSP1, its type I repeats, and murine TSP3...
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Biochem J (1999) 340 (1): 77–84.
Published: 10 May 1999
...M. Sharon STACK; Stephen GATELY; Lisa M. BAFETTI; Jan J. ENGHILD; Gerald A. SOFF Angiostatin, a kringle-containing fragment of plasminogen, is a potent inhibitor of angiogenesis. The mechanism(s) responsible for the anti-angiogenic properties of angiostatin are unknown. We now report that human...