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Keywords: antibiotic
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Biochem J (2021) 478 (18): 3423–3428.
Published: 23 September 2021
...Helen S. Toogood; Nigel S. Scrutton Nitroreductases catalyse the NAD(P)H-dependent nitro reduction in nitrofuran antibiotics, which activates them into cytotoxic molecules leading to cell death. The design of new effective nitrofuran antibiotics relies on knowledge of the kinetic mechanism...
Biochem J (2021) 478 (13): 2601–2617.
Published: 09 July 2021
... of nitrofuran antibiotics. The crystal structure of free Escherichia coli NfsA and several homologues have been determined previously, but there is no structure of the enzyme with ligands. We present here crystal structures of oxidised E. coli NfsA in the presence of several ligands, including the antibiotic...
Includes: Supplementary data
Biochem J (2013) 452 (1): 19–25.
Published: 25 April 2013
... of novel anti-infective agents. However, bacteria show a remarkable plasticity for isoprenoid biosynthesis that should be taken into account when targeting this metabolic pathway for the development of new antibiotics. For example, a few bacteria use the MVA pathway instead of the MEP pathway, whereas...
Biochem J (2010) 430 (2): 355–364.
Published: 13 August 2010
... into the energetics of RND-type transporters and their assembly into multiprotein complexes. antibiotic MexB multidrug resistance pathogen Pseudomonas aeruginosa resistance–nodulation–cell division transporter (RND transporter) 1 To whom correspondence should be addressed (email hv214...
Biochem J (2010) 430 (1): 1–19.
Published: 28 July 2010
... (email vogel@ucalgary.ca ). 31 3 2010 19 5 2010 24 5 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 acyl carrier protein antibiotic fatty acid biosynthesis lipid protein complex De novo FA (fatty acid) synthesis represents a crucial...
Includes: Multimedia, Supplementary data
Biochem J (2006) 394 (1): 105–114.
Published: 27 January 2006
.... Because anal-3 shows high selectivity towards bacterial and fungal cells, it may provide an avenue for the development of new antibiotics. 1 To whom correspondence should be addressed (email ymkim@konkuk.ac.kr ). The atomic co-ordinates for 20 final structures reported will appear...
Includes: Supplementary data
Biochem J (2005) 389 (3): 843–852.
Published: 26 July 2005
...Tracey L. Campbell; Denis M. Daigle; Eric D. Brown We present an analysis of the cellular phenotype and biochemical activity of a conserved bacterial GTPase of unknown function (YloQ and YjeQ in Bacillus subtilis and Escherichia coli respectively) using a collection of antibiotics of diverse...