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Keywords: antibiotic
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Biochem J (2021) 478 (18): 3423–3428.
Published: 23 September 2021
...Helen S. Toogood; Nigel S. Scrutton Nitroreductases catalyse the NAD(P)H-dependent nitro reduction in nitrofuran antibiotics, which activates them into cytotoxic molecules leading to cell death. The design of new effective nitrofuran antibiotics relies on knowledge of the kinetic mechanism...
Biochem J (2021) 478 (13): 2601–2617.
Published: 09 July 2021
... of nitrofuran antibiotics. The crystal structure of free Escherichia coli NfsA and several homologues have been determined previously, but there is no structure of the enzyme with ligands. We present here crystal structures of oxidised E. coli NfsA in the presence of several ligands, including the antibiotic...
Includes: Supplementary data
Biochem J (2013) 452 (1): 19–25.
Published: 25 April 2013
... of novel anti-infective agents. However, bacteria show a remarkable plasticity for isoprenoid biosynthesis that should be taken into account when targeting this metabolic pathway for the development of new antibiotics. For example, a few bacteria use the MVA pathway instead of the MEP pathway, whereas...
Biochem J (2010) 430 (2): 355–364.
Published: 13 August 2010
... into the energetics of RND-type transporters and their assembly into multiprotein complexes. antibiotic MexB multidrug resistance pathogen Pseudomonas aeruginosa resistance–nodulation–cell division transporter (RND transporter) 1 To whom correspondence should be addressed (email hv214@cam.ac.uk...
Biochem J (2010) 430 (1): 1–19.
Published: 28 July 2010
... © The Authors Journal compilation © 2010 Biochemical Society 2010 acyl carrier protein antibiotic fatty acid biosynthesis lipid protein complex 1 To whom correspondence should be addressed (email vogel@ucalgary.ca ). The FA biosynthesis process begins with the conversion...
Includes: Multimedia, Supplementary data
Biochem J (2006) 394 (1): 105–114.
Published: 27 January 2006
.... Because anal-3 shows high selectivity towards bacterial and fungal cells, it may provide an avenue for the development of new antibiotics. antibiotic antimicrobial peptide haemolysis HP (2-20) membrane NMR Antibiotic agents have become indispensable in the modern health care system...
Includes: Supplementary data
Biochem J (2005) 389 (3): 843–852.
Published: 26 July 2005
...Tracey L. Campbell; Denis M. Daigle; Eric D. Brown We present an analysis of the cellular phenotype and biochemical activity of a conserved bacterial GTPase of unknown function (YloQ and YjeQ in Bacillus subtilis and Escherichia coli respectively) using a collection of antibiotics of diverse...
Biochem J (2004) 383 (2): 201–208.
Published: 08 October 2004
...Arthur ABELIAN; Andrew P. WALSH; Georg LENTZEN; Fareed ABOUL-ELA; Michael J. GAIT The bacterial ribosome comprises 30 S and 50 S ribonucleoprotein subunits, contains a number of binding sites for known antibiotics and is an attractive target for selection of novel antibacterial agents. On the 30 S...
Biochem J (1999) 338 (1): 153–159.
Published: 08 February 1999
...Roger S. CHITTOCK; Simon WARD; Alan-Shaun WILKINSON; Patrick CASPERS; Barbara MENSCH; Malcolm G. P. PAGE; Christopher W. WHARTON A soluble form of Streptococcus pneumoniae PBP2x, a molecular target of penicillin and cephalosporin antibiotics, has been expressed and purified. IR difference spectra...