... the degradation of specific proteins of interest through the hijacking of the ClpCP machinery. These strategies represent an important emerging avenue for combatting antimicrobial resistance. The antibiotic resistance crisis is one of the top priorities for the scientific community in the 21st century...

... License 4.0 (CC BY) . Open access for this article was enabled by the participation of University of Strathclyde in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. antibiotic resistance bacteriocin...

... Press Limited on behalf of the Biochemical Society 2020 antibiotic resistance HigBA protein–DNA protein–protein interactions toxin–antitoxin X-ray structure Toxin–antitoxin (TA) systems are pairs of genes that are either located on bacterial plasmids or integrated in the bacterial...

... in multiple environmental stress response remained elusive. Here, we reported an organic peroxide- and antibiotic-sensing MarR (multiple antibiotics resistance regulators)-type regulator, called OasR (organic peroxide- and antibiotic-sensing regulator). The OasR regulator used Cys95 oxidation to sense...

... locations [ 5 , 6 ]. Colonization as biofilms enables bacterial communication (quorum sensing) [ 7 , 8 ], horizontal gene transfer and formation of synergistic micro-consortia, leading to antibiotic resistance [ 9 , 10 ]. Furthermore, the EPS layer protects the organisms embedded in it by reducing...

...Andreas Ioannis Karsisiotis; Christian F. Damblon; Gordon C. K. Roberts Metallo-β-lactamases, enzymes which inactivate β-lactam antibiotics, are of increasing biological and clinical significance as a source of antibiotic resistance in pathogenic bacteria. In the present study we describe the high...

... and the inhibition studies provide an important opportunity for structure-based design of compounds to target aminoglycoside phosphotransferases for inhibition, potentially overcoming this form of antibiotic resistance. Enzyme-mediated antibiotic resistance is especially amenable to this combinatory approach...

..., two phenazines from Streptomyces spp. [ 9 ], bis(1 N -tetrazol-5-yl)amine [ 10 ] and EGTA [ 11 ]. antibiotic resistance bulgecin A inhibitor metallo-β-lactamase Stenotrophomonas zinc co-ordination The metallo-β-lactamases are a family of clinically important zinc hydrolases. All...

.... Several Gram-negative bacteria efflux pumps have been described. These proteinaceous channels are capable of expelling structurally different drugs across the envelope and conferring antibiotic resistance in various bacterial pathogens. Combating antibiotic resistance is an urgency and the blocking...

... pump. When expressed in M. smegmatis, DrrAB conferred resistance to a number of clini- cally relevant, structurally unrelated antibiotics. The resistant phenotype could be reversed by verapamil and reserpine, two potent inhibitors of ABC transporters. Key words: antibiotic resistance, efflux pump...

... was purified by a one-step affinity-chromatography procedure as a correctly folded, dimeric protein. ShBle thus INTRODUCTION Few antibiotic resistance determinants are available for Halo- ferax Šolcanii and other members of the extremely halophilic subgroup of the Archaea. This paucity is due to the intrinsic...