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1-13 of 13
Keywords: antibodies
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Articles
Jonathan R. Gadsby, Pantelis Savvas Ioannou, Richard Butler, Julia Mason, Alison J. Smith, Ulrich Dobramysl, Stacey E. Chin, Claire Dobson, Jennifer L. Gallop
Journal:
Biochemical Journal
Biochem J (2024) 481 (24): 1977–1995.
Published: 23 December 2024
... antibodies that lengthen filopodia-like structures formed in a cell-free reconstitution system, and used them to uncover a key molecular switch governing length regulation. Using immunolabelling, enzyme-linked immunosorbent assays, immunoprecipitation and immunoblock experiments, we identified four...
Includes: Multimedia, Supplementary data
Articles
Paramesha Bugga, Michael W. Stoner, Janet R. Manning, Bellina A.S. Mushala, Nisha Bhattarai, Maryam Sharifi-Sanjani, Bradley R. Webster, Dharendra Thapa, Iain Scott
Journal:
Biochemical Journal
Biochem J (2024) 481 (10): 643–651.
Published: 10 May 2024
... these reagents have not been rigorously validated, leading to potentially misleading results. In this report we tested several commercially-available antibodies for GCN5L1, and found that two-thirds of those available did not unambiguously detect the protein by western blot in cultured mouse cells or ex vivo...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2021) 478 (8): 1485–1509.
Published: 21 April 2021
...J. Sebastian Temme; Dorothy L. Butler; Jeffrey C. Gildersleeve Carbohydrate-binding antibodies play diverse and critical roles in human health. Endogenous carbohydrate-binding antibodies that recognize bacterial, fungal, and other microbial carbohydrates prevent systemic infections and help...
Articles
Michael J. Knight, Rachel E. Woolley, Anthony Kwok, Stuart Parsons, Hannah B. L. Jones, Christina E. Gulácsy, Polly Phaal, Omar Kassaar, Kieran Dawkins, Elizabeth Rodriguez, Andreia Marques, Leo Bowsher, Stephen A. Wells, Andrew Watts, Jean M. H. van den Elsen, Alison Turner, John O'Hara, Christopher R. Pudney
Journal:
Biochemical Journal
Biochem J (2020) 477 (18): 3599–3612.
Published: 28 September 2020
...; Christopher R. Pudney Among the major challenges in the development of biopharmaceuticals are structural heterogeneity and aggregation. The development of a successful therapeutic monoclonal antibody (mAb) requires both a highly active and also stable molecule. Whilst a range of experimental (biophysical...
Includes: Supplementary data
Articles
Martin A. Rossotti, Kevin A. Henry, Henk van Faassen, Jamshid Tanha, Deborah Callaghan, Greg Hussack, Mehdi Arbabi-Ghahroudi, C. Roger MacKenzie
Journal:
Biochemical Journal
Biochem J (2019) 476 (1): 39–50.
Published: 07 January 2019
... and antibodies has clear clinical benefit. Here, we report the isolation and functional characterization of novel camelid single-domain antibodies ( sdAbs or V H Hs ) directed against human EGFR. The source of these V H Hs was a llama immunized with cDNA encoding human EGFR ectodomain alone (no protein or cell...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2018) 475 (1): 185–189.
Published: 05 January 2018
... Foundation (MJFF) for Parkinson's research to develop, and validate, a panel of exquisitely sensitive phospho-specific Rab antibodies. Of particular interest, the monoclonal antibody-designated MJFF-pRAB10 detects phosphorylated Rab 10 on Thr73 in a variety of cells, brain extracts, PD-derived samples...
Articles
In Collection
Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019
Pawel Lis, Sophie Burel, Martin Steger, Matthias Mann, Fiona Brown, Federico Diez, Francesca Tonelli, Janice L. Holton, Philip Winglok Ho, Shu-Leong Ho, Meng-Yun Chou, Nicole K. Polinski, Terina N. Martinez, Paul Davies, Dario R. Alessi
Journal:
Biochemical Journal
Biochem J (2018) 475 (1): 1–22.
Published: 02 January 2018
... motif. In the present study, we analyse the selectivity and sensitivity of polyclonal and monoclonal phospho-specific antibodies raised against nine different LRRK2-phosphorylated Rab proteins (Rab3A/3B/3C/3D, Rab5A/5B/5C, Rab8A/8B, Rab10, Rab12, Rab29[T71], Rab29[S72], Rab35 and Rab43). We identify...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (18): 3179–3188.
Published: 08 September 2017
...Chloe L. Stoyle; Paul E. Stephens; David P. Humphreys; Sam Heywood; Katharine Cain; Neil J. Bulleid Rodent monoclonal antibodies with specificity towards important biological targets are developed for therapeutic use by a process of humanisation. This process involves the creation of molecules...
Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (4): 517–519.
Published: 03 February 2017
... the host immune system. Many anti-fHbp monoclonal antibodies (mAbs) produced against fHbp fail to trigger complement-mediated bacteriolysis when used alone in vitro , but are highly synergistic and bactericidal when used in combination. This opened the door to defining the structural basis by which mAbs...
Articles
Neda Motamedi-Shad, Alistair M. Jagger, Maximilian Liedtke, Sarah V. Faull, Arjun Scott Nanda, Enrico Salvadori, Joshua L. Wort, Christopher W.M. Kay, Narinder Heyer-Chauhan, Elena Miranda, Juan Perez, Adriana Ordóñez, Imran Haq, James A. Irving, David A. Lomas
Journal:
Biochemical Journal
Biochem J (2016) 473 (19): 3269–3290.
Published: 27 September 2016
... serpin molecules, which accumulate at the site of synthesis. This is the basis of many pathologies termed the serpinopathies. We have previously identified a monoclonal antibody (mAb 4B12 ) that, in single-chain form, blocks α 1 -antitrypsin (α 1 -AT) polymerisation in cells. Here, we describe...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2001) 353 (3): 627–634.
Published: 25 January 2001
... correspondence should be addressed (e-mail [email protected] ). 25 8 2000 16 10 2000 7 11 2000 The Biochemical Society, London © 2001 2001 acylation antibodies G-protein-coupled receptors recombinant baculovirus signal transduction Biochem. J. (2001) 353, 627 634 (Printed...
Articles
Monique L. M. VAN DE POLL, Walter VAN ROTTERDAM, Mireille M. GADELLAA, Catelijne STORTELERS, Marianne J. H. VAN VUGT, Everardus J. J. VAN ZOELEN
Journal:
Biochemical Journal
Biochem J (2000) 349 (1): 267–274.
Published: 26 June 2000
... was performed on the epitope recognized by two polyclonal antibodies raised against hEGF, and one polyclonal antibody raised against hTGFα. All three antibodies recognized essentially the same antigenic site, a non-linear and conformation-dependent sequence that is located near the second and fourth disulphide...
Articles
Journal:
Biochemical Journal
Biochem J (1999) 344 (2): 293–296.
Published: 24 November 1999
... functional assays for the cytotoxic domain of Aβ and suggest a mechanism for some of the observed actions of Aβ plus catalase in vitro . 1 e-mail [email protected] 1 9 1999 24 9 1999 1 10 1999 The Biochemical Society, London © 1999 1999 Alzheimers antibodies...