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Keywords: antibodies
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Biochem J (2021) 478 (8): 1485–1509.
Published: 21 April 2021
...J. Sebastian Temme; Dorothy L. Butler; Jeffrey C. Gildersleeve Carbohydrate-binding antibodies play diverse and critical roles in human health. Endogenous carbohydrate-binding antibodies that recognize bacterial, fungal, and other microbial carbohydrates prevent systemic infections and help...
Biochem J (2020) 477 (18): 3599–3612.
Published: 28 September 2020
...; Christopher R. Pudney Among the major challenges in the development of biopharmaceuticals are structural heterogeneity and aggregation. The development of a successful therapeutic monoclonal antibody (mAb) requires both a highly active and also stable molecule. Whilst a range of experimental (biophysical...
Includes: Supplementary data
Biochem J (2019) 476 (1): 39–50.
Published: 07 January 2019
... antibodies has clear clinical benefit. Here, we report the isolation and functional characterization of novel camelid single-domain antibodies ( sdAbs or V H Hs ) directed against human EGFR. The source of these V H Hs was a llama immunized with cDNA encoding human EGFR ectodomain alone (no protein or cell...
Includes: Supplementary data
Biochem J (2018) 475 (1): 185–189.
Published: 05 January 2018
... Foundation (MJFF) for Parkinson's research to develop, and validate, a panel of exquisitely sensitive phospho-specific Rab antibodies. Of particular interest, the monoclonal antibody-designated MJFF-pRAB10 detects phosphorylated Rab 10 on Thr73 in a variety of cells, brain extracts, PD-derived samples and...
Biochem J (2018) 475 (1): 1–22.
Published: 02 January 2018
... motif. In the present study, we analyse the selectivity and sensitivity of polyclonal and monoclonal phospho-specific antibodies raised against nine different LRRK2-phosphorylated Rab proteins (Rab3A/3B/3C/3D, Rab5A/5B/5C, Rab8A/8B, Rab10, Rab12, Rab29[T71], Rab29[S72], Rab35 and Rab43). We identify...
Includes: Supplementary data
Biochem J (2017) 474 (18): 3179–3188.
Published: 08 September 2017
...Chloe L. Stoyle; Paul E. Stephens; David P. Humphreys; Sam Heywood; Katharine Cain; Neil J. Bulleid Rodent monoclonal antibodies with specificity towards important biological targets are developed for therapeutic use by a process of humanisation. This process involves the creation of molecules...
Biochem J (2017) 474 (4): 517–519.
Published: 03 February 2017
... the host immune system. Many anti-fHbp monoclonal antibodies (mAbs) produced against fHbp fail to trigger complement-mediated bacteriolysis when used alone in vitro , but are highly synergistic and bactericidal when used in combination. This opened the door to defining the structural basis by which...
Biochem J (2016) 473 (19): 3269–3290.
Published: 27 September 2016
... serpin molecules, which accumulate at the site of synthesis. This is the basis of many pathologies termed the serpinopathies. We have previously identified a monoclonal antibody (mAb 4B12 ) that, in single-chain form, blocks α 1 -antitrypsin (α 1 -AT) polymerisation in cells. Here, we describe the...
Includes: Supplementary data
Biochem J (2001) 353 (3): 627–634.
Published: 25 January 2001
... To whom correspondence should be addressed (e-mail d.richter@gwdg.de ). 25 8 2000 16 10 2000 7 11 2000 The Biochemical Society, London © 2001 2001 acylation antibodies G-protein-coupled receptors recombinant baculovirus signal transduction Biochem. J. (2001) 353...
Biochem J (2000) 349 (1): 267–274.
Published: 26 June 2000
... performed on the epitope recognized by two polyclonal antibodies raised against hEGF, and one polyclonal antibody raised against hTGFα. All three antibodies recognized essentially the same antigenic site, a non-linear and conformation-dependent sequence that is located near the second and fourth disulphide...
Biochem J (1999) 344 (2): 293–296.
Published: 24 November 1999
... functional assays for the cytotoxic domain of Aβ and suggest a mechanism for some of the observed actions of Aβ plus catalase in vitro . 1 e-mail nmilton@rfhsm.ac.uk 1 9 1999 24 9 1999 1 10 1999 The Biochemical Society, London © 1999 1999 Alzheimers antibodies...