... aminopeptidase) are three homologous enzymes that play critical roles in the generation of antigenic peptides. These aminopeptidases excise amino acids from N-terminally extended precursors of antigenic peptides in order to generate the correct length epitopes for binding on to MHC class I molecules...

... and effector T-cells, as well as the recirculation of naïve T-cells to secondary lymphoid organs. In addition to the acquisition of tissue-selective integrins and chemokine receptors, an additional level of specificity for T-cell trafficking into the tissue is provided by specific recognition of antigen...

..., but its use as an activator of PLD2 in intact cells to study function is limited due to toxicity. Key words: antigen, exocytosis, membrane ruffling, phosphatidic acid, PMA. Šitro [10]. PLD2 can be activated mildly by ARF, exhibiting 1.5 2-fold activation [11,12] ; however, when the N-terminal residues 1...