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Keywords: antimicrobial peptide
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Articles

Effects of CGA-N12 on the membrane structure of Candida tropicalis cells

Ruifang Li, Weini Shi, Ruiling Zhang, Liang Huang, Yanjie Yi, Aihua Li, Hongjuan Jing, Mengke Tao, Meng Zhang, Nanqi Pei
Journal: Biochemical Journal
Biochem J (2020) 477 (10): 1813–1825.
https://doi.org/10.1042/BCJ20190939
Published: 21 May 2020
...Ruifang Li; Weini Shi; Ruiling Zhang; Liang Huang; Yanjie Yi; Aihua Li; Hongjuan Jing; Mengke Tao; Meng Zhang; Nanqi Pei The antimicrobial peptide CGA-N12 (NH 2 -ALQGAKERAHQQ-COOH) is an active peptide derived from chromogranin A (CGA) and consists of the 65th to 76th amino acids of the N-terminus...
View article titled, Effects of CGA-N12 on the membrane structure of Candida tropicalis cells
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Articles

The chromogranin A-derived antifungal peptide CGA-N9 induces apoptosis in Candida tropicalis

Ruifang Li, Chen Chen, Beibei Zhang, Hongjuan Jing, Zichao Wang, Chunling Wu, Pu Hao, Yong Kuang, Minghang Yang
Journal: Biochemical Journal
Biochem J (2019) 476 (20): 3069–3080.
https://doi.org/10.1042/BCJ20190483
Published: 30 October 2019
.... antimicrobial peptide CGA-N9 cytochrome c membrane potential yeast apoptosis Invasive fungal infections continue to appear as the size of the immunocompromised population increases [ 1 , 2 ]. Candida tropicalis is one of only five Candida species accounting for 92% of candidemia cases [ 3 – 5...
View article titled, The chromogranin A-derived antifungal peptide CGA-N9 induces apoptosis in Candida tropicalis
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Articles

Periplanetasin-4, a novel antimicrobial peptide from the cockroach, inhibits communications between mitochondria and vacuoles

Heejeong Lee, Jae Sam Hwang, Dong Gun Lee
Journal: Biochemical Journal
Biochem J (2019) 476 (8): 1267–1284.
https://doi.org/10.1042/BCJ20180933
Published: 26 April 2019
... features, membrane damage, and apoptosis using antimicrobial peptide from American Cockroach. Periplanetasin-4 (LRHKVYGYCVLGP-NH 2 ) is a 13-mer peptide derived from Periplaneta americana and exhibits phosphatidylserine exposure and caspase activation without DNA fragmentation. Apoptotic features without...
View article titled, Periplanetasin-4, a novel <span class="search-highlight">antimicrobial</span> <span class="search-highlight">peptide</span> from the cockroach, inhibits communications between mitochondria and vacuoles
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Articles

CGA-N9, an antimicrobial peptide derived from chromogranin A: direct cell penetration of and endocytosis by Candida tropicalis

Ruifang Li, Chen Chen, Sha Zhu, Xueqin Wang, Yanhui Yang, Weini Shi, Sijia Chen, Congcong Wang, Lixing Yan, Jiaofan Shi
Journal: Biochemical Journal
Biochem J (2019) 476 (3): 483–497.
https://doi.org/10.1042/BCJ20180801
Published: 05 February 2019
... 2019 © 2019 The Author(s) 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . antimicrobial peptide cell uptake CGA-N9 entry route...
View article titled, CGA-N9, an <span class="search-highlight">antimicrobial</span> <span class="search-highlight">peptide</span> derived from chromogranin A: direct cell penetration of and endocytosis by Candida tropicalis
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Articles

Potential role of a series of lysine-/leucine-rich antimicrobial peptide in inhibiting lipopolysaccharide-induced inflammation

Weibing Dong, Xin Zhu, Xuan Zhou, Ying Yang, Xin Yan, Li Sun, Dejing Shang
Journal: Biochemical Journal
Biochem J (2018) 475 (22): 3687–3706.
https://doi.org/10.1042/BCJ20180483
Published: 30 November 2018
...Weibing Dong; Xin Zhu; Xuan Zhou; Ying Yang; Xin Yan; Li Sun; Dejing Shang Antimicrobial peptides have broad-spectrum killing activities against bacteria, enveloped viruses, fungi and several parasites via cell membrane permeation and exhibit primarily immunomodulatory and anti-infective functions...
View article titled, Potential role of a series of lysine-&#x2F;leucine-rich <span class="search-highlight">antimicrobial</span> <span class="search-highlight">peptide</span> in inhibiting lipopolysaccharide-induced inflammation
Open the PDF for Potential role of a series of lysine-/leucine-rich <span class="search-highlight">antimicrobial</span> <span class="search-highlight">peptide</span> in inhibiting lipopolysaccharide-induced inflammation in another window
Includes: Supplementary data
Articles

Scolopendin, an antimicrobial peptide from centipede, attenuates mitochondrial functions and triggers apoptosis in Candida albicans

Heejeong Lee, Jae-Sam Hwang, Dong Gun Lee
Journal: Biochemical Journal
Biochem J (2017) 474 (5): 635–645.
https://doi.org/10.1042/BCJ20161039
Published: 20 February 2017
...Heejeong Lee; Jae-Sam Hwang; Dong Gun Lee Centipedes, a type of arthropod, reportedly produce antimicrobial peptides as part of an innate immune response. Scolopendin (SPSEKAGLQPVGRIGRMLKK) is a novel antimicrobial peptide derived from Scolopendra subspinipes mutilans . Many antifungal agents have...
View article titled, Scolopendin, an <span class="search-highlight">antimicrobial</span> <span class="search-highlight">peptide</span> from centipede, attenuates mitochondrial functions and triggers apoptosis in Candida albicans
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Articles

Lachesana tarabaevi , an expert in membrane-active toxins

Alexey I. Kuzmenkov, Maria Y. Sachkova, Sergey I. Kovalchuk, Eugene V. Grishin, Alexander A. Vassilevski
Journal: Biochemical Journal
Biochem J (2016) 473 (16): 2495–2506.
https://doi.org/10.1042/BCJ20160436
Published: 11 August 2016
... (LtTx). Rpe are short (18 residues) amphiphilic molecules that are encoded by the same genes as antimicrobial peptides Ltc 4a and 4b. Isolation of Rpe confirms the validity of the iPQM (inverted processing quadruplet motif) proposed to mark the cleavage sites in spider toxin precursors...
View article titled, Lachesana tarabaevi , an expert in membrane-active toxins
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Includes: Supplementary data
Articles

Acyl carrier protein is a bacterial cytoplasmic target of cationic antimicrobial peptide LL-37

Myung-Chul Chung, Scott N. Dean, Monique L. van Hoek
Journal: Biochemical Journal
Biochem J (2015) 470 (2): 243–253.
https://doi.org/10.1042/BJ20150432
Published: 20 August 2015
...Myung-Chul Chung; Scott N. Dean; Monique L. van Hoek In addition to membrane disruption, the cathelicidin antimicrobial peptide (AMP) LL-37 translocates through the bacterial inner membrane to target intracellular molecules. The present study aims to identify an alternate mechanism...
View article titled, Acyl carrier protein is a bacterial cytoplasmic target of cationic <span class="search-highlight">antimicrobial</span> <span class="search-highlight">peptide</span> LL-37
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Includes: Supplementary data
Articles

Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Marc Torrent, David Pulido, Javier Valle, M. Victòria Nogués, David Andreu, Ester Boix
Journal: Biochemical Journal
Biochem J (2013) 456 (1): 99–108.
https://doi.org/10.1042/BJ20130123
Published: 24 October 2013
... 8 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 The antimicrobial mechanism of human RNases has been conserved along evolution and its activity is retained at an N-terminal antimicrobial domain. antimicrobial peptide drug discovery evolution innate...
View article titled, Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus
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Includes: Supplementary data
Articles

Inducing toxicity by introducing a leucine-zipper-like motif in frog antimicrobial peptide, magainin 2

Brijesh Kumar Pandey, Saurabh Srivastava, Manish Singh, Jimut Kanti Ghosh
Journal: Biochemical Journal
Biochem J (2011) 436 (3): 609–620.
https://doi.org/10.1042/BJ20110056
Published: 27 May 2011
...Brijesh Kumar Pandey; Saurabh Srivastava; Manish Singh; Jimut Kanti Ghosh Cytotoxicity, a major obstacle in therapeutic application of antimicrobial peptides, is controlled by leucine-zipper-like sequences in melittin and other naturally occurring antimicrobial peptides. Magainin 2 shows...
View article titled, Inducing toxicity by introducing a leucine-zipper-like motif in frog <span class="search-highlight">antimicrobial</span> <span class="search-highlight">peptide</span>, magainin 2
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Articles

Lipopolysaccharide interaction is decisive for the activity of the antimicrobial peptide NK-2 against Escherichia coli and Proteus mirabilis

Malte U. Hammer, Annemarie Brauser, Claudia Olak, Gerald Brezesinski, Torsten Goldmann, Thomas Gutsmann, Jörg Andrä
Journal: Biochemical Journal
Biochem J (2010) 427 (3): 477–488.
https://doi.org/10.1042/BJ20091607
Published: 14 April 2010
...Malte U. Hammer; Annemarie Brauser; Claudia Olak; Gerald Brezesinski; Torsten Goldmann; Thomas Gutsmann; Jörg Andrä Phosphatidylglycerol is a widely used mimetic to study the effects of AMPs (antimicrobial peptides) on the bacterial cytoplasmic membrane. However, the antibacterial activities...
View article titled, Lipopolysaccharide interaction is decisive for the activity of the <span class="search-highlight">antimicrobial</span> <span class="search-highlight">peptide</span> NK-2 against Escherichia coli and Proteus mirabilis
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Articles

Bactericidal and membrane disruption activities of the eosinophil cationic protein are largely retained in an N-terminal fragment

Marc Torrent, Beatriz G. de la Torre, Victòria M. Nogués, David Andreu, Ester Boix
Journal: Biochemical Journal
Biochem J (2009) 421 (3): 425–434.
https://doi.org/10.1042/BJ20082330
Published: 15 July 2009
... 2009 18 5 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 antimicrobial peptide electron microscopy host defence lipopolysaccharide liposome Host defence proteins and peptides of the innate immune system are potential candidates for chemotherapeutic...
View article titled, Bactericidal and membrane disruption activities of the eosinophil cationic protein are largely retained in an N-terminal fragment
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Includes: Supplementary data
Articles

Artificial β-defensin based on a minimal defensin template

Nikolinka Antcheva, Francesca Morgera, Luisa Creatti, Lisa Vaccari, Ulrike Pag, Sabrina Pacor, Yechiel Shai, Hans-Georg Sahl, Alessandro Tossi
Journal: Biochemical Journal
Biochem J (2009) 421 (3): 435–447.
https://doi.org/10.1042/BJ20082242
Published: 15 July 2009
...://www.expasy.ch/tools/protparam.html ). antimicrobial peptide chemotaxis β-defensin host defence peptide innate immunity Defensins are small cationic host defence peptides involved in the innate immunity of organisms ranging from moulds and plants to vertebrate and invertebrate animals [ 1 – 3...
View article titled, Artificial β-defensin based on a minimal defensin template
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Includes: Supplementary data
Articles

Membrane-targeted synergistic activity of docosahexaenoic acid and lysozyme against Pseudomonas aeruginosa

Jose G. Martinez, Michael Waldon, Qiyu Huang, Sandra Alvarez, Ami Oren, Natalie Sandoval, Ming Du, Feimeng Zhou, Alexandra Zenz, Karl Lohner, Robert Desharnais, Edith Porter
Journal: Biochemical Journal
Biochem J (2009) 419 (1): 193–200.
https://doi.org/10.1042/BJ20081505
Published: 13 March 2009
[email protected] ). 24 7 2008 15 12 2008 23 12 2008 23 12 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 antimicrobial peptide bacterial cell wall cystic fibrosis innate host defence large unilamellar vesicle (LUV) non-esterified fatty acid Non...
View article titled, Membrane-targeted synergistic activity of docosahexaenoic acid and lysozyme against Pseudomonas aeruginosa
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Articles

Primate cathelicidin orthologues display different structures and membrane interactions

Francesca Morgera, Lisa Vaccari, Nikolinka Antcheva, Denis Scaini, Sabrina Pacor, Alessandro Tossi
Journal: Biochemical Journal
Biochem J (2009) 417 (3): 727–735.
https://doi.org/10.1042/BJ20081726
Published: 16 January 2009
... be addressed (email [email protected] ). 27 8 2008 8 10 2008 16 10 2008 16 10 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 antimicrobial peptide attenuated total reflection (ATR) spectroscopy membrane interaction peptide...
View article titled, Primate cathelicidin orthologues display different structures and membrane interactions
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Articles

An exceptional salt-tolerant antimicrobial peptide derived from a novel gene family of haemocytes of the marine invertebrate Ciona intestinalis

Henning Fedders, Matthias Michalek, Joachim Grötzinger, Matthias Leippe
Journal: Biochemical Journal
Biochem J (2008) 416 (1): 65–75.
https://doi.org/10.1042/BJ20080398
Published: 28 October 2008
...Henning Fedders; Matthias Michalek; Joachim Grötzinger; Matthias Leippe A novel gene family coding for putative antimicrobial peptides was identified in the EST (expressed sequence tag) database of the sea squirt Ciona intestinalis , and one of these genes was molecularly cloned from the Northern...
View article titled, An exceptional salt-tolerant <span class="search-highlight">antimicrobial</span> <span class="search-highlight">peptide</span> derived from a novel gene family of haemocytes of the marine invertebrate Ciona intestinalis
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Articles

Cyto-insectotoxins, a novel class of cytolytic and insecticidal peptides from spider venom

Alexander A. Vassilevski, Sergey A. Kozlov, Olga V. Samsonova, Natalya S. Egorova, Dmitry V. Karpunin, Kirill A. Pluzhnikov, Alexei V. Feofanov, Eugene V. Grishin
Journal: Biochemical Journal
Biochem J (2008) 411 (3): 687–696.
https://doi.org/10.1042/BJ20071123
Published: 14 April 2008
... 2007 18 1 2008 18 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 antimicrobial peptide cytolytic peptide insecticide Lachesana tarabaevi planar lipid bilayer spider toxin Animal venoms represent complex mixtures of compounds that serve...
View article titled, Cyto-insectotoxins, a novel class of cytolytic and insecticidal peptides from spider venom
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Articles

Structure and mode of action of the antimicrobial peptide arenicin

Jörg Andrä, Igor Jakovkin, Joachim Grötzinger, Oliver Hecht, Anna D. Krasnosdembskaya, Torsten Goldmann, Thomas Gutsmann, Matthias Leippe
Journal: Biochemical Journal
Biochem J (2008) 410 (1): 113–122.
https://doi.org/10.1042/BJ20071051
Published: 29 January 2008
...Jörg Andrä; Igor Jakovkin; Joachim Grötzinger; Oliver Hecht; Anna D. Krasnosdembskaya; Torsten Goldmann; Thomas Gutsmann; Matthias Leippe The solution structure and the mode of action of arenicin isoform 1, an antimicrobial peptide with a unique 18-residue loop structure, from the lugworm Arenicola...
View article titled, Structure and mode of action of the <span class="search-highlight">antimicrobial</span> <span class="search-highlight">peptide</span> arenicin
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Articles

Novel molecules for intra-oral delivery of antimicrobials to prevent and treat oral infectious diseases

Periathamby Antony Raj, Latha Rajkumar, Andrew R. Dentino
Journal: Biochemical Journal
Biochem J (2008) 409 (2): 601–609.
https://doi.org/10.1042/BJ20070810
Published: 21 December 2007
... 10 2007 8 10 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 antimicrobial peptide bifunctional molecule dental plaque enamel-binding peptide hybrid peptide intra-oral drug-delivery molecule Caries and periodontal disease remain the most common...
View article titled, Novel molecules for intra-oral delivery of antimicrobials to prevent and treat oral infectious diseases
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Includes: Supplementary data
Articles

A novel horse α-defensin: gene transcription, recombinant expression and characterization of the structure and function

Oliver Bruhn, Petra Regenhard, Matthias Michalek, Sven Paul, Christoph Gelhaus, Sascha Jung, Georg Thaller, Rainer Podschun, Matthias Leippe, Joachim Grötzinger, Ernst Kalm
Journal: Biochemical Journal
Biochem J (2007) 407 (2): 267–276.
https://doi.org/10.1042/BJ20070747
Published: 25 September 2007
...Oliver Bruhn; Petra Regenhard; Matthias Michalek; Sven Paul; Christoph Gelhaus; Sascha Jung; Georg Thaller; Rainer Podschun; Matthias Leippe; Joachim Grötzinger; Ernst Kalm Defensins are a predominant class of antimicrobial peptides, which act as endogenous antibiotics. Defensins are classified...
View article titled, A novel horse α-defensin: gene transcription, recombinant expression and characterization of the structure and function
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Articles

Mechanism of interaction of optimized Limulus -derived cyclic peptides with endotoxins: thermodynamic, biophysical and microbiological analysis

Jörg Andrä, Jörg Howe, Patrick Garidel, Manfred Rössle, Walter Richter, José Leiva-León, Ignacio Moriyon, Rainer Bartels, Thomas Gutsmann, Klaus Brandenburg
Journal: Biochemical Journal
Biochem J (2007) 406 (2): 297–307.
https://doi.org/10.1042/BJ20070279
Published: 13 August 2007
..., but not with the action of the peptides on bacteria. antimicrobial peptide cytokine induction Fourier-transform infrared (FTIR) Limulus test lipopolysaccharide neutralization (LPS neutralization) small-angle X-ray scattering (SAXS) 1 To whom correspondence should be addressed (email kbranden@fz...
View article titled, Mechanism of interaction of optimized Limulus -derived cyclic peptides with endotoxins: thermodynamic, biophysical and microbiological analysis
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Articles

Cell-penetrating peptides and antimicrobial peptides: how different are they?

Sónia Troeira Henriques, Manuel Nuno Melo, Miguel A. R. B. Castanho
Journal: Biochemical Journal
Biochem J (2006) 399 (1): 1–7.
https://doi.org/10.1042/BJ20061100
Published: 13 September 2006
... been successfully used for drug delivery into mammalian cells; however, there is no consensus about the mechanism of cellular uptake. Both endocytic and non-endocytic pathways are supported by experimental evidence. The observation that some AMPs (antimicrobial peptides) can enter host cells without...
View article titled, Cell-penetrating peptides and <span class="search-highlight">antimicrobial</span> <span class="search-highlight">peptides</span>: how different are they?
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Articles

Interactions between the plasma membrane and the antimicrobial peptide HP (2-20) and its analogues derived from Helicobacter pylori

Kwang H. Lee, Dong G. Lee, Yoonkyung Park, Dong-Il Kang, Song Y. Shin, Kyung-Soo Hahm, Yangmee Kim
Journal: Biochemical Journal
Biochem J (2006) 394 (1): 105–114.
https://doi.org/10.1042/BJ20051574
Published: 27 January 2006
... in the Proten Data Base under the accession numbers 1P0G, 1P0J, 1P0L, 1P0O, 1P5L and 1P5K. 23 9 2005 27 10 2005 31 10 2005 31 10 2005 The Biochemical Society, London 2006 antibiotic antimicrobial peptide haemolysis HP (2-20) membrane NMR Antibiotic agents have...
View article titled, Interactions between the plasma membrane and the <span class="search-highlight">antimicrobial</span> <span class="search-highlight">peptide</span> HP (2-20) and its analogues derived from Helicobacter pylori
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Includes: Supplementary data
Articles

Conjugation of fatty acids with different lengths modulates the antibacterial and antifungal activity of a cationic biologically inactive peptide

Amir Malina, Yechiel Shai
Journal: Biochemical Journal
Biochem J (2005) 390 (3): 695–702.
https://doi.org/10.1042/BJ20050520
Published: 05 September 2005
...Amir Malina; Yechiel Shai Many studies have shown that an amphipathic structure and a threshold of hydrophobicity of the peptidic chain are crucial for the biological function of AMPs (antimicrobial peptides). However, the factors that dictate their cell selectivity are not yet clear...
View article titled, Conjugation of fatty acids with different lengths modulates the antibacterial and antifungal activity of a cationic biologically inactive peptide
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Articles

Controlled alteration of the shape and conformational stability of α-helical cell-lytic peptides: effect on mode of action and cell specificity

Igor Zelezetsky, Sabrina Pacor, Ulrike Pag, Niv Papo, Yechiel Shai, Hans-Georg Sahl, Alessandro Tossi
Journal: Biochemical Journal
Biochem J (2005) 390 (1): 177–188.
https://doi.org/10.1042/BJ20042138
Published: 09 August 2005
... The Biochemical Society, London 2005 amphipathic helix antimicrobial peptide cell specificity cell-lytic peptide mode of action surface plasmon resonance Peptide–membrane interactions are essential for many processes of physiological or pathological relevance, such as the effects of hormones...
View article titled, Controlled alteration of the shape and conformational stability of α-helical cell-lytic peptides: effect on mode of action and cell specificity
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Includes: Supplementary data
Articles

The iron–siderophore transporter FhuA is the receptor for the antimicrobial peptide microcin J25: role of the microcin Val 11 –Pro 16 β-hairpin region in the recognition mechanism

Delphine Destoumieux-Garzón, Sophie Duquesne, Jean Peduzzi, Christophe Goulard, Michel Desmadril, Lucienne Letellier, Sylvie Rebuffat, Pascale Boulanger
Journal: Biochemical Journal
Biochem J (2005) 389 (3): 869–876.
https://doi.org/10.1042/BJ20042107
Published: 26 July 2005
...Delphine Destoumieux-Garzón; Sophie Duquesne; Jean Peduzzi; Christophe Goulard; Michel Desmadril; Lucienne Letellier; Sylvie Rebuffat; Pascale Boulanger The role of the outer-membrane iron transporter FhuA as a potential receptor for the antimicrobial peptide MccJ25 (microcin J25) was studied...
View article titled, The iron–siderophore transporter FhuA is the receptor for the <span class="search-highlight">antimicrobial</span> <span class="search-highlight">peptide</span> microcin J25: role of the microcin Val 11 –Pro 16 β-hairpin region in the recognition mechanism
Open the PDF for The iron–siderophore transporter FhuA is the receptor for the <span class="search-highlight">antimicrobial</span> <span class="search-highlight">peptide</span> microcin J25: role of the microcin Val 11 –Pro 16 β-hairpin region in the recognition mechanism in another window
Articles

Candidacidal effects of two antimicrobial peptides: histatin 5 causes small membrane defects, but LL-37 causes massive disruption of the cell membrane

Alice L. den HERTOG, Jan van MARLE, Henk A. van VEEN, Wim van't HOF, Jan G. M. BOLSCHER, Enno C. I. VEERMAN, Arie V. NIEUW AMERONGEN
Journal: Biochemical Journal
Biochem J (2005) 388 (2): 689–695.
https://doi.org/10.1042/BJ20042099
Published: 24 May 2005
...Alice L. den HERTOG; Jan van MARLE; Henk A. van VEEN; Wim van't HOF; Jan G. M. BOLSCHER; Enno C. I. VEERMAN; Arie V. NIEUW AMERONGEN The effects of antimicrobial peptides on artificial membranes have been well-documented; however, reports on the ultrastructural effects on the membranes of micro...
View article titled, Candidacidal effects of two <span class="search-highlight">antimicrobial</span> <span class="search-highlight">peptides</span>: histatin 5 causes small membrane defects, but LL-37 causes massive disruption of the cell membrane
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Articles

Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide

Jörg ANDRÄ, Karl LOHNER, Sylvie E. BLONDELLE, Roman JERALA, Ignacio MORIYON, Michel H. J. KOCH, Patrick GARIDEL, Klaus BRANDENBURG
Journal: Biochemical Journal
Biochem J (2005) 385 (1): 135–143.
https://doi.org/10.1042/BJ20041270
Published: 14 December 2004
... 7 2004 27 8 2004 2 9 2004 2 9 2004 The Biochemical Society, London 2005 antimicrobial peptide antisepsis endotoxin hydrophobic extension lactoferricin lipopolysaccharide (LPS) Despite the existence of broad-range antibiotics, septic shock resulting from...
View article titled, Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide
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Articles

Structure, conformation and biological activity of a novel lipodepsipeptide from Pseudomonas corrugata : cormycin A

Andrea SCALONI, Mauro DALLA SERRA, Pietro AMODEO, Luisa MANNINA, Rosa Maria VITALE, Anna Laura SEGRE, Oscar CRUCIANI, Francesca LODOVICHETTI, Maria Luigia GRECO, Alberto FIORE, Monica GALLO, Chiara D'AMBROSIO, Manuela CORAIOLA, Gianfranco MENESTRINA, Antonio GRANITI, Vincenzo FOGLIANO
Journal: Biochemical Journal
Biochem J (2004) 384 (1): 25–36.
https://doi.org/10.1042/BJ20040422
Published: 09 November 2004
... contributed equally to this work. 3 To whom correspondence should be addressed (email [email protected] ). 15 3 2004 14 6 2004 15 6 2004 15 6 2004 The Biochemical Society, London 2004 antimicrobial peptide cormycin lipid bilayer lipodepsipeptide membrane...
View article titled, Structure, conformation and biological activity of a novel lipodepsipeptide from Pseudomonas corrugata : cormycin A
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Includes: Supplementary data
Articles

A new class (penaeidin class 4) of antimicrobial peptides from the Atlantic white shrimp ( Litopenaeus setiferus ) exhibits target specificity and an independent proline-rich-domain function

Brandon J. CUTHBERTSON, Erika E. BÜLLESBACH, Julie FIEVET, Evelyne BACHÈRE, Paul S. GROSS
Journal: Biochemical Journal
Biochem J (2004) 381 (1): 79–86.
https://doi.org/10.1042/BJ20040330
Published: 22 June 2004
...Brandon J. CUTHBERTSON; Erika E. BÜLLESBACH; Julie FIEVET; Evelyne BACHÈRE; Paul S. GROSS A highly pure, chemically defined representative of a new class of antimicrobial peptide from the Atlantic white shrimp ( Litopenaeus setiferus ), penaeidin class 4 [Pen4-1 (penaeidin class 4 isoform 1...
View article titled, A new class (penaeidin class 4) of <span class="search-highlight">antimicrobial</span> <span class="search-highlight">peptides</span> from the Atlantic white shrimp ( Litopenaeus setiferus ) exhibits target specificity and an independent proline-rich-domain function
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Articles

Effects of the antimicrobial peptide temporin L on cell morphology, membrane permeability and viability of Escherichia coli

Maria Luisa MANGONI, Niv PAPO, Donatella BARRA, Maurizio SIMMACO, Argante BOZZI, Antonio DI GIULIO, Andrea C. RINALDI
Journal: Biochemical Journal
Biochem J (2004) 380 (3): 859–865.
https://doi.org/10.1042/bj20031975
Published: 15 June 2004
...Maria Luisa MANGONI; Niv PAPO; Donatella BARRA; Maurizio SIMMACO; Argante BOZZI; Antonio DI GIULIO; Andrea C. RINALDI Antimicrobial peptides are produced by all organisms in response to microbial invasion and are considered as promising candidates for future antibiotics. There is a wealth...
View article titled, Effects of the <span class="search-highlight">antimicrobial</span> <span class="search-highlight">peptide</span> temporin L on cell morphology, membrane permeability and viability of Escherichia coli
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Articles

Interactions of histatin 5 and histatin 5-derived peptides with liposome membranes: surface effects, translocation and permeabilization

Alice L. den HERTOG, Harro W. WONG FONG SANG, Ruud KRAAYENHOF, Jan G. M. BOLSCHER, Wim VAN'T HOF, Enno C. I. VEERMAN, Arie V. NIEUW AMERONGEN
Journal: Biochemical Journal
Biochem J (2004) 379 (3): 665–672.
https://doi.org/10.1042/bj20031785
Published: 01 May 2004
...Alice L. den HERTOG; Harro W. WONG FONG SANG; Ruud KRAAYENHOF; Jan G. M. BOLSCHER; Wim VAN'T HOF; Enno C. I. VEERMAN; Arie V. NIEUW AMERONGEN A number of cationic antimicrobial peptides, among which are histatin 5 and the derived peptides dhvar4 and dhvar5, enter their target cells and interact...
View article titled, Interactions of histatin 5 and histatin 5-derived peptides with liposome membranes: surface effects, translocation and permeabilization
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Articles

Oncorhyncin III: a potent antimicrobial peptide derived from the non-histone chromosomal protein H6 of rainbow trout, Oncorhynchus mykiss

Jorge M. O. FERNANDES, Nathalie SAINT, Graham D. KEMP, Valerie J. SMITH
Journal: Biochemical Journal
Biochem J (2003) 373 (2): 621–628.
https://doi.org/10.1042/bj20030259
Published: 15 July 2003
...Jorge M. O. FERNANDES; Nathalie SAINT; Graham D. KEMP; Valerie J. SMITH A 6.7 kDa antimicrobial peptide was isolated from trout skin secretions using acid extraction followed by cation-exchange chromatography, t C 18 solid-phase extraction, and C 18 reversed-phase HPLC. The molecular mass...
View article titled, Oncorhyncin III: a potent <span class="search-highlight">antimicrobial</span> <span class="search-highlight">peptide</span> derived from the non-histone chromosomal protein H6 of rainbow trout, Oncorhynchus mykiss
Open the PDF for Oncorhyncin III: a potent <span class="search-highlight">antimicrobial</span> <span class="search-highlight">peptide</span> derived from the non-histone chromosomal protein H6 of rainbow trout, Oncorhynchus mykiss in another window
Articles

Lipid-binding and antimicrobial properties of synthetic peptides of bovine apolipoprotein A-II

Mitsuyoshi MOTIZUKI, Takehito ITOH, Takanori SATOH, Sadaki YOKOTA, Muneo YAMADA, Seiichi SHIMAMURA, Tatsuya SAMEJIMA, Kunio TSURUGI
Journal: Biochemical Journal
Biochem J (1999) 342 (1): 215–221.
https://doi.org/10.1042/bj3420215
Published: 10 August 1999
...] and many of them are studied to develop new therapeutic approaches for infectous diseases [15,16]. Antimicrobial peptides possess various Abbreviations used: ApoA-I, apolipoprotein A-I ; ApoA-II, apolipoprotein A-II ; calcein, 2«,7«bis(carboxymethyl)aminomethylfluorescein ; CL, cardiolipin ; CFU, colony...
View article titled, Lipid-binding and antimicrobial properties of synthetic peptides of bovine apolipoprotein A-II
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Articles

Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity

Ziv OREN, Jeffrey C. LERMAN, Gudmundur H. GUDMUNDSSON, Birgitta AGERBERTH, Yechiel SHAI
Journal: Biochemical Journal
Biochem J (1999) 341 (3): 501–513.
https://doi.org/10.1042/bj3410501
Published: 26 July 1999
...Ziv OREN; Jeffrey C. LERMAN; Gudmundur H. GUDMUNDSSON; Birgitta AGERBERTH; Yechiel SHAI The antimicrobial peptide LL-37 belongs to the cathelicidin family and is the first amphipathic α-helical peptide isolated from human. LL-37 is considered to play an important role in the first line of defence...
View article titled, Structure and organization of the human <span class="search-highlight">antimicrobial</span> <span class="search-highlight">peptide</span> LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity
Open the PDF for Structure and organization of the human <span class="search-highlight">antimicrobial</span> <span class="search-highlight">peptide</span> LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity in another window