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Keywords: antioxidant
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Biochem J (2012) 443 (2): 397–405.
Published: 27 March 2012
... crucial role of vitamin B 6 biosynthesis in the detoxification of 1 O 2 in P. falciparum . Besides the known role of PLP as a cofactor of many essential enzymes, this second important task of the vitamin B 6 de novo synthesis as antioxidant emphasizes the high potential of this pathway as a target of new...
Biochem J (2012) 442 (3): 671–680.
Published: 24 February 2012
... were performed at a commercial facility (Bangalore Genei, India). All1541 Anabaena antioxidant peroxiredoxin–glutaredoxin hybrid reaction mechanism stress tolerance ROS (reactive oxygen species), such as superoxide radicals (O 2 •− ), hydrogen peroxide (H 2 O 2 ) and hydroxyl...
Includes: Supplementary data
Biochem J (2012) 442 (3): 713–721.
Published: 24 February 2012
... contribute to apoD antioxidant function. 1 To whom correspondence should be addressed (email brettg@uow.edu.au ). 30 6 2011 12 12 2011 12 12 2011 12 12 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 Alzheimer's disease antioxidant...
Includes: Supplementary data
Biochem J (2011) 435 (3): 669–677.
Published: 13 April 2011
... permeability, MCP-1 secretion or HO-1 , TNF α, ICAM or VCAM gene expression. Similarly to DFOB, incubation of DFOB-AdA OH with Mb plus H 2 O 2 yielded nitroxide radicals as detected by EPR spectroscopy, indicating a potential antioxidant activity in addition to metal chelation; Fe(III)-loaded DFOB-AdA OH...
Biochem J (2010) 431 (2): 169–178.
Published: 28 September 2010
...Pedro Diaz Vivancos; Tonja Wolff; Jelena Markovic; Federico V. Pallardó; Christine H. Foyer The complex antioxidant network of plant and animal cells has the thiol tripeptide GSH at its centre to buffer ROS (reactive oxygen species) and facilitate cellular redox signalling which controls growth...
Includes: Multimedia, Supplementary data
Biochem J (2009) 421 (2): 163–169.
Published: 26 June 2009
... present study we show, using HUVECs in which AMPKα1 has been silenced, that this protein is responsible for the expression of genes involved in antioxidant defence, such as manganese superoxide dismutase, catalase, γ-glutamylcysteine synthase and thioredoxin. Furthermore, peroxisome proliferator-activated...
Includes: Supplementary data
Biochem J (2009) 421 (2): 293–299.
Published: 26 June 2009
...), its regeneration from the oxidized metabolites is critically important for humans and other animals that lack the ability to synthesize this antioxidant. To study the dynamic aspects of AA metabolism in the circulation, a long acting AOase (ascorbate oxidase) derivative was synthesized by covalently...
Biochem J (2008) 413 (3): 405–416.
Published: 15 July 2008
...Cicerone Tudor; Nicole Lerner-Marmarosh; Yves Engelborghs; Peter E. M. Gibbs; Mahin D. Maines hBVR (human biliverdin reductase) is an enzyme that reduces biliverdin (the product of haem oxygenases HO-1 and HO-2 activity) to the antioxidant bilirubin. It also functions as a kinase and as a...
Includes: Supplementary data
Biochem J (2007) 407 (3): 321–329.
Published: 12 October 2007
... 23 8 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 aging antioxidant protein oxidation methionine sulfoxide reductase (Msr) selenoprotein ROS (reactive oxygen species), such as superoxide anion, hydroxyl radical and hydrogen peroxide, may be...
Biochem J (2007) 404 (3): 467–476.
Published: 29 May 2007
... in cell viability or levels of nitrite produced. No significant differences in mRNA expression of antioxidant enzymes were observed when comparing WT and KO tissues; however, microarray analysis of islets indicated slightly enhanced expression of some antioxidant enzymes in the KO islets. Short-term...
Biochem J (2007) 401 (1): 1–11.
Published: 11 December 2006
... increased risk of cancer development in the aged. Indeed, knockout of various antioxidant defence enzymes raises oxidative damage levels and promotes age-related cancer development in animals. In explaining this, most attention has been paid to direct oxidative damage to DNA by certain RS, such as hydroxyl...
Biochem J (2005) 392 (3): 583–587.
Published: 06 December 2005
... 2005 antioxidant cytochrome c haemoprotein microperoxidase NO synthase tetrahydropterin BH 4 [(6 R )-5,6,7,8-tetrahydrobiopterin] is a cofactor required by several enzymes. Among tetrahydropterins, BH 4 , and its analogues diMePH 4 (6,7-dimethyltetrahydropterin) and 6...
Biochem J (2005) 389 (1): 83–89.
Published: 21 June 2005
...Gillian HUGHES; Michael P. MURPHY; Elizabeth C. LEDGERWOOD ROS (reactive oxygen species) from mitochondrial and non-mitochondrial sources have been implicated in TNFα (tumour necrosis factor α)-mediated signalling. In the present study, a new class of specific mitochondria-targeted antioxidants...
Biochem J (2003) 374 (2): 337–348.
Published: 01 September 2003
...-related factor 2)-dependent fashion, but the molecular basis for this observation remains unexplained. Through characterization of the murine nqo1 5′-upstream region, we now show that Nrf2 regulates this gene directly via an ARE (antioxidant response element) that lies within a 24 bp region spanning nt...
Biochem J (2003) 371 (3): 877–885.
Published: 01 May 2003
...), which catalyses the rate-limiting step in haem degradation, liberating iron, CO and biliverdin. The present study evaluated the role of ROS and the mitochondrial electron-transport chain in the induction of HO-1 by glucose deprivation in HepG2 hepatoma cells. Either N -acetylcysteine, an antioxidant, or...
Biochem J (2003) 369 (2): 375–386.
Published: 15 January 2003
... ). The sequence of the mouse EC-SOD genome has been submitted to the EMBL, GenBank ® , DDBJ and GSDB Nucleotide Sequence Databases under the accession number AF039602. 11 9 2002 8 10 2002 10 10 2002 10 10 2002 The Biochemical Society, London ©2003 2003 antioxidant...
Biochem J (2002) 367 (1): 255–261.
Published: 01 October 2002
... capable of acting as a general antioxidant by protecting a range of substrates including supercoiled DNA. Active-site Cys to Ala mutants show that all three cysteine residues are important for activity. Cys-61 plays a central role in activity and Cys-174 also appears to be crucial. Interestingly, the...
Biochem J (2002) 364 (3): 625–628.
Published: 15 June 2002
... that seen in the plasma of subjects with coronary heart disease. 1 To whom correspondence should be addressed (e-mail kcroft@cyllene.uwa.edu.au ). 28 3 2002 17 4 2002 18 4 2002 The Biochemical Society, London ©2002 2002 antioxidant atherosclerotic plaque carotid...
Biochem J (2001) 354 (3): 493–500.
Published: 08 March 2001
...Jeremy P. E. SPENCER; Hagen SCHROETER; Gunter KUHNLE; S. Kaila S. SRAI; Rex M. TYRRELL; Ulrich HAHN; Catherine RICE-EVANS There is considerable current interest in the cytoprotective effects of natural antioxidants against oxidative stress. In particular, epicatechin, a major member of the flavanol...
Biochem J (2000) 352 (3): 693–699.
Published: 08 December 2000
..., antioxidants inhibit the modification of LDL protein. To determine whether myeloperoxidase-generated aldehydes might modify LDL in vivo , we used a combination of isotope-dilution GC-MS to quantify pHA-lysine in aortic tissues at various stages of lesion evolution. We also analysed LDL isolated from...
Biochem J (2000) 346 (2): 491–499.
Published: 22 February 2000
...-density lipoprotein (LDL), resulting in uncontrolled uptake of HOCl-modified LDL by macrophages. We have investigated the efects of vitamin C (ascorbate), an effective water-soluble antioxidant, on the HOCl- and chloramine-dependent modification of LDL. Co-incubation of vitamin C (25-200 μ M) with LDL...
Biochem J (1999) 342 (1): 49–56.
Published: 10 August 1999
...Joanne M. UPSTON; Ari KARJALAINEN; Fyfe L. BYGRAVE; Roland STOCKER Ascorbate (AH, the reduced form of vitamin C) is an important radical scavenger and antioxidant in human plasma; the resulting ascorbyl radical can disproportionate to AH and dehydroascorbic acid (DHA). Here we address potential...
Biochem J (1999) 341 (2): 371–376.
Published: 08 July 1999
... high concentrations of antioxidants abolished lipid peroxidation and lactate dehydrogenase leakage and completely reversed the inhibitory effect of PUFA on gene expression. This suggests (i) that the results obtained previously in cultured hepatocytes in the presence of low concentrations of...