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Keywords: antioxidant
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Biochem J (2012) 442 (3): 671–680.
Published: 24 February 2012
... peroxidase activity. All1541 showed antioxidant activity in solution protecting plasmid DNA from ROS-dependent damage. To assess its role in oxidative stress tolerance, All1541 protein was overexpressed in Anabaena 7120. The recombinant Anabaena strain (An1541 + ) showed a superior ability to tolerate...
Includes: Supplementary data
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Biochem J (2010) 431 (2): 169–178.
Published: 28 September 2010
...Pedro Diaz Vivancos; Tonja Wolff; Jelena Markovic; Federico V. Pallardó; Christine H. Foyer The complex antioxidant network of plant and animal cells has the thiol tripeptide GSH at its centre to buffer ROS (reactive oxygen species) and facilitate cellular redox signalling which controls growth...
Includes: Multimedia, Supplementary data
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Biochem J (2009) 421 (2): 163–169.
Published: 26 June 2009
.... In the present study we show, using HUVECs in which AMPKα1 has been silenced, that this protein is responsible for the expression of genes involved in antioxidant defence, such as manganese superoxide dismutase, catalase, γ-glutamylcysteine synthase and thioredoxin. Furthermore, peroxisome proliferator-activated...
Includes: Supplementary data
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Biochem J (2007) 404 (3): 467–476.
Published: 29 May 2007
... in cell viability or levels of nitrite produced. No significant differences in mRNA expression of antioxidant enzymes were observed when comparing WT and KO tissues; however, microarray analysis of islets indicated slightly enhanced expression of some antioxidant enzymes in the KO islets. Short-term tBHQ...
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Biochem J (2007) 401 (1): 1–11.
Published: 11 December 2006
... for the increased risk of cancer development in the aged. Indeed, knockout of various antioxidant defence enzymes raises oxidative damage levels and promotes age-related cancer development in animals. In explaining this, most attention has been paid to direct oxidative damage to DNA by certain RS, such as hydroxyl...
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Biochem J (2005) 392 (3): 583–587.
Published: 06 December 2005
... antioxidant cytochrome c haemoprotein microperoxidase NO synthase tetrahydropterin BH 4 [(6 R )-5,6,7,8-tetrahydrobiopterin] is a cofactor required by several enzymes. Among tetrahydropterins, BH 4 , and its analogues diMePH 4 (6,7-dimethyltetrahydropterin) and 6-methyltetrahydropterin, were...
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Biochem J (2002) 367 (1): 255–261.
Published: 01 October 2002
... is capable of acting as a general antioxidant by protecting a range of substrates including supercoiled DNA. Active-site Cys to Ala mutants show that all three cysteine residues are important for activity. Cys-61 plays a central role in activity and Cys-174 also appears to be crucial. Interestingly...
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Biochem J (2000) 346 (2): 491–499.
Published: 22 February 2000
...-density lipoprotein (LDL), resulting in uncontrolled uptake of HOCl-modified LDL by macrophages. We have investigated the efects of vitamin C (ascorbate), an effective water-soluble antioxidant, on the HOCl- and chloramine-dependent modification of LDL. Co-incubation of vitamin C (25-200 μ M) with LDL...
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Biochem J (1999) 342 (1): 49–56.
Published: 10 August 1999
...Joanne M. UPSTON; Ari KARJALAINEN; Fyfe L. BYGRAVE; Roland STOCKER Ascorbate (AH, the reduced form of vitamin C) is an important radical scavenger and antioxidant in human plasma; the resulting ascorbyl radical can disproportionate to AH and dehydroascorbic acid (DHA). Here we address potential...
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