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1-23 of 23
Keywords: antioxidant
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Articles
Journal:
Biochemical Journal
Biochem J (2012) 443 (2): 397–405.
Published: 27 March 2012
... the crucial role of vitamin B 6 biosynthesis in the detoxification of 1 O 2 in P. falciparum . Besides the known role of PLP as a cofactor of many essential enzymes, this second important task of the vitamin B 6 de novo synthesis as antioxidant emphasizes the high potential of this pathway as a target of new...
Articles
Journal:
Biochemical Journal
Biochem J (2012) 442 (3): 671–680.
Published: 24 February 2012
... peroxidase activity. All1541 showed antioxidant activity in solution protecting plasmid DNA from ROS-dependent damage. To assess its role in oxidative stress tolerance, All1541 protein was overexpressed in Anabaena 7120. The recombinant Anabaena strain (An1541 + ) showed a superior ability to tolerate...
Includes: Supplementary data
Articles
Surabhi Bhatia, Bianca Knoch, Jenny Wong, Woojin S. Kim, Paul L. Else, Aaron J. Oakley, Brett Garner
Journal:
Biochemical Journal
Biochem J (2012) 442 (3): 713–721.
Published: 24 February 2012
... contribute to apoD antioxidant function. 1 To whom correspondence should be addressed (email [email protected] ). 30 6 2011 12 12 2011 12 12 2011 12 12 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 Alzheimer's disease antioxidant...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2011) 435 (3): 669–677.
Published: 13 April 2011
... in permeability, MCP-1 secretion or HO-1 , TNF α, ICAM or VCAM gene expression. Similarly to DFOB, incubation of DFOB-AdA OH with Mb plus H 2 O 2 yielded nitroxide radicals as detected by EPR spectroscopy, indicating a potential antioxidant activity in addition to metal chelation; Fe(III)-loaded DFOB-AdA OH...
Articles
Journal:
Biochemical Journal
Biochem J (2010) 431 (2): 169–178.
Published: 28 September 2010
...Pedro Diaz Vivancos; Tonja Wolff; Jelena Markovic; Federico V. Pallardó; Christine H. Foyer The complex antioxidant network of plant and animal cells has the thiol tripeptide GSH at its centre to buffer ROS (reactive oxygen species) and facilitate cellular redox signalling which controls growth...
Includes: Multimedia, Supplementary data
Articles
Emiko Kasahara, Misato Kashiba, Mika Jikumaru, Daisuke Kuratsune, Kumi Orita, Yurika Yamate, Kenjiro Hara, Atsuo Sekiyama, Eisuke F. Sato, Masayasu Inoue
Journal:
Biochemical Journal
Biochem J (2009) 421 (2): 293–299.
Published: 26 June 2009
...), its regeneration from the oxidized metabolites is critically important for humans and other animals that lack the ability to synthesize this antioxidant. To study the dynamic aspects of AA metabolism in the circulation, a long acting AOase (ascorbate oxidase) derivative was synthesized by covalently...
Articles
Journal:
Biochemical Journal
Biochem J (2009) 421 (2): 163–169.
Published: 26 June 2009
.... In the present study we show, using HUVECs in which AMPKα1 has been silenced, that this protein is responsible for the expression of genes involved in antioxidant defence, such as manganese superoxide dismutase, catalase, γ-glutamylcysteine synthase and thioredoxin. Furthermore, peroxisome proliferator-activated...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2008) 413 (3): 405–416.
Published: 15 July 2008
...Cicerone Tudor; Nicole Lerner-Marmarosh; Yves Engelborghs; Peter E. M. Gibbs; Mahin D. Maines hBVR (human biliverdin reductase) is an enzyme that reduces biliverdin (the product of haem oxygenases HO-1 and HO-2 activity) to the antioxidant bilirubin. It also functions as a kinase...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2007) 407 (3): 321–329.
Published: 12 October 2007
... sulfoxide reductases) are the enzymes responsible for this function and are thus viewed as antioxidant and protein repair enzymes. 1 Correspondence may be addressed to either author (email [email protected] or [email protected] ). 13 7 2007 21 8 2007 23 8 2007 © The Authors...
Articles
Journal:
Biochemical Journal
Biochem J (2007) 404 (3): 467–476.
Published: 29 May 2007
... in cell viability or levels of nitrite produced. No significant differences in mRNA expression of antioxidant enzymes were observed when comparing WT and KO tissues; however, microarray analysis of islets indicated slightly enhanced expression of some antioxidant enzymes in the KO islets. Short-term tBHQ...
Articles
Journal:
Biochemical Journal
Biochem J (2007) 401 (1): 1–11.
Published: 11 December 2006
... for the increased risk of cancer development in the aged. Indeed, knockout of various antioxidant defence enzymes raises oxidative damage levels and promotes age-related cancer development in animals. In explaining this, most attention has been paid to direct oxidative damage to DNA by certain RS, such as hydroxyl...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 392 (3): 583–587.
Published: 06 December 2005
... antioxidant cytochrome c haemoprotein microperoxidase NO synthase tetrahydropterin BH 4 [(6 R )-5,6,7,8-tetrahydrobiopterin] is a cofactor required by several enzymes. Among tetrahydropterins, BH 4 , and its analogues diMePH 4 (6,7-dimethyltetrahydropterin) and 6-methyltetrahydropterin, were...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 389 (1): 83–89.
Published: 21 June 2005
...Gillian HUGHES; Michael P. MURPHY; Elizabeth C. LEDGERWOOD ROS (reactive oxygen species) from mitochondrial and non-mitochondrial sources have been implicated in TNFα (tumour necrosis factor α)-mediated signalling. In the present study, a new class of specific mitochondria-targeted antioxidants...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 374 (2): 337–348.
Published: 01 September 2003
...-related factor 2)-dependent fashion, but the molecular basis for this observation remains unexplained. Through characterization of the murine nqo1 5′-upstream region, we now show that Nrf2 regulates this gene directly via an ARE (antioxidant response element) that lies within a 24 bp region spanning nt...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 371 (3): 877–885.
Published: 01 May 2003
...), which catalyses the rate-limiting step in haem degradation, liberating iron, CO and biliverdin. The present study evaluated the role of ROS and the mitochondrial electron-transport chain in the induction of HO-1 by glucose deprivation in HepG2 hepatoma cells. Either N -acetylcysteine, an antioxidant...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 369 (2): 375–386.
Published: 15 January 2003
... ). The sequence of the mouse EC-SOD genome has been submitted to the EMBL, GenBank ® , DDBJ and GSDB Nucleotide Sequence Databases under the accession number AF039602. 11 9 2002 8 10 2002 10 10 2002 10 10 2002 The Biochemical Society, London ©2003 2003 antioxidant gene...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 367 (1): 255–261.
Published: 01 October 2002
... is capable of acting as a general antioxidant by protecting a range of substrates including supercoiled DNA. Active-site Cys to Ala mutants show that all three cysteine residues are important for activity. Cys-61 plays a central role in activity and Cys-174 also appears to be crucial. Interestingly...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 364 (3): 625–628.
Published: 15 June 2002
... to that seen in the plasma of subjects with coronary heart disease. 1 To whom correspondence should be addressed (e-mail [email protected] ). 28 3 2002 17 4 2002 18 4 2002 The Biochemical Society, London ©2002 2002 antioxidant atherosclerotic plaque carotid artery...
Articles
Jeremy P. E. SPENCER, Hagen SCHROETER, Gunter KUHNLE, S. Kaila S. SRAI, Rex M. TYRRELL, Ulrich HAHN, Catherine RICE-EVANS
Journal:
Biochemical Journal
Biochem J (2001) 354 (3): 493–500.
Published: 08 March 2001
...Jeremy P. E. SPENCER; Hagen SCHROETER; Gunter KUHNLE; S. Kaila S. SRAI; Rex M. TYRRELL; Ulrich HAHN; Catherine RICE-EVANS There is considerable current interest in the cytoprotective effects of natural antioxidants against oxidative stress. In particular, epicatechin, a major member of the flavanol...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 352 (3): 693–699.
Published: 08 December 2000
..., antioxidants inhibit the modification of LDL protein. To determine whether myeloperoxidase-generated aldehydes might modify LDL in vivo , we used a combination of isotope-dilution GC-MS to quantify pHA-lysine in aortic tissues at various stages of lesion evolution. We also analysed LDL isolated from...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 346 (2): 491–499.
Published: 22 February 2000
...-density lipoprotein (LDL), resulting in uncontrolled uptake of HOCl-modified LDL by macrophages. We have investigated the efects of vitamin C (ascorbate), an effective water-soluble antioxidant, on the HOCl- and chloramine-dependent modification of LDL. Co-incubation of vitamin C (25-200 μ M) with LDL...
Articles
Journal:
Biochemical Journal
Biochem J (1999) 342 (1): 49–56.
Published: 10 August 1999
...Joanne M. UPSTON; Ari KARJALAINEN; Fyfe L. BYGRAVE; Roland STOCKER Ascorbate (AH, the reduced form of vitamin C) is an important radical scavenger and antioxidant in human plasma; the resulting ascorbyl radical can disproportionate to AH and dehydroascorbic acid (DHA). Here we address potential...
Articles
Journal:
Biochemical Journal
Biochem J (1999) 341 (2): 371–376.
Published: 08 July 1999
... of high concentrations of antioxidants abolished lipid peroxidation and lactate dehydrogenase leakage and completely reversed the inhibitory effect of PUFA on gene expression. This suggests (i) that the results obtained previously in cultured hepatocytes in the presence of low concentrations...