... 15 . Thus it appears that Aβ increases p53 expression via phosphorylation-mediated stabilization of the protein. Given the lack of availability of a JNK inhibitor that can distinguish between JNK1- and JNK2-mediated effects, we employed antisense technology to deplete cells of JNK1 or JNK2...

... 2002 The Biochemical Society, London ©2002 2002 antisense gene therapy hexagonal phase lipoplex Abbreviations used: Cer-C 8 (etc.), ceramide with a C 8 fatty acyl chain length (etc.); CHO, Chinese hamster ovary; CRF-R, corticotropin-releasing factor receptor; DOPE, dioleoyl...

... Pathways Laboratory, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3PX, U.K. 12 2 2002 1 3 2002 11 3 2002 The Biochemical Society, London ©2002 2002 antisense metals oncogenes Abbreviations used: FT, ferritin; H-FT, heavy ferritin chain; L-FT, light...

... and that, in contrast with PKC isotypes, PKD is not down-regulated. Therefore PKD may participate in NADPH oxidase activation. To obtain direct evidence for this we adopted an antisense approach. Antisense PKD inhibited NADPH oxidase induced by Fcγ-receptor stimulation by 50% and the Ro 31-8220-insensitive component...

...Or KAKHLON; Yosef GRUENBAUM; Z. Ioav CABANTCHIK The role of ferritin in the modulation of the labile iron pool was examined by repressing the heavy subunit of ferritin in K562 cells transfected with an antisense construct. Repression of the heavy ferritin subunit evoked an increase in the chemical...

... transfection of immortalized human prostatic epithelial cells (PNT1A and PNT2) with antisense ODC RNA or OAZ cDNA, or both, while effectively causing marked decreases of ODC activity and polyamine (especially putrescine) concentrations, resulted in accumulation of cells in the S phase of the cell cycle...

...-transduction systems to which these receptors are coupled in mediating these responses. In the present studies, we have employed an antisense approach to eliminate the ANP-C receptor and to examine the effect of this elimination on adenylyl cyclase inhibition. An 18-mer antisense phosphorothioate...