... information is available on the identification of cytotoxic products in snake serum. In the present study, we purified and characterized a new cytotoxic factor from serum of the non-venomous African rock python ( Python sebae ), endowed with antitumour activity. PSS ( P. sebae serum) exerted a cytotoxic...

... for the remarkable antitumour activity of the oligomers, displayed in vitro and in vivo , in contrast with monomeric RNase A, which lacks these activities. The RNase A multimers also show an aspermatogenic action, but lack any detectable embryotoxicity. The fact that both activity against double-stranded RNA...