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Keywords: apelin receptor
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Articles

Divergent roles of DRY and NPxxY motifs in selective activation of downstream signalling by the apelin receptor

Subhashree Murali, Gopala Krishna Aradhyam
Journal: Biochemical Journal
Biochem J (2024) 481 (23): 1707–1722.
https://doi.org/10.1042/BCJ20240320
Published: 21 November 2024
... changes of the active states of the receptor, and signal transduction is achieved by selectively binding to Gα proteins and/or adapter protein, arrestin. Apelin receptor (APJR) is a class-A GPCR that regulates a wide range of intracellular signalling cascades in response to apelin and elabela peptide...
View article titled, Divergent roles of DRY and NPxxY motifs in selective activation of downstream signalling by the <span class="search-highlight">apelin</span> <span class="search-highlight">receptor</span>
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Includes: Supplementary data
Articles

Loss of APJ mediated β-arrestin signalling improves high-fat diet induced metabolic dysfunction but does not alter cardiac function in mice

Na Li, Xiaochuan Ma, Ting Ban, Shaohua Xu, Yingli Ma, Brandon Ason, Liaoyuan A. Hu
Journal: Biochemical Journal
Biochem J (2020) 477 (17): 3313–3327.
https://doi.org/10.1042/BCJ20200343
Published: 10 September 2020
...Na Li; Xiaochuan Ma; Ting Ban; Shaohua Xu; Yingli Ma; Brandon Ason; Liaoyuan A. Hu Apelin receptor (APJ) is a G protein-coupled receptor that contributes to many physiological processes and is emerging as a therapeutic target to treat a variety of diseases. For most disease indications the role...
View article titled, Loss of APJ mediated β-arrestin signalling improves high-fat diet induced metabolic dysfunction but does not alter cardiac function in mice
Open the PDF for Loss of APJ mediated β-arrestin signalling improves high-fat diet induced metabolic dysfunction but does not alter cardiac function in mice in another window
Includes: Supplementary data
Articles

GPCR structure and function relationship: identification of a biased apelin receptor mutant

Ting Ban, Xun Li, Xiaochuan Ma, Hui Yang, Yunpeng Song, Yaping Sun, Michelle Shen, Na Li, Mei-Yun Zhang, Yingli Ma, Wenge Zhong, Mingqiang Zhang, Liaoyuan A. Hu
Journal: Biochemical Journal
Biochem J (2018) 475 (23): 3813–3826.
https://doi.org/10.1042/BCJ20180740
Published: 06 December 2018
... mechanism of GPCR biased signaling remains largely unknown. Using apelin receptor (APJ) as a model, we systematically investigated the potential effects of amino acid residues around the orthosteric binding site on biased signaling. We discovered that a single residue mutation I109A (I109 3.32...
View article titled, GPCR structure and function relationship: identification of a biased <span class="search-highlight">apelin</span> <span class="search-highlight">receptor</span> mutant
Open the PDF for GPCR structure and function relationship: identification of a biased <span class="search-highlight">apelin</span> <span class="search-highlight">receptor</span> mutant in another window
Includes: Supplementary data