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Keywords: apoptosis
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Biochem J (2025) 482 (03): 179.
Published: 30 January 2025
... 13 01 2025 08 01 2025 15 01 2025 © 2025 The Author(s). 2025 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis Bcl-2 cAMP...
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Biochem J (2024) 481 (22): 1603–1620.
Published: 07 November 2024
... (hHtrA2), which induces apoptosis through both caspase-dependent and independent pathways is implicated in several diseases including cancer, ischemic heart diseases, and neurodegeneration, thus making it a promising target molecule. In the recent past, the canine model has gained prominence...
Includes: Supplementary data
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Biochem J (2024) 481 (14): 903–922.
Published: 10 July 2024
...Dang Nguyen; Elizabeth Osterlund; Justin Kale; David W. Andrews Programmed cell death via the both intrinsic and extrinsic pathways is regulated by interactions of the Bcl-2 family protein members that determine whether the cell commits to apoptosis via mitochondrial outer membrane permeabilization...
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Biochem J (2022) 479 (22): 2351–2364.
Published: 23 November 2022
...Enoli De Silva; Dana V. Devine; Eric Jan; Calvin D. Roskelley; Hugh Kim Apoptosis is a critical process for the maintenance of cell populations, and involves mitochondrial depolarization, the sequential cleavage of caspase-9 and -3, followed by the externalization of phosphatidylserine (PS...
Includes: Supplementary data
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Biochem J (2022) 479 (19): 2049–2062.
Published: 14 October 2022
...Bart Tummers; Douglas R. Green Apoptosis and necroptosis regulate many aspects of organismal biology and are involved in various human diseases. TNF is well known to induce both of these forms of cell death and the underlying mechanisms have been elaborately described. However, cells can also...
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Biochem J (2022) 479 (15): 1621–1651.
Published: 05 August 2022
... to treat certain inflammatory skin diseases. Programmes to develop such inhibitors are already underway. In this review, we outline the mechanisms of skin-associated cell death programmes; apoptosis, necroptosis, pyroptosis, NETosis, and the epidermal terminal differentiation programme, cornification. We...
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Biochem J (2022) 479 (14): 1581–1608.
Published: 29 July 2022
... therapeutic regimes is needed. Recent studies indicate that modulation of autophagy in concert with apoptosis induction may provide a promising novel strategy in breast cancer treatment. Apoptosis and autophagy are two tightly regulated distinct cellular processes. To maintain tissue homeostasis abnormal...
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Biochem J (2022) 479 (10): 1103–1119.
Published: 24 May 2022
...Kim Newton; Alexander D. Gitlin Apoptosis, pyroptosis, and necroptosis are distinct forms of programmed cell death that eliminate infected, damaged, or obsolete cells. Many proteins that regulate or are a part of the cell death machinery undergo ubiquitination, a post-translational modification...
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Biochem J (2022) 479 (10): 1083–1102.
Published: 24 May 2022
... downstream of inflammasome activation, death receptor and mitochondrial apoptosis, and necroptosis. This new era in cell death research therefore holds significant promise in identifying how distinct, yet often networked, pyroptotic cell death pathways might be manipulated for therapeutic benefit to treat...
Articles
Biochem J (2022) 479 (9): 929–951.
Published: 06 May 2022
...-translational modifications in control of its function. Ubiquitination by E3 ligases, such as inhibitors of apoptosis (IAP) proteins and LUBAC, as well as the reversal of these modifications by deubiquitinating enzymes, such as A20 and CYLD, can greatly influence RIP1 mediated signaling. In addition, cleavage...
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Biochem J (2022) 479 (5): 677–685.
Published: 16 March 2022
... Limited on behalf of the Biochemical Society 2022 Correspondence: Hiroyasu Nakano ( [email protected] ) 2 2 2022 23 2 2022 25 2 2022 apoptosis DAMPs ESCRT HMGB1 imaging techniques necroptosis Necrosis is characterized by cell swelling and plasma...
Includes: Supplementary data
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Biochem J (2022) 479 (5): 609–628.
Published: 04 March 2022
... Apoptosis (extrinsic/p53) [ 27 , 50–52 ] NK and B-cells Apoptosis [ 53 ] pDCs Apoptosis [ 41 ] Macrophages Pyroptosis/Necroptosis [ 39 , 42 , 54 ] Monocytes Apoptosis/Pyroptosis [ 53 , 55 , 56 ] Pneumocyte Pyroptosis [ 23 ] Cardiomyocytes Apoptosis [ 57 ] Adipocytes...
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Biochem J (2022) 479 (3): 357–384.
Published: 11 February 2022
...Laura Lossi Regulated cell death is a vital and dynamic process in multicellular organisms that maintains tissue homeostasis and eliminates potentially dangerous cells. Apoptosis, one of the better-known forms of regulated cell death, is activated when cell-surface death receptors like Fas...
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Biochem J (2022) 479 (1): 75–90.
Published: 14 January 2022
... this cross-talk is disrupted, in the context of disease. Correspondence: Nektarios Tavernarakis ( [email protected] ) 14 11 2021 21 12 2021 23 12 2021 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 apoptosis...
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Biochem J (2021) 478 (13): 2681–2696.
Published: 16 July 2021
...Alexandre Desroches; Jean-Bernard Denault Apoptosis is a regulated form of cell death essential to the removal of unwanted cells. At its core, a family of cysteine peptidases named caspases cleave key proteins allowing cell death to occur. To do so, each caspase catalytic pocket recognizes...
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Biochem J (2021) 478 (8): 1547–1569.
Published: 21 April 2021
... of the Biochemical Society 2021 alpha kinase apoptosis cancer therapy protein synthesis translation MDA-MB-231 cells were seeded at a density of 2.5 × 10 4 cells per well in a 96-well black walled opaque plates with a clear bottom and left overnight in the incubator. Once the cells had reached 90...
Includes: Supplementary data
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Biochem J (2021) 478 (7): 1359–1375.
Published: 16 April 2021
... 3 2021 17 3 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 apoptosis atherosclerosis autophagy bioactive compounds foam cells macrophage Atherosclerosis is associated with chronic inflammation and dysregulated...
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Biochem J (2021) 478 (3): 669–684.
Published: 12 February 2021
... 1 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 apoptosis apoptosome cytochrome c molecular dynamics peroxidases thrombocytopenia The recent descriptions of naturally occurring mutations in cytochrome c raise new...
Includes: Supplementary data
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Biochem J (2020) 477 (23): 4527–4541.
Published: 03 December 2020
...Chathura D. Suraweera; Mark G. Hinds; Marc Kvansakul Premature apoptosis of cells is a strategy utilized by multicellular organisms to counter microbial threats. Orf virus (ORFV) is a large double-stranded DNA virus belonging to the poxviridae . ORFV encodes for an apoptosis inhibitory protein...
Includes: Supplementary data
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Biochem J (2020) 477 (17): 3287–3297.
Published: 10 September 2020
...Suresh Banjara; Jaison D Sa; Mark G. Hinds; Marc Kvansakul Apoptosis is regulated by evolutionarily conserved signaling pathways to remove damaged, diseased or unwanted cells. Proteins homologous to the B-cell lymphoma 2 (Bcl-2) family of proteins, the primary arbiters of mitochondrially mediated...
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Biochem J (2020) 477 (17): 3147–3165.
Published: 04 September 2020
... and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . Open access for this article was enabled by the participation of University of Minnesota in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society. apoptosis lectin molecular dynamics...
Includes: Supplementary data
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Biochem J (2020) 477 (12): 2383–2399.
Published: 26 June 2020
.... For A549 cells, L 2 and L 3 had higher anti-A549 activity. Furthermore, L 1 and L 3 may be the great promise antiproliferative drugs with nontoxic side effects, due to the high anti-HepG2 and anti-MCF-7 inhibition rate in vivo , 65% and 61%, respectively. L 1 , L 2 and L 3 could induce apoptosis through...
Includes: Supplementary data
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Biochem J (2020) 477 (1): 137–160.
Published: 10 January 2020
... while increasing caspase-3 dependent apoptosis. Additionally, inhibition of the TFEB-phosphatase calcineurin sensitized cells to DOX-induced apoptosis in a TFEB dependent fashion. Regulation of apoptosis by TFEB was not a consequence of altered lysosomal function, as TFEB continued to protect against...
Includes: Supplementary data
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Biochem J (2019) 476 (10): 1445–1463.
Published: 21 May 2019
... in oligomerization, stability and hence the formation of a functional enzyme. In silico structural comparison of HtrA4 with other human HtrAs, enzymology studies and cleavage assays with X-linked inhibitor of apoptosis protein (XIAP) show overall structural conservation and allosteric mode of protease activation...
Includes: Supplementary data
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Biochem J (2018) 475 (6): 1177–1196.
Published: 29 March 2018
...Kristen L. Huber; Banyuhay P. Serrano; Jeanne A. Hardy Caspase-9 is a critical factor in the initiation of apoptosis and as a result is tightly regulated by many mechanisms. Caspase-9 contains a Caspase Activation and Recruitment Domain (CARD), which enables caspase-9 to form a tight interaction...
Includes: Supplementary data
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Biochem J (2017) 474 (21): 3643–3657.
Published: 23 October 2017
... ( [email protected] ) 7 7 2017 29 8 2017 19 9 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 apoptosis Bcl-2 hematological malignancy Apoptosis is a highly regulated form of programmed cell death...
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Biochem J (2017) 474 (18): 3093–3107.
Published: 31 August 2017
... by inoculating lentiviral particles carrying the sequence of a short-hairpin RNA targeting Gpat2 mRNA into mouse testis. Histological and gene expression analysis showed impaired spermatogenesis and arrest at the pachytene stage. Defects in reproductive fitness were also observed, and the analysis of apoptosis...
Includes: Supplementary data
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Biochem J (2017) 474 (17): 3011–3025.
Published: 22 August 2017
... dysplasia led to the inhibition of SCC, thereby reducing the tumor burden. The antioxidant capacity of AN and EG was also brought out via biochemical analysis. Further investigation of biomarkers in tongue tissues revealed the involvement of apoptosis in vivo . Moreover, no adverse or toxic effect...
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Biochem J (2017) 474 (17): 3027–3043.
Published: 22 August 2017
.... Periplanetasin-2 induced oxidative stress by generation of reactive oxygen species (ROS) and lipid peroxidation. Periplanetasin-2 also caused apoptosis by exposure of phosphatidylserine and fragmentation of DNA, exerted in a concentration-dependent manner. Hence, we investigated the mitochondrial apoptotic...
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Biochem J (2016) 473 (19): 2973–2994.
Published: 27 September 2016
... factor for NMSC is ultraviolet radiation (UVR) from sunlight, specifically UVB, which is the leading cause of DNA damage, photoaging, and malignant transformation in the skin. Activation of apoptosis following UVR exposure allows the elimination of irreversibly damaged cells that may harbor oncogenic...
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Biochem J (2016) 473 (8): 1073–1083.
Published: 08 April 2016
... by Bcl-2 homology 3 domain (BH3) proteins. Some of the compounds induced Bax/Bak-dependent apoptosis in cells. Activation of Bax by the most active compound was poorly inhibited by the anti-apoptotic protein Bcl-XL and requires a cysteine residue at position 126 of Bax that is not required for activation...
Includes: Supplementary data
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Biochem J (2015) 470 (1): 145–154.
Published: 06 August 2015
...Hsiang Yu; Huey-Jen Lai; Tai-Wei Lin; Chang-Shi Chen; Szecheng J. Lo Three waves of apoptosis shape the development of Caenorhabditis elegans . Although the exact roles of the three DNase II genes ( nuc-1 , crn-6 and crn-7 ), which are known to mediate degradation of apoptotic DNA, in the embryonic...
Includes: Multimedia, Supplementary data
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Biochem J (2015) 467 (3): 495–505.
Published: 17 April 2015
...Aisha Shamas-Din; Scott Bindner; Xiaoke Chi; Brian Leber; David W. Andrews; Cécile Fradin tBid (truncated Bid/p15) and Bim activate Bax to permeabilize mitochondria and induce apoptosis. Binding of tBid and Bim to membranes is facilitated by electrostatic interactions. Additionally, cardiolipin (CL...
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Biochem J (2015) 466 (3): 537–546.
Published: 06 March 2015
... taken with an LSM 510 inverted confocal microscope using a 40× oil-immersion objective. apoptosis calcium reactive oxygen species Type 1 diabetes transient receptor potential (melastatin) 2 (TRPM2) channels zinc Human embryonic kidney (HEK)-293 and insulin secreting (INS1) cells were...
Includes: Supplementary data
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Biochem J (2015) 465 (1): 115–125.
Published: 12 December 2014
... no such effects. The chaperone activities of the peptides were better than those from αA- and αB-crystallin. HeLa cells took up the FITC-conjugated Hsp20 peptide and, when the cells were thermally stressed, the peptide was translocated from the cytoplasm to the nucleus. The two peptides inhibited apoptosis...
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In Collection
Coronavirus
Biochem J (2014) 464 (3): 439–447.
Published: 05 December 2014
...Ho Tsoi; Li Li; Zhefan S. Chen; Kwok-Fai Lau; Stephen K. W. Tsui; Ho Yin Edwin Chan A number of viral gene products are capable of inducing apoptosis by interfering with various cellular signalling cascades. We previously reported the pro-apoptotic property of the SARS-CoV (severe acute respiratory...
Includes: Supplementary data
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Biochem J (2014) 462 (3): 489–497.
Published: 22 August 2014
... transgene protects cortical neurons from H 2 O 2 -induced apoptosis, and this protective effect is abrogated by knocking down RACK1. Similarly, deletion of DJ-1 in cortical neurons increases the sensitivity to H 2 O 2 , and the damage can be significantly rescued by DJ-1 or DJ-1/RACK1 co-transfection...
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Biochem J (2014) 462 (2): 267–277.
Published: 07 August 2014
... of autophagy impairs myoblast differentiation and increases apoptotic cell death. apoptosis autophagy beclin 1 (BECN1) caspase 3 (CASP3) differentiation skeletal muscle Cellular differentiation is associated with rapid biochemical and morphological alterations as well as the removal of pre...
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Biochem J (2014) 459 (2): 397–404.
Published: 28 March 2014
...Shang H. Lin; Nuval Cherian; Benjamin Wu; Hyo Phee; Christy Cho; Marco Colombini Bax, despite being a cytosolic protein, has the distinct ability to form channels in the mitochondrial outer membrane, which are capable of releasing proteins that initiate the execution phase of apoptosis. When...
Includes: Supplementary data
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Biochem J (2014) 459 (1): 149–160.
Published: 14 March 2014
... experiments were carried out using cells without treatment. The same amount of protein lysate was subjected to immunoblot analysis using anti-Hsp70, anti-LC3 and anti-CA8 antibodies. To induce apoptosis, cells were grown on glass coverslips at a density of 2×10 5 cells/well in a six-well tissue...
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Biochem J (2014) 457 (1): 151–162.
Published: 10 December 2013
... shown that miRNAs are extensively involved in the pathogenesis of cardiac hypertrophy. In the present study, we examined the hypothesis that the miR-19a/b family acts as a key regulator of cardiac hypertrophy and apoptosis. Forced overexpression of miR-19a/b was sufficient to induce hypertrophy in rat...
Includes: Supplementary data
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Biochem J (2013) 456 (2): 185–194.
Published: 08 November 2013
... of cysts with coarse shells in which two chitin-binding proteins were missing. Western blotting showed that the level of trehalase was increased and apoptosis was induced in these ArTAP-knockdown cysts compared with controls. Taken together, these results show that ArTAP is a key regulator of trehalase...
Includes: Supplementary data