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Articles

Substrate-inactivated cyclooxygenase-2 is disposed of by exosomes through the ER–Golgi pathway

Esraa Saadi, Sharon Tal, Liza Barki-Harrington

Biochem J (2018) 475 (19): 3141–3151.

https://doi.org/10.1042/BCJ20180530

Published: 12 October 2018

...Esraa Saadi; Sharon Tal; Liza Barki-Harrington Catalysis of arachidonic acid (AA) by cyclooxygenase-2 (COX-2) gives rise to a single product that serves as a precursor for all prostaglandins, which are central mediators of inflammation. Rapid up-regulation of COX-2 expression in response to pro...

View articletitled, Substrate-inactivated cyclooxygenase-2 is disposed of by exosomes through the ER–Golgi pathway

Includes: Supplementary data

Articles

Group IVA phospholipase A 2 regulates testosterone biosynthesis by murine Leydig cells and is required for timely sexual maturation

Shiro Kurusu, Adam Sapirstein, Harumi Sawada, Mitsumori Kawaminami, Joseph V. Bonventre

Biochem J (2011) 439 (3): 403–411.

https://doi.org/10.1042/BJ20102167

Published: 13 October 2011

..., a site enriched in AA (arachidonic acid). AA is as an important intracellular signalling molecule [ 2 ] and serves as a precursor of eicosanoids that are pleiotropic lipid mediators [ 3 , 4 ]. AA is metabolized primarily by two different groups of enzymes, PTGSs (cyclo-oxygenases) and ALOXs...

View articletitled, Group IVA phospholipase A 2 regulates testosterone biosynthesis by murine Leydig cells and is required for timely sexual maturation

Articles

Arachidonic acid modulates Na + currents by non-metabolic and metabolic pathways in rat cerebellar granule cells

Yan-Jia Fang, Meng-Hua Zhou, Xiao-Fei Gao, Hua Gu, Yan-Ai Mei

Biochem J (2011) 438 (1): 203–215.

https://doi.org/10.1042/BJ20110569

Published: 27 July 2011

...Yan-Jia Fang; Meng-Hua Zhou; Xiao-Fei Gao; Hua Gu; Yan-Ai Mei AA (arachidonic acid), which possesses both neurotoxic and neurotrophic activities, has been implicated as a messenger in both physiological and pathophysiological processes. In the present study, we investigated the effects of both...

View articletitled, Arachidonic acid modulates Na + currents by non-metabolic and metabolic pathways in rat cerebellar granule cells

Articles

Eicosanoid formation by a cytochrome P450 isoform expressed in the pharynx of Caenorhabditis elegans

Mandy Kosel, Waltraud Wild, Alexandra Bell, Michael Rothe, Carsten Lindschau, Christian E. W. Steinberg, Wolf-Hagen Schunck, Ralph Menzel

Biochem J (2011) 435 (3): 689–700.

https://doi.org/10.1042/BJ20101942

Published: 13 April 2011

... of physiologically active AA (arachidonic acid) metabolites. We tested the hypothesis that mammals and C. elegans may share similar basic mechanisms of CYP-dependent eicosanoid formation and action. We focused on CYP33E2, an isoform related to the human AA-epoxygenases CYP2C8 and CYP2J2. Co-expression of CYP33E2...

View articletitled, Eicosanoid formation by a cytochrome P450 isoform expressed in the pharynx of Caenorhabditis elegans

Includes: Supplementary data

Articles

Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102

Julia Esser, Marija Rakonjac, Bettina Hofmann, Lutz Fischer, Patrick Provost, Gisbert Schneider, Dieter Steinhilber, Bengt Samuelsson, Olof Rådmark

Biochem J (2010) 425 (1): 265–274.

https://doi.org/10.1042/BJ20090856

Published: 14 December 2009

... 10 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 arachidonic acid eicosanoid leukotriene oxylipin 5-LO (5-lipoxygenase) catalyses two initial steps in LT (leukotriene) biosynthesis, oxygenation of AA (arachidonic acid) to 5-HPETE [5( S )-hydroperoxy-6...

View articletitled, Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102

Articles

Peroxisome-proliferator-activated receptors and the control of levels of prostaglandin-endoperoxide synthase 2 by arachidonic acid in the bovine uterus

E. Linda R. Sheldrick, Kamila Derecka, Elaine Marshall, Evonne C. Chin, Louise Hodges, D. Claire Wathes, D. Robert E. Abayasekara, Anthony P. F. Flint

Biochem J (2007) 406 (1): 175–183.

https://doi.org/10.1042/BJ20070089

Published: 26 July 2007

...E. Linda R. Sheldrick; Kamila Derecka; Elaine Marshall; Evonne C. Chin; Louise Hodges; D. Claire Wathes; D. Robert E. Abayasekara; Anthony P. F. Flint Arachidonic acid is a potential paracrine agent released by the uterine endometrial epithelium to induce PTGS2 [PG (prostaglandin)-endoperoxide...

View articletitled, Peroxisome-proliferator-activated receptors and the control of levels of prostaglandin-endoperoxide synthase 2 by arachidonic acid in the bovine uterus

Articles

Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation

Dominik N. Muller, Cosima Schmidt, Eduardo Barbosa-Sicard, Maren Wellner, Volkmar Gross, Hantz Hercule, Marija Markovic, Horst Honeck, Friedrich C. Luft, Wolf-Hagen Schunck

Biochem J (2007) 403 (1): 109–118.

https://doi.org/10.1042/BJ20061328

Published: 13 March 2007

...Dominik N. Muller; Cosima Schmidt; Eduardo Barbosa-Sicard; Maren Wellner; Volkmar Gross; Hantz Hercule; Marija Markovic; Horst Honeck; Friedrich C. Luft; Wolf-Hagen Schunck AA (arachidonic acid) hydroxylation to 20-HETE (20-hydroxyeicosatetraenoic acid) influences renal vascular and tubular...

View articletitled, Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation

Articles

Zymosan-induced glycerylprostaglandin and prostaglandin synthesis in resident peritoneal macrophages: roles of cyclo-oxygenase-1 and -2

Carol A. Rouzer, Susanne Tranguch, Haibin Wang, Hao Zhang, Sudhansu K. Dey, Lawrence J. Marnett

Biochem J (2006) 399 (1): 91–99.

https://doi.org/10.1042/BJ20060615

Published: 13 September 2006

...Carol A. Rouzer; Susanne Tranguch; Haibin Wang; Hao Zhang; Sudhansu K. Dey; Lawrence J. Marnett COX [cyclo-oxygenase; PG (prostaglandin) G/H synthase] oxygenates AA (arachidonic acid) and 2-AG (2-arachidonylglycerol) to endoperoxides that are converted into PGs and PG-Gs (glycerylprostaglandins...

View articletitled, Zymosan-induced glycerylprostaglandin and prostaglandin synthesis in resident peritoneal macrophages: roles of cyclo-oxygenase-1 and -2

Articles

Cytochrome P450/NADPH-dependent biosynthesis of 5,6- trans -epoxyeicosatrienoic acid from 5,6- trans -arachidonic acid

Uzzal Roy, Robert Joshua, Russell L. Stark, Michael Balazy

Biochem J (2005) 390 (3): 719–727.

https://doi.org/10.1042/BJ20050681

Published: 05 September 2005

...Uzzal Roy; Robert Joshua; Russell L. Stark; Michael Balazy 5,6- trans -AA (5,6-TAA, where TAA stands for trans -arachidonic acid) is a recently identified trans fatty acid that originates from the cis – trans isomerization of AA initiated by the NO 2 radical. This trans fatty acid has been detected...

View articletitled, Cytochrome P450/NADPH-dependent biosynthesis of 5,6- trans -epoxyeicosatrienoic acid from 5,6- trans -arachidonic acid

Articles

Roles of Rac and p38 kinase in the activation of cytosolic phospholipase A 2 in response to PMA

Hye Jin YOU, Chang-Hoon WOO, Eun-Young CHOI, Sung-Hoon CHO, Yung Joon YOO, Jae-Hong KIM

Biochem J (2005) 388 (2): 527–535.

https://doi.org/10.1042/BJ20041614

Published: 24 May 2005

... assayed for luciferase activity as well as protein concentration and β-galactosidase activity. anisomycin arachidonic acid cPLA 2 p38 kinase PMA Rac Phospholipase A 2 catalyses the hydrolysis of the central ( sn -2) ester bond of glycerophospholipids, producing a non-esterified fatty...

View articletitled, Roles of Rac and p38 kinase in the activation of cytosolic phospholipase A 2 in response to PMA

Articles

Probing conformational changes of human serum albumin due to unsaturated fatty acid binding by chemical cross-linking and mass spectrometry

Bill X. HUANG, Chhabil DASS, Hee-Yong KIM

Biochem J (2005) 387 (3): 695–702.

https://doi.org/10.1042/BJ20041624

Published: 26 April 2005

...Bill X. HUANG; Chhabil DASS; Hee-Yong KIM Mass spectrometry with chemical cross-linking was used to probe the conformational changes of HSA (human serum albumin) in solution on interaction with monounsaturated OA (oleic acid) or polyunsaturated AA (arachidonic acid) or DHA (docosahexaenoic acid...

View articletitled, Probing conformational changes of human serum albumin due to unsaturated fatty acid binding by chemical cross-linking and mass spectrometry

Articles

Expression of secretory phospholipase A 2 enzymes in lungs of humans with pneumonia and their potential prostaglandin-synthetic function in human lung-derived cells

Seiko MASUDA, Makoto MURAKAMI, Michiko MITSUISHI, Kazuo KOMIYAMA, Yukio ISHIKAWA, Toshiharu ISHII, Ichiro KUDO

Biochem J (2005) 387 (1): 27–38.

https://doi.org/10.1042/BJ20041307

Published: 22 March 2005

... other functions. 1 To whom correspondence should be addressed (email [email protected] ). 2 8 2004 25 10 2004 27 10 2004 27 10 2004 The Biochemical Society, London 2005 arachidonic acid immunohistochemistry lung phospholipase A 2 prostaglandin E 2...

View articletitled, Expression of secretory phospholipase A 2 enzymes in lungs of humans with pneumonia and their potential prostaglandin-synthetic function in human lung-derived cells

Articles

Arachidonic acid inhibits the store-operated Ca 2+ current in rat liver cells

Grigori Y. RYCHKOV, Tom LITJENS, Michael L. ROBERTS, Greg J. BARRITT

Biochem J (2005) 385 (2): 551–556.

https://doi.org/10.1042/BJ20041604

Published: 07 January 2005

...+ in intracellular stores through Ca 2+ inflow across the plasma membrane. While this may be achieved by SOCs (store-operated Ca 2+ channels), some studies in other cell types indicate that it is dependent on AA (arachidonic acid)-activated Ca 2+ channels. We studied the effects of AA on membrane conductance of rat...

View articletitled, Arachidonic acid inhibits the store-operated Ca 2+ current in rat liver cells

Articles

Human cyclo-oxygenase-1 and an alternative splice variant: contrasts in expression of mRNA, protein and catalytic activities

Claus SCHNEIDER, William E. BOEGLIN, Alan R. BRASH

Biochem J (2005) 385 (1): 57–64.

https://doi.org/10.1042/BJ20041115

Published: 14 December 2004

...Claus SCHNEIDER; William E. BOEGLIN; Alan R. BRASH The two COX (cyclo-oxygenase) isoenzymes COX-1 and -2 catalyse the initial step in the conversion of arachidonic acid into PG (prostaglandin) hormones. The identification of an mRNA transcript encoding a splice variant of human COX-1 was reported...

View articletitled, Human cyclo-oxygenase-1 and an alternative splice variant: contrasts in expression of mRNA, protein and catalytic activities

Articles

Calmidazolium and arachidonate activate a calcium entry pathway that is distinct from store-operated calcium influx in HeLa cells

Claire M. PEPPIATT, Anthony M. HOLMES, Jeong T. SEO, Martin D. BOOTMAN, Tony J. COLLINS, Fraser McMDONALD, H. Llewelyn RODERICK

Biochem J (2004) 381 (3): 929–939.

https://doi.org/10.1042/BJ20040097

Published: 27 July 2004

... suggested that alternative pathways activated by metabolites such as arachidonic acid are responsible for physiological Ca 2+ influx. It is not clear whether such messenger-activated pathways exist in all cells, whether they are truly distinct from SOCE and which metabolites are involved. In the present...

View articletitled, Calmidazolium and arachidonate activate a calcium entry pathway that is distinct from store-operated calcium influx in HeLa cells

Articles

Regulation of cytosolic prostaglandin E synthase by phosphorylation

Tsuyoshi KOBAYASHI, Yoshihito NAKATANI, Toshihiro TANIOKA, Masafumi TSUJIMOTO, Shigeo NAKAJO, Kazuyasu NAKAYA, Makoto MURAKAMI, Ichiro KUDO

Biochem J (2004) 381 (1): 59–69.

https://doi.org/10.1042/BJ20040118

Published: 22 June 2004

... by and associated with CK-II in vitro , resulting in marked reduction of the K m for the substrate PGH 2 . In activated cells, cPGES phosphorylation occurred in parallel with increased cPGES enzymic activity and PGE 2 production from exogenous and endogenous arachidonic acid, and these processes were facilitated...

View articletitled, Regulation of cytosolic prostaglandin E synthase by phosphorylation

Includes: Supplementary data

Articles

Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells

Yves GORIN, Jill M. RICONO, Brent WAGNER, Nam-Ho KIM, Basant BHANDARI, Goutam Ghosh CHOUDHURY, Hanna E. ABBOUD

Biochem J (2004) 381 (1): 231–239.

https://doi.org/10.1042/BJ20031614

Published: 22 June 2004

... targets of Ang II are the extracellular-signal-regulated kinases 1 and 2 (ERK1/ERK2). We demonstrate that Ang II activates ERK1/ERK2 via the AT 1 receptor. Arachidonic acid (AA) mimics the action of Ang II on ERK1/ERK2 and phospholipase A 2 inhibitors blocked Ang II-induced ERK1/ERK2 activation...

View articletitled, Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells

Articles

A novel omega3-fatty acid desaturase involved in the biosynthesis of eicosapentaenoic acid

Suzette L. PEREIRA, Yung-Sheng HUANG, Emil G. BOBIK, Anthony J. KINNEY, Kevin L. STECCA, Jeremy C. L. PACKER, Pradip MUKERJI

Biochem J (2004) 378 (2): 665–671.

https://doi.org/10.1042/bj20031319

Published: 01 March 2004

... desaturate 20-carbon n −6 fatty acid substrates with a distinct preference for ARA (arachidonic acid; 20:4 n −6), converting it into EPA. This activity differs from that of the known ω3-desaturases from any organism. Plant and cyanobacterial ω3-desaturases exclusively desaturate 18-carbon n −6 PUFAs...

View articletitled, A novel omega3-fatty acid desaturase involved in the biosynthesis of eicosapentaenoic acid

Articles

Differential modulation of glucocorticoid action by FK506 in A549 cells

Jamie D. CROXTALL, Mark PAUL-CLARK, Peter Th. W. van HAL

Biochem J (2003) 376 (1): 285–290.

https://doi.org/10.1042/bj20030821

Published: 15 November 2003

... of arachidonic acid and prostaglandin E 2 from A549 cells and also inhibits their proliferation. Simultaneous treatment of FK506 together with the glucocorticoids dexamethasone, methyl-prednisolone, fluticasone or mometasone (10 nM) enhances the growth inhibitory effect of these steroids. Furthermore...

View articletitled, Differential modulation of glucocorticoid action by FK506 in A549 cells

Articles

The requirement of cytosolic phospholipase A2 for the PMA activation of proton efflux through the N-terminal 230-amino-acid fragment of gp91phox

Tosti J. MANKELOW, Etai PESSACH, Rachel LEVY, Lydia M. HENDERSON

Biochem J (2003) 374 (2): 315–319.

https://doi.org/10.1042/bj20030495

Published: 01 September 2003

... deficient in cPLA 2 (PLB-D). The flux of protons in Chinese-Hamster ovary (CHO) cells that express the N-terminal 230-amino-acid (NT) fragment of gp91 phox is activated by arachidonic acid (AA) added externally. To investigate the physiological role of cPLA 2 , and the intracellular AA that it releases...

View articletitled, The requirement of cytosolic phospholipase A2 for the PMA activation of proton efflux through the N-terminal 230-amino-acid fragment of gp91phox

Articles

Attenuation of glucocorticoid functions in an Anx-A1-/- cell line

Jamie D. CROXTALL, Derek W. GILROY, Egle SOLITO, Qamrul CHOUDHURY, Barbara J. WARD, Julia C. BUCKINGHAM, Rod J. FLOWER

Biochem J (2003) 371 (3): 927–935.

https://doi.org/10.1042/bj20021856

Published: 01 May 2003

... that Anx-A1 functions as an inhibitor of signal- transduction pathways that lead to cell proliferation and may help to explain how glucocorticoids regulate these processes. Key words: annexin, arachidonic acid, cell proliferation, JACRO cells, lipocortin, lung fibroblast. INTRODUCTION The annexins...

View articletitled, Attenuation of glucocorticoid functions in an Anx-A1-/- cell line

Articles

Nitric oxide co-ordinates the activities of the capacitative and non-capacitative Ca2+-entry pathways regulated by vasopressin

Zahid MONEER, Jeanette L. DYER, Colin W. TAYLOR

Biochem J (2003) 370 (2): 439–448.

https://doi.org/10.1042/bj20021104

Published: 01 March 2003

...Zahid MONEER; Jeanette L. DYER; Colin W. TAYLOR In A7r5 vascular smooth muscle cells vasopressin, via arachidonic acid, regulates two Ca 2+ -entry pathways. Capacitative Ca 2+ entry (CCE), activated by empty Ca 2+ stores, is inhibited by arachidonic acid, and non-capacitative Ca 2+ entry (NCCE...

View articletitled, Nitric oxide co-ordinates the activities of the capacitative and non-capacitative Ca2+-entry pathways regulated by vasopressin

Articles

Roles of various phospholipases A2 in providing lysophospholipid acceptors for fatty acid phospholipid incorporation and remodelling

Jesús BALSINDE

Biochem J (2002) 364 (3): 695–702.

https://doi.org/10.1042/bj20020142

Published: 15 June 2002

.... 2 e-mail [email protected] 23 1 2002 25 2 2002 4 4 2002 The Biochemical Society, London ©2002 2002 arachidonic acid reacylation transacylation Abbreviations used: AA, arachidonic acid; Con A, concanavalin A; EPA, eicosa-5,8,11,14,17-pentaenoic acid...

View articletitled, Roles of various phospholipases A2 in providing lysophospholipid acceptors for fatty acid phospholipid incorporation and remodelling

Articles

Reciprocal regulation of capacitative and non-capacitative Ca2+ entry in A7r5 vascular smooth muscle cells: only the latter operates during receptor activation

Zahid MONEER, Colin W. TAYLOR

Biochem J (2002) 362 (1): 13–21.

https://doi.org/10.1042/bj3620013

Published: 08 February 2002

...+ and Ca 2+ , and is selectively blocked by Gd 3+ (1 μ M). A7r5 cells also express a non-capacitative Ca 2+ entry (NCCE) pathway, which is activated by arachidonic acid that is released by the sequential activities of phospholipase C and diacylglycerol lipase. This pathway is permeable to Sr 2+ , Ba 2...

View articletitled, Reciprocal regulation of capacitative and non-capacitative Ca2+ entry in A7r5 vascular smooth muscle cells: only the latter operates during receptor activation

Articles

Sulphatides trigger polymorphonuclear granulocyte spreading on collagen-coated surfaces and inhibit subsequent activation of 5-lipoxygenase

Galina F. SUD'INA, Thomas G. BROCK, Marina A. PUSHKAREVA, Svetlana I. GALKINA, Denis V. TURUTIN, Marc PETERS-GOLDEN, Volker ULLRICH

Biochem J (2001) 359 (3): 621–629.

https://doi.org/10.1042/bj3590621

Published: 25 October 2001

... release of arachidonic acid and the synthesis of 5-LO metabolites. In contrast, in PMNs attached to collagen, the enzymic conversion of arachidonic acid by 5-LO was inhibited by sulphatides. Inhibition of 5-LO metabolism by sulphatides was observed even in the presence of exogenous substrate, suggesting...

View articletitled, Sulphatides trigger polymorphonuclear granulocyte spreading on collagen-coated surfaces and inhibit subsequent activation of 5-lipoxygenase

Articles

Cytosolic phospholipase A2-α associates with plasma membrane, endoplasmic reticulum and nuclear membrane in glomerular epithelial cells

Jianhong LIU, Tomoko TAKANO, Joan PAPILLON, Abdelkrim KHADIR, Andrey V. CYBULSKY

Biochem J (2001) 353 (1): 79–90.

https://doi.org/10.1042/bj3530079

Published: 18 December 2000

...Jianhong LIU; Tomoko TAKANO; Joan PAPILLON; Abdelkrim KHADIR; Andrey V. CYBULSKY Eicosanoids mediate complement-dependent glomerular epithelial injury in experimental membranous nephropathy. The release of arachidonic acid from phospholipids by cytosolic phospholipase A 2 (cPLA 2 ) is the rate...

View articletitled, Cytosolic phospholipase A2-α associates with plasma membrane, endoplasmic reticulum and nuclear membrane in glomerular epithelial cells

Articles

Negative regulation of cytosolic phospholipase A2 by melatonin in the rat pineal gland

Beibei LI, Hongjian ZHANG, Mohammed AKBAR, Hee-Yong KIM

Biochem J (2000) 351 (3): 709–716.

https://doi.org/10.1042/bj3510709

Published: 24 October 2000

... 3 2000 3 7 2000 3 8 2000 The Biochemical Society, London © 2000 2000 arachidonic acid gas chromatography/mass spectrometry isoproterenol melatonin receptor Biochem. J. (2000) 351, 709 716 (Printed in Great Britain) 709 Negative regulation of cytosolic phospholipase A2...

View articletitled, Negative regulation of cytosolic phospholipase A2 by melatonin in the rat pineal gland

Articles

Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids

Amanda E. LEONARD, Emil G. BOBIK, Joseph DORADO, Paul E. KROEGER, Lu-Te CHUANG, Jennifer M. THURMOND, Jennifer M. PARKER-BARNES, Tapas DAS, Yung-Sheng HUANG, Pradip MUKERJI

Biochem J (2000) 350 (3): 765–770.

https://doi.org/10.1042/bj3500765

Published: 08 September 2000

... fatty acids, as determined by the conversion of γ-linolenic acid (C 18:3, n -6 ) into dihomo-γ-linolenic acid (C 20:3, n -6 ), arachidonic acid (C 20:4, n -6 ) into adrenic acid (C 22:4, n -6 ), stearidonic acid (C 18:4, n -3 ) into eicosatetraenoic acid (C 20:4, n -3 ), eicosapentaenoic acid (C 20:5, n...

View articletitled, Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids

Articles

Positional- and stereo-selectivity of fatty acid oxygenation catalysed by mouse (12S)-lipoxygenase isoenzymes

Friederike BÜRGER, Peter KRIEG, Friedrich MARKS, Gerhard FÜRSTENBERGER

Biochem J (2000) 348 (2): 329–335.

https://doi.org/10.1042/bj3480329

Published: 23 May 2000

...Friederike BÜRGER; Peter KRIEG; Friedrich MARKS; Gerhard FÜRSTENBERGER A quantitative stereochemical analysis of the products generated by recombinant mouse (12 S )-lipoxygenase isoenzymes was performed with arachidonic acid and linoleic acid as substrates. The leucocyte-type (12 S )-lipoxygenase...

View articletitled, Positional- and stereo-selectivity of fatty acid oxygenation catalysed by mouse (12S)-lipoxygenase isoenzymes

Articles

Involvement of lipoxygenase in lysophosphatidic acid-stimulated hydrogen peroxide release in human HaCaT keratinocytes

Madhavi SEKHARAM, Jess M. CUNNICK, Jie WU

Biochem J (2000) 346 (3): 751–758.

https://doi.org/10.1042/bj3460751

Published: 07 March 2000

... The Biochemical Society, London © 2000 2000 arachidonic acid calcium H 2 O 2 leukotrienes phospholipase A 2 Biochem. J. (2000) 346, 751 758 (Printed in Great Britain) 751 Involvement of lipoxygenase in lysophosphatidic acid-stimulated hydrogen peroxide release in human HaCaT keratinocytes Madhavi...

View articletitled, Involvement of lipoxygenase in lysophosphatidic acid-stimulated hydrogen peroxide release in human HaCaT keratinocytes

Articles

Different roles of protein kinase C α and δ isoforms in the regulation of neutral sphingomyelinase activity in HL-60 cells

Dora VIŠNJIĆ, Drago BATINIŠ, Hrvoje BANFIŠ

Biochem J (1999) 344 (3): 921–928.

https://doi.org/10.1042/bj3440921

Published: 08 December 1999

... of 1,25(OH) 2 D 3 but had no effect on the IFN-γ-mediated increase in activity of sphingomyelinase. Isoform-specific antibodies were used to deplete different PKC isoforms from cytosol before the treatment of the cytosolic fraction with 1,25(OH) 2 D 3 , arachidonic acid (AA) and PMA. The depletion of PKC...

View articletitled, Different roles of protein kinase C α and δ isoforms in the regulation of neutral sphingomyelinase activity in HL-60 cells

Articles

Melatonin: an endogenous negative modulator of 12-lipoxygenation in the rat pineal gland

Hongjian ZHANG, Mohammed AKBAR, Hee-Yong KIM

Biochem J (1999) 344 (2): 487–493.

https://doi.org/10.1042/bj3440487

Published: 24 November 1999

...-Myer Squibb Company, Pharmaceutical Research Institute, PO Box 400, Princeton, NJ 08543, U.S.A. 22 4 1999 23 8 1999 21 9 1999 The Biochemical Society, London © 1999 1999 arachidonic acid 12-hydroxyeicosatetraenoic acid (12-HETE) 12-lipoxygenase Biochem. J. (1999) 344...

View articletitled, Melatonin: an endogenous negative modulator of 12-lipoxygenation in the rat pineal gland

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