1-32 of 32
Keywords: arachidonic acid
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles
Biochem J (2018) 475 (19): 3141–3151.
Published: 12 October 2018
...Esraa Saadi; Sharon Tal; Liza Barki-Harrington Catalysis of arachidonic acid (AA) by cyclooxygenase-2 (COX-2) gives rise to a single product that serves as a precursor for all prostaglandins, which are central mediators of inflammation. Rapid up-regulation of COX-2 expression in response to pro...
Includes: Supplementary data
Articles
Biochem J (2011) 439 (3): 403–411.
Published: 13 October 2011
... arachidonic acid Group IVA phospholipase A 2 (PLA 2 G4A) Leydig cell sexual maturation testosterone PLA 2 s (phospholipases A 2 ) are a growing family of enzymes that function in lipid digestion, microbial degradation, membrane remodelling and signal transduction [ 1 ]. More than 20 isoforms...
Articles
Biochem J (2011) 438 (1): 203–215.
Published: 27 July 2011
...Yan-Jia Fang; Meng-Hua Zhou; Xiao-Fei Gao; Hua Gu; Yan-Ai Mei AA (arachidonic acid), which possesses both neurotoxic and neurotrophic activities, has been implicated as a messenger in both physiological and pathophysiological processes. In the present study, we investigated the effects of both...
Articles
Biochem J (2011) 435 (3): 689–700.
Published: 13 April 2011
... of physiologically active AA (arachidonic acid) metabolites. We tested the hypothesis that mammals and C. elegans may share similar basic mechanisms of CYP-dependent eicosanoid formation and action. We focused on CYP33E2, an isoform related to the human AA-epoxygenases CYP2C8 and CYP2J2. Co-expression of CYP33E2...
Includes: Supplementary data
Articles
Biochem J (2010) 425 (1): 265–274.
Published: 14 December 2009
... 10 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 arachidonic acid eicosanoid leukotriene oxylipin 5-LO (5-lipoxygenase) catalyses two initial steps in LT (leukotriene) biosynthesis, oxygenation of AA (arachidonic acid) to 5-HPETE [5( S )-hydroperoxy-6...
Articles
Biochem J (2007) 406 (1): 175–183.
Published: 26 July 2007
...E. Linda R. Sheldrick; Kamila Derecka; Elaine Marshall; Evonne C. Chin; Louise Hodges; D. Claire Wathes; D. Robert E. Abayasekara; Anthony P. F. Flint Arachidonic acid is a potential paracrine agent released by the uterine endometrial epithelium to induce PTGS2 [PG (prostaglandin)-endoperoxide...
Articles
Biochem J (2007) 403 (1): 109–118.
Published: 13 March 2007
...Dominik N. Muller; Cosima Schmidt; Eduardo Barbosa-Sicard; Maren Wellner; Volkmar Gross; Hantz Hercule; Marija Markovic; Horst Honeck; Friedrich C. Luft; Wolf-Hagen Schunck AA (arachidonic acid) hydroxylation to 20-HETE (20-hydroxyeicosatetraenoic acid) influences renal vascular and tubular...
Articles
Biochem J (2006) 399 (1): 91–99.
Published: 13 September 2006
...Carol A. Rouzer; Susanne Tranguch; Haibin Wang; Hao Zhang; Sudhansu K. Dey; Lawrence J. Marnett COX [cyclo-oxygenase; PG (prostaglandin) G/H synthase] oxygenates AA (arachidonic acid) and 2-AG (2-arachidonylglycerol) to endoperoxides that are converted into PGs and PG-Gs (glycerylprostaglandins...
Articles
Biochem J (2005) 390 (3): 719–727.
Published: 05 September 2005
...Uzzal Roy; Robert Joshua; Russell L. Stark; Michael Balazy 5,6- trans -AA (5,6-TAA, where TAA stands for trans -arachidonic acid) is a recently identified trans fatty acid that originates from the cis – trans isomerization of AA initiated by the NO 2 radical. This trans fatty acid has been detected...
Articles
Biochem J (2005) 388 (2): 527–535.
Published: 24 May 2005
... was further demonstrated after a treatment with anisomycin, a very effective activator of p38 kinase. Consistent with the mediatory role of p38 kinase in stimulating cPLA 2 , anisomycin induced the translocation and activation of cPLA 2 in a p38 kinase-dependent manner. anisomycin arachidonic acid cPLA 2...
Articles
Biochem J (2005) 387 (3): 695–702.
Published: 26 April 2005
...Bill X. HUANG; Chhabil DASS; Hee-Yong KIM Mass spectrometry with chemical cross-linking was used to probe the conformational changes of HSA (human serum albumin) in solution on interaction with monounsaturated OA (oleic acid) or polyunsaturated AA (arachidonic acid) or DHA (docosahexaenoic acid...
Articles
Biochem J (2005) 387 (1): 27–38.
Published: 22 March 2005
...-blot system (NEN™ Life Science Products) as described in [ 8 ]. 1 To whom correspondence should be addressed (email mako@pharm.showa-u.ac.jp ). 2 8 2004 25 10 2004 27 10 2004 27 10 2004 The Biochemical Society, London 2005 arachidonic acid...
Articles
Biochem J (2005) 385 (2): 551–556.
Published: 07 January 2005
...+ in intracellular stores through Ca 2+ inflow across the plasma membrane. While this may be achieved by SOCs (store-operated Ca 2+ channels), some studies in other cell types indicate that it is dependent on AA (arachidonic acid)-activated Ca 2+ channels. We studied the effects of AA on membrane conductance of rat...
Articles
Biochem J (2005) 385 (1): 57–64.
Published: 14 December 2004
...Claus SCHNEIDER; William E. BOEGLIN; Alan R. BRASH The two COX (cyclo-oxygenase) isoenzymes COX-1 and -2 catalyse the initial step in the conversion of arachidonic acid into PG (prostaglandin) hormones. The identification of an mRNA transcript encoding a splice variant of human COX-1 was reported...
Articles
Biochem J (2004) 381 (3): 929–939.
Published: 27 July 2004
... suggested that alternative pathways activated by metabolites such as arachidonic acid are responsible for physiological Ca 2+ influx. It is not clear whether such messenger-activated pathways exist in all cells, whether they are truly distinct from SOCE and which metabolites are involved. In the present...
Articles
Biochem J (2004) 381 (1): 59–69.
Published: 22 June 2004
... by and associated with CK-II in vitro , resulting in marked reduction of the K m for the substrate PGH 2 . In activated cells, cPGES phosphorylation occurred in parallel with increased cPGES enzymic activity and PGE 2 production from exogenous and endogenous arachidonic acid, and these processes were facilitated...
Includes: Supplementary data
Articles
Biochem J (2004) 381 (1): 231–239.
Published: 22 June 2004
... targets of Ang II are the extracellular-signal-regulated kinases 1 and 2 (ERK1/ERK2). We demonstrate that Ang II activates ERK1/ERK2 via the AT 1 receptor. Arachidonic acid (AA) mimics the action of Ang II on ERK1/ERK2 and phospholipase A 2 inhibitors blocked Ang II-induced ERK1/ERK2 activation...
Articles
Biochem J (2004) 378 (2): 665–671.
Published: 01 March 2004
... desaturate 20-carbon n −6 fatty acid substrates with a distinct preference for ARA (arachidonic acid; 20:4 n −6), converting it into EPA. This activity differs from that of the known ω3-desaturases from any organism. Plant and cyanobacterial ω3-desaturases exclusively desaturate 18-carbon n −6 PUFAs...
Articles
Biochem J (2003) 376 (1): 285–290.
Published: 15 November 2003
... of arachidonic acid and prostaglandin E 2 from A549 cells and also inhibits their proliferation. Simultaneous treatment of FK506 together with the glucocorticoids dexamethasone, methyl-prednisolone, fluticasone or mometasone (10 nM) enhances the growth inhibitory effect of these steroids. Furthermore...
Articles
Biochem J (2003) 374 (2): 315–319.
Published: 01 September 2003
... deficient in cPLA 2 (PLB-D). The flux of protons in Chinese-Hamster ovary (CHO) cells that express the N-terminal 230-amino-acid (NT) fragment of gp91 phox is activated by arachidonic acid (AA) added externally. To investigate the physiological role of cPLA 2 , and the intracellular AA that it releases...
Articles
Biochem J (2003) 371 (3): 927–935.
Published: 01 May 2003
... to cell proliferation and may help to explain how glucocorticoids regulate these processes. 28 11 2002 22 1 2003 28 1 2003 28 1 2003 The Biochemical Society, London ©2003 2003 annexin arachidonic acid cell proliferation JACRO cells lipocortin lung fibroblast...
Articles
Biochem J (2003) 370 (2): 439–448.
Published: 01 March 2003
...Zahid MONEER; Jeanette L. DYER; Colin W. TAYLOR In A7r5 vascular smooth muscle cells vasopressin, via arachidonic acid, regulates two Ca 2+ -entry pathways. Capacitative Ca 2+ entry (CCE), activated by empty Ca 2+ stores, is inhibited by arachidonic acid, and non-capacitative Ca 2+ entry (NCCE...
Articles
Biochem J (2002) 364 (3): 695–702.
Published: 15 June 2002
.... 2 e-mail jbalsinde@ibgm.uva.es 23 1 2002 25 2 2002 4 4 2002 The Biochemical Society, London ©2002 2002 arachidonic acid reacylation transacylation Abbreviations used: AA, arachidonic acid; Con A, concanavalin A; EPA, eicosa-5,8,11,14,17-pentaenoic acid...
Articles
Biochem J (2002) 362 (1): 13–21.
Published: 08 February 2002
...+ and Ca 2+ , and is selectively blocked by Gd 3+ (1 μ M). A7r5 cells also express a non-capacitative Ca 2+ entry (NCCE) pathway, which is activated by arachidonic acid that is released by the sequential activities of phospholipase C and diacylglycerol lipase. This pathway is permeable to Sr 2+ , Ba 2...
Articles
Biochem J (2001) 359 (3): 621–629.
Published: 25 October 2001
... release of arachidonic acid and the synthesis of 5-LO metabolites. In contrast, in PMNs attached to collagen, the enzymic conversion of arachidonic acid by 5-LO was inhibited by sulphatides. Inhibition of 5-LO metabolism by sulphatides was observed even in the presence of exogenous substrate, suggesting...
Articles
Biochem J (2001) 353 (1): 79–90.
Published: 18 December 2000
...Jianhong LIU; Tomoko TAKANO; Joan PAPILLON; Abdelkrim KHADIR; Andrey V. CYBULSKY Eicosanoids mediate complement-dependent glomerular epithelial injury in experimental membranous nephropathy. The release of arachidonic acid from phospholipids by cytosolic phospholipase A 2 (cPLA 2 ) is the rate...
Articles
Biochem J (2000) 351 (3): 709–716.
Published: 24 October 2000
... 3 2000 3 7 2000 3 8 2000 The Biochemical Society, London © 2000 2000 arachidonic acid gas chromatography/mass spectrometry isoproterenol melatonin receptor Biochem. J. (2000) 351, 709 716 (Printed in Great Britain) 709 Negative regulation of cytosolic phospholipase A2...
Articles
Biochem J (2000) 350 (3): 765–770.
Published: 08 September 2000
... fatty acids, as determined by the conversion of γ-linolenic acid (C 18:3, n -6 ) into dihomo-γ-linolenic acid (C 20:3, n -6 ), arachidonic acid (C 20:4, n -6 ) into adrenic acid (C 22:4, n -6 ), stearidonic acid (C 18:4, n -3 ) into eicosatetraenoic acid (C 20:4, n -3 ), eicosapentaenoic acid (C 20:5, n...
Articles
Biochem J (2000) 348 (2): 329–335.
Published: 23 May 2000
...Friederike BÜRGER; Peter KRIEG; Friedrich MARKS; Gerhard FÜRSTENBERGER A quantitative stereochemical analysis of the products generated by recombinant mouse (12 S )-lipoxygenase isoenzymes was performed with arachidonic acid and linoleic acid as substrates. The leucocyte-type (12 S )-lipoxygenase...
Articles
Biochem J (2000) 346 (3): 751–758.
Published: 07 March 2000
... The Biochemical Society, London © 2000 2000 arachidonic acid calcium H 2 O 2 leukotrienes phospholipase A 2 Biochem. J. (2000) 346, 751 758 (Printed in Great Britain) 751 Involvement of lipoxygenase in lysophosphatidic acid-stimulated hydrogen peroxide release in human HaCaT keratinocytes Madhavi...
Articles
Biochem J (1999) 344 (3): 921–928.
Published: 08 December 1999
... of 1,25(OH) 2 D 3 but had no effect on the IFN-γ-mediated increase in activity of sphingomyelinase. Isoform-specific antibodies were used to deplete different PKC isoforms from cytosol before the treatment of the cytosolic fraction with 1,25(OH) 2 D 3 , arachidonic acid (AA) and PMA. The depletion of PKC...
Articles
Biochem J (1999) 344 (2): 487–493.
Published: 24 November 1999
...-Myer Squibb Company, Pharmaceutical Research Institute, PO Box 400, Princeton, NJ 08543, U.S.A. 22 4 1999 23 8 1999 21 9 1999 The Biochemical Society, London © 1999 1999 arachidonic acid 12-hydroxyeicosatetraenoic acid (12-HETE) 12-lipoxygenase Biochem. J. (1999) 344...