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Keywords: arrestin
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Biochem J (2016) 473 (22): 4173–4192.
Published: 10 November 2016
... and kidney where it modulates extracellular Ca 2+ homeostasis and bone turnover. It is well established that phosphorylation of GPCRs constitutes a key event in regulating receptor function by promoting arrestin recruitment and coupling to G-protein-independent signaling pathways. Mapping phosphorylation...
Biochem J (2010) 428 (2): 235–245.
Published: 13 May 2010
...); β 2 AR is phosphorylated by both second messenger-activated PKA (protein kinase A) and GRKs with slower kinetics. TRHR co-internalizes with arrestin, whereas β 2 AR recruits arrestin, but internalizes without it. Both receptors are dephosphorylated following agonist removal, but TRHR...
Biochem J (2007) 408 (2): 221–230.
Published: 14 November 2007
...-arrestin-1-dependent inhibition of class IA PI3K (phosphoinositide 3-kinase), and we sought to characterize further the role of β-arrestins in the regulation of PI3K activity. Whereas the ability of β-arrestin-1 to inhibit p110α (PI3K catalytic subunit α) has been demonstrated, the role of β-arrestin-2...
Biochem J (2005) 385 (3): 625–637.
Published: 24 January 2005
... the concept of GPCR oligomerization, as well as demonstrating GPCR interactions with GPCR kinases, β-arrestins, adenylate cyclase and a subunit of an inwardly rectifying K + channel. The present review examines recent technological advances and experimental applications of FRET and BRET, discussing...
Biochem J (2003) 370 (1): 1–18.
Published: 15 February 2003
... over 16 isoforms, each of which is characterized by a unique N-terminal region. PDE4 isoforms play a pivotal role in controlling functionally and spatially distinct pools of cAMP by virtue of their unique intracellular targeting. Targeting occurs by association with proteins, such as arrestins, SRC...