... transition (EMT) of lens epithelial cells (LECs) in response to transforming growth factor β2 (TGFβ2) has been considered an obligatory mechanism for PCO. In this study, we tested the efficacy of aspirin in inhibiting the TGFβ2-mediated EMT of human LECs, LECs in human lens capsular bags, and lensectomized...

...Andrew J. O’Brien; Linda A. Villani; Lindsay A. Broadfield; Vanessa P. Houde; Sandra Galic; Giovanni Blandino; Bruce E. Kemp; Theodoros Tsakiridis; Paola Muti; Gregory R. Steinberg Aspirin, the pro-drug of salicylate, is associated with reduced incidence of death from cancers of the colon, lung...

... diabetes (T2D) and many patients also take salicylate-based drugs [i.e., aspirin (ASA)] for cardioprotection. Metformin and salicylate both increase AMP-activated protein kinase (AMPK) activity but by distinct mechanisms, with metformin altering cellular adenylate charge (increasing AMP) and salicylate...

...Naveen Babbar; Eugene W. Gerner; Robert A. Casero, Jr Epidemiological, experimental and clinical results suggest that aspirin and other NSAIDs (non-steroidal anti-inflammatory drugs) inhibit the development of colon cancer. It has been shown that the NSAID sulindac induces apoptosis and suppresses...

... and methylglyoxal, all of which are pertinent to cataract. Also modification by aspirin, which is known to delay cataract and other diseases, has been investigated. Recently, two point mutations of arginine residues were shown to cause congenital cataract. 1,2-Cyclohexanedione modifies arginine residues...

...-tyrosine phosphatase activity in nuclear extracts of interferon-γ-treated cells. The enhanced activation of STAT1 resulted in increased induction of mRNA encoding interferon regulatory factor-1. These results not only demonstrate that aspirin and its metabolite salicylate may have pro-inflammatory as well...