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Articles

Role of macrophage autophagy in atherosclerosis: modulation by bioactive compounds

MD Khurshidul Zahid, Hazera Binte Sufian, Mahua Choudhury, Masao Yamasaki, Ahmed Al-Harrasi, Naima Moustaid-Moussa, Shaikh Mizanoor Rahman

Biochem J (2021) 478 (7): 1359–1375.

https://doi.org/10.1042/BCJ20200894

Published: 16 April 2021

...MD Khurshidul Zahid; Hazera Binte Sufian; Mahua Choudhury; Masao Yamasaki; Ahmed Al-Harrasi; Naima Moustaid-Moussa; Shaikh Mizanoor Rahman Atherosclerosis is a chronic inflammatory disease associated with lipid metabolism disorder. Autophagy is a catabolic process and contributes to maintaining...

View articletitled, Role of macrophage autophagy in atherosclerosis: modulation by bioactive compounds

Articles

Lack of mitochondrial NADP(H)-transhydrogenase expression in macrophages exacerbates atherosclerosis in hypercholesterolemic mice

Alessandro G. Salerno, Thiago Rentz, Gabriel G. Dorighello, Ana Carolina Marques, Estela Lorza-Gil, Amarylis C. B. A. Wanschel, Audrey de Moraes, Anibal E. Vercesi, Helena C. F. Oliveira

Biochem J (2019) 476 (24): 3769–3789.

https://doi.org/10.1042/BCJ20190543

Published: 20 December 2019

...Alessandro G. Salerno; Thiago Rentz; Gabriel G. Dorighello; Ana Carolina Marques; Estela Lorza-Gil; Amarylis C. B. A. Wanschel; Audrey de Moraes; Anibal E. Vercesi; Helena C. F. Oliveira The atherosclerosis prone LDL receptor knockout mice (Ldlr −/− , C57BL/6J background) carry a deletion...

View articletitled, Lack of mitochondrial NADP(H)-transhydrogenase expression in macrophages exacerbates atherosclerosis in hypercholesterolemic mice

Includes: Supplementary data

Articles

The arterial microenvironment: the where and why of atherosclerosis

Arif Yurdagul, Jr, Alexandra C. Finney, Matthew D. Woolard, A. Wayne Orr

Biochem J (2016) 473 (10): 1281–1295.

https://doi.org/10.1042/BJ20150844

Published: 11 May 2016

.... atherosclerosis extracellular matrix inflammation microenvironment shear stress Atherosclerosis is a lipid-driven chronic inflammatory disease of large and medium sized arteries, hinders arterial function and prevents adequate blood flow to target tissues. Lipid deposition in the arterial wall...

View articletitled, The arterial microenvironment: the where and why of atherosclerosis

Articles

High-density lipoprotein mimetics: promises and challenges

Dmitri Sviridov, Alan T. Remaley

Biochem J (2015) 472 (3): 249–259.

https://doi.org/10.1042/BJ20150832

Published: 27 November 2015

... in medicine and biology. In the present review, we discuss the fundamental design principles used to create lipoprotein mimetics, mechanisms of their action, medical indications and efficacy in animal models and human studies. apolipoproteins atherosclerosis cholesterol metabolism lipoprotein metabolism...

View articletitled, High-density lipoprotein mimetics: promises and challenges

Articles

Insulin resistance and atherosclerosis: convergence between metabolic pathways and inflammatory nodes

Robert Stöhr, Massimo Federici

Biochem J (2013) 454 (1): 1–11.

https://doi.org/10.1042/BJ20130121

Published: 26 July 2013

...Robert Stöhr; Massimo Federici For some time now it has been known that diabetes and atherosclerosis are chronic inflammatory diseases that are closely associated with one another and often develop together. In both there is an increase in tissue-wide inflammation that is exhibited...

View articletitled, Insulin resistance and atherosclerosis: convergence between metabolic pathways and inflammatory nodes

Articles

PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress

Joshua K. Salabei, Timothy D. Cummins, Mahavir Singh, Steven P. Jones, Aruni Bhatnagar, Bradford G. Hill

Biochem J (2013) 451 (3): 375–388.

https://doi.org/10.1042/BJ20121344

Published: 12 April 2013

... should be addressed (email [email protected] ). 27 8 2012 12 2 2013 20 2 2013 20 2 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 atherosclerosis autophagy growth factor 4-hydroxy-nonenal (4-HNE) restenosis spautin VSMCs...

View articletitled, PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress

Includes: Supplementary data

Articles

Myeloperoxidase-derived oxidants modify apolipoprotein A-I and generate dysfunctional high-density lipoproteins: comparison of hypothiocyanous acid (HOSCN) with hypochlorous acid (HOCl)

Katrina A. Hadfield, David I. Pattison, Bronwyn E. Brown, Liming Hou, Kerry-Anne Rye, Michael J. Davies, Clare L. Hawkins

Biochem J (2013) 449 (2): 531–542.

https://doi.org/10.1042/BJ20121210

Published: 14 December 2012

... of atherosclerosis. Although it has been established that HOCl (hypochlorous acid) produced by MPO targets apoA-I (apolipoprotein A-I), the major apolipoprotein of HDLs, the role of the other major oxidant generated by MPO, HOSCN (hypothiocyanous acid), in the generation of dysfunctional HDLs has not been examined...

View articletitled, Myeloperoxidase-derived oxidants modify apolipoprotein A-I and generate dysfunctional high-density lipoproteins: comparison of hypothiocyanous acid (HOSCN) with hypochlorous acid (HOCl)

Includes: Supplementary data

Articles

Identification of 4-hydroxy-2-nonenal–histidine adducts that serve as ligands for human lectin-like oxidized LDL receptor-1

Miyuki Kumano-Kuramochi, Yuuki Shimozu, Chika Wakita, Mayumi Ohnishi-Kameyama, Takahiro Shibata, Shigeru Matsunaga, Yuko Takano-Ishikawa, Jun Watanabe, Masao Goto, Qiuhong Xie, Shiro Komba, Koji Uchida, Sachiko Machida

Biochem J (2012) 442 (1): 171–180.

https://doi.org/10.1042/BJ20111029

Published: 27 January 2012

...) is an endothelial scavenger receptor that is important for the uptake of OxLDL (oxidized low-density lipoprotein) and contributes to the pathogenesis of atherosclerosis. However, the precise structural motifs of OxLDL that are recognized by LOX-1 are unknown. In the present study, we have identified products...

View articletitled, Identification of 4-hydroxy-2-nonenal–histidine adducts that serve as ligands for human lectin-like oxidized LDL receptor-1

Includes: Supplementary data

Articles

Novel mechanism for regulation of plasma platelet-activating factor acetylhydrolase expression in mammalian cells

Alison A. Gardner, Ethan C. Reichert, Timothy S. Alexander, Matthew K. Topham, Diana M. Stafforini

Biochem J (2010) 428 (2): 269–279.

https://doi.org/10.1042/BJ20100039

Published: 13 May 2010

... compilation © 2010 Biochemical Society 2010 atherosclerosis inflammation lipoprotein oxidized phospholipid phospholipase platelet-activating factor (PAF) PAF-AH [PAF (platelet-activating factor; 1-O-alkyl-2-acetyl- sn -glycero-3-phosphocholine) acetylhydrolase; also known as PLA 2 G7, LpPLA...

View articletitled, Novel mechanism for regulation of plasma platelet-activating factor acetylhydrolase expression in mammalian cells

Includes: Supplementary data

Articles

Apolipoprotein E inhibits Toll-like receptor (TLR)-3- and TLR-4-mediated macrophage activation through distinct mechanisms

Yanjuan Zhu, Ahmer Kodvawala, David Y. Hui

Biochem J (2010) 428 (1): 47–54.

https://doi.org/10.1042/BJ20100016

Published: 28 April 2010

... Biochemical Society 2010 apolipoprotein E (apoE) atherosclerosis c-Jun N-terminal kinase (JNK) inflammation lipoprotein receptor macrophage Atherosclerosis is a chronic inflammatory disease of the vessel wall. A prominent event associated with the development and progression...

View articletitled, Apolipoprotein E inhibits Toll-like receptor (TLR)-3- and TLR-4-mediated macrophage activation through distinct mechanisms

Articles

Hydrogen sulfide destroys lipid hydroperoxides in oxidized LDL

Markus K. Muellner, Sabine M. Schreier, Hilde Laggner, Marcela Hermann, Harald Esterbauer, Markus Exner, Bernhard M. K. Gmeiner, Stylianos Kapiotis

Biochem J (2009) 420 (2): 277–281.

https://doi.org/10.1042/BJ20082421

Published: 13 May 2009

... brought to 0.4 mg/ml by the addition of native LDL, and after incubation with or without NaHS for 30 min at 37 °C, the preparations were subjected to gel chromatography to get rid of NaHS. atherosclerosis hydrogen sulfide (H 2 S) low-densitylipoprotein (LDL) oxidation lipid hydroperoxide (9 S...

View articletitled, Hydrogen sulfide destroys lipid hydroperoxides in oxidized LDL

Articles

Unsaturated lipid peroxidation-derived aldehydes activate autophagy in vascular smooth-muscle cells

Bradford G. Hill, Petra Haberzettl, Yonis Ahmed, Sanjay Srivastava, Aruni Bhatnagar

Biochem J (2008) 410 (3): 525–534.

https://doi.org/10.1042/BJ20071063

Published: 27 February 2008

... To whom correspondence should be addressed (email [email protected] ). 6 8 2007 27 11 2007 3 12 2007 3 12 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 atherosclerosis autophagy 4-hydroxynonenal (4-HNE) oxidative stress oxidized lipid...

View articletitled, Unsaturated lipid peroxidation-derived aldehydes activate autophagy in vascular smooth-muscle cells

Includes: Supplementary data

Articles

The lectin-like oxidized low-density-lipoprotein receptor: a pro-inflammatory factor in vascular disease

Sarah Dunn, Ravinder S. Vohra, Jane E. Murphy, Shervanthi Homer-Vanniasinkam, John H. Walker, Sreenivasan Ponnambalam

Biochem J (2008) 409 (2): 349–355.

https://doi.org/10.1042/BJ20071196

Published: 21 December 2007

... 2007 24 10 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 apoptosis atherosclerosis lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) oxidized low-density lipoprotein (OxLDL) scavenger receptor Although LOX-1/OxLDL activation...

View articletitled, The lectin-like oxidized low-density-lipoprotein receptor: a pro-inflammatory factor in vascular disease

Articles

Oxidative stress regulates IGF1R expression in vascular smooth-muscle cells via p53 and HDAC recruitment

Mary M. Kavurma, Nichola Figg, Martin R. Bennett, John Mercer, Levon M. Khachigian, Trevor D. Littlewood

Biochem J (2007) 407 (1): 79–87.

https://doi.org/10.1042/BJ20070380

Published: 12 September 2007

[email protected] ). 19 3 2007 26 6 2007 29 6 2007 29 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 apoptosis atherosclerosis histone deacetylase (HDAC) insulin-like growth factor 1 receptor (IGF1R) p53 vascular smooth-muscle cell (VSMC...

View articletitled, Oxidative stress regulates IGF1R expression in vascular smooth-muscle cells via p53 and HDAC recruitment

Articles

Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity

Jun Li, Christine Tumanut, Julie-Ann Gavigan, Waan-Jeng Huang, Eric N. Hampton, Rachelle Tumanut, Ka Fai Suen, John W. Trauger, Glen Spraggon, Scott A. Lesley, Gene Liau, David Yowe, Jennifer L. Harris

Biochem J (2007) 406 (2): 203–207.

https://doi.org/10.1042/BJ20070664

Published: 13 August 2007

... Journal compilation © 2007 Biochemical Society 2007 atherosclerosis coronary heart disease hypercholesterolaemia low-density lipoprotein receptor (LDL-R) proprotein convertase subtilisin/kexin 9 (PCSK9) trans -assembly PCSK9 (proprotein convertase subtilisin/kexin 9) also known as NARC...

View articletitled, Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity

Includes: Supplementary data

Articles

Substrate specificity and catalytic efficiency of aldo-keto reductases with phospholipid aldehydes

Matthew Spite, Shahid P. Baba, Yonis Ahmed, Oleg A. Barski, Kanchan Nijhawan, J. Mark Petrash, Aruni Bhatnagar, Sanjay Srivastava

Biochem J (2007) 405 (1): 95–105.

https://doi.org/10.1042/BJ20061743

Published: 13 June 2007

... oxide production [ 15 ], and serve as pattern recognition ligands in oxLDL [ 16 ] and in apoptotic cells [ 17 ] for their uptake by macrophages. aldo-keto reductase atherosclerosis electrospray ionization mass spectrometry lipid peroxidation 1-palmitoyl-2-(5-oxovaleroyl)- sn -glycero-3...

View articletitled, Substrate specificity and catalytic efficiency of aldo-keto reductases with phospholipid aldehydes

Articles

Inhibition of PDGF-BB by Factor VII-activating protease (FSAP) is neutralized by protease nexin-1, and the FSAP–inhibitor complexes are internalized via LRP

Lars Muhl, Anders Nykjaer, Malgorzata Wygrecka, Denis Monard, Klaus T. Preissner, Sandip M. Kanse

Biochem J (2007) 404 (2): 191–196.

https://doi.org/10.1042/BJ20061630

Published: 14 May 2007

... correspondence should be addressed (email [email protected] ). 31 10 2006 29 1 2007 14 2 2007 14 2 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 atherosclerosis Factor VII-activating protease (FSAP) low-density lipoprotein...

View articletitled, Inhibition of PDGF-BB by Factor VII-activating protease (FSAP) is neutralized by protease nexin-1, and the FSAP–inhibitor complexes are internalized via LRP

Includes: Supplementary data

Articles

Nucleic acids potentiate Factor VII-activating protease (FSAP)-mediated cleavage of platelet-derived growth factor-BB and inhibition of vascular smooth muscle cell proliferation

Aya Shibamiya, Lars Muhl, Susanne Tannert-Otto, Klaus T. Preissner, Sandip M. Kanse

Biochem J (2007) 404 (1): 45–50.

https://doi.org/10.1042/BJ20070166

Published: 26 April 2007

... for receptor binding and activation [ 12 ]. 1 To whom correspondence should be addressed (email [email protected] ). 31 1 2007 14 2 2007 14 2 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 atherosclerosis cofactor Factor...

View articletitled, Nucleic acids potentiate Factor VII-activating protease (FSAP)-mediated cleavage of platelet-derived growth factor-BB and inhibition of vascular smooth muscle cell proliferation

Articles

Homocysteine stimulates phosphorylation of NADPH oxidase p47 phox and p67 phox subunits in monocytes via protein kinase Cβ activation

Yaw L. Siow, Kathy K. W. Au-Yeung, Connie W. H. Woo, Karmin O

Biochem J (2006) 398 (1): 73–82.

https://doi.org/10.1042/BJ20051810

Published: 27 July 2006

...Yaw L. Siow; Kathy K. W. Au-Yeung; Connie W. H. Woo; Karmin O Hyperhomocysteinaemia is an independent risk factor for cardiovascular diseases due to atherosclerosis. The development of atherosclerosis involves reactive oxygen species-induced oxidative stress in vascular cells. Our previous study...

View articletitled, Homocysteine stimulates phosphorylation of NADPH oxidase p47 phox and p67 phox subunits in monocytes via protein kinase Cβ activation

Articles

ABCA1-dependent but apoA-I-independent cholesterol efflux mediated by fatty acid–bile acid conjugates (FABACs)

Ilana Goldiner, Astrid E. van der Velde, Kristin E. Vandenberghe, Michel A. van Wijland, Zamir Halpern, Tuvia Gilat, Fred M. Konikoff, Robert Jan Veldman, Albert K. Groen

Biochem J (2006) 396 (3): 529–536.

https://doi.org/10.1042/BJ20051694

Published: 29 May 2006

... molecule that induces ABCA1-dependent cholesterol efflux without affecting transcriptional control. These findings may explain the beneficial effect of the compound on atherosclerosis. 1 These authors contributed equally to this work. 2 To whom correspondence should be addressed (email...

View articletitled, ABCA1-dependent but apoA-I-independent cholesterol efflux mediated by fatty acid–bile acid conjugates (FABACs)

Articles

Herpes simplex virus type 1-encoded glycoprotein C contributes to direct coagulation Factor X–virus binding

Joel R. Livingston, Michael R. Sutherland, Harvey M. Friedman, Edward L. G. Pryzdial

Biochem J (2006) 393 (2): 529–535.

https://doi.org/10.1042/BJ20051313

Published: 23 December 2005

... 2005 7 10 2005 7 10 2005 The Biochemical Society, London 2006 atherosclerosis coagulation Factor X herpes simplex virus Herpesvirus thrombosis HSV1 (herpes simplex virus type 1) is a highly prevalent human pathogen with the ability to injure the vascular endothelium...

View articletitled, Herpes simplex virus type 1-encoded glycoprotein C contributes to direct coagulation Factor X–virus binding

Articles

Decreased lipid efflux and increased susceptibility to cholesterol-induced apoptosis in macrophages lacking phosphatidylcholine transfer protein

Juan M. BAEZ, Ira TABAS, David E. COHEN

Biochem J (2005) 388 (1): 57–63.

https://doi.org/10.1042/BJ20041899

Published: 10 May 2005

...-induced cytotoxicity. apolipoprotein AI atherosclerosis cholesterol macrophage mice phosphatidylcholine transfer protein Cellular homogenates were prepared by adding chilled (4 °C) lysis buffer [20 mM sodium phosphate, 150 mM NaCl, 0.1% SDS, 1% Nonidet P40 and Complete protease inhibitor...

View articletitled, Decreased lipid efflux and increased susceptibility to cholesterol-induced apoptosis in macrophages lacking phosphatidylcholine transfer protein

Articles

Expression and regulation of sterol 27-hydroxylase (CYP27A1) in human macrophages: a role for RXR and PPARγ ligands

Carmel M. QUINN, Wendy JESSUP, Jenny WONG, Leonard KRITHARIDES, Andrew J. BROWN

Biochem J (2005) 385 (3): 823–830.

https://doi.org/10.1042/BJ20041776

Published: 24 January 2005

...Carmel M. QUINN; Wendy JESSUP; Jenny WONG; Leonard KRITHARIDES; Andrew J. BROWN CYP27A1 (sterol 27-hydroxylase) catalyses an important sterol elimination pathway in the human macrophage, and consequently may protect against atherosclerosis. We studied the expression and regulation of CYP27A1...

View articletitled, Expression and regulation of sterol 27-hydroxylase (CYP27A1) in human macrophages: a role for RXR and PPARγ ligands

Articles

Identification of the growth hormone-releasing peptide binding site in CD36: a photoaffinity cross-linking study

Annie DEMERS, Normand McNICOLL, Maria FEBBRAIO, Marc SERVANT, Sylvie MARLEAU, Roy SILVERSTEIN, Huy ONG

Biochem J (2004) 382 (2): 417–424.

https://doi.org/10.1042/BJ20040036

Published: 24 August 2004

... Society, London 2004 atherosclerosis CD36 growth hormone-releasing peptide hexarelin oxidized low-density lipoprotein photoaffinity labelling The GHRPs (growth hormone-releasing peptides) comprise a family of small synthetic peptides derived from Met-enkephalin that demonstrate potent...

View articletitled, Identification of the growth hormone-releasing peptide binding site in CD36: a photoaffinity cross-linking study

Articles

Galactose-specific asialoglycoprotein receptor is involved in lipoprotein (a) catabolism

Andelko HRZENJAK, Sasa FRANK, Xingde WO, Yonggang ZHOU, Theo van BERKEL, Gert M. KOSTNER

Biochem J (2003) 376 (3): 765–771.

https://doi.org/10.1042/bj20030932

Published: 15 December 2003

... and 2-fold faster degradation of native Lp(a) com- pared with control cells. Our results for the first time demonstrate a physiological function of ASGPR in the catabolism of Lp(a). Key words: adenoviral vector, atherosclerosis, glycoprotein, hedgehog, lipoprotein (a), sialic acid. INTRODUCTION...

View articletitled, Galactose-specific asialoglycoprotein receptor is involved in lipoprotein (a) catabolism

Articles

Functional specificity of two hormone response elements present on the human apoA-II promoter that bind retinoid X receptor α/thyroid receptor β heterodimers for retinoids and thyroids: synergistic interactions between thyroid receptor β and upstream stimulatory factor 2a

Eudoxia HATZIVASSILIOU, George KOUKOS, Agnes RIBEIRO, Vassilis ZANNIS, Dimitris KARDASSIS

Biochem J (2003) 376 (2): 423–431.

https://doi.org/10.1042/bj20030549

Published: 01 December 2003

... The Biochemical Society, London ©2003 2003 apolipoprotein atherosclerosis gene regulation hormone nuclear receptor thyroid hormone-responsive element transcriptional synergism Abbreviations used: apoA-II, apolipoprotein A-II; ARP-1, apoA-I regulatory protein 1; CAT, chloramphenicol...

View articletitled, Functional specificity of two hormone response elements present on the human apoA-II promoter that bind retinoid X receptor α/thyroid receptor β heterodimers for retinoids and thyroids: synergistic interactions between thyroid receptor β and upstream stimulatory factor 2a

Articles

Fractalkine (CX3CL1) stimulated by nuclear factor kappaB (NF-kappaB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway

Bysani CHANDRASEKAR, Srinivas MUMMIDI, Rao P. PERLA, Sailaja BYSANI, Nickolai O. DULIN, Feng LIU, Peter C. MELBY

Biochem J (2003) 373 (2): 547–558.

https://doi.org/10.1042/bj20030207

Published: 15 July 2003

... SMC proliferation, indicating a role in initiation and progression of atherosclerotic vascular disease. Key words: atherosclerosis, autoregulation, cell adhesion, CX3C receptor 1 (CX3CR1), fractalkine (CX3CL1), mitosis, nuclear factor B (NF- B). INTRODUCTION Recruitment, activation and subsequent...

View articletitled, Fractalkine (CX3CL1) stimulated by nuclear factor kappaB (NF-kappaB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway

Articles

Heparan sulphate glycosaminoglycans derived from endothelial cells and smooth muscle cells differentially modulate fibroblast growth factor-2 biological activity through fibroblast growth factor receptor-1

David BERRY, Zachary SHRIVER, Barbara NATKE, Chi-Pong KWAN, Ganesh VENKATARAMAN, Ram SASISEKHARAN

Biochem J (2003) 373 (1): 241–249.

https://doi.org/10.1042/bj20021760

Published: 01 July 2003

... cell types. 1 To whom correspondence should be addressed (e-mail [email protected] ). 11 11 2002 11 3 2003 27 3 2003 27 3 2003 The Biochemical Society, London ©2003 2003 atherosclerosis extracellular matrix heparin Abbreviations used: BAEC, bovine aortic...

View articletitled, Heparan sulphate glycosaminoglycans derived from endothelial cells and smooth muscle cells differentially modulate fibroblast growth factor-2 biological activity through fibroblast growth factor receptor-1

Articles

Paraoxonase-1 promoter haplotypes and serum paraoxonase: a predominant role for polymorphic position −107, implicating the Sp1 transcription factor

Sara DEAKIN, Ilia LEVIEV, Marie-Claude BRULHART-MEYNET, Richard W. JAMES

Biochem J (2003) 372 (2): 643–649.

https://doi.org/10.1042/bj20021670

Published: 01 June 2003

... 2003 14 3 2003 The Biochemical Society, London ©2003 2003 atherosclerosis haplotype lipoprotein oxidative stress polymorphism promoter Abbreviations used: ASO, allele-specific oligonucleotides; EMSA, electrophoretic mobility-shift assay; HDL, high-density lipoprotein...

View articletitled, Paraoxonase-1 promoter haplotypes and serum paraoxonase: a predominant role for polymorphic position −107, implicating the Sp1 transcription factor

Articles

Early stimulation and late inhibition of peroxisome proliferator-activated receptor gamma (PPARgamma) gene expression by transforming growth factor beta in human aortic smooth muscle cells: role of early growth-response factor-1 (Egr-1), activator protein 1 (AP1) and Smads

Mingui FU, Jifeng ZHANG, Yimin LIN, Xiaojun ZHU, Luning ZHAO, Mushtaq AHMAD, Markus U. EHRENGRUBER, Yuqing E. CHEN

Biochem J (2003) 370 (3): 1019–1025.

https://doi.org/10.1042/bj20021503

Published: 15 March 2003

...: atherosclerosis, peroxisome proliferator-activated receptor c (PPARc), signal transduction, transcriptional factor, transforming growth factor b (TGFb). data suggest that the TGFb and PPARc signal transduction pathways may regulate each other. PPARc is a ligand-activated nuclear transcriptional factor [7,8...

View articletitled, Early stimulation and late inhibition of peroxisome proliferator-activated receptor gamma (PPARgamma) gene expression by transforming growth factor beta in human aortic smooth muscle cells: role of early growth-response factor-1 (Egr-1), activator protein 1 (AP1) and Smads

Articles

Detection of HOCl-mediated protein oxidation products in the extracellular matrix of human atherosclerotic plaques

Alan A. WOODS, Stuart M. LINTON, Michael J. DAVIES

Biochem J (2003) 370 (2): 729–735.

https://doi.org/10.1042/bj20021710

Published: 01 March 2003

...Alan A. WOODS; Stuart M. LINTON; Michael J. DAVIES Oxidation is believed to play a role in atherosclerosis. Oxidized lipids, sterols and proteins have been detected in early, intermediate and advanced human lesions at elevated levels. The spectrum of oxidized side-chain products detected...

View articletitled, Detection of HOCl-mediated protein oxidation products in the extracellular matrix of human atherosclerotic plaques

Articles

Comparison of nitration and oxidation of tyrosine in advanced human carotid plaque proteins

Lincoln W. MORTON, Ian B. PUDDEY, Kevin D. CROFT

Biochem J (2003) 370 (1): 339–344.

https://doi.org/10.1042/bj20020964

Published: 15 February 2003

...Lincoln W. MORTON; Ian B. PUDDEY; Kevin D. CROFT The importance of reactive nitrogen species in atherosclerosis remains poorly understood, despite the semi-quantitative evidence for the presence of 3-nitrotyrosine provided by immunohistochemical staining studies. At this time, there appear...

View articletitled, Comparison of nitration and oxidation of tyrosine in advanced human carotid plaque proteins

Articles

Transcriptional regulation of the rat type IIA phospholipase A2 gene by cAMP and interleukin-1β in vascular smooth muscle cells: interplay of the CCAAT/enhancer binding protein (C/EBP), nuclear factor-κB and Ets transcription factors

Valérie ANTONIO, Arthur BROUILLET, Brigitte JANVIER, Claire MONNE, Gilbert BEREZIAT, Marise ANDREANI, Michel RAYMONDJEAN

Biochem J (2002) 368 (2): 415–424.

https://doi.org/10.1042/bj20020658

Published: 01 December 2002

...Valérie ANTONIO; Arthur BROUILLET; Brigitte JANVIER; Claire MONNE; Gilbert BEREZIAT; Marise ANDREANI; Michel RAYMONDJEAN The abundant secretion of type IIA secreted phospholipase A 2 (sPLA 2 ) is a major feature of the inflammatory process of atherosclerosis. sPLA 2 is crucial for the development...

View articletitled, Transcriptional regulation of the rat type IIA phospholipase A2 gene by cAMP and interleukin-1β in vascular smooth muscle cells: interplay of the CCAAT/enhancer binding protein (C/EBP), nuclear factor-κB and Ets transcription factors

Articles

Pre- and post-translational negative effect of β-adrenoceptor agonists on adiponectin secretion: in vitro and in vivo studies

Marie-Laure DELPORTE, Tohru FUNAHASHI, Masahiko TAKAHASHI, Yuji MATSUZAWA, Sonia M. BRICHARD

Biochem J (2002) 367 (3): 677–685.

https://doi.org/10.1042/bj20020610

Published: 01 November 2002

...Marie-Laure DELPORTE; Tohru FUNAHASHI; Masahiko TAKAHASHI; Yuji MATSUZAWA; Sonia M. BRICHARD The adipose-derived hormone, adiponectin (ApN), has a role in fuel homoeostasis, insulin action and atherosclerosis. Regulation of ApN by catecholamines has scarcely been investigated. We examined...

View articletitled, Pre- and post-translational negative effect of β-adrenoceptor agonists on adiponectin secretion: in vitro and in vivo studies

Articles

Binding of C-reactive protein to modified low-density-lipoprotein particles: identification of cholesterol as a novel ligand for C-reactive protein

Sanna TASKINEN, Petri T. KOVANEN, Hanna JARVA, Seppo MERI, Markku O. PENTIKÄINEN

Biochem J (2002) 367 (2): 403–412.

https://doi.org/10.1042/bj20020492

Published: 15 October 2002

... in mediating CRP binding. Consistent with this hypothesis were the following INTRODUCTION There is compelling evidence that inflammation plays an im- portant role in atherosclerosis [1]. A major cause of chronic inflammation in the atherosclerotic arterial wall is the presence of extracellularly located low...

View articletitled, Binding of C-reactive protein to modified low-density-lipoprotein particles: identification of cholesterol as a novel ligand for C-reactive protein

Articles

Transcriptional regulation of the human carboxyl ester lipase gene in THP-1 monocytes: an E-box required for activation binds upstream stimulatory factors 1 and 2

Sara H.M. BENGTSSON, Katja MADEYSKI-BENGTSON, Jeanette NILSSON, Gunnar BJURSELL

Biochem J (2002) 365 (2): 481–488.

https://doi.org/10.1042/bj20020223

Published: 15 July 2002

..., the presence of CEL in human plasma suggests that the role of CEL in lipid metabolism may stretch beyond its function in the intestinal lumen, and possibly include interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. We have used the CEL-expressing human...

View articletitled, Transcriptional regulation of the human carboxyl ester lipase gene in THP-1 monocytes: an E-box required for activation binds upstream stimulatory factors 1 and 2

Articles

The terminal six amino-acids of the carboxy cytoplasmic tail of CD36 contain a functional domain implicated in the binding and capture of oxidized low-density lipoprotein

Eric MALAUD, Delphine HOURTON, Louise Marie GIROUX, Ewa NINIO, Robin BUCKLAND, John L. McGREGOR

Biochem J (2002) 364 (2): 507–515.

https://doi.org/10.1042/bj20011373

Published: 01 June 2002

.... 1 To whom correspondence should be addressed (e-mail [email protected] ). 27 9 2001 29 1 2002 13 3 2002 The Biochemical Society, London ©2002 2002 atherosclerosis foam cells macrophages scavenger receptors Abbreviations used: LDL, low-density...

View articletitled, The terminal six amino-acids of the carboxy cytoplasmic tail of CD36 contain a functional domain implicated in the binding and capture of oxidized low-density lipoprotein

Articles

Macrophage metalloproteinases degrade high-density-lipoprotein-associated apolipoprotein A-I at both the N- and C-termini

Ivano EBERINI, Laura CALABRESI, Robin WAIT, Gabriella TEDESCHI, Angela PIRILLO, Lina PUGLISI, Cesare R. SIRTORI, Elisabetta GIANAZZA

Biochem J (2002) 362 (3): 627–634.

https://doi.org/10.1042/bj3620627

Published: 08 March 2002

... The Biochemical Society, London ©2002 2002 atherosclerosis mass spectrometry matrix metalloproteinase proteolysis two-dimensional electrophoresis Abbreviations used: apoA-I, apolipoprotein A-I; GGE, gradient gel electrophoresis; HDL, high-density lipoprotein; HUVEC, human umbilical vein...

View articletitled, Macrophage metalloproteinases degrade high-density-lipoprotein-associated apolipoprotein A-I at both the N- and C-termini

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Induction of glutathione synthesis by oxidized low-density lipoprotein and 1-palmitoyl-2-arachidonyl phosphatidylcholine: protection against quinone-mediated oxidative stress

Douglas R. MOELLERING, Anna-Liisa LEVONEN, Young-Mi GO, Rakesh P. PATEL, Dale A. DICKINSON, Henry Jay FORMAN, Victor M. DARLEY-USMAR

Biochem J (2002) 362 (1): 51–59.

https://doi.org/10.1042/bj3620051

Published: 08 February 2002

... be addressed ([email protected]). 19 9 2001 28 11 2001 The Biochemical Society, London ©2002 2002 antioxidants apoptosis atherosclerosis glutamate–cysteine ligase Abbreviations used: oxLDL, oxidized low-density lipoprotein; nLDL, native LDL; GCL, glutamate—cysteine ligase...

View articletitled, Induction of glutathione synthesis by oxidized low-density lipoprotein and 1-palmitoyl-2-arachidonyl phosphatidylcholine: protection against quinone-mediated oxidative stress

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Platelet-activating factor acetylhydrolase and transacetylase activities in human plasma low-density lipoprotein

Demokritos C. TSOUKATOS, Theodoros A. LIAPIKOS, Alexandros D. TSELEPIS, M. John CHAPMAN, Ewa NINIO

Biochem J (2001) 357 (2): 457–464.

https://doi.org/10.1042/bj3570457

Published: 09 July 2001

... and acetylhydrolase activities which remove PAF and its ether-linked analogues from LDL particles upon LDL oxidation. However, in atherogenic small dense LDL-5 particles, the transacetylase activity may acetylate extracellular lyso-PAF into biologically active PAF. Key words: atherosclerosis, inflammation...

View articletitled, Platelet-activating factor acetylhydrolase and transacetylase activities in human plasma low-density lipoprotein

Articles

Homocysteine stimulates the expression of monocyte chemoattractant protein-1 receptor (CCR2) in human monocytes: possible involvement of oxygen free radicals

Guoping WANG, Karmin O

Biochem J (2001) 357 (1): 233–240.

https://doi.org/10.1042/bj3570233

Published: 25 June 2001

...Guoping WANG; Karmin O Homocysteinaemia is an independent risk factor for atherosclerosis. The development of atherosclerosis involves monocyte chemoattractant protein 1 (MCP-1)-mediated monocyte recruitment to the lesion site. The action of MCP-1 is mostly via its interaction with MCP-1 receptor...

View articletitled, Homocysteine stimulates the expression of monocyte chemoattractant protein-1 receptor (CCR2) in human monocytes: possible involvement of oxygen free radicals

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Triacylglycerol-rich lipoproteins alter the secretion, and the cholesterol-effluxing function, of apolipoprotein E-containing lipoprotein particles from human (THP-1) macrophages

E. Marie LINDHOLM, Anna M. PALMER, Annette GRAHAM

Biochem J (2001) 356 (2): 515–523.

https://doi.org/10.1042/bj3560515

Published: 24 May 2001

... risk of atherosclerosis in individuals with Type II diabetes. Biochem. J. (2001) 356, 515 523 (Printed in Great Britain) 515 Triacylglycerol-rich lipoproteins alter the secretion, and the cholesterol- effluxing function, of apolipoprotein E-containing lipoprotein particles from human (THP-1...

View articletitled, Triacylglycerol-rich lipoproteins alter the secretion, and the cholesterol-effluxing function, of apolipoprotein E-containing lipoprotein particles from human (THP-1) macrophages

Articles

Hydrolysis of platelet-activating factor by human serum paraoxonase

Lourdes RODRIGO, Bharti MACKNESS, Paul N. DURRINGTON, Antonio HERNANDEZ, Michael I. MACKNESS

Biochem J (2001) 354 (1): 1–7.

https://doi.org/10.1042/bj3540001

Published: 08 February 2001

... 18 10 2000 1 12 2000 The Biochemical Society, London © 2001 2001 PON1 PAF acetylhydrolase atherosclerosis inflammation Biochem. J. (2001) 354, 1 7 (Printed in Great Britain) 1 Hydrolysis of platelet-activating factor by human serum paraoxonase Lourdes RODRIGO*, Bharti...

View articletitled, Hydrolysis of platelet-activating factor by human serum paraoxonase

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Oxidized low-density lipoprotein and peroxisome-proliferator-activated receptor α down-regulate platelet-activating-factor receptor expression in human macrophages

Delphine HOURTON, Philippe DELERIVE, Jana STANKOVA, Bart STAELS, M. John CHAPMAN, Ewa NINIO

Biochem J (2001) 354 (1): 225–232.

https://doi.org/10.1042/bj3540225

Published: 08 February 2001

... correspondence should be addressed (e-mail [email protected] ). 27 7 2000 29 9 2000 26 10 2000 The Biochemical Society, London © 2001 2001 atherosclerosis inflammation thiobarbituric-acid-reactive substances Biochem. J. (2001) 354, 225 232 (Printed in Great Britain) 225...

View articletitled, Oxidized low-density lipoprotein and peroxisome-proliferator-activated receptor α down-regulate platelet-activating-factor receptor expression in human macrophages

Articles

Tunicamycin induces ubiquitination and degradation of apolipoprotein B in HepG2 cells

Wei LIAO, Lawrence CHAN

Biochem J (2001) 353 (3): 493–501.

https://doi.org/10.1042/bj3530493

Published: 25 January 2001

[email protected] ). 3 8 2000 25 10 2000 13 11 2000 The Biochemical Society, London © 2001 2001 atherosclerosis lactacystin lipoproteins proteasome ubiquitin Biochem. J. (2001) 353, 493 501 (Printed in Great Britain) 493 Tunicamycin induces ubiquitination and degradation...

View articletitled, Tunicamycin induces ubiquitination and degradation of apolipoprotein B in HepG2 cells

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The latent transforming growth factor β binding protein (LTBP) family

Rahmi ÖKLÜ, Robin HESKETH

Biochem J (2000) 352 (3): 601–610.

https://doi.org/10.1042/bj3520601

Published: 08 December 2000

... correspondence should be addressed (e-mail [email protected] ). The Biochemical Society, London © 2000 2000 atherosclerosis cancer fibrillin Marfans syndrome TGFβ Biochem. J. (2000) 352, 601 610 (Printed in Great Britain) 601 REVIEW ARTICLE The latent transforming growth factor b...

View articletitled, The latent transforming growth factor β binding protein (LTBP) family

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Homocysteine stimulates nuclear factor κB activity and monocyte chemoattractant protein-1 expression in vascular smooth-muscle cells: a possible role for protein kinase C

Guoping WANG, Yaw L. SIOW, Karmin O

Biochem J (2000) 352 (3): 817–826.

https://doi.org/10.1042/bj3520817

Published: 08 December 2000

... activation may play an important role in atherogenesis. atherosclerosis calcium IκBα oxidative stress phosphorylation Biochem. J. (2000) 352, 817 826 (Printed in Great Britain) 817 Homocysteine stimulates nuclear factor jB activity and monocyte chemoattractant protein-1 expression in vascular...

View articletitled, Homocysteine stimulates nuclear factor κB activity and monocyte chemoattractant protein-1 expression in vascular smooth-muscle cells: a possible role for protein kinase C

Articles

Oxidized low-density lipoprotein impairs the anti-coagulant function of tissue-factor-pathway inhibitor through oxidative modification by its high association and accelerated degradation in cultured human endothelial cells

Shuichi HORIE, Sayuri HIRAISHI, Yukiyo HIRATA, Mutsuyoshi KAZAMA, Juzo MATSUDA

Biochem J (2000) 352 (2): 277–285.

https://doi.org/10.1042/bj3520277

Published: 24 November 2000

... should be addressed (e-mail [email protected] ). 2 6 2000 21 8 2000 15 9 2000 The Biochemical Society, London © 2000 2000 atherosclerosis Factor X lactacystin lysophosphatidic acid Biochem. J. (2000) 352, 277 285 (Printed in Great Britain) 277 Oxidized low...

View articletitled, Oxidized low-density lipoprotein impairs the anti-coagulant function of tissue-factor-pathway inhibitor through oxidative modification by its high association and accelerated degradation in cultured human endothelial cells

Articles

Vitamin C protects against and reverses specific hypochlorous acid- and chloramine-dependent modifications of low-density lipoprotein

Anitra C. CARR, Terry TIJERINA, Balz FREI

Biochem J (2000) 346 (2): 491–499.

https://doi.org/10.1042/bj3460491

Published: 22 February 2000

... of atherosclerosis, our data indicate that vitamin C could contribute to the anti-atherogenic defence against HOCl. 14 10 1999 1 12 1999 4 1 2000 The Biochemical Society, London © 2000 2000 Biochem. J. (2000) 346, 491 499 (Printed in Great Britain) 491 Vitamin C protects against and reverses...

View articletitled, Vitamin C protects against and reverses specific hypochlorous acid- and chloramine-dependent modifications of low-density lipoprotein

Articles

Apolipoprotein serum amyloid A down-regulates smooth-muscle cell lipid biosynthesis

Barbara M. SCHREIBER, Mara VEVERBRANTS, Richard E. FINE, Jan K. BLUSZTAJN, Mario SALMONA, Apurva PATEL, Jean D. SIPE

Biochem J (1999) 344 (1): 7–13.

https://doi.org/10.1042/bj3440007

Published: 08 November 1999

... of cholesterol and phospholipid. The implications of these findings for atherosclerosis and Alzheimer's disease are discussed. 1 To whom correspondence should be addressed (e-mail [email protected]). 2 Present address: National Institutes of Health, SSS2, CSR, 6701 Rockledge Drive...

View articletitled, Apolipoprotein serum amyloid A down-regulates smooth-muscle cell lipid biosynthesis

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