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Keywords: autoinhibition
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Articles
Biochem J (2021) 478 (8): 1525–1545.
Published: 21 April 2021
...-associated and partly autoinhibited form, in which concealing the W 57 L and E 160 xxxLL motifs prevents premature down-regulation in absence of CD4 or other surface receptors, such as CD3. Once a specific ligand binds to the ɑ1–ɑ2 groove, W 57 L and the endocytosis motif would get exposed to trigger down...
Includes: Supplementary data
Articles
Biochem J (2020) 477 (19): 3769–3790.
Published: 12 October 2020
... cations. Correspondence: Rosa Laura López-Marqués ( rlo@plen.ku.dk ) 2 7 2020 2 9 2020 16 9 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 autoinhibition CDC50 protein cryo-electron microscopy flippases lipid...
Articles
Biochem J (2017) 474 (3): 385–398.
Published: 20 January 2017
... domain. Using site-directed mutagenesis, we identify residues in the KA1 domain required for this autoinhibitory activity, and find that residues involved in autoinhibition and in anionic phospholipid binding are the same. We also demonstrate that a ‘mini’ MARK1 becomes activated upon association...
Includes: Supplementary data
Articles
Biochem J (2012) 448 (2): 213–220.
Published: 07 November 2012
... A, a nerve growth factor receptor) and Ror2 (receptor tyrosine kinase-like orphan receptor 2, an unconventional Wnt receptor). TrkA autoinhibition closely resembles that seen for the insulin receptor, relying on projection of an activation loop tyrosine residue into the substrate-binding site and occlusion...
Articles
Biochem J (2012) 443 (1): 125–131.
Published: 14 March 2012
...Irene C. Mangialavori; Gerardo Corradi; Débora E. Rinaldi; María Candelaria de la Fuente; Hugo P. Adamo; Juan Pablo F. C. Rossi The autoinhibition/activation of the PMCA (plasma membrane Ca 2+ -ATPase) involves conformational changes in the membrane region of the protein that affect the amount...
Articles
Biochem J (2010) 432 (3): 525–538.
Published: 25 November 2010
... ], the autoinhibition-sensitive 1A3 or 2H12 antibody specifically recognizes Patch 2 in the Bro1 domain or the p6 Gag /p9 Gag -binding site (Phe 676 pocket) in the V domain, whereas the 1F7 and 1A12/3A9 antibodies recognize the PRD-adjacent 436–709 and 605–709 regions of ALIX respectively. Figure 1 (B) illustrates...
Includes: Supplementary data
Articles
Biochem J (2003) 373 (2): 571–581.
Published: 15 July 2003
...Angie F. KIRWAN; Ashley C. BIBBY; Thierry MVILONGO; Heimo RIEDEL; Thomas BURKE; Sherri Z. MILLIS; Amadeo M. PARISSENTI The N-terminal pseudosubstrate site within the protein kinase Cα (PKCα)-regulatory domain has long been regarded as the major determinant for autoinhibition of catalytic domain...
Articles
Biochem J (2002) 364 (3): 593–611.
Published: 15 June 2002
... protein kinase. 1 To whom correspondence should be addressed (e-mail ahudmon@stanford.edu or schulman@cmgm.stanford.edu ). The Biochemical Society, London ©2002 2002 autoinhibition autophosphorylation calmodulin calcium oscillation learning and memory Abbreviations used: CaM...
Articles
Biochem J (2000) 348 (2): 241–255.
Published: 23 May 2000
... analysis of Rho GTPases in lower eukaryotes is making increasingly important contributions to this field. 1 To whom correspondence should be addressed (e-mail anne.bishop@;ucl.ac.uk). The Biochemical Society, London © 2000 2000 actin reorganization autoinhibition CRIB motif HR1 motif...