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Articles

Mitophagy in yeast: known unknowns and unknown unknowns

Hagai Abeliovich

Biochem J (2023) 480 (20): 1639–1657.

https://doi.org/10.1042/BCJ20230279

Published: 18 October 2023

... selectivity. The term autophagy refers to a group of cellular processes that transport material from the cytoplasm into the lumen of the lysosome/vacuole. Various mechanisms have been identified to carry out autophagy [ 1 ], but the two most extensively studied mechanisms in yeast are macroautophagy...

View articletitled, Mitophagy in yeast: known unknowns and unknown unknowns

Articles

The N-coil and the globular N-terminal domain of plant ARGONAUTE1 are interaction hubs for regulatory factors

Simon Bressendorff, Swathi Kausika, Ida Marie Zobbe Sjøgaard, Emilie Duus Oksbjerg, Alec Michels, Christian Poulsen, Peter Brodersen

Biochem J (2023) 480 (13): 957–974.

https://doi.org/10.1042/BCJ20230025

Published: 06 July 2023

.... Here, we use yeast two-hybrid screening with the N domain of the founding member of the AGO protein family, Arabidopsis AGO1, to reveal that it interacts with many factors involved in regulated proteolysis. Interaction with a large group of proteins, including the autophagy cargo receptors ATI1...

View articletitled, The N-coil and the globular N-terminal domain of plant ARGONAUTE1 are interaction hubs for regulatory factors

Includes: Supplementary data

Articles

The cross-talk of autophagy and apoptosis in breast carcinoma: implications for novel therapies?

In Collection

Cell death and survival

Kamil Seyrek, Fabian Wohlfromm, Johannes Espe, Inna N. Lavrik

Biochem J (2022) 479 (14): 1581–1608.

https://doi.org/10.1042/BCJ20210676

Published: 29 July 2022

... therapeutic regimes is needed. Recent studies indicate that modulation of autophagy in concert with apoptosis induction may provide a promising novel strategy in breast cancer treatment. Apoptosis and autophagy are two tightly regulated distinct cellular processes. To maintain tissue homeostasis abnormal...

View articletitled, The cross-talk of autophagy and apoptosis in breast carcinoma: implications for novel therapies?

Articles

FoxO transcription factors in mitochondrial homeostasis

Zhiyong Cheng

Biochem J (2022) 479 (4): 525–536.

https://doi.org/10.1042/BCJ20210777

Published: 23 February 2022

..., and cancer. Mitochondrial homeostasis is controlled by a triad of mitochondrial biogenesis, dynamics (fusion and fission), and autophagy (mitophagy). Studies have underscored FoxO transcription factors as key mitochondrial regulators. Specifically, FoxOs regulate mitochondrial biogenesis by dampening NRF1...

View articletitled, FoxO transcription factors in mitochondrial homeostasis

Articles

The complex interplay between autophagy and cell death pathways

In Collection

Cell death and survival

Christina Ploumi, Margarita-Elena Papandreou, Nektarios Tavernarakis

Biochem J (2022) 479 (1): 75–90.

https://doi.org/10.1042/BCJ20210450

Published: 14 January 2022

...Christina Ploumi; Margarita-Elena Papandreou; Nektarios Tavernarakis Autophagy is a universal cellular homeostatic process, required for the clearance of dysfunctional macromolecules or organelles. This self-digestion mechanism modulates cell survival, either directly by targeting cell death...

View articletitled, The complex interplay between autophagy and cell death pathways

Articles

TFEB phosphorylation on Serine 211 is induced by autophagy in human synovial fibroblasts and by p62/SQSTM1 overexpression in HEK293 cells

Biserka Relic, Celine Deroyer, Olivier Malaise, Zelda Plener, Philippe Gillet, Dominique de Seny, Michel G. Malaise

Biochem J (2021) 478 (16): 3145–3155.

https://doi.org/10.1042/BCJ20210174

Published: 27 August 2021

...Biserka Relic; Celine Deroyer; Olivier Malaise; Zelda Plener; Philippe Gillet; Dominique de Seny; Michel G. Malaise Autophagy receptor p62/SQSTM1 signals a complex network that links autophagy-lysosomal system to proteasome. Phosphorylation of p62 on Serine 349 (P-Ser349 p62) is involved in a cell...

View articletitled, TFEB phosphorylation on Serine 211 is induced by autophagy in human synovial fibroblasts and by p62/SQSTM1 overexpression in HEK293 cells

Articles

Inhibition of selective autophagy by members of the herpesvirus ubiquitin-deconjugase family

Päivi Ylä-Anttila, Maria G. Masucci

Biochem J (2021) 478 (12): 2297–2308.

https://doi.org/10.1042/BCJ20210225

Published: 18 June 2021

...Päivi Ylä-Anttila; Maria G. Masucci Autophagy is an important component of the innate immune response that restricts infection by different types of pathogens. Viruses have developed multiple strategies to avoid autophagy to complete their replication cycle and promote spreading to new hosts. Here...

View articletitled, Inhibition of selective autophagy by members of the herpesvirus ubiquitin-deconjugase family

Articles

Understanding amphisomes

Dhasarathan Ganesan, Qian Cai

Biochem J (2021) 478 (10): 1959–1976.

https://doi.org/10.1042/BCJ20200917

Published: 28 May 2021

... the intersection of the autophagy and endo-lysosomal pathways. Importantly, amphisomes can also participate in non-canonical functions, such as retrograde neurotrophic signaling or autophagy-based unconventional secretion by fusion with the plasma membrane. In this review, we provide an updated overview...

View articletitled, Understanding amphisomes

Articles

Plasmodium falciparum Atg18 localizes to the food vacuole via interaction with the multi-drug resistance protein 1 and phosphatidylinositol 3-phosphate

Renu Sudhakar, Divya Das, Subramanian Thanumalayan, Somesh Gorde, Puran Singh Sijwali

Biochem J (2021) 478 (9): 1705–1732.

https://doi.org/10.1042/BCJ20210001

Published: 10 May 2021

...Renu Sudhakar; Divya Das; Subramanian Thanumalayan; Somesh Gorde; Puran Singh Sijwali Autophagy, a lysosome-dependent degradative process, does not appear to be a major degradative process in malaria parasites and has a limited repertoire of genes. To better understand the autophagy process, we...

View articletitled, Plasmodium falciparum Atg18 localizes to the food vacuole via interaction with the multi-drug resistance protein 1 and phosphatidylinositol 3-phosphate

Includes: Supplementary data

Articles

Role of macrophage autophagy in atherosclerosis: modulation by bioactive compounds

MD Khurshidul Zahid, Hazera Binte Sufian, Mahua Choudhury, Masao Yamasaki, Ahmed Al-Harrasi, Naima Moustaid-Moussa, Shaikh Mizanoor Rahman

Biochem J (2021) 478 (7): 1359–1375.

https://doi.org/10.1042/BCJ20200894

Published: 16 April 2021

...MD Khurshidul Zahid; Hazera Binte Sufian; Mahua Choudhury; Masao Yamasaki; Ahmed Al-Harrasi; Naima Moustaid-Moussa; Shaikh Mizanoor Rahman Atherosclerosis is a chronic inflammatory disease associated with lipid metabolism disorder. Autophagy is a catabolic process and contributes to maintaining...

View articletitled, Role of macrophage autophagy in atherosclerosis: modulation by bioactive compounds

Articles

Bulk autophagy induction and life extension is achieved when iron is the only limited nutrient in Saccharomyces cerevisiae

Sandra Montella-Manuel, Nuria Pujol-Carrion, Mónica A. Mechoud, Maria Angeles de la Torre-Ruiz

Biochem J (2021) 478 (4): 811–837.

https://doi.org/10.1042/BCJ20200849

Published: 24 February 2021

...Sandra Montella-Manuel; Nuria Pujol-Carrion; Mónica A. Mechoud; Maria Angeles de la Torre-Ruiz We have investigated the effects that iron limitation provokes in Saccharomyces cerevisiae exponential cultures. We have demonstrated that one primary response is the induction of bulk autophagy mediated...

View articletitled, Bulk autophagy induction and life extension is achieved when iron is the only limited nutrient in Saccharomyces cerevisiae

Articles

Amino acid starvation inhibits autophagy in lipid droplet-deficient cells through mitochondrial dysfunction

Pierre Voisin, Marianne Bernard, Thierry Bergès, Matthieu Régnacq

Biochem J (2020) 477 (18): 3613–3623.

https://doi.org/10.1042/BCJ20200551

Published: 28 September 2020

... that lipid droplets are required for autophagy to proceed in response to nitrogen starvation and that they play an essential role in maintaining ER homeostasis. Autophagy is a major catabolic pathway that helps degradation and recycling of potentially harmful proteins and organelles. It can...

View articletitled, Amino acid starvation inhibits autophagy in lipid droplet-deficient cells through mitochondrial dysfunction

Includes: Supplementary data

Articles

Structure, dynamics and functions of UBQLNs: at the crossroads of protein quality control machinery

Tongyin Zheng, Yiran Yang, Carlos A. Castañeda

Biochem J (2020) 477 (18): 3471–3497.

https://doi.org/10.1042/BCJ20190497

Published: 23 September 2020

..., including facilitating degradation of substrates through the ubiquitin–proteasome system (UPS), autophagy, and endoplasmic-reticulum-associated protein degradation (ERAD) pathways. In addition, UBQLNs engage with chaperones to sequester, degrade, or assist repair of misfolded client proteins. Furthermore...

View articletitled, Structure, dynamics and functions of UBQLNs: at the crossroads of protein quality control machinery

Articles

The identification and characterisation of autophagy inhibitors from the published kinase inhibitor sets

Maria Zachari, Julie M. Rainard, George C. Pandarakalam, Lindsay Robinson, Jonathan Gillespie, Muralikrishnan Rajamanickam, Veronique Hamon, Angus Morrison, Ian G. Ganley, Stuart P. McElroy

Biochem J (2020) 477 (4): 801–814.

https://doi.org/10.1042/BCJ20190846

Published: 27 February 2020

...Maria Zachari; Julie M. Rainard; George C. Pandarakalam; Lindsay Robinson; Jonathan Gillespie; Muralikrishnan Rajamanickam; Veronique Hamon; Angus Morrison; Ian G. Ganley; Stuart P. McElroy Autophagy is a critical cellular homeostatic mechanism, the dysfunction of which has been linked to a wide...

View articletitled, The identification and characterisation of autophagy inhibitors from the published kinase inhibitor sets

Includes: Supplementary data

Articles

MitoTimer-based high-content screen identifies two chemically-related benzothiophene derivatives that enhance basal mitophagy

Fernanda M. Cerqueira, Noga Kozer, Anton Petcherski, Boris M. Baranovski, Dane Wolf, Essam A. Assali, Yaelle Roth, Roi Gazit, Haim Barr, Eli C. Lewis, Guy Las, Orian S. Shirihai

Biochem J (2020) 477 (2): 461–475.

https://doi.org/10.1042/BCJ20190616

Published: 31 January 2020

... autophagy, mitophagy [ 1–4 ]. The balance between these two opposing forces determines the mitochondrial turnover rate, allowing for a constant, tissue-specific, mitochondrial mass, which can be challenged by physiological demands [ 5 ]. Physical exercise and calorie restriction, for example, enhance...

View articletitled, MitoTimer-based high-content screen identifies two chemically-related benzothiophene derivatives that enhance basal mitophagy

Includes: Supplementary data

Articles

A lysosome independent role for TFEB in activating DNA repair and inhibiting apoptosis in breast cancer cells

Logan Slade, Dipsikha Biswas, Francis Ihionu, Yassine El Hiani, Petra C. Kienesberger, Thomas Pulinilkunnil

Biochem J (2020) 477 (1): 137–160.

https://doi.org/10.1042/BCJ20190596

Published: 10 January 2020

...Logan Slade; Dipsikha Biswas; Francis Ihionu; Yassine El Hiani; Petra C. Kienesberger; Thomas Pulinilkunnil Transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis and autophagy with critical roles in several cancers. Lysosomal autophagy promotes cancer survival through...

View articletitled, A lysosome independent role for TFEB in activating DNA repair and inhibiting apoptosis in breast cancer cells

Includes: Supplementary data

Articles

Starvation-induced autophagy is up-regulated via ROS-mediated ClC-3 chloride channel activation in the nasopharyngeal carcinoma cell line CNE-2Z

Yanfang Zheng, Zhanru Chen, Zhuoyu Gu, Xiaoya Yang, Meisheng Yu, Chan Zhao, Jiawei Lin, Peisheng Xu, Linyan Zhu, Tim J. C. Jacob, Shuang Peng, Lixin Chen, Liwei Wang

Biochem J (2019) 476 (9): 1323–1333.

https://doi.org/10.1042/BCJ20180979

Published: 07 May 2019

... and uncontrolled proliferation. Therefore, starvation can induce autophagy in these cells. Chloride channel 3 (ClC-3), a member of the chloride channel family, is involved in various biological processes. However, whether ClC-3 plays an important role in starvation-induced autophagy is unclear. In this study...

View articletitled, Starvation-induced autophagy is up-regulated via ROS-mediated ClC-3 chloride channel activation in the nasopharyngeal carcinoma cell line CNE-2Z

Includes: Supplementary data

Articles

PAS domain-containing phosphoglycerate kinase deficiency in Leishmania major results in increased autophagosome formation and cell death

Ayan Adhikari, Saroj Biswas, Aditi Mukherjee, Sumit Das, Subrata Adak

Biochem J (2019) 476 (8): 1303–1321.

https://doi.org/10.1042/BCJ20190041

Published: 30 April 2019

... stimulate PGK activity. Localization studies demonstrate that the protein is highly enriched in the glycosome and its presence can also be seen in the lysosome. Gene knockout, overexpression and complement studies suggest that LmPAS-PGK plays a fundamental role in cell survival through autophagy...

View articletitled, PAS domain-containing phosphoglycerate kinase deficiency in Leishmania major results in increased autophagosome formation and cell death

Includes: Supplementary data

Articles

Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2)

In Collection

Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019

Apirat Chaikuad, Sebastian E. Koschade, Alexandra Stolz, Katarina Zivkovic, Christian Pohl, Shabnam Shaid, Huiyu Ren, Lester J. Lambert, Nicholas D.P. Cosford, Christian H. Brandts, Stefan Knapp

Biochem J (2019) 476 (5): 875–887.

https://doi.org/10.1042/BCJ20190038

Published: 12 March 2019

...Apirat Chaikuad; Sebastian E. Koschade; Alexandra Stolz; Katarina Zivkovic; Christian Pohl; Shabnam Shaid; Huiyu Ren; Lester J. Lambert; Nicholas D.P. Cosford; Christian H. Brandts; Stefan Knapp Autophagy is essential for cellular homeostasis and when deregulated this survival mechanism has been...

View articletitled, Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2)

Includes: Supplementary data

Articles

New insights into niclosamide action: autophagy activation in colorectal cancer

Phillip T. Newton

Biochem J (2019) 476 (5): 779–781.

https://doi.org/10.1042/BCJ20190020

Published: 06 March 2019

... signalling pathway. In a recent paper published in the Biochemical Journal [ Biochem. J. (2019) 476 , 535–546], Wang and colleagues revealed that niclosamide down-regulates β-catenin-dependent WNT signalling in colorectal cancer cells by degrading components of the pathway via autophagy. Autophagy...

View articletitled, New insights into niclosamide action: autophagy activation in colorectal cancer

Articles

Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy

In Collection

Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019

Jiangbo Wang, Xiu-rong Ren, Hailan Piao, Shengli Zhao, Takuya Osada, Richard T. Premont, Robert A. Mook, Jr, Michael A. Morse, Herbert Kim Lyerly, Wei Chen

Biochem J (2019) 476 (3): 535–546.

https://doi.org/10.1042/BCJ20180385

Published: 08 February 2019

... effective inhibitor of Wnt-responsive genes (β-catenin, c-Myc, and Survivin) in the niclosamide-resistant cells than in the niclosamide-sensitive cells, suggesting that deficient autophagy induction by niclosamide compromises the effect of niclosamide on Wnt signaling. Our findings provide a mechanistic...

View articletitled, Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy

Includes: Supplementary data

Articles

The transmembrane autophagy cargo receptors ATI1 and ATI2 interact with ATG8 through intrinsically disordered regions with distinct biophysical properties

Ida Marie Zobbe Sjøgaard, Simon Bressendorff, Andreas Prestel, Swathi Kausika, Emilie Oksbjerg, Birthe B. Kragelund, Peter Brodersen

Biochem J (2019) 476 (3): 449–465.

https://doi.org/10.1042/BCJ20180748

Published: 05 February 2019

...Ida Marie Zobbe Sjøgaard; Simon Bressendorff; Andreas Prestel; Swathi Kausika; Emilie Oksbjerg; Birthe B. Kragelund; Peter Brodersen Selective autophagy has emerged as an important mechanism by which eukaryotic cells control the abundance of specific proteins. This mechanism relies on cargo...

View articletitled, The transmembrane autophagy cargo receptors ATI1 and ATI2 interact with ATG8 through intrinsically disordered regions with distinct biophysical properties

Includes: Supplementary data

Articles

Autophagy in cancer: a complex relationship

Lindsay Wilde, Katherina Tanson, Joseph Curry, Ubaldo Martinez-Outschoorn

Biochem J (2018) 475 (11): 1939–1954.

https://doi.org/10.1042/BCJ20170847

Published: 11 June 2018

... has been made in understanding the mechanisms that underlie this vital cellular process and its specificity. Furthermore, macroautophagy is linked to pathologic conditions such as cancer and is being studied as a therapeutic target. In this review, we will explore the connections between autophagy...

View articletitled, Autophagy in cancer: a complex relationship

Articles

Lipid-based DNA/siRNA transfection agents disrupt neuronal bioenergetics and mitophagy

Eleonora Napoli, Siming Liu, Ilaria Marsilio, Konstantinos Zarbalis, Cecilia Giulivi

Biochem J (2017) 474 (23): 3887–3902.

https://doi.org/10.1042/BCJ20170632

Published: 10 November 2017

...Eleonora Napoli; Siming Liu; Ilaria Marsilio; Konstantinos Zarbalis; Cecilia Giulivi A multitude of natural and artificial compounds have been recognized to modulate autophagy, providing direct or, through associated pathways, indirect entry points to activation and inhibition. While...

View articletitled, Lipid-based DNA/siRNA transfection agents disrupt neuronal bioenergetics and mitophagy

Includes: Supplementary data

Articles

Protease-activated receptor-2 promotes kidney tubular epithelial inflammation by inhibiting autophagy via the PI3K/Akt/mTOR signalling pathway

Chunyang Du, Tao Zhang, Xia Xiao, Yonghong Shi, Huijun Duan, Yunzhuo Ren

Biochem J (2017) 474 (16): 2733–2747.

https://doi.org/10.1042/BCJ20170272

Published: 02 August 2017

.... Autophagy has been previously shown to affect inflammation. In the present study, we examine the effect of PAR2 on kidney tubular epithelial autophagy and on autophagy-related inflammation and reveal the underlying mechanism involved. Autophagic activity and levels of autophagic marker LC3 were examined...

View articletitled, Protease-activated receptor-2 promotes kidney tubular epithelial inflammation by inhibiting autophagy via the PI3K/Akt/mTOR signalling pathway

Articles

The lysosome: a crucial hub for AMPK and mTORC1 signalling

Bernadette Carroll, Elaine A. Dunlop

Biochem J (2017) 474 (9): 1453–1466.

https://doi.org/10.1042/BCJ20160780

Published: 13 April 2017

...-activated protein kinase (AMPK), at the lysosome and how both AMPK and mTORC1 signalling pathways feedback to lysosomal biogenesis and regeneration following autophagy. This review will cover the classical role of the lysosome in autophagy, the dynamic signalling interactions which take place...

View articletitled, The lysosome: a crucial hub for AMPK and mTORC1 signalling

Articles

The pro-inflammatory cytokines IFNγ/TNFα increase chromogranin A-positive neuroendocrine cells in the colonic epithelium

José Antonio Hernández-Trejo, Dimelza Suárez-Pérez, Itzel Zenidel Gutiérrez-Martínez, Omar Eduardo Fernandez-Vargas, Carolina Serrano, Aurora Antonia Candelario-Martínez, Marco Antonio Meraz-Ríos, Alí Francisco Citalán-Madrid, Marcela Hernández-Ruíz, Elba Reyes-Maldonado, Ricardo Valle-Rios, Jacobo H. Feintuch-Unger, Michael Schnoor, Nicolás Villegas-Sepúlveda, Oscar Medina-Contreras, Porfirio Nava

Biochem J (2016) 473 (21): 3805–3818.

https://doi.org/10.1042/BCJ20160390

Published: 27 October 2016

... A (CgA) in the colonic mucosa of C57BL/6J mice. CgA-positive cells were non-proliferating cells enriched with inactive phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and autophagy markers. Moreover, inhibition of Akt and autophagy prevented the increase in CgA-positive cells after IFNγ...

View articletitled, The pro-inflammatory cytokines IFNγ/TNFα increase chromogranin A-positive neuroendocrine cells in the colonic epithelium

Includes: Supplementary data

Articles

Doxorubicin impairs cardiomyocyte viability by suppressing transcription factor EB expression and disrupting autophagy

Jordan J. Bartlett, Purvi C. Trivedi, Pollen Yeung, Petra C. Kienesberger, Thomas Pulinilkunnil

Biochem J (2016) 473 (21): 3769–3789.

https://doi.org/10.1042/BCJ20160385

Published: 27 October 2016

... cellular viability. Collectively, loss of TFEB inhibits lysosomal autophagy, rendering cardiomyocytes susceptible to DOX-induced proteotoxicity and injury. Our data reveal a novel mechanism wherein DOX primes cardiomyocytes for cell death by depleting cellular TFEB. Correspondence: Thomas Pulinilkunnil...

View articletitled, Doxorubicin impairs cardiomyocyte viability by suppressing transcription factor EB expression and disrupting autophagy

Includes: Supplementary data

Articles

The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34

Jonathan M. Backer

Biochem J (2016) 473 (15): 2251–2271.

https://doi.org/10.1042/BCJ20160170

Published: 28 July 2016

[email protected] ). 29 2 2016 25 3 2016 30 3 2016 © 2016 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2016 autophagy Class III phosphoinositide 3-kinase endocytosis phosphoinositide 3-kinase phosphorylation/dephosphorylation Vps34...

View articletitled, The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34

Articles

Nuclear localizations of phosphatidylinositol 5-phosphate 4-kinases α and β are dynamic and independently regulated during starvation-induced stress

Alaa Droubi, Simon J. Bulley, Jonathan H. Clarke, Robin F. Irvine

Biochem J (2016) 473 (14): 2155–2163.

https://doi.org/10.1042/BCJ20160380

Published: 12 July 2016

... a greater degree of nutrient deprivation than their wild-type counterparts possibly as a result of up-regulation of autophagy. The antibody for immunoprecipitation was conjugated to Protein G–Sepharose beads which were then used to immunoprecipitate the target protein from cell-free extract. An excess...

View articletitled, Nuclear localizations of phosphatidylinositol 5-phosphate 4-kinases α and β are dynamic and independently regulated during starvation-induced stress

Includes: Supplementary data

Articles

α-Lipoic acid promotes α-tubulin hyperacetylation and blocks the turnover of mitochondria through mitophagy

Michael W. Stoner, Dharendra Thapa, Manling Zhang, Gregory A. Gibson, Michael J. Calderon, Claudette M. St. Croix, Iain Scott

Biochem J (2016) 473 (12): 1821–1830.

https://doi.org/10.1042/BCJ20160281

Published: 10 June 2016

..., acetylation and autophagy, using chemical inducers of mitochondrial acetyl-CoA production. Treatment of cells with α-lipoic acid (αLA), a cofactor of the pyruvate dehydrogenase complex, led to the unexpected hyperacetylation of α-tubulin in the cytosol. This acetylation was blocked by pharmacological...

View articletitled, α-Lipoic acid promotes α-tubulin hyperacetylation and blocks the turnover of mitochondria through mitophagy

Articles

An essential role for functional lysosomes in ferroptosis of cancer cells

Seiji Torii, Ryosuke Shintoku, Chisato Kubota, Makoto Yaegashi, Ryoko Torii, Masaya Sasaki, Toshinobu Suzuki, Masanobu Mori, Yuhei Yoshimoto, Toshiyuki Takeuchi, Keiichi Yamada

Biochem J (2016) 473 (6): 769–777.

https://doi.org/10.1042/BJ20150658

Published: 10 March 2016

... suggest that lysosomal activity is involved in lipid ROS-mediated ferroptotic cell death through regulation of cellular iron equilibria and ROS generation. autophagy iron necrosis oxidative stress Ras Cell death plays an important role in the normal development and homoeostasis of living...

View articletitled, An essential role for functional lysosomes in ferroptosis of cancer cells

Includes: Supplementary data

Articles

TSPO: kaleidoscopic 18-kDa amid biochemical pharmacology, control and targeting of mitochondria

Jemma Gatliff, Michelangelo Campanella

Biochem J (2016) 473 (2): 107–121.

https://doi.org/10.1042/BJ20150899

Published: 05 January 2016

... cellular processes such as apoptosis and autophagy. It interacts and forms complexes with other mitochondrial proteins such as the voltage-dependent anion channel (VDAC) via which signalling and regulatory transduction of these core cellular events may be influenced. Despite nearly 40 years of study...

View articletitled, TSPO: kaleidoscopic 18-kDa amid biochemical pharmacology, control and targeting of mitochondria

Articles

A calreticulin-dependent nuclear export signal is involved in the regulation of liver receptor homologue-1 protein folding

Feng-Ming Yang, Shan-Jung Feng, Tsai-Chun Lai, Meng-Chun Hu

Biochem J (2015) 471 (2): 199–209.

https://doi.org/10.1042/BJ20150252

Published: 02 October 2015

... be addressed (email [email protected] ). 3 3 2015 27 7 2015 12 8 2015 12 8 2015 aggresome autophagy calreticulin heat shock protein 70 liver receptor homologue-1 (LRH-1) nuclear export signal Liver receptor homologue-1 (LRH-1; NR5A1), related to Drosophila Ftz-F1...

View articletitled, A calreticulin-dependent nuclear export signal is involved in the regulation of liver receptor homologue-1 protein folding

Includes: Supplementary data

Articles

The mucolipidosis IV Ca 2+ channel TRPML1 (MCOLN1) is regulated by the TOR kinase

Rob U. Onyenwoke, Jonathan Z. Sexton, Feng Yan, María Cristina Huertas Díaz, Lawrence J. Forsberg, Michael B. Major, Jay E. Brenman

Biochem J (2015) 470 (3): 331–342.

https://doi.org/10.1042/BJ20150219

Published: 04 September 2015

...Rob U. Onyenwoke; Jonathan Z. Sexton; Feng Yan; María Cristina Huertas Díaz; Lawrence J. Forsberg; Michael B. Major; Jay E. Brenman Autophagy is a complex pathway regulated by numerous signalling events that recycles macromolecules and may be perturbed in lysosomal storage disorders (LSDs). During...

View articletitled, The mucolipidosis IV Ca 2+ channel TRPML1 (MCOLN1) is regulated by the TOR kinase

Includes: Supplementary data

Articles

GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling

Clare Stretton, Thorsten M. Hoffmann, Michael J. Munson, Alan Prescott, Peter M. Taylor, Ian G. Ganley, Harinder S. Hundal

Biochem J (2015) 470 (2): 207–221.

https://doi.org/10.1042/BJ20150404

Published: 20 August 2015

...) signalling in response to amino acid availability. GSK3 inhibition is associated with reduced mTORC1 signalling that impacts negatively on cell growth, protein synthesis and promotes cellular autophagy. amino acid autophagy growth insulin L-type (leucine) amino acid transporter 1 (LAT1) leucine...

View articletitled, GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling

Includes: Supplementary data

Articles

KEAP1–NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity

Matthew Dodson, Matthew Redmann, Namakkal S. Rajasekaran, Victor Darley-Usmar, Jianhua Zhang

Biochem J (2015) 469 (3): 347–355.

https://doi.org/10.1042/BJ20150568

Published: 23 July 2015

... with electrophilic therapeutics can be deleterious. Furthermore, it suggests that the autophagy–lysosomal pathway is particularly important in protecting the cell against redox-stress-induced proteotoxicity, since it can degrade redox-damaged proteins without causing aberrant changes to the redox network needed...

View articletitled, KEAP1–NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity

Articles

Loss of conserved Gsdma3 self-regulation causes autophagy and cell death

Peiliang Shi, An Tang, Li Xian, Siyuan Hou, Dayuan Zou, Yasu Lv, Zan Huang, Qinghua Wang, Anying Song, Zhaoyu Lin, Xiang Gao

Biochem J (2015) 468 (2): 325–336.

https://doi.org/10.1042/BJ20150204

Published: 22 May 2015

... is not essential for differentiation of epidermal cells and maintenance of the hair cycle in normal physiological conditions. Consistently, human embryonic kidney (HEK)293 and HaCaT cells transfected with wild-type (WT) Gsdma3 did not show abnormal morphology. However, Gsdma3 Y344H mutation induced autophagy...

View articletitled, Loss of conserved Gsdma3 self-regulation causes autophagy and cell death

Includes: Supplementary data

Articles

Ischaemia-induced autophagy leads to degradation of gap junction protein connexin43 in cardiomyocytes

Tania Martins-Marques, Steve Catarino, Monica Zuzarte, Carla Marques, Paulo Matafome, Paulo Pereira, Henrique Girão

Biochem J (2015) 467 (2): 231–245.

https://doi.org/10.1042/BJ20141370

Published: 02 April 2015

... by autophagy, which according to the severity of the insult involves different molecular partners. 1 To whom correspondence should be addressed (email [email protected] ). 5 11 2014 19 1 2015 21 1 2015 21 1 2015 © The Authors Journal compilation © 2015 Biochemical Society...

View articletitled, Ischaemia-induced autophagy leads to degradation of gap junction protein connexin43 in cardiomyocytes

Includes: Supplementary data

Articles

Cinderella finds her shoe: the first Vps34 inhibitor uncovers a new PI3K–AGC protein kinase connection

Benoit Bilanges, Bart Vanhaesebroeck

Biochem J (2014) 464 (2): e7–e10.

https://doi.org/10.1042/BJ20141218

Published: 14 November 2014

... 1019 1137 10.1152/physrev.00028.2012 23899561 5 Miller S. Tavshanjian B. Oleksy A. Perisic O. Houseman B. T. Shokat K. M. Williams R. L. Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34 Science 2010 327 1638 1642...

View articletitled, Cinderella finds her shoe: the first Vps34 inhibitor uncovers a new PI3K–AGC protein kinase connection

Articles

Autophagy is required and protects against apoptosis during myoblast differentiation

Elliott M. McMillan, Joe Quadrilatero

Biochem J (2014) 462 (2): 267–277.

https://doi.org/10.1042/BJ20140312

Published: 07 August 2014

...Elliott M. McMillan; Joe Quadrilatero Several degradative systems assist in formation of multinucleated terminally differentiated myotubes. However, the role of autophagy in this process has not been examined. GFP–LC3B (light chain 3 beta) puncta, LC3B-II protein and LysoTracker fluorescence...

View articletitled, Autophagy is required and protects against apoptosis during myoblast differentiation

Articles

NRBF2 regulates macroautophagy as a component of Vps34 Complex I

Yanyan Cao, Yichen Wang, Widian F. Abi Saab, Fajun Yang, Jeffrey E. Pessin, Jonathan M. Backer

Biochem J (2014) 461 (2): 315–322.

https://doi.org/10.1042/BJ20140515

Published: 26 June 2014

... recruitment to a complex that includes Vps15, Beclin-1 and Atg14L (autophagy-related 14-like protein) and is known as Vps34 Complex I. We have now identified NRBF2 (nuclear receptor-binding factor 2) as a new member of Vps34 Complex I. NRBF2 binds to complexes that include Vps34, Vps15, Beclin-1 and ATG-14L...

View articletitled, NRBF2 regulates macroautophagy as a component of Vps34 Complex I

Articles

Effects of carbonic anhydrase-related protein VIII on human cells harbouring an A8344G mitochondrial DNA mutation

Tze-Kai Wang, Che-Kun Cheng, Tang-Hao Chi, Yi-Shing Ma, Shi-Bei Wu, Yau-Huei Wei, Mingli Hsieh

Biochem J (2014) 459 (1): 149–160.

https://doi.org/10.1042/BJ20131235

Published: 14 March 2014

...-regulated CA8 expression, suggesting that reduced expression of CA8 leads to autophagy activation. Furthermore, cybrids exhibiting down-regulated CA8 showed increased cytosolic Ca 2+ signals and reduced levels of phospho-Akt compared with those in the cybrids with overexpressed CA8, indicating that phospho...

View articletitled, Effects of carbonic anhydrase-related protein VIII on human cells harbouring an A8344G mitochondrial DNA mutation

Articles

Autophagy impairment aggravates the inhibitory effects of high glucose on osteoblast viability and function

Alberto Bartolomé, Ana López-Herradón, Sergio Portal-Núñez, Ana García-Aguilar, Pedro Esbrit, Manuel Benito, Carlos Guillén

Biochem J (2013) 455 (3): 329–337.

https://doi.org/10.1042/BJ20130562

Published: 10 October 2013

...Alberto Bartolomé; Ana López-Herradón; Sergio Portal-Núñez; Ana García-Aguilar; Pedro Esbrit; Manuel Benito; Carlos Guillén Autophagy is a highly regulated homoeostatic process involved in the lysosomal degradation of damaged cell organelles and proteins. This process is considered an important pro...

View articletitled, Autophagy impairment aggravates the inhibitory effects of high glucose on osteoblast viability and function

Includes: Supplementary data

Articles

Mitochondrion-associated protein LRPPRC suppresses the initiation of basal levels of autophagy via enhancing Bcl-2 stability

Jing Zou, Fei Yue, Xianhan Jiang, Wenjiao Li, Jinglin Yi, Leyuan Liu

Biochem J (2013) 454 (3): 447–457.

https://doi.org/10.1042/BJ20130306

Published: 29 August 2013

... named C19ORF5 (chromosome 19 open reading frame 5), to form a complex. MAP1S interacts with LC3 (light chain 3), the mammalian homologue of yeast autophagy marker ATG8 and one of the most important autophagy markers in mammalian cells, and helps the attachment of autophagosomes with microtubules...

View articletitled, Mitochondrion-associated protein LRPPRC suppresses the initiation of basal levels of autophagy via enhancing Bcl-2 stability

Articles

Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts

Qiuli Liang, Gloria A. Benavides, Athanassios Vassilopoulos, David Gius, Victor Darley-Usmar, Jianhua Zhang

Biochem J (2013) 454 (2): 249–257.

https://doi.org/10.1042/BJ20130414

Published: 09 August 2013

...-dependent increase in oxidative stress and protein damage. Damaged proteins and organelles depend on autophagy for removal and this is critical for cell survival, but the role of Sirt3 is unclear. To examine this, we used Sirt3-KO (knockout) mouse embryonic fibroblast cells, and found that, under basal...

View articletitled, Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts

Includes: Supplementary data

Articles

Biochemistry of cardiomyopathy in the mitochondrial disease Friedreich's ataxia

Darius J. R. Lane, Michael Li-Hsuan Huang, Samantha Ting, Sutharshani Sivagurunathan, Des R. Richardson

Biochem J (2013) 453 (3): 321–336.

https://doi.org/10.1042/BJ20130079

Published: 12 July 2013

... (email [email protected] ). 14 1 2013 12 4 2013 15 5 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 apoptosis autophagy cardiomyopathy frataxin Friedreich's ataxia integrated stress response FRDA (Friedreich's ataxia...

View articletitled, Biochemistry of cardiomyopathy in the mitochondrial disease Friedreich's ataxia

Articles

Aggrephagy: lessons from C. elegans

Qun Lu, Fan Wu, Hong Zhang

Biochem J (2013) 452 (3): 381–390.

https://doi.org/10.1042/BJ20121721

Published: 31 May 2013

...Qun Lu; Fan Wu; Hong Zhang Autophagy is a lysosome-mediated degradation process that involves the formation of an enclosed double-membrane autophagosome. Yeast genetic screens have laid the groundwork for a molecular understanding of autophagy. The process, however, exhibits fundamental differences...

View articletitled, Aggrephagy: lessons from C. elegans

Articles

PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress

Joshua K. Salabei, Timothy D. Cummins, Mahavir Singh, Steven P. Jones, Aruni Bhatnagar, Bradford G. Hill

Biochem J (2013) 451 (3): 375–388.

https://doi.org/10.1042/BJ20121344

Published: 12 April 2013

... trigger VSMC phenotype transitions remain unclear. Because cellular reprogramming initiated by growth factors requires not only the induction of genes involved in cell proliferation, but also the removal of contractile proteins, we hypothesized that autophagy is an essential modulator of VSMC phenotype...

View articletitled, PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress

Includes: Supplementary data

Articles

Glucose induces autophagy under starvation conditions by a p38 MAPK-dependent pathway

Jose Félix Moruno-Manchón, Eva Pérez-Jiménez, Erwin Knecht

Biochem J (2013) 449 (2): 497–506.

https://doi.org/10.1042/BJ20121122

Published: 14 December 2012

...Jose Félix Moruno-Manchón; Eva Pérez-Jiménez; Erwin Knecht Autophagy is a natural process of ‘self-eating’ that occurs within cells and can be either pro-survival or can cause cell death. As a pro-survival mechanism, autophagy obtains energy by recycling cellular components such as macromolecules...

View articletitled, Glucose induces autophagy under starvation conditions by a p38 MAPK-dependent pathway

Includes: Supplementary data

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