... of alternative functions has been proposed. UCH-L1 is not essential for neuronal development but it is absolutely required for the maintenance of axonal integrity and UCH-L1 dysfunction is implicated in neurodegenerative disease. Here we review the properties of UCH-L1, and how understanding its complex...

... ]. Down-regulation of Sox2 expression correlates with the loss of regenerative capacity as the Xenopus undergoes metamorphosis. These findings also suggest that, in the context of spinal cord transections, these cells migrate and form a substrate for supporting axonal regeneration [ 30 ], which...