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Keywords: bifunctional
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Biochem J (2009) 417 (3): 757–764.
Published: 16 January 2009
... hominis , contain a bifunctional form of the enzymes on a single polypeptide chain having both catalytic activities. The crystal structure of the bifunctional enzyme TS–DHFR C. hominis reveals a dimer with a ‘crossover helix’, a swap domain between DHFR domains, unique in that this helical region from one...