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Keywords: biguanide
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Biochem J (2014) 462 (3): 475–487.
Published: 22 August 2014
...Hannah R. Bridges; Andrew J. Y. Jones; Michael N. Pollak; Judy Hirst The biguanide metformin is widely prescribed for Type II diabetes and has anti-neoplastic activity in laboratory models. Despite evidence that inhibition of mitochondrial respiratory complex I by metformin is the primary cause...