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1-16 of 16
Keywords: bile acid
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Articles
Yaochen Zhang, Don-Kyu Kim, Ji-Min Lee, Seung Bum Park, Won-IL Jeong, Seong Heon Kim, In-Kyu Lee, Chul-Ho Lee, John Y.L. Chiang, Hueng-Sik Choi
Journal:
Biochemical Journal
Biochem J (2015) 470 (2): 181–193.
Published: 20 August 2015
...Yaochen Zhang; Don-Kyu Kim; Ji-Min Lee; Seung Bum Park; Won-IL Jeong; Seong Heon Kim; In-Kyu Lee; Chul-Ho Lee; John Y.L. Chiang; Hueng-Sik Choi Bile acids are primarily synthesized from cholesterol in the liver and have important roles in dietary lipid absorption and cholesterol homoeostasis...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2014) 462 (3): 547–553.
Published: 22 August 2014
...Dellys M. Soler; Ayantika Ghosh; Frank Chen; Benjamin L. Shneider mRNA stability appears to play a key role in the ontogenic regulation of the apical sodium-dependent bile acid transporter (ASBT). The RNA-binding proteins Hu antigen R (HuR) and tristetraprolin (TTP) stabilize and destabilize ASBT...
Articles
Kaija J. Autio, Werner Schmitz, Remya R. Nair, Eija M. Selkälä, Raija T. Sormunen, Ilkka J. Miinalainen, Peter J. Crick, Yuqin Wang, William J. Griffiths, Janardan K. Reddy, Myriam Baes, J. Kalervo Hiltunen
Journal:
Biochemical Journal
Biochem J (2014) 461 (1): 125–135.
Published: 13 June 2014
...Kaija J. Autio; Werner Schmitz; Remya R. Nair; Eija M. Selkälä; Raija T. Sormunen; Ilkka J. Miinalainen; Peter J. Crick; Yuqin Wang; William J. Griffiths; Janardan K. Reddy; Myriam Baes; J. Kalervo Hiltunen Cholesterol is catabolized to bile acids by peroxisomal β-oxidation in which the side chain...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2013) 454 (2): 267–274.
Published: 09 August 2013
... the mRNA and protein expression of DGKθ in the HepG2 cell line and in primary human hepatocytes. Reporter gene studies using 1.5 kB of the DGKθ promoter fused to the luciferase gene revealed that bile acids increase DGKθ transcriptional activity. Mutation of putative FXR-binding sites attenuated...
Articles
Journal:
Biochemical Journal
Biochem J (2013) 450 (2): 387–395.
Published: 15 February 2013
... during solubilization, whereas a detergent-induced dissociation of the ABCG2 dimer causes an irreversible inactivation. By using the purified and reconstituted protein we demonstrate that cholesterol is an essential activator, whereas bile acids are important modulators of ABCG2 activity. Both wild-type...
Includes: Supplementary data
Articles
Ingrid T. G. W. Bijsmans, Rianne A. M. Bouwmeester, Joachim Geyer, Klaas Nico Faber, Stan F. J. van de Graaf
Journal:
Biochemical Journal
Biochem J (2012) 441 (3): 1007–1016.
Published: 16 January 2012
...Ingrid T. G. W. Bijsmans; Rianne A. M. Bouwmeester; Joachim Geyer; Klaas Nico Faber; Stan F. J. van de Graaf The NTCP (Na + –taurocholate co-transporting protein)/SLC10A [solute carrier family 10 (Na + /bile acid co-transporter family)] 1 is tightly controlled to ensure hepatic bile salt uptake...
Includes: Supplementary data
Articles
Fan Lian, Xiangbin Xing, Gang Yuan, Claus Schäfer, Sandra Rauser, Axel Walch, Christoph Röcken, Martin Ebeling, Matthew B. Wright, Roland M. Schmid, Matthias P. A. Ebert, Elke Burgermeister
Journal:
Biochemical Journal
Biochem J (2011) 438 (2): 315–323.
Published: 12 August 2011
...Fan Lian; Xiangbin Xing; Gang Yuan; Claus Schäfer; Sandra Rauser; Axel Walch; Christoph Röcken; Martin Ebeling; Matthew B. Wright; Roland M. Schmid; Matthias P. A. Ebert; Elke Burgermeister Bile acids from duodenogastric reflux promote inflammation and increase the risk for gastro-oesophageal...
Includes: Supplementary data
Articles
Alex Odermatt, Thierry Da Cunha, Carlos A. Penno, Charlie Chandsawangbhuwana, Christian Reichert, Armin Wolf, Min Dong, Michael E. Baker
Journal:
Biochemical Journal
Biochem J (2011) 436 (3): 621–629.
Published: 27 May 2011
...Alex Odermatt; Thierry Da Cunha; Carlos A. Penno; Charlie Chandsawangbhuwana; Christian Reichert; Armin Wolf; Min Dong; Michael E. Baker The oxidized bile acid 7-oxoLCA (7-oxolithocholic acid), formed primarily by gut micro-organisms, is reduced in human liver to CDCA (chenodeoxycholic acid...
Includes: Supplementary data
Articles
Guillaume Piessen, Nicolas Jonckheere, Audrey Vincent, Brigitte Hémon, Marie-Paule Ducourouble, Marie-Christine Copin, Christophe Mariette, Isabelle VAN Seuningen
Journal:
Biochemical Journal
Biochem J (2007) 402 (1): 81–91.
Published: 25 January 2007
... progression. We previously showed that bile acids, main components of gastro-oesophageal reflux and tumour promoters, up-regulate MUC4 expression [Mariette, Perrais, Leteurtre, Jonckheere, Hemon, Pigny, Batra, Aubert, Triboulet and Van Seuningen (2004) Biochem. J. 377 , 701–708]. HNF (hepatocyte nuclear...
Includes: Supplementary data
Articles
Galya Vassileva, Andrei Golovko, Lisa Markowitz, Susan J. Abbondanzo, Ming Zeng, Shijun Yang, Lizbeth Hoos, Glen Tetzloff, Diane Levitan, Nicholas J. Murgolo, Kevin Keane, Harry R. Davis, Jr, Joseph Hedrick, Eric L. Gustafson
Journal:
Biochemical Journal
Biochem J (2006) 398 (3): 423–430.
Published: 29 August 2006
...Galya Vassileva; Andrei Golovko; Lisa Markowitz; Susan J. Abbondanzo; Ming Zeng; Shijun Yang; Lizbeth Hoos; Glen Tetzloff; Diane Levitan; Nicholas J. Murgolo; Kevin Keane; Harry R. Davis, Jr; Joseph Hedrick; Eric L. Gustafson The Gpbar1 [G-protein-coupled BA (bile acid) receptor 1] is a recently...
Includes: Supplementary data
Articles
Gregory G. Martin, Barbara P. Atshaves, Avery L. Mcintosh, John T. Mackie, Ann B. Kier, Friedhelm Schroeder
Journal:
Biochemical Journal
Biochem J (2005) 391 (3): 549–560.
Published: 25 October 2005
...Gregory G. Martin; Barbara P. Atshaves; Avery L. Mcintosh; John T. Mackie; Ann B. Kier; Friedhelm Schroeder Although the physiological roles of the individual bile acid synthetic enzymes have been extensively examined, relatively little is known regarding the function of intracellular bile acid...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 388 (3): 857–867.
Published: 07 June 2005
... of cytochrome P450 reductase, hepatic cytochrome P450 activity is ablated, with consequent changes in bile acid and lipid homoeostasis. In order to gain insights into the metabolic changes resulting from this phenotype, we have analysed changes in hepatic mRNA expression using microarray analysis and real-time...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2004) 382 (3): 913–921.
Published: 07 September 2004
...Eiko KANAYA; Takuma SHIRAKI; Hisato JINGAMI The nuclear bile acid receptor FXR (farnesoid X receptor) is one of the key factors that suppress bile acid biosynthesis in the liver. PGC-1α [PPARγ (peroxisome-proliferator-activated receptor γ) co-activator-1α] is known to control energy homoeostasis...
Articles
Christophe MARIETTE, Michaël PERRAIS, Emmanuelle LETEURTRE, Nicolas JONCKHEERE, Brigitte HÉMON, Pascal PIGNY, Surinder BATRA, Jean-Pierre AUBERT, Jean-Pierre TRIBOULET, Isabelle Van SEUNINGEN
Journal:
Biochemical Journal
Biochem J (2004) 377 (3): 701–708.
Published: 01 February 2004
...Christophe MARIETTE; Michaël PERRAIS; Emmanuelle LETEURTRE; Nicolas JONCKHEERE; Brigitte HÉMON; Pascal PIGNY; Surinder BATRA; Jean-Pierre AUBERT; Jean-Pierre TRIBOULET; Isabelle Van SEUNINGEN Abnormal gastro-oesophageal reflux and bile acids have been linked to the presence of Barrett's oesophageal...
Articles
Naeem SHAFQAT, Hanns-Ulrich MARSCHALL, Charlotta FILLING, Erik NORDLING, Xiao-Qiu WU, Lars BJÖRK, Johan THYBERG, Eva MÅRTENSSON, Samina SALIM, Hans JÖRNVALL, Udo OPPERMANN
Journal:
Biochemical Journal
Biochem J (2003) 376 (1): 49–60.
Published: 15 November 2003
... on the orthologous rat crystal structure, showing a wide hydrophobic cleft, capable of accommodating steroids in different orientations. These properties suggest that the human enzyme is involved in glucocorticoid and gestagen catabolism, and participates in bile acid isomerization. Confocal microscopy and electron...
Articles
Noam ZELCER, Glen REID, Peter WIELINGA, Annemieke KUIL, Ingrid van der HEIJDEN, John D. SCHUETZ, Piet BORST
Journal:
Biochemical Journal
Biochem J (2003) 371 (2): 361–367.
Published: 15 April 2003
... that Mrp4 is induced in the livers of Fxr (-/-) mice, which have increased levels of serum bile acids. Since MRP4, like MRP1–3, also mediates transport of a model steroid conjugate substrate, oestradiol 17-β- d -glucuronide (E 2 17βG), we tested whether MRP4 may be involved in the transport of steroid...