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Keywords: binding
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Articles
Biochem J (2021) 478 (19): 3613–3619.
Published: 08 October 2021
... of the methyllysine binding mechanisms. 25 8 2021 17 9 2021 21 9 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 aromatic cage binding methylation structure Correspondence: Nikolay V. Dokholyan ( dokh@psu.edu...
Includes: Supplementary data
Articles
Biochem J (2020) 477 (17): 3199–3217.
Published: 10 September 2020
... functions in energy metabolism by tuning the ghrelin–GHSR1a system. However, the molecular mechanism by which LEAP2 binds to GHSR1a is largely unknown. In the present study, we first conducted alanine-scanning mutagenesis on the N-terminal fragment of human LEAP2 and demonstrated that the positively charged...
Includes: Supplementary data
Articles
Biochem J (2018) 475 (14): 2271–2291.
Published: 25 July 2018
... with an affinity of 0.4 µM and interacted with the ‘hot-spot’ region of NUPR1. Thus, we suggest that the regulation of NUPR1 gene by NUPR1L does not only happen at the DNA level, but it could also involve direct interactions with NUPR1 natural partners. binding IDP molecular interactions nuclear–protein...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (5): 537.
Published: 24 February 2016
... binds TGF-β with high affinity as determined by surface plasmon resonance (SPR) and cell-based radioligand binding and affinity labelling competition assays. SPR detected slow dissociation kinetics between sCD109 and TGF-β at low concentrations, indicating a stable and effective interaction. In addition...
Includes: Supplementary data
Articles
Biochem J (2003) 369 (2): 311–318.
Published: 15 January 2003
...Steven B. LUDBROOK; Simon T. BARRY; Chris J. DELVES; Carmel M.T. HORGAN The integrins α v β 1 , α v β 5 , α v β 6 and α v β 8 have all recently been shown to interact with the RGD motif of the latency-associated peptide (LAPβ 1 ) of transforming growth factor β 1 (TGFβ 1 ), with binding to α v β 6...
Articles
Biochem J (2001) 355 (3): 779–785.
Published: 24 April 2001
... mutations (K946A/K962A, K946A/V950A and K962A/V950A) caused an almost total loss. Co-immunoprecipitation studies also showed that the mutated forms of rPLD 1 described above failed to bind V14RhoA compared with wild-type rPLD 1 , whereas rPLD 1 with mutations outside the region K946–K962 bound V14RhoA...
Articles
Biochem J (1999) 343 (3): 681–685.
Published: 25 October 1999
... is presented to describe quantitatively the equilibrium ligand binding in the presence of T-state chain heterogeneity. A molecular model is described in which the putative interaction of αGln 38 and βTyr 145 is identified which make a significant contribution to the previously reported unusual ligand-binding...
Articles
Biochem J (1999) 339 (3): 675–683.
Published: 26 April 1999
...-dependent specificity is lacking. We show here that if signalling is transmitted through a single effector, binding coincidentally with hormone to the insulin receptor and whose association and dissociation kinetics are slow relative to the hormone dissociation rate, the resulting biological effect...
Articles
Biochem J (1999) 339 (1): 37–42.
Published: 25 March 1999
...-directed mutagenesis. The variant permeases were correctly targeted to the plasma membrane and their stabilities were similar to that of the wild-type permease. The effect of the mutations was studied by measuring the uptake constants for uracil on whole cells and equilibrium binding parameters on plasma...