... with JISC. bioenergetics F 0 -F 1 -ATPase inorganic polyphosphates mitochondria Inorganic polyphosphate (polyP) is the oldest polymer found in living nature. It consists of a large number of orthophosphate residues which are connected by high energy bonds. In lower organisms, it is used...

... mitochondrial density, high vascularization and sympathetic innervation. These characteristics are present whether BAT is active or inactive. bioenergetics brown adipose tissue lipid metabolism positron emission tomography thermogenesis Since the earliest observations describing a gland...

... on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . bioenergetics cell senescence hemotherapy melanoma mitochondria mitofusin Correspondence: Celia Quijano ( [email protected] ; [email protected] ) 22 5...

... bioenergetics mitochondria reactive oxygen species The work performed by Goldberg et al. [ 3 ] addresses important issues surrounding BCKA oxidation within mitochondria, however, some important questions remain open. Exogenous bicarbonate was used in the present study to stimulate BCKA metabolism...

... pellets were washed in 1.4 ml of Buffer A and spun at 10 000× g for 10 min at 4°C. The resulting pellets were resuspended in Buffer A. Protein content was determined using the Pierce BCA assay. amino acid metabolism bioenergetics Buffer C electron transport chain mitochondria High...

...-conductance Ca 2+ -regulated potassium channel in the inner mitochondrial membrane of human dermal fibroblasts. bioenergetics dermal fibroblasts electrophysiology mitochondria potassium channel Fibroblasts are a predominant cell type in the dermis and play a crucial role in the regulation...

... its precise mode of action remains unclear. It has been reported to perturb the bioenergetics of cells by inhibiting glycolysis and mitochondrial respiration, whereas indirect evidence suggests it may also inhibit L -lactic acid efflux from cells mediated by members of the proton-linked...

... and consequent exocytosis. Since distinct ion channels operate in oscillating and non-oscillating cells, quantitative analysis of Δψ p and [Ca 2+ ] c oscillations in a β-cell population may help to improve our understanding of the link between metabolism and insulin secretion. bioenergetics calcium...

... stress, lipid accumulation and fibrogenesis. Mitochondrial dysfunction and bioenergetic defects also contribute to NAFLD. In the present study, we examined whether differences in mtDNA influence NAFLD. To determine the role of mitochondrial and nuclear genomes in NAFLD, MNX (mitochondrial–nuclear...

...; Louis J. Dell’italia; Victor M. Darley-Usmar; Danny R. Welch; Scott W. Ballinger Dysfunctional bioenergetics has emerged as a key feature in many chronic pathologies such as diabetes and cardiovascular disease. This has led to the mitochondrial paradigm in which it has been proposed that mtDNA sequence...

... correspondence should be addressed (email [email protected] ). 16 7 2012 25 4 2013 1 5 2013 1 5 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 adenine nucleotide 5-amino-4-imidazolecarboxamide ribofuranoside (AICAR) bioenergetics glucose...

... sphingolipid drug that is effective in many animal cancer models, selectively starves cancer cells to death by down-regulating nutrient transporter proteins. Consistent with a bioenergetic mechanism of action, FTY720 induced homoeostatic autophagy. Cells were protected from FTY720 by cell-permeant nutrients...

.... bioenergetics blebbistatin creatine kinase myosin-ATPase N -benzyltoluene sulfonamide skeletal muscle contraction Determining the sensitivity and responsiveness of the respiratory system to ADP is commonly performed in the diagnosis of mitochondrial diseases as well as in a variety of basic...

...-conductance calcium-activated potassium channel activity influenced the bioenergetics of potato tuber mitochondria. In isolated mitochondria, Ca 2+ and NS1619 {1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2 H -ben-zimidazole-2-one; a potassium channel opener} were found...

... to a sterile holding tube on ice. This cycle was repeated, with collection of the concentrated cells into one tube, until all of the flasks were processed. © The Authors Journal compilation © 2008 Biochemical Society 2008 Anopheles stephensi bioenergetics malaria mitochondria mosquito...

... experimental biochemical data to test this hypothesis. Measurements of the bioenergetic capacity of cybrid cells harbouring specific Arctic or tropical climate mtDNA haplogroups on a control nuclear background reveal no significant changes in coupling efficiency between the two groups, indicating that mtDNA...

.... The Biochemical Society, London 2004 adenine nucleotide transport bioenergetics microscopic fluorescence imaging mitochondrial carrier family peroxisome pH homoeostasis In another set of experiments the uptake of ADP and AMP into liposomes containing 20 mM ATP were found to be inhibited (by 23...

... data referred to, but not actually shown, will appear in the DDBJ, EMBL, GenBank ® and GSDB Nucleotide Sequence Databases under the accession number AF287144. 30 10 2000 20 11 2000 29 11 2000 The Biochemical Society, London © 2001 2001 bioenergetics mitochondria...