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Keywords: breast cancer
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Biochem J (2023) 480 (20): 1675–1691.
Published: 19 October 2023
... in cancer cell migration and invasion is yet undeciphered. Here, we identified for the first time that MORC2, a chromatin remodeler, regulates E-cadherin expression and, subsequently regulates breast cancer cell migration and invasion. We observed a negative correlation between the expression levels...
Includes: Supplementary data
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Biochem J (2022) 479 (14): 1581–1608.
Published: 29 July 2022
...Kamil Seyrek; Fabian Wohlfromm; Johannes Espe; Inna N. Lavrik Breast cancer is still the most common cancer in women worldwide. Resistance to drugs and recurrence of the disease are two leading causes of failure in treatment. For a more efficient treatment of patients, the development of novel...
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Biochem J (2021) 478 (2): 389–406.
Published: 27 January 2021
... of PRMT6 is up-regulated in human breast cancers and is associated with oncogenesis, we used the human breast cancer cell line system to study the effect of licochalcone A treatment on PRMT6 activity, cell viability, cell cycle, and apoptosis. We demonstrated that licochalcone A is a non-S-adenosyl L...
Includes: Supplementary data
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Biochem J (2018) 475 (11): 1965–1977.
Published: 11 June 2018
... that plays pivotal roles in breast cancer biology. To search for small molecule inhibitors of AP-2γ, we performed a high-throughput fluorescence anisotropy screen and identified a polyoxometalate compound with Wells–Dawson structure K 6 [P 2 Mo 18 O 62 ] (Dawson-POM) that blocks the DNA-binding activity...
Includes: Supplementary data
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Biochem J (2016) 473 (8): 1027–1035.
Published: 08 April 2016
... allosteric site of KIFC1 that appears suitable for developing selective inhibitors of KIFC1. Importantly, SR31527 prevented bipolar clustering of extra centrosomes in triple negative breast cancer (TNBC) cells and significantly reduced TNBC cell colony formation and viability, but was less toxic to normal...
Includes: Supplementary data
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Biochem J (2015) 466 (3): 613–624.
Published: 06 March 2015
...David C.A. Gaboriau; Pamela J.E. Rowling; Ciaran G. Morrison; Laura S. Itzhaki Mutations in breast cancer susceptibility gene BRCA1 (breast cancer early-onset 1) are associated with increased risk of developing breast and ovarian cancers. BRCA1 is a large protein of 1863 residues with two small...
Includes: Supplementary data
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Biochem J (2015) 465 (1): 89–101.
Published: 12 December 2014
...-mediated gene silencing to investigate the consequences of loss of MIM on the migration and invasion of the MCF10A mammary epithelial cell model of breast cancer. We observed that suppression of MIM by RNAi enhanced migration and invasion of MCF10A cells, effects that were associated with increased levels...
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Biochem J (2013) 456 (2): 195–204.
Published: 08 November 2013
... or expression vector for FLAG–HEXIM1 as described previously [ 16 ]. RCC4 cells (pVHL-deficient or transfected with wild-type pVHL, see [ 17 ]) were maintained as described previously [ 18 ]. breast cancer hexamethylene-bis-acetamide-inducible protein-1 (HEXIM1) hypoxia-inducible factor 1α (HIF-1α...
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Biochem J (2013) 451 (1): 123–134.
Published: 14 March 2013
...Ji-hyun Ju; Wonseok Yang; Sunhwa Oh; KeeSoo Nam; Kyung-min Lee; Dong-young Noh; Incheol Shin In breast cancer, the HER2 (human epidermal growth factor receptor 2) receptor tyrosine kinase is associated with extremely poor prognosis and survival. Notch signalling has a key role in cell-fate...
Includes: Supplementary data
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Biochem J (2012) 444 (3): 581–590.
Published: 29 May 2012
... proliferation in breast cancer cells. In this loop ATBF1 inhibits the function of oestrogen–ERα signalling, whereas ATBF1 protein levels are fine-tuned by oestrogen-induced transcriptional up-regulation as well as UPP (ubiquitin–proteasome pathway)-mediated protein degradation. In the present study we show...
Includes: Supplementary data
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Biochem J (2012) 442 (2): 433–442.
Published: 13 February 2012
... signalling through G αi and Akt, whereas dimeric CXCL12 more effectively promoted recruitment of β-arrestin 2 to CXCR4 and chemotaxis of CXCR4-expressing breast cancer cells. We also showed that CXCR7 preferentially sequestered monomeric CXCL12 from the extracellular space and had minimal effects on dimeric...
Includes: Supplementary data
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Biochem J (2011) 440 (1): 157–166.
Published: 27 October 2011
... the basement membrane. Several genes that are up-regulated in breast carcinoma are responsible for mediating the metastatic cascade. Recent studies have revealed that the NFAT (nuclear factor of activated T-cells) is a transcription factor that is highly expressed in aggressive breast cancer cells and tissues...
Includes: Supplementary data
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Biochem J (2005) 385 (1): 279–287.
Published: 14 December 2004
..., but not oestrogen, in breast cancer cells via ERβ (oestrogen receptor β) transactivation. Such QR induction appears to protect breast cells against oestrogen-induced oxidative DNA damage, most likely by reducing reactive oestrogen metabolites termed catecholestrogen-quinones back to the hydroxy-catecholestrogens...
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