... under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . adipogenesis brown adipose tissue insulin resistance obesity surface markers white adipose tissue Adipose tissue is the primary organ storing and releasing energy at times of energy surplus or demand and an important...

... and the Biochemical Society under a transformative agreement with JISC. adipocytes brown adipose tissue thermogenesis white adipose tissue The dramatic rise in the incidence of metabolic disease has promoted a major increase in adipose tissue research over the last decade. The loss of metabolic...

...Marie Anne Richard; Hannah Pallubinsky; Denis P. Blondin Brown adipose tissue (BAT) has long been described according to its histological features as a multilocular, lipid-containing tissue, light brown in color, that is also responsive to the cold and found especially in hibernating mammals...

...Anna Roesler; Lawrence Kazak Obesity results from energy imbalance, when energy intake exceeds energy expenditure. Brown adipose tissue (BAT) drives non-shivering thermogenesis which represents a powerful mechanism of enhancing the energy expenditure side of the energy balance equation. The best...

... in permeabilized perirenal, inguinal, and interscapular adipose tissue. White adipose tissue (WAT) mitochondria (inguinal and perirenal) respire at substantially lower rates compared with brown adipose tissue (BAT). Insulin treatment resulted in a significant reduction in mitochondrial respiration in inguinal WAT...

... tone on brown adipose tissue. This knowledge may open new ways to counteract the chronic imbalance underlying obesity. Here, we review the current state of the art on the role of hypothalamus in the regulation of energy balance with particular focus on thermogenesis. The ARC has been identified...

... of obesity, not all fat depots are created equal. Adipocytes found in white adipose tissue contain a single large lipid droplet and play well-known roles in energy storage. By contrast, brown adipose tissue is specialized for thermogenic energy expenditure. Owing to its significant capacity to dissipate...

...Jordi Armengol; Josep A. Villena; Elayne Hondares; María C. Carmona; Hei Sook Sul; Roser Iglesias; Marta Giralt; Francesc Villarroya Pref-1 (pre-adipocyte factor-1) is known to play a central role in regulating white adipocyte differentiation, but the role of Pref-1 in BAT (brown adipose tissue...

[email protected] ). 2 3 2012 23 3 2012 27 3 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 BAT brown adipose tissue C/EBP CCAAT/enhancer-binding protein GC glucocorticoid KO knockout PPARγ peroxisome-proliferator-activated receptor γ...

...Aleksandra Swida-Barteczka; Andrzej Woyda-Ploszczyca; Francis E. Sluse; Wieslawa Jarmuszkiewicz We studied non-esterified fatty acid-induced uncoupling of heterologously expressed rat UCP1 (uncoupling protein 1) in yeast mitochondria, as well as UCP1 in rat BAT (brown adipose tissue) mitochondria...

...Siu Chiu Chan; Sheng-Cai Lin; Peng Li Cidea, one of three members of the CIDE (cell-death-inducing DNA-fragmentation-factor-45-like effector) family of proteins, is highly enriched in brown adipose tissue, in which it plays a critical role in adaptive thermogenesis and fat accumulation. Cidea-null...

... mitochondria from UCP1 −/− mice. However, in liver, only Ant2 mRNA was found, whereas in brown adipose tissue, Ant1 and Ant2 mRNA levels were equal. The data are therefore compatible with a tentative model in which the ANT2 isoform mediates fatty-acid-induced uncoupling, whereas the ANT1 isoform may mediate...

... recombinant UCP3 showed that mouse and rat skeletal muscle contained 0.14 μ g of UCP3/mg of mitochondrial protein. This very low UCP3 content is 200–700-fold less than the concentration of UCP1 in brown-adipose-tissue mitochondria from warm-adapted hamster (24–84 μ g of UCP1/mg of mitochondrial protein). UCP3...

...Dagmar KRATKY; Juliane G. STRAUSS; Rudolf ZECHNER Uncoupling protein (UCP)-2 and UCP-3 are two recently discovered proteins similar to UCP-1, which regulates thermogenesis in brown adipose tissue (BAT). Whereas UCP-1 expression is restricted to BAT, UCP-2 is widely expressed. UCP-3 is found mainly...