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Keywords: c-myc
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Articles

Aurora A binds to the transactivation domain of c-Myc and recognizes the phosphorylated N-terminal degron motif

Open Access
Nidhi Joshi, Katie M. Dunleavy, Kaitlin M. Beel, Tiffany A. Engel, Andrew R. Thompson, Felix L. John, David D. Thomas, Nicholas M. Levinson
Journal: Biochemical Journal
Biochem J (2025) 482 (08): 369–381.
https://doi.org/10.1042/BCJ20240726
Published: 16 April 2025
...Nidhi Joshi; Katie M. Dunleavy; Kaitlin M. Beel; Tiffany A. Engel; Andrew R. Thompson; Felix L. John; David D. Thomas; Nicholas M. Levinson The oncoprotein c-Myc is overexpressed or mutated in a large fraction of human cancers. The stability of c-Myc is controlled by phosphorylation of T58 and S62...
View articletitled, Aurora A binds to the transactivation domain of c-Myc and recognizes the phosphorylated N-terminal degron motif
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Includes: Supplementary data
Articles

Id2 leaves the chromatin of the E2F4–p130-controlled c- myc promoter during hepatocyte priming for liver regeneration

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José L. Rodríguez, Juan Sandoval, Gaetano Serviddio, Juan Sastre, María Morante, Maria-Giulia Perrelli, María L. Martínez-Chantar, José Viña, Juan R. Viña, José M. Mato, Matías A. Ávila, Luis Franco, Gerardo López-Rodas, Luis Torres
Journal: Biochemical Journal
Biochem J (2006) 398 (3): 431–437.
https://doi.org/10.1042/BJ20060380
Published: 29 August 2006
... hepatectomy, following the early induction of its gene. Co-immunoprecipitation shows that Id2 forms a complex with E2F4, p130 and mSin3A in quiescent liver and all these components are present at the c- myc promoter as shown using ChIP (chromatin immunoprecipitation). Activation of c- myc during hepatocyte...
View articletitled, Id2 leaves the chromatin of the E2F4–p130-controlled c- myc promoter during hepatocyte priming for liver regeneration
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Articles

Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function

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Iyad Sultan, Can E. Senkal, Suriyan Ponnusamy, Jacek Bielawski, Zdzislaw Szulc, Alicja Bielawska, Yusuf A. Hannun, Besim Ogretmen
Journal: Biochemical Journal
Biochem J (2006) 393 (2): 513–521.
https://doi.org/10.1042/BJ20051083
Published: 23 December 2005
... of TPx I (thioredoxin peroxidase I), an enzyme that reduces the generation of intracellular ROS (reactive oxygen species). Additional data showed that ROS regulated both the deacylation and reacylation steps of C 6 -cer. At a functional level, C 6 -cer inhibited the DNA-binding function of the c-Myc/Max...
View articletitled, Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function
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Articles

An AU-rich stem–loop structure is a critical feature of the perinuclear localization signal of c- myc mRNA

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Hervé Chabanon, Ian Mickleburgh, Brian Burtle, Christopher Pedder, John Hesketh
Journal: Biochemical Journal
Biochem J (2005) 392 (3): 475–483.
https://doi.org/10.1042/BJ20050812
Published: 06 December 2005
...Hervé Chabanon; Ian Mickleburgh; Brian Burtle; Christopher Pedder; John Hesketh In eukaryotic cells, several mRNAs including those of c- myc and c- fos are localized to the perinuclear cytoplasm and associated with the cytoskeleton. The localization element of c- myc mRNA is present within its 3...
View articletitled, An AU-rich stem–loop structure is a critical feature of the perinuclear localization signal of c- myc mRNA
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Includes: Supplementary data
Articles

Targeting of the transcription factor Max during apoptosis: phosphorylation-regulated cleavage by caspase-5 at an unusual glutamic acid residue in position P1

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Anja KRIPPNER-HEIDENREICH, Robert V. TALANIAN, Renate SEKUL, Regine KRAFT, Hubert THOLE, Holger OTTLEBEN, Bernhard LÜSCHER
Journal: Biochemical Journal
Biochem J (2001) 358 (3): 705–715.
https://doi.org/10.1042/bj3580705
Published: 10 September 2001
... The Biochemical Society, London ©2001 2001 caspase-7 c-Myc DNA binding IC 50 protein kinase CK2 Abbreviations used: EMSA, electrophoretic mobility-shift assay; bHLHZip, basic region/helix-loop-helix/leucine zipper; ODC, ornithine decarboxylase; PARP, poly(ADP-ribose) polymerase; USF, upstream...
View articletitled, Targeting of the transcription factor Max during apoptosis: phosphorylation-regulated cleavage by caspase-5 at an unusual glutamic acid residue in position P1
Open the PDF for Targeting of the transcription factor Max during apoptosis: phosphorylation-regulated cleavage by caspase-5 at an unusual glutamic acid residue in position P1 in another window