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Keywords: cAMP signaling
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Articles

GPCR signaling via cAMP nanodomains

Open Access
Rahul Yadav, Manuela Zaccolo
Journal: Biochemical Journal
Biochem J (2025) 482 (10): 519–533.
https://doi.org/10.1042/BCJ20253088
Published: 13 May 2025
... and intracellular receptors—including endosomal, Golgi, and nuclear GPCRs—elicit unique cAMP signaling profiles. This review examines the mechanisms underlying GPCR signaling through cAMP nanodomains. We focus on the role of PDE-mediated cAMP degradation in shaping local cAMP signals, the emerging views...
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Articles

PKA Cβ: a forgotten catalytic subunit of cAMP-dependent protein kinase opens new windows for PKA signaling and disease pathologies

Available to Purchase
Susan S. Taylor, Maximilian Wallbott, Erik M. F. Machal, Kristoffer Søberg, Faihaa Ahmed, Jessica Bruystens, Lily Vu, Blaine Baker, Jian Wu, Francesco Raimondi, Elimelda M. Ongeri, Friedrich W. Herberg, Bjørn S. Skålhegg
Journal: Biochemical Journal
Biochem J (2021) 478 (11): 2101–2119.
https://doi.org/10.1042/BCJ20200867
Published: 11 June 2021
... to non-redundant Cα and Cβ functions. Correspondence: Susan S. Taylor ([email protected]) 18 3 2021 30 4 2021 5 5 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cAMP signaling dark kinome PKA Cβ subunit PKA...
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Includes: Multimedia, Supplementary data