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Keywords: cancer
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Articles
Biochem J (2025) 482 (04): 241–262.
Published: 17 February 2025
..., a critical feature of solid tumor growth and progression. Finally, we discuss the current landscape in the development of MDM2 and MDM4 inhibitors for cancer therapy. Table 1: Summary of MDM2 and MDM4 protein–protein interactions (PPIs). Category Partner Interaction type Role of MDM proteins...
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Biochem J (2024) 481 (22): 1659–1677.
Published: 14 November 2024
...Kacey J. Rosenthal; John D. Gordan; John D. Scott Protein kinase A (PKA) is a basophilic kinase implicated in the modulation of many cell-signaling and physiological processes. PKA also contributes to cancer-relevant events such as growth factor action, cell cycle control, cell migration and tumor...
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Biochem J (2024) 481 (22): 1603–1620.
Published: 07 November 2024
... (hHtrA2), which induces apoptosis through both caspase-dependent and independent pathways is implicated in several diseases including cancer, ischemic heart diseases, and neurodegeneration, thus making it a promising target molecule. In the recent past, the canine model has gained prominence...
Includes: Supplementary data
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Biochem J (2024) 481 (21): 1497–1518.
Published: 18 October 2024
...Madhura R. Pandkar; Sanjeev Shukla In recent years, significant strides in both conceptual understanding and technological capabilities have bolstered our comprehension of the factors underpinning cancer initiation and progression. While substantial insights have unraveled the molecular mechanisms...
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Biochem J (2024) 481 (12): 759–775.
Published: 10 June 2024
... suggests that PKCθ may be involved in cancer, particularly blood cancers, breast cancer, and gastrointestinal stromal tumors, yet how to target this kinase (as an oncogene or as a tumor suppressor) has not been established. Here, we examine the effect of four cancer-associated mutations, R145H/C...
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Biochem J (2023) 480 (1): 1–23.
Published: 06 January 2023
...Walter Kolch; Dénes Berta; Edina Rosta RAS proteins regulate most aspects of cellular physiology. They are mutated in 30% of human cancers and 4% of developmental disorders termed Rasopathies. They cycle between active GTP-bound and inactive GDP-bound states. When active, they can interact...
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Biochem J (2022) 479 (13): 1429–1439.
Published: 04 July 2022
..., but not identical, because Ru(II) shows no evidence of forming intramolecular crossbridges in the DNA. The reaction is slow, and with excess Ru, intermolecular DNA crossbridges are formed. The addition of CORM-3 to human colorectal cancer cells leads to strand breaks in the DNA, as assessed by the alkaline comet...
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Biochem J (2022) 479 (12): 1375–1392.
Published: 24 June 2022
..., self-renewal capacity of epithelial stem cells, proliferation/expansion of basal keratinocytes, differentiation of stratified epithelia. In cancer, ΔNp63 is implicated in squamous cancers pathogenesis of different origin including skin, head and neck and lung and in sustaining self-renewal of cancer...
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Biochem J (2022) 479 (11): 1149–1164.
Published: 08 June 2022
... Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . cancer metastasis natural killer nucleoside kinase uridine kinase Uridine-cytidine kinase (UCK) is a pyrimidine ribonucleoside kinase that catalyzes...
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Biochem J (2022) 479 (1): 75–90.
Published: 14 January 2022
... autophagic cell death autophagy cancer necroptosis neurodegeneration Cellular recycling is essential for both survival and organismal homeostasis. These clearance mechanisms bidirectionally interact with cell death pathways either to prevent them or to promote cell destruction due to extensive...
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Biochem J (2021) 478 (20): 3791–3805.
Published: 28 October 2021
... explain the frequent re-expression of normally silent meiotic genes in a variety of human cancers. Correspondence: Urszula Lucja McClurg ( [email protected] ) or Wee-Wei Tee ( [email protected] ) 2 6 2021 29 9 2021 6 10 2021 © 2021 The Author(s) 2021...
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Biochem J (2021) 478 (8): 1485–1509.
Published: 21 April 2021
.... Gildersleeve ( [email protected] ) 25 1 2021 23 3 2021 26 3 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 antibodies antigens autoimmunity cancer glycobiology Carbohydrate chains, also referred to as glycans...
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Biochem J (2021) 478 (3): 597–617.
Published: 12 February 2021
...(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cancer galectins lectins metastasis tumor immunity In the past decade, galectins, a family of highly conserved β-galactoside-binding proteins, emerged as key regulators of tumor progression, not only...
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Biochem J (2021) 478 (1): 21–39.
Published: 08 January 2021
...Giulia Pinto; Inés Saenz-de-Santa-Maria; Patricia Chastagner; Emeline Perthame; Caroline Delmas; Christine Toulas; Elizabeth Moyal-Jonathan-Cohen; Christel Brou; Chiara Zurzolo Glioblastoma (GBM) is the most aggressive brain cancer and its relapse after surgery, chemo and radiotherapy appears...
Includes: Multimedia, Supplementary data
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Biochem J (2020) 477 (23): 4675–4688.
Published: 11 December 2020
.... 15 6 2020 11 11 2020 19 11 2020 19 11 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 c-fos cancer dominant-negative glioblastoma phospholipids Among cancers of the central nervous system (CNS...
Includes: Supplementary data
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Biochem J (2020) 477 (19): 3649–3672.
Published: 05 October 2020
... found in pathological states. In the last few years, a role in cancer has been proposed, supported by the evidence that various oncoproteins undergo gain- or loss-of-function modifications upon S -nitrosylation. Here, we aim at providing insight into the current knowledge about the role of S...
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Biochem J (2020) 477 (15): 2893–2919.
Published: 14 August 2020
...Walaa E. Kattan; John F. Hancock The three human RAS proteins are mutated and constitutively activated in ∼20% of cancers leading to cell growth and proliferation. For the past three decades, many attempts have been made to inhibit these proteins with little success. Recently; however, multiple...
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Biochem J (2020) 477 (15): 2755–2770.
Published: 07 August 2020
... and mutations in these are pathogenic in cancer and a class of developmental disorders termed RASopathies. Emerging clinical evidences have now demonstrated a role for RIT1 in RASopathies, namely Noonan syndrome, and various cancers including lung adenocarcinoma and myeloid malignancies. While RIT1 has been...
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Biochem J (2020) 477 (14): 2715–2720.
Published: 29 July 2020
.... showed that when DNA is damaged by ɣ-radiation in cancer cells, LBR is lost causing chromatin structure changes and promoting cellular senescence. Cellular senescence is characterized by terminal cell cycle arrest and the expression and secretion of various growth factors, cytokines, metalloproteinases...
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Biochem J (2020) 477 (8): 1363–1366.
Published: 23 April 2020
... 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cancer cell penetrating peptide lipid microdomains membranes therapeutics trafficking In a recent issue of this journal Eissa et al. highlight a novel membrane-active...
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Biochem J (2020) 477 (5): 905–923.
Published: 04 March 2020
...’ subfamily HECT and influences several crucial cellular processes, including innate immunity, proteasome processivity, and cancer metastasis. Here, we report the crystal structure of the HECT domain of UBE3C (amino acids (aa) 744–1083) with an additional fifty N-terminal amino acids (aa 693–743) at 2.7...
Includes: Supplementary data
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Biochem J (2020) 477 (1): 111–120.
Published: 08 January 2020
..., such as oligomers and amyloid fibrils. p53 is an essential tumor suppressor that is prone to such conformational transitions, resulting in its compromised ability to avert cancer. This work explores the biophysical properties of early-, mid-, and late-stage p53 core domain (p53C) aggregates. Atomistic and coarse...
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Biochem J (2019) 476 (20): 3053–3066.
Published: 28 October 2019
...Han-Sae Lee; Hye-Ran Seo; Shin-Ai Lee; Soohee Choi; Dongmin Kang; Jongbum Kwon The recovery from replication stress by restarting stalled forks to continue DNA synthesis is crucial for maintaining genome stability and thereby preventing diseases such as cancer. We previously showed that BRCA1...
Includes: Supplementary data
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Biochem J (2019) 476 (15): 2209–2219.
Published: 09 August 2019
...Catherine E. Scull; Yinfeng Zhang; Nichole Tower; Lynn Rasmussen; Indira Padmalayam; Robert Hunter; Ling Zhai; Robert Bostwick; David A. Schneider Over the past two decades, ribosome biogenesis has emerged as an attractive target for cancer treatment. In this study, two high-throughput screens were...
Includes: Supplementary data
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Biochem J (2019) 476 (6): 931–950.
Published: 22 March 2019
... from structural and signaling aspects to their associations with cancer, physiology, and development. Correspondence: Anna M. Schmoker ( [email protected] ) or Bryan A. Ballif ( [email protected] ) © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society...
Includes: Supplementary data
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Biochem J (2019) 476 (1): 39–50.
Published: 07 January 2019
... over 20 column volumes to separate species bearing one or two 6×His tags. V H Hs and V H H-Fcs were dialyzed against or buffer-exchanged into phosphate-buffered saline ( PBS ), pH 7.4. antibodies cancer DNA immunization epidermal growth factor receptor single-domain antibodies V H H...
Includes: Supplementary data
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Biochem J (2018) 475 (24): 4011–4023.
Published: 21 December 2018
... Attribution License 4.0 (CC BY-NC-ND) . brain hypoxia cancer cell toxicity hypertension melatonin prion encephalopathies Correspondence: Antonio Villalobo ( [email protected] ; [email protected] ) 18 9 2018 23 11 2018 30 11 2018 Pleiotrophin...
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Biochem J (2017) 474 (24): 4219–4251.
Published: 14 December 2017
... development in cancer. Although microRNAs (miRNAs) are the most studied regulatory ncRNAs to date, and miRNA-targeted therapeutics have already reached clinical development, including the mimics of the tumour suppressive miRNAs miR-34 and miR-16, which reached phase I clinical trials for the treatment...
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Biochem J (2017) 474 (11): 1919–1934.
Published: 19 May 2017
...Moitri Basu; Isha Sengupta; Md Wasim Khan; Dushyant Kumar Srivastava; Partha Chakrabarti; Siddhartha Roy; Chandrima Das Enhanced migratory potential and invasiveness of cancer cells contribute crucially to cancer progression. These phenotypes are achieved by precise alteration of invasion...
Includes: Supplementary data
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Biochem J (2017) 474 (11): 1755–1768.
Published: 10 May 2017
... role of RUNX1. Furthermore, in solid cancers, RUNX1 is overexpressed compared with normal tissue, and RUNX factors have recently been discovered to promote growth of skin, oral, breast and ovarian tumour cells, amongst others. RUNX factors have key roles in stem cell fate regulation during homeostasis...
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Biochem J (2016) 473 (22): 4083–4101.
Published: 10 November 2016
... article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . cancer functional genomics neurodegeneration proteomics proteostasis ubiquitin Conjugation of the small protein modifier...
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Biochem J (2016) 473 (17): 2603–2610.
Published: 30 August 2016
...Unbin Chae; Sun-Ji Park; Bokyung Kim; Shou Wei; Ju-Sik Min; Jun-Hyeog Lee; Se Hoon Park; Ann-Hwee Lee; Kun Ping Lu; Dong-Seok Lee; Sang-Hyun Min XBP1 (X-box-binding protein 1) is activated in cancer and has a pivotal role in tumorigenesis and progression of human cancer. In particular, the XBP1...
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Biochem J (2016) 473 (16): 2531–2544.
Published: 11 August 2016
...Kathryn M. Taylor; Issa A. Muraina; Dylan Brethour; Gerold Schmitt-Ulms; Thirayost Nimmanon; Silvia Ziliotto; Peter Kille; Christer Hogstrand There is growing evidence that zinc and its transporters are involved in cell migration during development and in cancer. In the present study, we show...
Includes: Supplementary data
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Biochem J (2016) 473 (9): 1247–1255.
Published: 26 April 2016
... glucagon signalling that leads to increased β-catenin activity that can be reversed with the antihelminthic drug niclosamide, which has recently shown promise as a potential treatment of T2D (Type 2 diabetes). This novel finding could be useful in liver cancer treatment, particularly in the context of T2D...
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Biochem J (2015) 471 (3): 307–322.
Published: 16 October 2015
... the diseases of old age, including type 2 diabetes (T2D), cardiovascular disease (CVD) and cancer. Developing new ways to improve health in the elderly is therefore a top priority for biomedical research. Although our understanding of the molecular basis of these morbidities has advanced rapidly, effective...
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Biochem J (2015) 471 (2): 243–253.
Published: 02 October 2015
...)/mTOR [mammalian (or mechanistic) target of rapamycin] signalling pathway in cervical cancer cell lines. We provided evidence that activated Akt/mTOR pathway increased NPC1 degradation by ∼50% in C33A cells when compared with SiHa or HeLa cells. NPC1 degradation in C33A cells was reversed when Akt/mTOR...
Includes: Supplementary data
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Biochem J (2015) 471 (2): 267–279.
Published: 02 October 2015
... PRDX6 knockdown by protein blotting. The relative impedance values measured at 80 h after the start of the experiment were used for calculation of the percentage of growth. Statistical analyses were carried out using an unpaired Student's t test. cancer lipid signalling melanoma oxidative...
Includes: Supplementary data
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Biochem J (2015) 469 (3): 421–432.
Published: 23 July 2015
...Marco Kloos; Antje Brüser; Jürgen Kirchberger; Torsten Schöneberg; Norbert Sträter Phosphofructokinase-1 (Pfk) acts as the main control point of flux through glycolysis. It is involved in complex allosteric regulation and Pfk mutations have been linked to cancer development. Whereas the 3D...
Includes: Supplementary data
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Biochem J (2015) 468 (1): 1–15.
Published: 05 May 2015
... microenvironment is not entirely understood owing to the complex cross-talk between pro-inflammatory and tumorigenic mediators such as cytokines, chemokines, oncogenes, enzymes, transcription factors and immune cells. These molecular mediators are critical linchpins between inflammation and cancer...