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Keywords: cancer therapy
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Articles
Biochem J (2021) 478 (19): 3621–3642.
Published: 14 October 2021
... of sphingolipids is tightly controlled at the level of enzymes and cellular compartments in response to endogenous or exogenous stimuli, such as anticancer drugs, including retinoids. Over the past two decades, evidence emerged that retinoids owe part of their potency in cancer therapy to modulation...
Articles
Biochem J (2021) 478 (8): 1547–1569.
Published: 21 April 2021
... ) 1 3 2021 22 3 2021 29 3 2021 29 3 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 alpha kinase apoptosis cancer therapy protein synthesis translation Cells within solid tumours may be subject...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (19): 2937–2953.
Published: 27 September 2016
... chemotherapy and, possibly more importantly, chemoprevention. Correspondence: Robert A. Casero ( rcasero@jhmi.edu ) 26 4 2016 9 6 2016 10 6 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 cancer therapy chemoprevention...
Articles
Biochem J (2016) 473 (10): 1329–1341.
Published: 11 May 2016
..., prostate, breast and pancreatic cancers. cancer therapy directed evolution enzyme inhibition mesotrypsin protease inhibitor protein engineering proteolysis X-ray structure 25 1 2016 29 2 2016 8 3 2016 8 3 2016 Cells, reagents and additional methods...
Includes: Supplementary data
Articles
Biochem J (2014) 463 (1): 53–63.
Published: 08 September 2014
... Society 2014 A new cytotoxic compound was found in our chemical library. We revealed that the compound induced reactive oxygen species through glutathione depletion. Moreover, the compound was effective against several cancer cell lines including those harbouring KRAS. cancer therapy chemical...
Includes: Supplementary data
Articles
Biochem J (2010) 430 (2): 199–205.
Published: 13 August 2010
... 2010 cancer therapy inhibitor of apoptosis (IAP) mitochondrion nuclear factor κB (NF-κB) survivin Although there are various morphologically distinct and biochemically separate forms of cell death, only apoptosis embodies an orderly genetic programme of cellular suicide [ 1...
Articles
Biochem J (2009) 424 (3): 335–345.
Published: 10 December 2009
... Attribution Non-Commercial Licence ( http://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. apoptosis cancer therapy conformational switch co-operative dimer interface...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2008) 414 (3): 343–355.
Published: 27 August 2008
... nutrition cancer therapy 1-methyltryptophan solute carrier family 6 member 14 (SLC6A14) transport blocker tumour cell growth The cytosolic enzyme IDO (indoleamine 2,3-dioxygenase) is an important component of tumour-associated immune tolerance [ 1 – 4 ]. The relevance of IDO to immune tolerance...
Articles
Biochem J (2008) 410 (3): 439–453.
Published: 27 February 2008
... ATPase inhibitor cancer therapy client protein co-chaperone protein activation and degradation ubiquitination Hsp90 (90 kDa heat-shock protein) is one of a group of molecular chaperones responsible for managing protein folding and quality control in the crowded environment of the cell [ 1...
Articles
Biochem J (2006) 393 (1): 21–41.
Published: 12 December 2005
... correspondence should be addressed (email epstein@nso1.uchc.edu ). 22 8 2005 26 9 2005 4 10 2005 The Biochemical Society, London 2006 cAMP cancer therapy glucocorticoid leukaemia methylxanthine phosphodiesterase Following the identification of cAMP in 1958 by Rall...