... of sphingolipids is tightly controlled at the level of enzymes and cellular compartments in response to endogenous or exogenous stimuli, such as anticancer drugs, including retinoids. Over the past two decades, evidence emerged that retinoids owe part of their potency in cancer therapy to modulation...

... ) 1 3 2021 22 3 2021 29 3 2021 29 3 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 alpha kinase apoptosis cancer therapy protein synthesis translation Both autophagy and eEF2K are inhibited by signalling...

... chemotherapy and, possibly more importantly, chemoprevention. Correspondence: Robert A. Casero ( [email protected] ) 26 4 2016 9 6 2016 10 6 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 cancer therapy chemoprevention...

... and identifies a promising mesotrypsin inhibitor as a starting point for the development of anticancer protein therapeutics. cancer therapy directed evolution enzyme inhibition mesotrypsin protease inhibitor protein engineering proteolysis X-ray structure The human serine protease...

... Society 2014 A new cytotoxic compound was found in our chemical library. We revealed that the compound induced reactive oxygen species through glutathione depletion. Moreover, the compound was effective against several cancer cell lines including those harbouring KRAS. cancer therapy chemical...

... of tissues and organs throughout adult life [ 3 ]. Deregulation of apoptosis is a pathogenic factor of many human diseases, and aberrantly increased cell survival is a hallmark of virtually every human tumour [ 4 ]. cancer therapy inhibitor of apoptosis (IAP) mitochondrion nuclear factor κB (NF-κB...

... use, distribution and reproduction in any medium, provided the original work is properly cited. apoptosis cancer therapy conformational switch co-operative dimer interface procaspase activation Caspase activation, more than any other event, defines a cellular response to apoptosis...

... nutrition cancer therapy 1-methyltryptophan solute carrier family 6 member 14 (SLC6A14) transport blocker tumour cell growth The cytosolic enzyme IDO (indoleamine 2,3-dioxygenase) is an important component of tumour-associated immune tolerance [ 1 – 4 ]. The relevance of IDO to immune tolerance...

... in other structures are of little biological significance. 1 To whom correspondence should be addressed (email [email protected] ). © The Authors Journal compilation © 2008 Biochemical Society 2008 ATPase inhibitor cancer therapy client protein co-chaperone protein...

... correspondence should be addressed (email [email protected] ). 22 8 2005 26 9 2005 4 10 2005 The Biochemical Society, London 2006 cAMP cancer therapy glucocorticoid leukaemia methylxanthine phosphodiesterase Following the identification of cAMP in 1958 by Rall...