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Keywords: caspase
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Biochem J (2021) 478 (12): 2233–2245.
Published: 18 June 2021
...Izabela Maluch; Justyna Grzymska; Scott J. Snipas; Guy S. Salvesen; Marcin Drag Caspases are a family of enzymes that play roles in cell death and inflammation. It has been suggested that in the execution phase of the apoptotic pathway, caspase-3, -6 and -7 are involved. The substrate specificities...
Includes: Supplementary data
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Biochem J (2019) 476 (22): 3475–3492.
Published: 21 November 2019
...Robert D. Grinshpon; Suman Shrestha; James Titus-McQuillan; Paul T. Hamilton; Paul D. Swartz; A. Clay Clark Apoptotic caspases evolved with metazoans more than 950 million years ago (MYA), and a series of gene duplications resulted in two subfamilies consisting of initiator and effector caspases...
Includes: Supplementary data
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Biochem J (2015) 466 (2): 219–232.
Published: 20 February 2015
...Karen McLuskey; Jeremy C. Mottram Clan CD forms a structural group of cysteine peptidases, containing seven individual families and two subfamilies of structurally related enzymes. Historically, it is most notable for containing the mammalian caspases, on which the structures of the clan were...
Includes: Supplementary data
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Biochem J (2012) 442 (2): 391–401.
Published: 13 February 2012
.... In the present study, we show that Golgi disassembly during pro-apoptotic stress induced by TNFα (tumour necrosis factor α) and anisomycin results in decreased levels of CERT at the Golgi region. This is accompanied by a caspase-dependent loss of full-length CERT and reduction in de novo SM synthesis. In vitro...
Includes: Supplementary data
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Biochem J (2011) 435 (1): 175–185.
Published: 15 March 2011
... regulation. In the present study, we show that depleting cancer cells of UHRF1 causes activation of the DNA damage response pathway, cell cycle arrest in G 2 /M-phase and apoptosis dependent on caspase 8. The DNA damage response in cells depleted of UHRF1 is illustrated by: phosphorylation of histone H2AX...
Includes: Supplementary data
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Biochem J (2010) 426 (2): 229–241.
Published: 09 February 2010
... study, we have demonstrated that Ets-1 p51, but not the spliced variant Ets-1 p42, is processed in a caspase-dependent manner in Jurkat T-leukaemia cells undergoing apoptosis, resulting in three C-terminal fragments Cp20, Cp17 and Cp14 and a N-terminal fragment, Np36. In vitro cleavage of Ets-1 p51...
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Biochem J (2009) 417 (3): 765–771.
Published: 16 January 2009
... of neoplastic cells, and synthetic IAP antagonists represent a promising novel class of chemotherapeutic agents. Early work focused on the ability of these compounds to block the caspase-inhibitory function of XIAP (X-linked IAP). However, recent studies have shown that IAP antagonists, although primarily...
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Biochem J (2008) 415 (2): 165–182.
Published: 25 September 2008
...Elena M. Ribe; Esther Serrano-Saiz; Nsikan Akpan; Carol M. Troy Dysregulation of life and death at the cellular level leads to a variety of diseases. In the nervous system, aberrant neuronal death is an outstanding feature of neurodegenerative diseases. Since the discovery of the caspase family...
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Biochem J (2008) 412 (3): 527–534.
Published: 28 May 2008
... necrosis factor α). We have also investigated the integrity of Dicer, and provide evidence that Dicer is a target for caspases during apoptosis. The cleavage of Dicer is stimulidependent and more pronounced when apoptosis is induced by PKC (protein kinase C) inhibitors, and can also be observed in HIV-1...
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Biochem J (2005) 392 (2): 399–406.
Published: 22 November 2005
...), caspase-9 and other cofactors. The issue of whether the redox state of the haem in cyt c affects the initiation of the apoptotic pathway is currently a subject of debate. In a cell-free reconstitution system, we found that only oxidized cyt c was capable of activating the caspase cascade. Oxidized cyt c...
Includes: Supplementary data
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Biochem J (2005) 385 (1): E1.
Published: 14 December 2004
...Colin S. DUCKETT Dogma has it that suppression of the programmed cell death pathway by the IAP (inhibitor of apoptosis) proteins is achieved by their direct enzymic inhibition of the chief executioners of the apoptotic process, the caspases. In turn, the IAPs themselves can be neutralized by Smac...
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Biochem J (2004) 384 (2): 201–232.
Published: 23 November 2004
.... Fundamentally new mechanisms in protease regulation have been disclosed. Structural evidence suggests that caspases have an unusual catalytic mechanism, and that they are activated by apparently unrelated events, depending on which position in the apoptotic pathway they occupy. Some naturally occurring caspase...
Includes: Supplementary data
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Biochem J (2004) 383 (1): 13–18.
Published: 24 September 2004
..., and activated caspases 3 and 7. However, apoptosis was independent of the p53 and Fas signalling pathways. Furthermore, activation of the p38 MAPK pathway was found to induce actin reorganization in cells devoid of growth factors. At the cytoskeletal level, SARS-CoV N down-regulated FAK (focal adhesion kinase...
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Biochem J (2004) 381 (1): 43–49.
Published: 22 June 2004
... by centrifuging at 500  g for 3 min were resuspended in caspase lysis buffer, and lysates were placed on ice for 10 min. Lysates were pre-cleared by centrifugation at 10000  g for 1 min, and the pellet was discarded. Bradford assays [ 12a ] were performed on the lysates, and 100 μg of protein/well...
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Biochem J (2003) 373 (3): 965–971.
Published: 01 August 2003
... 2003 caspase cell death inhibitor of apoptosis protein (IAP) mass spectrometry ubiquitin Abbreviations used: Ac-DEVD-AFC, N -acetyl-Asp-Glu-Val-Asp 7-amino-4-trifluoromethylcoumarin; DTT, dithiothreitol; GST, glutathione S-transferase; IAP, inhibitor of apoptosis protein; BIR...
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Biochem J (2002) 368 (3): 905–913.
Published: 15 December 2002
...Sabrina LEVERRIER; Alice VALLENTIN; Dominique JOUBERT In contrast with protein kinase Cα (PKCα) and PKC∊, which are better known for promoting cell survival, PKCΔ is known for its pro-apoptotic function, which is exerted mainly through a caspase-3-dependent proteolytic activation pathway...
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Biochem J (2002) 367 (1): 307–312.
Published: 01 October 2002
.... IPENSpm was cytotoxic to these cells at concentrations greater than 2.5 μ M. It induced apoptosis in a caspase-dependent manner and its toxicity profile was comparable with etoposide, a well-known anti-tumour agent and inducer of apoptosis. IPENSpm decreased intracellular polyamine content as a result...
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Biochem J (2002) 364 (3): 881–885.
Published: 15 June 2002
... a cleavage of the p53 C-terminal region (p40ΔC). Furthermore, this cleavage was not dependent on caspase activity. In conclusion, these results support the hypothesis that this post-translational modification plays a significant role in the regulation of multiple p53 signalling pathways. These results also...
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Biochem J (2002) 362 (3): 561–571.
Published: 08 March 2002
... is protective. Transfection or infection with JNK inhibitory mutants increased the rates of apoptosis by almost 2-fold compared with control cultures grown aerobically or subjected to hypoxia and reoxygenation. Caspase 9 activity, measured by LEHD cleavage, increased > 3-fold during reoxygenation...
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Biochem J (2001) 356 (2): 531–537.
Published: 24 May 2001
... in the HepII domain [peptide V, WQPPRARI (single-letter amino acid codes)], which has previously been implicated in cytoskeletal organization, rescued apoptotic changes. Consistently, pp125FAK phosphorylation was increased, and both cleavage of pp125FAK and activation of caspase 3 on FN120 were partly blocked...
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Biochem J (2000) 347 (3): 875–880.
Published: 25 April 2000
... of the caspase cascade. In this report, we show that addition of micromolar concentrations of polyamines to isolated rat heart mitochondria induces the release of cytochrome c . Spermine, which is effective at concentrations of 10-100 μ M, is more potent than spermidine, whereas putrescine has no effect up to 1...
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Biochem J (1999) 344 (2): 477–485.
Published: 24 November 1999
... that proteasome activities were the same in these two cell lines. At 24 h after treatment with 500 nM MG132, apoptosis in bcl-x L cells (22%) was less than that observed in control cells (34%). Concomitantly, caspase activity in control cells, as assessed by N -acetyl- L -aspartyl- L -glutamyl- L -valyl- L...