...Jean-Bernard Denault; Brendan P. Eckelman; Hwain Shin; Cristina Pop; Guy S. Salvesen During apoptosis, the initiator caspase 9 is activated at the apoptosome after which it activates the executioner caspases 3 and 7 by proteolysis. During this process, caspase 9 is cleaved by caspase 3 at Asp 330...

... the behaviour in differential and isopycnic centrifugation of β-galactosidase. Apoptosis was monitored by measuring caspase 3 activity (DEVDase) and the release of sulfite cytochrome c reductase, an enzyme located in the mitochondrial intermembrane space. Results show that an injection of 10 μg of aFas causes...

[email protected] ). 14 2 2006 27 4 2006 2 5 2006 2 5 2006 The Biochemical Society, London 2006 β3 integrin caspase 3 α-difluoromethylornithine (DFMO) intestinal epithelial cell polyamine Src Apoptosis is a genetically determined process of programmed cell...

... are presented as means±S.E.M. Statistical analyses were performed using ANOVA. A post hoc test was performed by the Tukey method. P <0.05 was considered to be statistically significant. cardiac myocyte casein kinase 2 caspase 3 H11 hypertrophy small heat-shock protein An important...

... is a substrate of the apoptosis-associated caspase 3 protease, and we therefore investigated whether the increased Aβ levels could reflect caspase activation. We report that caspase activation was not required for proteasome-inhibitor-mediated effects on APP (SPA4CT) processing. Cleavage of Ac-DEVD-AMC ( N...

..., the molecular signalling mechanisms linking iron, reactive oxygen species (ROS) and apoptosis are still unknown. We investigated these aspects using cerebellar granule neurons (CGNs) and human SH-SY5Y neuroblastoma cells. MPP + enhanced caspase 3 activity after 24h with significant increases as early as 12h...