... injection of the peptides prevented sodium-selenite-induced cataract formation in rats by inhibiting protein aggregation and oxidative stress. Our study has identified peptides from Hsp20 and Hsp27 that may have therapeutic benefit in diseases where protein aggregation and apoptosis are contributing factors...

...Paul Evans; Christine Slingsby; B. A. Wallace Age-related cataract is a result of crystallins, the predominant lens proteins, forming light-scattering aggregates. In the low protein turnover environment of the eye lens, the crystallins are susceptible to modifications that can reduce stability...

... various stress conditions. Non-enzymic glycation of long-lived proteins has been implicated in several age- and diabetes-related complications, including cataract. Dicarbonyl compounds such as methylglyoxal and glyoxal have been identified as the predominant source for the formation of advanced glycation...

...Hong YAN; Antony C. WILLIS; John J. HARDING Several mechanisms have been proposed for the way in which glucose and its metabolites cause cataract, retinopathy and other complications of diabetes, the most convincing being glycation. Glycation, the reaction of sugars with free amino groups...

.... 3 To whom correspondence should be addressed (e-mail [email protected] ). 19 1 2001 1 6 2001 14 6 2001 The Biochemical Society, London ©2001 2001 cataract epithelial-to-mesenchymal transformation TGF-β 1 transformation Abbreviations used: APMA, 4...