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Keywords: cathepsins
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Biochem J (2001) 359 (2): 335–343.
Published: 08 October 2001
... benzyloxycarbonyl-Val-Ala- d l -Asp-fluoromethylketone (‘Z-VAD-FMK’), although they did not by themselves inhibit caspases. We conclude that cathepsin D and one or more cysteine proteases, such as cathepsins B or L, are important mediators of sphingosine-induced apoptosis, working upstream of the caspase cascade...