1-50 of 82
Keywords: cell cycle
Close
Sort by
Articles
Biochem J (2022) 479 (20): 2153–2173.
Published: 21 October 2022
... are regulated through cell cycle dependent expression, chromatin localization, activation and inactivation through post-translational modifications, and through associations with each other, with other factors and with the chromatin template itself. There are still many open questions about how condensins...
Articles
Articles
Biochem J (2020) 477 (12): 2281–2293.
Published: 24 June 2020
...′-UTR sequence of OCT4 gene . Unlike in HCT116 cells, overexpression of miR-3658 in SW480 cells brought about growth inhibition, cell cycle arrest and reduced cell migration, detected by flow cytometry, and scratch test assay. Overall, these findings demonstrated that miR-3658 as a tumor suppressor...
Articles
Biochem J (2016) 473 (18): 2783–2798.
Published: 12 September 2016
... cell cycle by phosphorylating serine and threonine residues in key regulatory proteins, but some Cdk family members may exert kinase-independent functions that cannot easily be assessed using gene knockout approaches. While Cdk2-deficient mice display near-normal mitotic cell proliferation due...
Includes: Supplementary data
Articles
Articles
Biochem J (2016) 473 (3): 257–266.
Published: 25 January 2016
... stimulates growth factor-mediated hepatocyte proliferation in mice, at least in part, through inhibiting FOXO3 from accelerating cell-cycle progression. 1 These authors contributed equally to this work. 2 Current address: Department of Food Science and Technology, National Fisheries...
Includes: Supplementary data
Articles
Biochem J (2014) 461 (2): 233–245.
Published: 26 June 2014
... that NUAK1 and PLK1 are reciprocally controlled in the cell cycle. In G 2 –M-phase, when PLK1 is most active, NUAK1 levels are low and vice versa in S-phase, when PLK1 expression is low, NUAK1 is more highly expressed. Moreover, NUAK1 inhibitors (WZ4003 or HTH-01-015) suppress proliferation by reducing...
Includes: Supplementary data
Articles
Articles
Biochem J (2014) 457 (1): 69–77.
Published: 10 December 2013
... growth factor 1 receptor) are incompletely understood. We demonstrate that in L6 myoblasts expressing only IGF-IRs as well as in the same cells overexpressing the IR, IGF-I (insulin-like growth factor 1), insulin and X10 (AspB10 insulin) down-regulate the mRNA expression level of the cell cycle inhibitor...
Includes: Supplementary data
Articles
Biochem J (2014) 457 (1): 43–56.
Published: 10 December 2013
... expression causes a G 1 -phase cell-cycle arrest, but overexpression of CCND1 (wild-type or T286A) fails to overcome this; indeed, DYRK1B also promotes the expression of p21 CIP1 (21 kDa CDK-interacting protein 1) and p27 KIP1 (CDK-inhibitory protein 1). The results of the present study demonstrate...
Includes: Supplementary data
Articles
Biochem J (2013) 454 (2): 333–343.
Published: 09 August 2013
... Biochemical Society 2013 Cdc45 cell cycle DNA replication genome stability Mcm10 In eukaryotic systems, replication initiation is characterized by a multi-step sequential loading of many proteins on to the DNA. One key component of the DNA replication machinery is the pre-RC (pre-replication...
Includes: Supplementary data
Articles
Articles
Biochem J (2013) 451 (2): 135–143.
Published: 28 March 2013
... to generate all somatic cell types upon differentiation (pluripotency). Conditions have been defined in vitro in which pluripotency is maintained, or else differentiation is favoured and is directed towards specific somatic cell types. However, an unanswered question is whether or not the core cell cycle...
Articles
Biochem J (2013) 449 (2): 333–341.
Published: 14 December 2012
... for DNA binding thus oscillates during the cell cycle to peak at the time of initiation, and the rate at which the amount of DnaA–ATP increases during the cell cycle can affect the timing of initiation [ 1 , 14 ]. 1 To whom correspondence should be addressed (email [email protected]...
Includes: Supplementary data
Articles
Biochem J (2013) 449 (2): 365–371.
Published: 14 December 2012
... describe the generation of recombinant human APC/C (anaphase-promoting complex/cyclosome), an E3 ubiquitin ligase that regulates cell-cycle progression. Human APC/C is composed of 14 distinct proteins that assemble into a complex of at least 19 subunits with a combined molecular mass of ~1.2 MDa. We show...
Articles
Biochem J (2012) 446 (1): 1–7.
Published: 27 July 2012
...Salvador Moncada; E. Annie Higgs; Sergio L. Colombo The activity of key metabolic enzymes is regulated by the ubiquitin ligases that control the function of the cyclins; therefore the activity of these ubiquitin ligases explains the coordination of cell-cycle progression with the supply...
Articles
Biochem J (2012) 444 (3): 375–382.
Published: 29 May 2012
...Christopher Hindley; Anna Philpott During embryonic development, cells must divide to produce appropriate numbers, but later must exit the cell cycle to allow differentiation. How these processes of proliferation and differentiation are co-ordinated during embryonic development has been poorly...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2012) 443 (1): 13–26.
Published: 14 March 2012
... separation during mitosis. 1 To whom correspondence should be addressed (email [email protected] ). 30 11 2011 10 1 2012 11 1 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 cell cycle checkpoint DNA repair DNA helicase homologous...
Articles
Biochem J (2012) 442 (1): 139–149.
Published: 27 January 2012
... compilation © 2012 Biochemical Society 2012 apoptosis BAD Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) cell cycle cell proliferation Mammalian cells have an intricate network of signalling molecules to sense and interpret internal and external signals; the balance of these events...
Includes: Supplementary data
Articles
Biochem J (2011) 436 (1): 133–143.
Published: 27 April 2011
...Ivette Hernández-Negrete; Graciela B. Sala-Newby; Andras Perl; Gary R. Kunkel; Andrew C. Newby; Mark Bond Cell adhesion is essential for cell cycle progression in most normal cells. Loss of adhesion dependence is a hallmark of cellular transformation. The F-box protein Skp2 (S-phase kinase...
Includes: Supplementary data
Articles
Biochem J (2011) 435 (1): 17–31.
Published: 15 March 2011
... cell growth and in diseases such as cancers. 1 To whom correspondence should be addressed (email [email protected] ). 23 2 2010 11 1 2011 13 1 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 cell cycle kinase mitosis phosphatase...
Articles
Biochem J (2011) 435 (1): 175–185.
Published: 15 March 2011
...Amy L. Tien; Sucharita Senbanerjee; Atul Kulkarni; Raksha Mudbhary; Bernadette Goudreau; Shridar Ganesan; Kirsten C. Sadler; Chinweike Ukomadu UHRF1 [ubiquitin-like protein, containing PHD (plant homeodomain) and RING finger domains 1] is required for cell cycle progression and epigenetic...
Includes: Supplementary data
Articles
Biochem J (2011) 434 (2): 297–308.
Published: 11 February 2011
...Matthew J. Cecchini; Frederick A. Dick The pRB (retinoblastoma protein) has a central role in the control of the G 1 –S phase transition of the cell cycle that is mediated in part through the regulation of E2F transcription factors. Upon S-phase entry pRB is phosphorylated extensively, which...
Articles
Biochem J (2010) 431 (2): 169–178.
Published: 28 September 2010
.... Moreover, GSH recruitment and sequestration in the nucleus during the G 1 - and S-phases of the cell cycle has a profound impact on cellular redox homoeostasis and on gene expression. For example, the abundance of transcripts encoding stress and defence proteins is decreased when GSH is sequestered...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2010) 428 (1): 103–111.
Published: 28 April 2010
...Pierre-Luc Tanguay; Geneviève Rodier; Sylvain Meloche ERK3 (extracellular-signal-regulated kinase 3) is an atypical MAPK (mitogen-activated protein kinase) that is suggested to play a role in cell-cycle progression and cellular differentiation. However, it is not known whether the function of ERK3...
Includes: Supplementary data
Articles
Biochem J (2009) 424 (3): 367–374.
Published: 10 December 2009
...Despina Smirlis; Haralabia Boleti; Maria Gaitanou; Manuel Soto; Ketty Soteriadou Ran-GTPase regulates multiple cellular processes such as nucleocytoplasmic transport, mitotic spindle assembly, nuclear envelope assembly, cell-cycle progression and the mitotic checkpoint. The leishmanial Ran protein...
Includes: Supplementary data
Articles
Biochem J (2009) 419 (2): 457–466.
Published: 27 March 2009
... inflammation response syndrome) and MODS (multiple organ failure syndrome), post-severe trauma and burns. Thus we are interested in investigating the mechanism of CASK-mediated cell proliferation regulation in ECV304 cells, which are similar to the cell lines of HUVECs. cell cycle E2A E-box human...
Articles
Articles
Articles
Articles
Biochem J (2008) 410 (3): 535–542.
Published: 27 February 2008
...Ana Dinarina; E. Josué Ruiz; Ana O'loghlen; Silvana Mouron; Laurent Perez; Angel R. Nebreda Cell-cycle transitions are controlled by CDKs (cyclin-dependent kinases), whose activation is usually associated with the binding of cyclins. RINGO/Speedy proteins can also bind to and activate CDKs...
Articles
Articles
Articles
Biochem J (2007) 403 (1): 119–127.
Published: 13 March 2007
...Shen Kiat Lim; Ganesan Gopalan Mitotic Aurora-A is an oncogene, which undergoes a cell-cycle-dependent regulation of both its synthesis and degradation. Overexpression of Aurora-A leads to aneuploidy and cellular transformation in cultured cells. It has been shown that the cell-cycle-dependent...
Includes: Supplementary data
Articles
Articles
Articles
Articles
Biochem J (2006) 397 (2): 233–246.
Published: 28 June 2006
..., Hammersmith Campus, Du Cane Road, London W12 0NN, U.K. (email [email protected] ). 10 3 2006 4 5 2006 5 5 2006 The Biochemical Society, London 2006 cell cycle development forkhead Fox immunoregulation transcription factor Spatial and temporal gene...
Articles
Biochem J (2006) 396 (3): 547–556.
Published: 29 May 2006
... known as MAP3K5. Its mRNA expression is cell-cycle-regulated in human T98G cells released from serum starvation. Moreover, overexpression and RNA interference experiments support the requirement of endogenous E2F/DP (E2F dimerization partner) activity for ASK-1 expression. Characterization of the human...
Articles
Articles
Articles
Articles
Biochem J (2005) 388 (2): 705–712.
Published: 24 May 2005
...Catriona A. L. CLARKE; Paul R. CLARKE Cell-cycle checkpoints induced by DNA damage or replication play critical roles in the maintenance of genomic integrity during cell proliferation. Biochemical analysis of checkpoint pathways has been greatly facilitated by the use of cell-free systems made from...
Articles
Biochem J (2005) 388 (1): 185–194.
Published: 10 May 2005
...Mário GRÃOS; Alexandra D. ALMEIDA; Sukalyan CHATTERJEE The regulation of survival and cell death is a key determinant of cell fate. Recent evidence shows that survival and death machineries are regulated along the cell cycle. In the present paper, we show that BimEL [a BH3 (Bcl-2 homology 3)-only...
Articles
Biochem J (2005) 387 (3): 659–667.
Published: 26 April 2005
.... In the present study, we show a cell-cycle-regulatory role of Mcl-1 involving a shortened form of the Mcl-1 polypeptide, primarily localized to the nucleus, which we call snMcl-1. snMcl-1 interacts with the cell-cycle-regulatory protein Cdk1 (cyclin-dependent kinase 1; also known as cdc2) in the nucleus...
Articles
Biochem J (2005) 387 (1): 257–269.
Published: 22 March 2005
...Anupama SINHA; Douglas V. FALLER; Gerald V. DENIS Cyclin A is regulated primarily through transcription control during the mammalian cell cycle. A dual mechanism of cyclin A transcriptional repression involves, on the one hand, promoter-bound inhibitory complexes of E2F transcription factors and RB...
Articles
Biochem J (2005) 386 (2): 349–355.
Published: 22 February 2005
...Ana DINARINA; Laurent H. PEREZ; Amparo DAVILA; Markus SCHWAB; Tim HUNT; Angel R. NEBREDA Progression through the cell cycle is regulated by CDKs (cyclin-dependent kinases), which associate with activating partners, named cyclins, to efficiently phosphorylate substrates. We previously reported...
Articles
Biochem J (2005) 386 (1): 1–13.
Published: 08 February 2005
... ). 18 8 2004 5 10 2004 2 11 2004 2 11 2004 The Biochemical Society, London 2005 cell cycle checkpoint kinetochore mitotic exit spindle Almost a century ago, it was recognized that the segregation of chromosomes from mother to daughter cells constituted the basis...
Articles
Biochem J (2004) 384 (2): 317–326.
Published: 23 November 2004
..., London 2004 CCAAT-binding factor/nuclear factor-Y (CBF/NF-Y) CCAAT box cell cycle histone H3 gene promoter structure transcriptional regulation Reporter gene assays were performed with the Dual-Luciferase® Reporter Assay system (Promega, Madison, WI, U.S.A.). Promoter fragments were...
Articles
Biochem J (2004) 383 (1): 27–35.
Published: 24 September 2004
... nucleocytoplasmic shuttling. During the cell cycle, EEN/EA2 shows dynamic localization: it is perichromosomal in prometaphase, co-localizes with the bipolar spindle in metaphase and anaphase and redistributes to the midzone and midbody in telophase. This pattern of distribution coincides with changes in protein...